Insecticide Mode of Action ClassificationCropLife, SA, IRAC working group

Acetylcholine esterase inhibitors

GABA – gated chloride channel antagonists

Sodium channel modulatorsNicotinic Acetylcholine receptor agonists/antagonists

Nicotinic Acetylcholine receptor agonists (not group 4)Chloride channel activatorsJuvenile hormone mimics

Compounds of unknown or non-specificmode of action (fumigants)

Compounds of unknown or non-specific mode of action(selective feeding blockers)

Compounds of unknown or non-specific mode of action(mite growth inhibitors)Microbial disruptors of insect midgut membranes (includestransgenic crops expressing Bacillus thuringiensis toxins)

Inhibitors of oxidative phosphorylation disruptors of ATPformationUncoupler of oxidative phosphorylation via disruption ofH proton gradientInhibition of mitochondrial ATPaseInhibitors of chitin biosynthesis, type O, LepidopteranInhibitors of chitin biosynthesis, type 1, HomopteranInhibitors of chitin biosynthesis, type 2, DipteranEcdysone agonist / disruptorOctopaminergic agonistSite 11 electron transport inhibitorsSite 1 electron transport inhibitorsVoltage-dependent sodium channel blockerInhibitors of lipid synthesisSite 111 electron transport inhibitorsUnknown mode of action

CarbamatesOrganophosphatesCyclodiene organochlorinesFipronil (or Phenylpyrazoles?)Pyrethroids, Pyrethrins, DDTNeonicotinoidsNicotineCartap, BensultapSpinosynsAvermectins, MilbemycinsJuvenile hormone analoguesFenoxcarbPyriproxyfenMethyl bromideAluminium phosphideSulfuryl fluorideCryolitePymetrozineFlonicamidClofentezine, HexythiazoxEtoxazoleBacillus thuringiensis var. israelensisBacillus thuringiensis var. sphaericusBacillus thuringiensis var. aizawaiBacillus thuringiensis var. kurstakiBacillus thuringiensis var. tenebrionensisDiafenthiuronOrganotin miticidesChlorfenapyr, DNOC

PropargiteBenzoylureasBuprofezinCyromazineDiacylhydrazinesAmitrazHydramethylnon, DicofolMETI acaricides, RotenoneIndoxacarbTetronic acid derivativesAcequinocyl, FluacrypyrimAzadirachtin, Bifenazate

1*

2*

34*

567*

8*

9*

10*

11*

12*

13

141516171819202122232425

ABAB

ABC

ABCABCABCABA1A2B1B2CAB

Primary Target Site of Action Chemical Sub Group orrepresentative Active Ingredient

SubGroupGroup

Each product label identifies the Insecticide Group Code on the front panel. The insecticides are allocated to specificgroups based on their target site. An effective resistance management strategy seeks to minimise the selection forresistance for any one product. To achieve this objective :• Avoid exclusive repeated use of insecticides from the same Insecticide Group Code• Alternate or tank mix with products from different Insecticide Group Codes.• Integrate other control methods (chemical, cultural or biological) into insect control programmes.

Use Mode of Action wisely for good Insecticide Resistance Management, IRM.

Syngenta Logo

Insecticide Mode of Action ClassificationCropLife, SA, IRAC working group

Acetylcholine esterase inhibitors

GABA – gated chloride channel antagonists

Sodium channel modulatorsNicotinic Acetylcholine receptor agonists/antagonists

Nicotinic Acetylcholine receptor agonists (not group 4)Chloride channel activatorsJuvenile hormone mimics

Compounds of unknown or non-specificmode of action (fumigants)

Compounds of unknown or non-specific mode of action(selective feeding blockers)

Compounds of unknown or non-specific mode of action(mite growth inhibitors)Microbial disruptors of insect midgut membranes (includestransgenic crops expressing Bacillus thuringiensis toxins)

Inhibitors of oxidative phosphorylation disruptors of ATPformationUncoupler of oxidative phosphorylation via disruption ofH proton gradientInhibition of mitochondrial ATPaseInhibitors of chitin biosynthesis, type O, LepidopteranInhibitors of chitin biosynthesis, type 1, HomopteranInhibitors of chitin biosynthesis, type 2, DipteranEcdysone agonist / disruptorOctopaminergic agonistSite 11 electron transport inhibitorsSite 1 electron transport inhibitorsVoltage-dependent sodium channel blockerInhibitors of lipid synthesisSite 111 electron transport inhibitorsUnknown mode of action

CarbamatesOrganophosphatesCyclodiene organochlorinesFipronil (or Phenylpyrazoles?)Pyrethroids, Pyrethrins, DDTNeonicotinoidsNicotineCartap, BensultapSpinosynsAvermectins, MilbemycinsJuvenile hormone analoguesFenoxcarbPyriproxyfenMethyl bromideAluminium phosphideSulfuryl fluorideCryolitePymetrozineFlonicamidClofentezine, HexythiazoxEtoxazoleBacillus thuringiensis var. israelensisBacillus thuringiensis var. sphaericusBacillus thuringiensis var. aizawaiBacillus thuringiensis var. kurstakiBacillus thuringiensis var. tenebrionensisDiafenthiuronOrganotin miticidesChlorfenapyr, DNOC

PropargiteBenzoylureasBuprofezinCyromazineDiacylhydrazinesAmitrazHydramethylnon, DicofolMETI acaricides, RotenoneIndoxacarbTetronic acid derivativesAcequinocyl, FluacrypyrimAzadirachtin, Bifenazate

1*

2*

34*

567*

8*

9*

10*

11*

12*

13

141516171819202122232425

ABAB

ABC

ABCABCABCABA1A2B1B2CAB

Primary Target Site of Action Chemical Sub Group orrepresentative Active Ingredient

SubGroupGroup

Each product label identifies the Insecticide Group Code on the front panel. The insecticides are allocated to specificgroups based on their target site. An effective resistance management strategy seeks to minimise the selection forresistance for any one product. To achieve this objective :• Avoid exclusive repeated use of insecticides from the same Insecticide Group Code• Alternate or tank mix with products from different Insecticide Group Codes.• Integrate other control methods (chemical, cultural or biological) into insect control programmes.

Use Mode of Action wisely for good Insecticide Resistance Management, IRM. Syngenta Logo

Insecticide Mode of Action ClassificationCropLife, SA, IRAC working group

Acetylcholine esterase inhibitors

GABA – gated chloride channel antagonists

Sodium channel modulatorsNicotinic Acetylcholine receptor agonists/antagonists

Nicotinic Acetylcholine receptor agonists (not group 4)Chloride channel activatorsJuvenile hormone mimics

Compounds of unknown or non-specificmode of action (fumigants)

Compounds of unknown or non-specific mode of action(selective feeding blockers)

Compounds of unknown or non-specific mode of action(mite growth inhibitors)Microbial disruptors of insect midgut membranes (includestransgenic crops expressing Bacillus thuringiensis toxins)

Inhibitors of oxidative phosphorylation disruptors of ATPformationUncoupler of oxidative phosphorylation via disruption ofH proton gradientInhibition of mitochondrial ATPaseInhibitors of chitin biosynthesis, type O, LepidopteranInhibitors of chitin biosynthesis, type 1, HomopteranInhibitors of chitin biosynthesis, type 2, DipteranEcdysone agonist / disruptorOctopaminergic agonistSite 11 electron transport inhibitorsSite 1 electron transport inhibitorsVoltage-dependent sodium channel blockerInhibitors of lipid synthesisSite 111 electron transport inhibitorsUnknown mode of action

CarbamatesOrganophosphatesCyclodiene organochlorinesFipronil (or Phenylpyrazoles?)Pyrethroids, Pyrethrins, DDTNeonicotinoidsNicotineCartap, BensultapSpinosynsAvermectins, MilbemycinsJuvenile hormone analoguesFenoxcarbPyriproxyfenMethyl bromideAluminium phosphideSulfuryl fluorideCryolitePymetrozineFlonicamidClofentezine, HexythiazoxEtoxazoleBacillus thuringiensis var. israelensisBacillus thuringiensis var. sphaericusBacillus thuringiensis var. aizawaiBacillus thuringiensis var. kurstakiBacillus thuringiensis var. tenebrionensisDiafenthiuronOrganotin miticidesChlorfenapyr, DNOC

PropargiteBenzoylureasBuprofezinCyromazineDiacylhydrazinesAmitrazHydramethylnon, DicofolMETI acaricides, RotenoneIndoxacarbTetronic acid derivativesAcequinocyl, FluacrypyrimAzadirachtin, Bifenazate

1*

2*

34*

567*

8*

9*

10*

11*

12*

13

141516171819202122232425

ABAB

ABC

ABCABCABCABA1A2B1B2CAB

Primary Target Site of Action Chemical Sub Group orrepresentative Active Ingredient

SubGroupGroup

Each product label identifies the Insecticide Group Code on the front panel. The insecticides are allocated to specificgroups based on their target site. An effective resistance management strategy seeks to minimise the selection forresistance for any one product. To achieve this objective :• Avoid exclusive repeated use of insecticides from the same Insecticide Group Code• Alternate or tank mix with products from different Insecticide Group Codes.• Integrate other control methods (chemical, cultural or biological) into insect control programmes.

Use Mode of Action wisely for good Insecticide Resistance Management, IRM. Syngenta Logo

Insecticide Mode of Action ClassificationCropLife, SA, IRAC working group

Acetylcholine esterase inhibitors

GABA – gated chloride channel antagonists

Sodium channel modulatorsNicotinic Acetylcholine receptor agonists/antagonists

Nicotinic Acetylcholine receptor agonists (not group 4)Chloride channel activatorsJuvenile hormone mimics

Compounds of unknown or non-specificmode of action (fumigants)

Compounds of unknown or non-specific mode of action(selective feeding blockers)

Compounds of unknown or non-specific mode of action(mite growth inhibitors)Microbial disruptors of insect midgut membranes (includestransgenic crops expressing Bacillus thuringiensis toxins)

Inhibitors of oxidative phosphorylation disruptors of ATPformationUncoupler of oxidative phosphorylation via disruption ofH proton gradientInhibition of mitochondrial ATPaseInhibitors of chitin biosynthesis, type O, LepidopteranInhibitors of chitin biosynthesis, type 1, HomopteranInhibitors of chitin biosynthesis, type 2, DipteranEcdysone agonist / disruptorOctopaminergic agonistSite 11 electron transport inhibitorsSite 1 electron transport inhibitorsVoltage-dependent sodium channel blockerInhibitors of lipid synthesisSite 111 electron transport inhibitorsUnknown mode of action

CarbamatesOrganophosphatesCyclodiene organochlorinesFipronil (or Phenylpyrazoles?)Pyrethroids, Pyrethrins, DDTNeonicotinoidsNicotineCartap, BensultapSpinosynsAvermectins, MilbemycinsJuvenile hormone analoguesFenoxcarbPyriproxyfenMethyl bromideAluminium phosphideSulfuryl fluorideCryolitePymetrozineFlonicamidClofentezine, HexythiazoxEtoxazoleBacillus thuringiensis var. israelensisBacillus thuringiensis var. sphaericusBacillus thuringiensis var. aizawaiBacillus thuringiensis var. kurstakiBacillus thuringiensis var. tenebrionensisDiafenthiuronOrganotin miticidesChlorfenapyr, DNOC

PropargiteBenzoylureasBuprofezinCyromazineDiacylhydrazinesAmitrazHydramethylnon, DicofolMETI acaricides, RotenoneIndoxacarbTetronic acid derivativesAcequinocyl, FluacrypyrimAzadirachtin, Bifenazate

1*

2*

34*

567*

8*

9*

10*

11*

12*

13

141516171819202122232425

ABAB

ABC

ABCABCABCABA1A2B1B2CAB

Primary Target Site of Action Chemical Sub Group orrepresentative Active Ingredient

SubGroupGroup

Each product label identifies the Insecticide Group Code on the front panel. The insecticides are allocated to specificgroups based on their target site. An effective resistance management strategy seeks to minimise the selection forresistance for any one product. To achieve this objective :• Avoid exclusive repeated use of insecticides from the same Insecticide Group Code• Alternate or tank mix with products from different Insecticide Group Codes.• Integrate other control methods (chemical, cultural or biological) into insect control programmes.

Use Mode of Action wisely for good Insecticide Resistance Management, IRM. Syngenta Logo

Insecticide Mode of Action ClassificationCropLife, SA, IRAC working group

Acetylcholine esterase inhibitors

GABA – gated chloride channel antagonists

Sodium channel modulatorsNicotinic Acetylcholine receptor agonists/antagonists

Nicotinic Acetylcholine receptor agonists (not group 4)Chloride channel activatorsJuvenile hormone mimics

Compounds of unknown or non-specificmode of action (fumigants)

Compounds of unknown or non-specific mode of action(selective feeding blockers)

Compounds of unknown or non-specific mode of action(mite growth inhibitors)Microbial disruptors of insect midgut membranes (includestransgenic crops expressing Bacillus thuringiensis toxins)

Inhibitors of oxidative phosphorylation disruptors of ATPformationUncoupler of oxidative phosphorylation via disruption ofH proton gradientInhibition of mitochondrial ATPaseInhibitors of chitin biosynthesis, type O, LepidopteranInhibitors of chitin biosynthesis, type 1, HomopteranInhibitors of chitin biosynthesis, type 2, DipteranEcdysone agonist / disruptorOctopaminergic agonistSite 11 electron transport inhibitorsSite 1 electron transport inhibitorsVoltage-dependent sodium channel blockerInhibitors of lipid synthesisSite 111 electron transport inhibitorsUnknown mode of action

CarbamatesOrganophosphatesCyclodiene organochlorinesFipronil (or Phenylpyrazoles?)Pyrethroids, Pyrethrins, DDTNeonicotinoidsNicotineCartap, BensultapSpinosynsAvermectins, MilbemycinsJuvenile hormone analoguesFenoxcarbPyriproxyfenMethyl bromideAluminium phosphideSulfuryl fluorideCryolitePymetrozineFlonicamidClofentezine, HexythiazoxEtoxazoleBacillus thuringiensis var. israelensisBacillus thuringiensis var. sphaericusBacillus thuringiensis var. aizawaiBacillus thuringiensis var. kurstakiBacillus thuringiensis var. tenebrionensisDiafenthiuronOrganotin miticidesChlorfenapyr, DNOC

PropargiteBenzoylureasBuprofezinCyromazineDiacylhydrazinesAmitrazHydramethylnon, DicofolMETI acaricides, RotenoneIndoxacarbTetronic acid derivativesAcequinocyl, FluacrypyrimAzadirachtin, Bifenazate

1*

2*

34*

567*

8*

9*

10*

11*

12*

13

141516171819202122232425

ABAB

ABC

ABCABCABCABA1A2B1B2CAB

Primary Target Site of Action Chemical Sub Group orrepresentative Active Ingredient

SubGroupGroup

Each product label identifies the Insecticide Group Code on the front panel. The insecticides are allocated to specificgroups based on their target site. An effective resistance management strategy seeks to minimise the selection forresistance for any one product. To achieve this objective :• Avoid exclusive repeated use of insecticides from the same Insecticide Group Code• Alternate or tank mix with products from different Insecticide Group Codes.• Integrate other control methods (chemical, cultural or biological) into insect control programmes.

Use Mode of Action wisely for good Insecticide Resistance Management, IRM. Syngenta Logo

Insecticide Mode of Action ClassificationCropLife, SA, IRAC working group

Acetylcholine esterase inhibitors

GABA – gated chloride channel antagonists

Sodium channel modulatorsNicotinic Acetylcholine receptor agonists/antagonists

Nicotinic Acetylcholine receptor agonists (not group 4)Chloride channel activatorsJuvenile hormone mimics

Compounds of unknown or non-specificmode of action (fumigants)

Compounds of unknown or non-specific mode of action(selective feeding blockers)

Compounds of unknown or non-specific mode of action(mite growth inhibitors)Microbial disruptors of insect midgut membranes (includestransgenic crops expressing Bacillus thuringiensis toxins)

Inhibitors of oxidative phosphorylation disruptors of ATPformationUncoupler of oxidative phosphorylation via disruption ofH proton gradientInhibition of mitochondrial ATPaseInhibitors of chitin biosynthesis, type O, LepidopteranInhibitors of chitin biosynthesis, type 1, HomopteranInhibitors of chitin biosynthesis, type 2, DipteranEcdysone agonist / disruptorOctopaminergic agonistSite 11 electron transport inhibitorsSite 1 electron transport inhibitorsVoltage-dependent sodium channel blockerInhibitors of lipid synthesisSite 111 electron transport inhibitorsUnknown mode of action

CarbamatesOrganophosphatesCyclodiene organochlorinesFipronil (or Phenylpyrazoles?)Pyrethroids, Pyrethrins, DDTNeonicotinoidsNicotineCartap, BensultapSpinosynsAvermectins, MilbemycinsJuvenile hormone analoguesFenoxcarbPyriproxyfenMethyl bromideAluminium phosphideSulfuryl fluorideCryolitePymetrozineFlonicamidClofentezine, HexythiazoxEtoxazoleBacillus thuringiensis var. israelensisBacillus thuringiensis var. sphaericusBacillus thuringiensis var. aizawaiBacillus thuringiensis var. kurstakiBacillus thuringiensis var. tenebrionensisDiafenthiuronOrganotin miticidesChlorfenapyr, DNOC

PropargiteBenzoylureasBuprofezinCyromazineDiacylhydrazinesAmitrazHydramethylnon, DicofolMETI acaricides, RotenoneIndoxacarbTetronic acid derivativesAcequinocyl, FluacrypyrimAzadirachtin, Bifenazate

1*

2*

34*

567*

8*

9*

10*

11*

12*

13

141516171819202122232425

ABAB

ABC

ABCABCABCABA1A2B1B2CAB

Primary Target Site of Action Chemical Sub Group orrepresentative Active Ingredient

SubGroupGroup

Each product label identifies the Insecticide Group Code on the front panel. The insecticides are allocated to specificgroups based on their target site. An effective resistance management strategy seeks to minimise the selection forresistance for any one product. To achieve this objective :• Avoid exclusive repeated use of insecticides from the same Insecticide Group Code• Alternate or tank mix with products from different Insecticide Group Codes.• Integrate other control methods (chemical, cultural or biological) into insect control programmes.

Use Mode of Action wisely for good Insecticide Resistance Management, IRM. Syngenta Logo