40324512 Tmd175 Slide Pharmacology of Antifungi Anthelminthics Antiprotozoal
modification and antiprotozoal activity Adamantylated ... · 1 Adamantylated organosilatranes:...
Transcript of modification and antiprotozoal activity Adamantylated ... · 1 Adamantylated organosilatranes:...
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Adamantylated organosilatranes: Design, synthesis and potential appraisal in surface
modification and antiprotozoal activity
Gurjaspreet Singha,*, Sunita Rania, Sanchita Gawria, Shweta Sinhab, Rakesh Sehgalb
a Department of Chemistry, Panjab University, Chandigarh, 160014, India
b Department of Medical Parasitology, Research Block-A, PGIMER, Chandigarh, 160012,
India
Table of contents
Entry Page No.
[1H, 13C]NMR and mass spectra of 1 2-3
[1H, 13C]NMR and mass spectra of 2 3-4
[1H, 13C]NMR and mass spectra of 3 5-6
[1H, 13C]NMR and mass spectra of 4 6-7
[1H, 13C]NMR and mass spectra of 5 8-9
[1H, 13C]NMR and mass spectra of 6 9-10
[1H, 13C]NMR and mass spectra of 7 11-12
FT-IR spectra of Fe3O4 (A) and Fe3O4@SiO2
(B) 12
Zeta potential of Ad-HNPs13
Electronic Supplementary Material (ESI) for New Journal of Chemistry.This journal is © The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2017
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Figure S1. 1H NMR spectrum of 1
Figure S2. 13C NMR spectrum of 1
3
WATERS, Q-TOF MICROMASS (ESI-MS) SAIF/CIL,PANJAB UNIVERSITY,CHANDIGARH
m/z100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 950 1000
%
0
100SUNITA ADE-1 8 (0.148) TOF MS ES+
4.09e3395.18074085
215.0833794
174.0474777
396.05253795
417.20422125
811.4274776
418.1696478 812.4404
371
HN SiO
OO
N
O1
Figure S3. Mass spectrum of 1
Figure S4. 1H NMR spectrum of 2
4
Figure S5. 13C NMR spectrum of 2
WATERS, Q-TOF MICROMASS (LC-MS) SAIF/CIL,PANJAB UNIVERSITY,CHANDIGARH
m/z100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 950 1000
%
0
100SUNITA S-5 12 (0.135) Sm (SG, 2x3.00); Cm (8:39) TOF MS ES+
2.31e3413.12311
150.01996
84.9561
148.9381
116.9292
103.073
287.5639
157.9447
233.0343180.9
287
283.0323
258.0114
288.0336
304.0275
342.0213
326.195
451.01663
414.1989
847.11326
452.0672
497.0494
453.0381
454.0122
638.0417
529.0219
584.196
562.193
844.5395
825.1304
645.1302
738.2138
754.197
863.11295
864.1846
865.1513
909.1253
866.1229
S SiO
OO
N
O2
Figure S6. Mass spectrum of 2
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Figure S7. 1H NMR spectrum of 3
Figure S8. 13C NMR spectrum of 3
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WATERS, Q-TOF MICROMASS (LC-MS) SAIF/CIL,PANJAB UNIVERSITY,CHANDIGARH
m/z100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 950 1000
%
0
100PROMILA MA-1 26 (0.291) Cm (8:40) TOF MS ES+
1.20e4462.311977
216.18025
234.22427
248.21590
463.32971
464.3639
NH
O
HN SiO
OO
N
O
3
Figure S9. Mass spectrum of 3
Figure S10. 1H NMR spectrum of 4
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Figure S11. 13C NMR spectrum of 4
m/z100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 950 1000
%
0
100SUNITA L-1 21 (0.305) Cm (8:31) TOF MS ES+
2.27e4492.222729
470.314724
508.221153
509.27883
510.22041
961.5988
NH
O
HN SiO
OO
NS
4
Figure S12. Mass spectrum of 4
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Figure S13. 1H NMR spectrum of 5
Figure S14. 13C NMR spectrum of 5
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WATERS, Q-TOF MICROMASS (LC-MS) SAIF/CIL,PANJAB UNIVERSITY,CHANDIGARH
m/z150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 950 1000
%
0
100SUNITA S-6 17 (0.191) Sm (SG, 2x3.00); Cm (7:45) TOF MS ES+
6.13e3455.06126
192.11992
148.9588
116.9377
295.01587248.0
1413
216.0424
279.0535
346.11494
295.5658
368.1936
369.0263 419.6
245
477.14597 931.2
4432
701.22169
478.12164
539.01042
493.1756
523.1341
693.5396
540.0385 571.1
305 646.6258
928.52054
701.42028
909.31438
822.3727
874.2222
932.33070
933.31553
993.2681947.2
423
NH
O
S SiO
OO
NO
5
Figure S15. Mass spectrum of 5
Figure S16. 1H NMR spectrum of 6
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Figure S17. 13C NMR spectrum of 6
WATERS, Q-TOF MICROMASS (LC-MS) SAIF/CIL,PANJAB UNIVERSITY,CHANDIGARH
m/z100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 950 1000 1050 1100 1150
%
0
100AMANDEEP A-5 12 (0.134) Cm (7:40) TOF MS ES+
1.20e4470.111977
448.26418
275.62667
243.61652
143.0100391.1
751144.1;386
259.61042
396.11657
276.1876
315.1368
404.21542
405.2429
690.74869
471.24083
486.22185
532.11670
487.2591
682.8654533.2
499
691.34157
691.82640 917.4
2622
692.31022
918.41328
979.4618
919.4508
NH
O
S SiO
OO
NS
6
Figure S18. Mass spectrum of 6
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Figure S19. 1H NMR spectrum of 7
Figure S20. 13C NMR spectrum of 7
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WATERS, Q-TOF MICROMASS (LC-MS) SAIF/CIL,PANJAB UNIVERSITY,CHANDIGARH
m/z100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 950 1000
%
0
100AMANDEEP MA-5- 13 (0.145) Cm (12:22) TOF MS ES+
8.97e3478.28967
216.15192
192.21377
174.2531
149.0446
234.13174
301.12477
275.21317
235.1519
419.2618302.2
424
479.23483
752.41308500.2
1206
510.3398 560.2
309
753.4624
754.4;279
O
O NNN
SiO
OO
N
7
Figure S21. Mass spectrum of 7
Figure S22. FT-IR spectra of Fe3O4 (A) and Fe3O4@SiO2 (B)
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Figure S23. Zeta potential of Ad-HNPs