Adverse  Childhood  Experiences  

(ACEs)  

Autonomic    Dysregula1on  

Allosta1c    Load  

Telomerase  Telemeres  

ROS,  CASP9,  CREB,  Bcl2  etc.  

Apoptosis  Regulators  

Cell  Markers  of    Cell  Health    and  Self  

Removal  of    Healthy  Cells  

Neuroplas1c    Immunofunc1ons    

Neuroplas1c  Changes  

Remove  Brake  On  Plas1city  

Increase  Rate    of  Brain  Tissue    Change  

Glial  Func1oning  •     Glutamate  Reuptake  •     Immune  Barrior  •     Synap1c  Plas1city  •     Apop1c  Signal  

Rapid  Tissue    Loss  

Cell  Repair  Cycles  •  Neurogenesis    •  LTP  •  Cell  Repair  

Lesion    Regrowth  

Metabolic  Changes  

(e.g.  Sugar/Insulin,    Mitochondria  fxn)  

Model  of  Mul1ple  Sclerosis  

Balance    

Decrease  Cell  Replacement  And  Reduced  Cell  Health  

Gene1c  &  Other    Factors