Modern Medical Imaging :The exemple of NMR

Pierre G. Carlier and Paulo Loureiro de Sousa

NMR Laboratory,Institute of Myology and CEA,

Pitié-Salpêtrière University Hospital, Parisp.carlier@institut-myologie.orgp.loureiro@institut-myologie.org

NMR

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?IRM

MR

MRI"spectro"

NMR

RMNSpectro RMN

Spectro IRM

fMRI

MRSNMRS

IRMf

H2O, CH2, CH3

1H NMR

NMR Imaging

NMR Spectroscopy

1H : myoglobin, creatine, lactate, carnosine, acyl-carnitine

31P : ATP, Pcreatine, Pi, pH23Na : viability13C : glycogen, Krebs cycle

AnatomyMorphometryLesion DetectionStaging, T1, T2

v, f, D, T, k,

Flow, Kinematics, ContractilityPerfusionDiffusion, Temperature, viscosityChemical or Site exchangeMagnetic Environment, Chemical Moiety

Functional NMR ImagingNMR Spectroscopy

1H : myoglobin, creatine, lactate, carnosine, acyl-carnitine

31P : ATP, Pcreatine, Pi, pH23Na : viability13C : glycogen, Krebs cycle

v, f, D, T, k,

Flow, Kinematics, ContractilityPerfusionDiffusion, Temperature, viscosityChemical or Site exchangeMagnetic Environment, Chemical Moiety

H2O, CH2, CH3

1H NMR

NMR Imaging

AnatomyMorphometryLesion DetectionStaging, T1, T2

Crosse de l’aorte

Tronc artériel brachio-céphalique

Artère sous-clavière droite

Carotide primitive droite

Artère sous-clavière gauche

Carotide primitive gauche

Artère vertébrale gauche

Artère vertébrale droite

Carotide interne gauche

Carotide externe gauche

Carotide externe gauche et ses branches

H2O, CH2, CH3

1H NMR

NMR Imaging

NMR Spectroscopy1H : myoglobin, creatine, lactate,

carnosine, acyl-carnitine31P : ATP, Pcreatine, Pi, pH23Na : viability13C : glycogen, Krebs cycle

AnatomyMorphometryLesion DetectionStaging, T1, T2

v, f, D, T, k,

Flow, Kinematics, ContractilityPerfusionDiffusion, Temperature, viscosityChemical or Site exchangeMagnetic Environment, Chemical Moiety

AnatomyAnatomy

BiochemistryBiochemistry

PhysiologyPhysiology

# IMAGING

# FUNCTIONAL IMAGING

# SPECTROSCOPY or METABOLIC IMAGING

NMR