MMX™Multi Matrix System

Presentation

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Disclaimer

Important Notice For the use of the recipient only. Not to be copied or distributed to any other person.

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Drug Delivery Platform

New oral delivery technology Designed for off-patent drugs Focus on inflammatory bowel diseases Scaleable/low cost of goods

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Gastroprotectant layer LV hydrophilic - amphipatic polymer matrix HV hydrophilic polym. matrix inert matrix material

drug (+ excipient)

The Drug Delivery Platform

Multi Matrix System™ (MMX ™)

Inert matrix

Hydrophilicmatrix

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stomach

Duodenum Dejunum

Ileum Colon

MMX™ - Release of active ingredient

Time

%

6enemas MMX ™ tablets

Site of action

Oral dosage forms

IBD medications: sites of actionMMX™ tablets vs. other dosage forms

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10h trasverse colon

3h 30’ ileum 4h 30’ ascending colon

7h 30’ trasverse colon 15h descending colon

1h 30’ small intestine

8 16h descending colon 24h rectum

MMX™

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II

1

10

100

1000

10000

0 2 4 6 8 10 12 14 16 18 20 22 24

Time (h)

Pla

sma c

once

ntr

ati

on (

ng/m

L) TC

SC

DC

AC IL

SI

MMX™Low absorption after single dose administration in Drug (•) and Metabolite (o)