Mitosis

A Sequencing Activity

Prometaphase

• The nuclear membrane dissolves

• Proteins attach to the centromeres creating the kinetochores.

• Microtubules attach at the kinetochores and the chromosomes begin moving.

Interphase

• Interphase is the "holding" stage or the stage between two successive cell divisions. DNA replicates, the centrioles divide, and proteins are actively produced.

Prophase

• Chromatin in the nucleus begins to condense and becomes visible in the light microscope as chromosomes.

• The nucleolus disappears.

• Centrioles begin moving to opposite ends of the cell and fibers extend from the centromeres.

Anaphase

• Attachments between the two sister chromatids of each chromosome break and are now separate chromosomes that move to opposite spindle poles.

Telophase

• Lastly, the chromosomes decondense.

• New patches of membrane fuse to form new nuclear envelopes around them.

Metaphase

• The microtubules penetrate the nuclear region and form a spindle apparatus. They attach to sister chromatids of each chromosome.

• All the chromosomes line up at the equator of the spindle.