University of Toronto

Cardiovascular Sciences Collaborative Program

ANNUAL REPORT

2001 – 2002

FitzGerald Bldg., 150 College Street, Room 83D, Toronto ON M5S 3E2Tel: 416/978-0746 Fax: 416/946-5713 E-mail: cv.program@utoronto.caWeb site: www.cscp.utoronto.ca

CONTENTS

DIRECTOR’S REPORT

MISSION STATEMENT

COLLABORATING DEPARTMENTS

COMMITTEES- Executive- Program- Student

COURSES OFFERED

PROGRAM SPONSORED ACTIVITIES- Annual Student Research Day- Debate Night- Human Biology Job Fair- Summer Activities

AWARDS- Medtronic Travel Award- Bigelow Book Prize- Lorne Phenix Graduate Award- Ontario Student Opportunity Trust Funds (OSOTF) Award- Life Sciences Committee Summer Undergraduate Research Fellowships

ADVERTISING MATERIAL

FUTURE DIRECTION

STUDENTS- Currently Enrolled- Convocated/Follow-Up- Awards

FACULTY- Members- Awards and Honors- Peer Reviewed Funding

PUBLICATIONS- Students- Faculty

ACKNOWLEDGEMENTS

DIRECTOR’S REPORT

The Cardiovascular Sciences Collaborative Program (CSCP) was officially established and recognized by Governing Council of the University of Toronto in 1992 and underwent its 7-year review in 1999 where it received a resounding endorsement from the Ontario Council of Graduate Schools. Cardiovascular sciences has a rich and illustrious history at the University of Toronto. Some achievements include contributions to the discovery of atrial natriuretic factor (ANF), the first clinical use of heparin and more recently the use of gene therapy to treat heart disease. Faculty were among the first to perform successful open heart surgery and implement the use of hypothermia to protect hearts during surgery. In order to further encourage graduate training in such a rich environment, the CSCP was created as an interdisciplinary graduate training program which also crosses departments and Faculties, thus permitting cross-fertilization of our student trainees. As each year passes I believe that the Cardiovascular Sciences Collaborative Program becomes a more important link for the students. I am proud to present this Annual Report which summarizes the achievements of the Program and its students and faculty over the past academic year.

StudentsIn this academic year we had 26 Masters and 14 PhD trainees active in the Program (see graph below). We also had a number of our trainees who completed and convocated. The PhD category was counterbalanced by new recruits while at the MSc level enrolment exceeded the convocated numbers. This is a reflection of initiatives focused in promoting more student activities and available funding.

The recently established Student Committee has strived to inform and guide trainees in the Program. Specifically, their mandate is to (1) enhance trainee interaction through the organization of both academic and social events and (2) to provide trainees with the tools to make informed decisions about their graduate work in the form of mentoring and course assessments. They continue to organize a very successful “Annual Student Research Day”, hold various social functions, and launched their inaugural “Debate Night” that was well attended by various faculty and students. It was a lively night and kudos to the students on such an exciting event.

Our annual student interviews continue to show a high degree of satisfaction with the Program. The increase in events targeted specifically for students resulted in more effective student participation. The postgraduate follow-up illustrated that once again the students have gone on to pursue either academic or research careers (see Convocated section). As part of our ongoing tradition, bound copies of each graduating student’s thesis is kept in the Program office (total: 27 MSc and 13 PhD).

The student section of the web site is undergoing a revamping and we look forward to their initiatives on the web. With such an enthusiastic and diverse group of students, it should be very exciting to follow their initiatives in the upcoming year!

Events:The Bigelow Book Prize is awarded to an outstanding Program student for sustained academic excellence, innovative experimental approaches, original discoveries and good scientific productivity. A plaque in Dr. Bigelow’s honour, mounted on the wall outside the Program

office, was unveiled and a reception held on October 1, 2001. All the previous awardees and their supervisors were invited to attend and be honoured with a miniature version of the plaque presented to them by Dr. Bigelow. A number of distinguished guests and faculty and students of the Program were invited to share in this honour. Dean Naylor welcomed everyone on behalf of the Faculty of Medicine and shared his pleasure in being able to participate in the recognition of a man of such stature as Dr. Wilfred G. Bigelow. Dr. Umberto de Boni, Associate Dean, Division IV, brought greetings from the School of Graduate Studies, then Dr. Ronald Baird, a personal friend and colleague of Dr. Bigelow’s, gave an overview of the life of this famous surgeon, scientist, and Canadian. It was clear to all who attended

that Dr. Bigelow is a roll model to all scientists and clinicians no matter what the specialty.

FR: Dr. Vivek Rao (1997), Dr. Saeid Babaei (2001), Dr. Michael Borger (2000)BR: Dr. Richard D. Weisel, Head, Division of Cardiac Surgery, Dr. Ronald Baird, Dr. Wilfred G. Bigelow, Dr. Catharine Whiteside, Associate Dean, Inter-Faculty & Graduate Affairs, Professor Umberto De Boni, Associate Dean, Division IV – The Life Sciences, Dr. Carin Wittnich, Director, CSCP, Dr. John Ikonomidis (1995)

Education:Due to their ongoing popularity, the MSC 3060/3061/3062/3063 courses have now been assigned new joint listing designations “JCV” and approved by the School of Graduate Studies. Ongoing and frequent review of these courses continues to ensure that leading edge technologies and research foci are represented. This is considered critical if they are to continue to serve as our flagship courses for our trainees. Enrolment continues to be strong in these courses and their popularity is reflected in the strong reviews by the students.

The Program also has an established reputation in the area of Continuing Medical Education, usually partnering with industry. This year, we hosted the first “Debate Night”, a venue to discuss contentious issues relevant to both our students and faculty. We anticipate holding a few of these throughout each academic year.

Financial:Over the years the Collaborative Program has been very successful in raising an endowment as well as funds for student travel, bursaries and other student related activity. For example, the Medtronic Travel Award makes it possible for students to attend scientific meetings and present their work and the OSOTF bursary provides much needed financial relief to deserving students. These funds are available on an annual basis to help those with demonstrated academic and research excellence that are in financial need. Major corporate sponsors such as Merck Frosst Canada & Co., and Solvay Pharma, are to be recognised, once again, for their outstanding annual support of education in the cardiovascular sciences at the University of Toronto.

Despite these successes, it is clear that to ensure the Program’s long-term stability, stable infrastructure for the day-to-day operations is absolutely critical and to that end, the Dean of the Faculty of Medicine recommended the creation of a task force to review and make recommendations on its future. This task force consisted of representatives familiar with the Program but not necessarily intimately involved to ensure an unbiased review of its past activities and future direction. I am pleased to report that the task force resoundingly endorsed the Program and clearly identified and agreed with its value-added for the graduate students interested in the field of cardiovascular sciences. It is heartwarming to realize that the Cardiovascular Sciences Collaborative Program is highly regarded across the campus. Its interdisciplinary nature and the fact that faculty and student research crosses the pillars of the CIHR as well as the departments across the Faculty of Medicine makes this a truly model program at the University of Toronto. All agreed that it did need to have a stable infrastructure support to permit it to continue to develop and grow and a number of suggestions and initiatives were proposed. In order to position the Program to be as successful as possible in this venture it

L-R: Dr. Ronald Baird, Dr. David Naylor, Dean of Medicine, Dr. Richard D. Weisel, Head, Division of Cardiac Surgery & Dr. Wilfred G. Bigelow

would be important for the participating groups to provide some financial support. This would serve to indicate to potential donors that this is an extremely important initiative at the University. Over the upcoming academic year, we will be addressing the Programs infrastructure stability.

Summary:As you continue to read through this report, you will see that it has undergone some modification and a change in its look to reflect the tremendous growth that has occurred. I would like to thank Miss Victoria Simpson, our Business Officer, for her hard work and contribution that has made the Cardiovascular Sciences Collaborative Program the success it is today.

Finally, I would like to take this opportunity to thank all our faculty and students for another successful year and to those individuals who have continued to provide both moral and tangible support for this Program.

Dr. Carin Wittnich, O.Ont.Director, CSCPProfessor of Surgery & PhysiologyNorthrop Frye Scholar

MISSION STATEMENT

“The Cardiovascular Sciences Collaborative Program, approved by the University and Ontario Council on Graduate Studies in 1992, and listed in the calendar of the School of Graduate Studies, exists to give formal, organized expression to cardiovascular studies and research at the graduate level. It builds on the strengths of all participating academic units, and other agencies, to enhance the visibility of cardiovascular studies and to facilitate collaborative, interdisciplinary training and research.”

The above mission is achieved by advertising and promoting the importance of, and opportunities in, cardiovascular studies, by making known the results of such studies, by recruitment of excellent students, and by coordinating the graduate collaborative program in cooperation with the academic units in which they are registered. Students in this collaborative program must fulfill the requirements of their home units as well as the Program. Upon graduation the notation “Specialization in Cardiovascular Sciences” will appear on the student’s academic transcript and the Program will present the student with a certificate and gift.

COLLABORATING FACULTIESMedicinePhysical Education and Health

COLLABORATING GRADUATE UNITSDepartment of Exercise Sciences

Department of Laboratory Medicine and PathobiologyDepartment of Medical BiophysicsDepartment of PharmacologyDepartment of PhysiologyDepartment of Public Health SciencesDepartment of Rehabilitation ScienceInstitute of Biomaterials and Biomedical EngineeringInstitute of Medical Science

SUPPORTING CLINICAL DEPARTMENTSDepartment of Anaesthesia Department of MedicineDepartment of Surgery

COMMITTEES

ExecutiveThe Executive Committee consists of 4 members of the Program Committee representing as wide a range of disciplines as possible and includes the Director. The Executive Committee provides student counselling, screens applicants, provides advice and acts as a Steering Committee.

Dr. C. Wittnich (Chair)Dr. M. Rand (Laboratory Medicine & Pathobiology)Dr. S. Thomas (Exercise Sciences)Dr. R. Weisel (Institute of Medical Science)

ProgramThe Program Committee consists of a representative from each collaborating department as well as two student representatives. It administers the Program, selects the Director, and generally meets twice per year.

Dr. C. Wittnich (Chair)Dr. L. Adamson (Physiology)Dr. D. Brooks (Rehabilitation Science)Dr. D. Mazer (Anaesthesia)Dr. R.I. Ogilvie (Pharmacology)Dr. M. Ojha (Institute of Biomaterials and Biomedical Engineering)Dr. M. Rand (Laboratory Medicine and Pathobiology)Dr. S. Thomas (Exercise Sciences)Dr. R.D. Weisel (Institute of Medical Science)Dr. G. Wright (Medical Biophysics)Nathalie Lapointe (Sr. Student Representative)

Renee Suen (Jr. Student Representative)

StudentThe Student Committee was set up by the students and consists of the two student representatives from the Program Committee (who act as Co-Chairs) and 2 student members. They meet and oversee all student activities of the Program.

Ms. Nathalie Lapointe (Chair)Ms. Renee Suen (Co-Chair)Ms. Nesime Askin (Member)Ms. Sonja Reichert (Member)

COURSES OFFERED

BME1448H Cardiovascular Fluid Mechanics (BME)EXS5508H Cardiovascular Disease and Exercise (EXS)JCV3060H* Advanced Topics in Cardiovascular Sciences – Molecular Biology & Heart Signal

Transduction (IMS/PSL)JCV3061H* Advanced Topics in Cardiovascular Sciences – Hormones in the Cardiovascular

System (IMS/PSL)JCV3062H* Advanced Topics in Cardiovascular Sciences – Heart Function (IMS/PSL)JCV3063H* Advanced Topics in Cardiovascular Sciences – Vascular (IMS/PSL)JEB1365H Ultrasound: Theory and Applications in Biology and Medicine (BME)JTC1331H Biomaterials Science (BME)LMP1015H Vascular Pathobiology (LMP)LMP1504H Biochemistry, Molecular Biology of Cardiovascular Diseases (LMP)PSL1038H Volume, Electrolyte and Pressure Regulation in Body Fluid Compartments

(PSL)PSL1060H Developmental Cardiovascular Physiology (PSL)PSL1462H Molecular Aspects of Cardiac Function (PSL)

* Core Courses for PhD Trainees

Suggested Courses (Considered valuable but does not fulfill Program requirements)

CHL5201 Introducing Biostatistics for Students in Biological Sciences (CHL)LMP1404S Cellular and Molecular Mechanisms of Disease (LMP)PSL1052H Fundamentals on Ion Channel Function (PSL)

PROGRAM SPONSORED ACTIVITIES

Annual Student Research DayOn Wednesday, February 27, 2002, the Cardiovascular Sciences Collaborative Program held its 3rd Annual Student Research Day in the Medical Sciences Bldg. This was a fun filled day that was attended by CSCP trainees and faculty. Trainees began the day by giving a ten minute talk related to their research, followed by a question/answer period as below.

SESSION I: Chair – Renee SuenAsim Cheema (PhD – Institute of Medical Science)“Adenoviral Mediated Decorin Overexpression Inhibits Intimal Hyperplasia in a Rabbit Angioplasty Model”Roland Leung (MSc – Institute of Medical Science)“Persistence of Procoagulant Surface Expression by Activated Platelets”Carol Kolb (MSc – Physiology)“Effects of Gestational Age and Ultrasound Frequency on the Echogenicity of Structures in the Developing Mouse Embryo”Shathiyah Kulandavelu (MSc – Physiology)“Maternal Cardiovascular Changes During Pregnancy in eNOS Knockout Mice”Sonja Reichert (MSc – Exercise Sciences)“Effects of Combined Resistance and Aerobic Training on Muscular Strength, Blood Flow and Aerobic Power in Patients with Coronary Artery Disease”Paul Fedak (PhD – Institute of Medical Science)“Unraveling Aortic Dilatation in Patients with Congenital Aortic Valve Malformations: A Novel Mechanism”

SESSION II: Chair – Sonja ReichertRenee Suen (MSc – Institute of Medical Science)“Role of Endothelin-1 in Accelerated Atherosclerosis and Aortic Aneurysm Formation”Li Yang (PhD – Laboratory Medicine and Pathobiology)“Conditional Cardiac Endothelin-1 Over Expression in Transgenic Mice Causes Myocardial Hypertrophy and Inflammation”Jennifer Sarjeant (MSc – Institute of Medical Science)“The Role of Apolipoprotein D in Vascular Smooth Muscle Cell Proliferation”Anjum Khan (MSc – Institute of Medical Science)“Atrial Remodeling in Congestive Heart Failure”Neelesh Jain (MSc – Institute of Medical Science)“The Role of NF-kB in Human Atherosclerosis”Nataly Kogan (MSc – Physiology)“Substance P in the Cardiovascular Actions of ‘New Pressor Protein’ (NPP)”Sandra Merklinger (MSc – Institute of Medical Science)“MMP Inhibition and b3 Blockade Induce the Regression of Pulmonary Vascular Disease in Organ Culture”

In the afternoon trainees were given valuable advice from Drs. Gary Webb and Bill Williams who also shared with the students how they began their research/clinical careers. This session was followed by a discussion period in which students had an opportunity to discuss the trials and tribulations of living a life devoted to education and research with these highly respected

and successful clinicians. The day concluded with a wine and cheese reception where students and faculty mixed and mingled, after which most of the students continued their interactions at a student planned social event.

The Student Research Day met with resounding success. This day would not have been possible without the efforts of the Planning Committee: Nesime Askin (Chair), Sonja Reichert and Renee Suen (Co-Chairs) and Nathalie Lapointe (Member). Congratulations on a job well done!

Debate NightThe Student Committee organized this exciting event for the cardiovascular community at the University of Toronto. The goal of this event was to provide graduate students with the chance to learn and form their own opinions in delicate subject matters that challenge the scientific community and to provide an opportunity for the faculty to voice their point-of-view. The topic of the inaugural debate was “Be It Resolved that the Impact Factors is an Important Determinant of Success in Research”. The debate was moderated by Dr. Peter Liu, who introduced the protagonist, Dr. Jean Rouleau, and the antagonist, Dr. Dan Osmond. Both debaters passionately made their case. Despite their eloquence the vote was split fairly even, certainly showing the controversy that this issue raises and the fixed views held by those in attendance. With the success of this event, we look forward to organizing future debates.

Lecture SeriesFor this academic year the lecture series was focused in the two main areas of “Molecular Biology & Heart Signal Transduction” and “Hormones in the Cardiovascular System”. A number of interesting speakers contributed their time and knowledge. Both these areas were covered from the perspective of whole body and organ to the molecular level including genetics, with a particular emphasis on bridging basic science and clinical approaches to these areas.

Human Biology Student Union Career FairThe Cardiovascular Sciences Collaborative Program participated in the Human Biology Undergraduate Student Association Career Fair on November 15, 2001. Various graduate programs had displays and students in the Collaborative Program manned a table and provided information to interested future graduate students.

Summer Seminar SeriesThe Collaborative Program ran another very successful summer program. Applicants included undergraduate and medical school students from the University of Toronto as well as other universities. The Program provided a number of summer scholarships to help students who were unable to procure funding. Over the course of the summer, seminars were presented by graduate students currently enrolled in the Program and covered a range of topics with both clinical and basic science relevance (see below). The purpose of the seminar series is to provide a common and relaxed forum for presentation of timely topics and a review of basic science. As well, the summer students were given the opportunity to present their summer work. An “end-of-summer” luncheon was held for both faculty and students. This highly successful program is enjoyed by all who participate.

May 31st Dr. Carin Wittnich

“Introduction & Video: William Harvey and the Circulation of Blood”June 7th Asim Cheema (Institute of Medical Science – PhD)

“Arterial Repair After Balloon Angioplasty”Sandra Merklinger (Institute of Medical Science – MSc)“Matrix Metalloproteinase, Alpha vs. Beta 3 and EGF Receptor Blockade Induce the Regression of Pulmonary Vascular Disease”

June 14th Roland Leung (Institute of Medical Science – MSc)“Platelets and Their Role in Hemostasis and Thrombosis”

June 21st Carol Kolb (Department of Physiology – MSc)“Effects of Gestational Age and Ultrasound Frequency on the Echogenicity of Structures in the Developing Mouse Embryo”

June 28th Rohan Dharmakumar (Medical Biophysics – PhD)“Magetic Resonance Imaging Based Intro-Cardiac and Intravascular Pressure Measurement”

July 5th Summer Student Presentations – Project IntroductionsJuly 12th Golnaz Karoubi (Biomedical Engineering – MSc)

“Single Cell Gene Expression for Optimization of Cell Therapy”July 19th Shawn Brady (Rehabilitation Science – MSc)

“Predicting Participation in Cardiac Rehabilitation After Coronary Artery Bypass Surgery”

July 26th Mona Shawky (Institute of Medical Science – MSc)“Chlamydia Pneumonia and Atherosclerosis”

August 2nd John Esposito (Rehabilitation Science – MSc)“The Effects of Recombinant Human Growth Hormone on Physical Function in Patients with HIV Wasting”

August 9th I. Eser Adiguzel (Laboratory Medicine & Pathobiology – MSc)“Type VIII Collagen Functions in Vascular Disease”

August 16th Summer Student Presentations – Project Results

AWARDS

Medtronic Travel AwardTwo competitions were held (spring and fall) for the Medtronic Travel Award. This award, established in 1995, helps to defray costs of travel for Program students presenting their research work at recognized scientific meetings. Students supported by this award this academic year were:

Fall 2001:Sheila Riazi, MSc, Institute of Medical Science: “The Role of Elastin and Elastin Receptor Subunit in Modulation of Cellular Proliferation.” Canadian Cardiovascular Congress 2001 (Supervisor: Dr. A. Hinek)Karim Bandal, PhD, Physiology: “Could High Oxygen Levels (Hyperoxia) in Newborns Alter Glucose Metabolism and Decrease Heart Function?” Canadian Cardiovascular Congress 2001 (Supervisor: Dr. C. Wittnich)

Jack Wallen, PhD, Physiology: “Does the Presence of LV Hypertrophy Alter Expression of Estrogen Receptor Isoforms?” Canadian Cardiovascular Congress 2001 (Supervisor: Dr. C. Wittnich)

Spring 2002:Renee Suen, MSc, Institute of Medical Science: “Role of Endothelin-1 (ET-1) in Accelerated Atherosclerosis and Aortic Aneurysm Formation in Response to Angiotensin II (AII).” Experimental Biology 2002 (Supervisor: Dr. D. Stewart)Nataly Kogan, MSc, Physiology: “Cardiovascular Actions of ‘New Pressor Protein’ (NPP, Related to Coagulation -FXIIa) are Influenced by Both ACE and NEP Inhibition” and “Cardiovascular Effects of Coagulation FXIIa – Related ‘New Pressor Protein’ (NPP) are Mediated by a Non-Cholinergic Mechanism”, International Society of Hypertension and European Society of Hypertension (joint meetings). (Supervisor: Dr. D. Osmond)Akis Amfilochiadis, MSc, Physiology: “Dose-Dependant Effects of ACE-Inhibition on the Cardiovascular Actions of Human FXIIa-Related ‘New Pressor Protein’ (NPP)”, International Society of Hypertension and European Society of Hypertension (joint meetings). (Supervisor: Dr. D. Osmond)

Bigelow Book PrizeThe Bigelow Book Prize consists of 2 books written by Dr. W.G. Bigelow entitled “Cold Hearts” and “Mysterious Heparin” and a miniature version keeper plaque created to honor Dr. Bigelow. This prize was established in 1995 by the Cardiovascular Sciences Collaborative Program to recognize and honor a pioneer clinician and scientist in the field of cardiovascular sciences. Awardees should exemplify the personal traits of Dr. Bigelow -- curiosity, drive, and scientific integrity. The award is given in every year that a qualified student is identified. Qualifications include sustained academic scientific excellence, innovative experimental approaches, original discoveries and good scientific productivity. Some weight is given to work that has recognizable clinical relevance, especially that which promises to improve patient care. Appropriate candidates were identified and the final decision was made by the Program Committee.

1995 – Dr. John S. Ikonomidis1996 – Ms. Shona M. Torrance1997 – Dr. Vivek Rao1998 – Dr. Bryce Cowan1999 – Dr. Gideon Cohen2000 – Dr. Michael Borger2001 – Dr. Saeid Babaei2002 – Mr. Wm. Jack Wallen

Lorne Phenix Graduate AwardThis award was made possible by a generous donation in the memory of Mr. Lorne Phenix by Mrs. Geraldine Phenix. It is her hope that this award will focus attention on the issue of heart disease – which is still the #1 killer of both men and women in Canada. In addition, women who have heart problems are at least equal if not at greater risk than men and Mrs. Phenix hopes that this award will serve to encourage trainees to pursue this area of research to address this

particular problem. It is awarded to a graduate student in the Faculty of Medicine on the basis of research and academic excellence. The award consists of a cash prize and certificate and is presented to the recipient at the Annual Student Research Day. Appropriate candidates are identified and a winner is selected by a subcommittee chaired by Dr. Donna Stewart.

2001 – Wm. Jack Wallen

Ontario Student Opportunity Trust Funds (OSOTF) AwardThe OSOTF award refers to a class of awards that have resulted from the Ontario government’s “matching” program. Under the program every dollar of donation received for student assistance has been matched by the government as well as the university on a dollar-for-dollar basis. The Cardiovascular Sciences Collaborative Program participates in this program. There are two major conditions for all OSOTF awards; recipients must be Ontario residents and demonstrate financial need. However, the Program has additional eligibility criteria that must be adhered to, including excellence in science and academic performance. One competition is held per academic year.

The applications are handled centrally through the Office of the Associate Dean, Inter-Faculty and Graduate Affairs. Applications pertaining to the CSCP are sent to us and are then adjudicated by a subcommittee; this year chaired by Professor M. Ojha. Committee recommendations are then forwarded to the OSOTF Awards Committee (Faculty of Medicine) where the final decision is made. This competition, normally held in the Spring, was deferred to the fall of 2002 to capture all needy candidates.

Life Sciences Committee Summer Undergraduate Research FellowshipsThese fellowships are awarded to support research at the University of Toronto to assist undergraduate students seeking training for graduate level research. Funds were awarded to the Cardiovascular Sciences Collaborative Program for 8 undergraduate trainees. All candidates put forward by the Program were awarded funding.

Emily Chan – Supervisor: Dr. Stephen FremesMichael Charnish – Supervisor: Dr. Greg WilsonSarah Munce – Supervisor: Dr. Donna StewartAvi Orner – Supervisor: Dr. Vivek RaoBheeshma Ravi – Supervisor: Dr. Mansoor HusainDavid Santone – Supervisor: Dr. Tom LindsayN. Raj Satkunasivam – Supervisor: Dr. John ColesNazneen Tata – Supervisor: Dr. Michael Sole

ADVERTISING MATERIAL

The Cardiovascular Sciences Collaborative Program maintains and updates its web site (www.cscp.utoronto.ca) on a regular basis. Faculty information is updated whenever we are notified of relevant changes. This year Victoria Simpson revamped the entire website look to optimize efficient use by visitors. The Program students took an active part in creating their

own sections, including short bios on each student, course summaries/surveys to help other students pick courses suitable for their needs, and are working on a bulletin board section to keep everyone updated on cardiovascular activities. Collaborating departments are encouraged to provide hypertext links to the Collaborative Program on their web site.

The Program distributes brochures at the various campus activities and the collaborating departments are encouraged to have links with the CSCP’s web site and distribute brochures.

FUTURE DIRECTION

For the 2002-2003 academic year, we plan to continue our current activities and pursue the following priorities:

Continue developing endowments to provide permanent infrastructure support. Firm up a 5-year plan for the program. Create a Cardiovascular Resource Centre Target recruitment of PhD students. Recruit clinical residents doing 1-2 years of research into a formal graduate program

where appropriate. Graduate training grant application (CIHR) Further develop the student section in the Program’s web site. Further develop CME programs in cardiovascular sciences.

STUDENTS

Currently EnrolledStudent Supervisor Degree DepartmentI. Eser Adiguzel M. Bendeck MSc LMPAkis Amfilochiadis D. Osmond MSc PSLNesime Askin C. Wittnich MSc PSLKarim Bandali C. Wittnich PhD PSLShawn Brady S. Thomas/D. Brooks MSc REHAndrew Campbell D. Stewart PhD IMS (inactive status)Asim Cheema B. Strauss PhD IMSRohan Dharmakumar G. Wright PhD MBPJohn Esposito S. Thomas MSc REHPaul Fedak R. Weisel PhD IMSWarren Foltz G. Wright PhD MBPTommaso Gori J. Parker MSc IMSNeelesh Jain K.W. JohnstonMSc IMSGolnaz Karoubi D. Courtman MSc BMEAnjum Khan B. Strauss MSc IMSNataly Kogan D. Osmond MSc PSLCarol Kolb L. Adamson MSc PSLShathiyah Kulandavelu L. Adamson PhD PSLNathalie Lapointe J. Rouleau PhD IMSRoland Leung M. Rand MSc IMSNegin Liaghati-Nasseri S. Fremes MSc IMS (inactive status)Sarah McCutcheon S. Thomas MSc REHSandra Merklinger M. Rabinovitch MSc IMSVaska Micevski D. Stewart PhD IMSPeter Papageorgiou D. Osmond MSc PSLAli Pourdjabbar J. Rouleau MSc IMSSonja Reichert J. Goodman MSc EXSClea Senechal P. Liu MSc IMSMona Shawky P. Liu MSc IMSRenee Suen D. Stewart MSc IMSShona Torrance C. Wittnich PhD IMS (inactive status)Jack Wallen C. Wittnich PhD PSLLi Yang D. Stewart PhD LMP

Convocated Students/Follow-UpZakaria Ahmed, PhD, Laboratory Medicine & Pathobiology (Supervisor: Dr. P. Connelly)“Characterization of Phosphatidylcholine Oxidation Products Obtained by Exposure of High Density Lipoprotein to Peroxynitrite Donor, SIN-1”Is working as a Post-Doctoral Fellow in Clinical Chemistry at the University of Louisville.

Saeid Babaei, PhD, Laboratory Medicine & Pathobiology (Supervisor: Dr. D. Stewart)

“Role of Nitric Oxide in Angiogenesis”Is working as a Research Associate with Dr. Duncan Stewart.

Sloane Hechter, MSc, Institute of Medical Science (Supervisor, Dr. P. Liu)“Factors that Limit Exercise Performance and the Use of Angiotensin Converting Enzyme Inhibitors in Adult Survivors of the Mustard Procedure”Has been accepted into medical school at McMaster University.

Nikolaos Mamalias, MSc, Institute of Medical Science (Supervisor, Dr. P. Dorian)“Effect of Combination Potassium Channel Blockers on Cardiac Refractoriness in Isolated Rabbit Hearts and Intact Guinea Pig Hearts”Has been accepted into medical school at the University of Toronto.

Sheila Riazi, MSc, Institute of Medical Science (Supervisor, Dr. A. Hinek)“Pathophysiological Links Between Impaired Elastogenesis and Increased Cellular Proliferation in Development of Cardiovascular Disorders”Plans on obtaining her medical license and getting more involved in cardiovascular research.

Jennifer Sarjeant, MSc, Institute of Medical Science (Supervisor, Dr. M. Rabinovitch)“The Role of Apolipoprotein D in Vascular Smooth Muscle Cell Proliferation”Returning to cardiac surgery residency.

Damir Simic, MSc, Laboratory Medicine & Pathobiology (Supervisor, Dr. A. Hinek)“Disclosure of Novel Mechanisms in Which Nicotine Triggers Structural and Functional Alterations of Arterial Smooth Muscle Cells – Implications to Pathogenesis of the Occlusive Arterial Diseases”Plans to work in a laboratory setting with a biotech company.

AwardsZakaria Ahmed University of Toronto Fellowship

American Association of Clinical Chemists, Graduate Student Travel Award, Chicago

Akis Amfilochiadis University of Toronto Bursary AwardMedtronic Travel Award, Cardiovascular Sciences Collaborative Program

Nesime Askin Heart & Stroke/Richard Lewar Centre of Excellence FellowshipOERS Volunteer of the Year Award 2001National Science and Engineering Research Council (NSERC-PGSB) Scholarship

Karim Bandali Medtronic Travel Award, Cardiovascular Sciences Collaborative ProgramRichard Rowe Prize for Excellence in Research, Pediatric CardiologyOntario Student Opportunity Trust Fund (OSOTF) Award, Cardiovascular Sciences Collaborative ProgramDepartment of Physiology, Doctoral ScholarshipOntario Graduate Scholarship in Science and Technology (OGSST)

Shawn Brady Ruth Bradshaw Award

Toronto Rehabilitation Institute Student AwardAsim Cheema Heart & Stroke/Richard Lewar Centre of Excellence FellowshipJohn Esposito Connaught Scholarship, Department of Rehabilitation SciencePaul Fedak C. Walton Lillehei Research Award Finalist, American Association for

Thoracic SurgeryTommaso Gori Trainee Travel Award, American Society of Clinical Investigation and

American Association of Physicians (joint meeting)Research Fellowship, Heart & Stroke Foundation of CanadaE. McGloin Fellowship for highest rated trainee in Ontario, Heart & Stroke Foundation of OntarioBorsa di Ricerca Progetto Giovani Ricercatori, University of SienaYoung Investigator Award, First Place, American College of CardiologyS.A. Levine’s Young Investigator Award, First Place, American Heart Association

Nataly Kogan Ontario Graduate Scholarship in Science and Technology (OGSST), Heart & Stroke Foundation of OntarioMedtronic Travel Award, Cardiovascular Sciences Collaborative Program

S. Kulandavelu Heart & Stroke/Richard Lewar Centre of Excellence FellowshipYoung Investigator’s Award, 13th World Congress International Society

Nathalie Lapointe FRSQ (Fonds de la recherche en sante du Quebec) FellowshipRoland Leung John D. Schultz Science Student Scholarship, Heart & Stroke Foundation

of OntarioSt. Michael’s Hospital Summer Student Scholarship

Sarah McCutcheon University of Toronto Open ScholarshipCIHR Burroughs Wellcome Student Award

Sandra Merklinger Ontario Graduate Scholarship in Science and Technology (OGSST), Heart & Stroke Foundation of OntarioStudentship Appointment, Research Training Centre, Hospital for Sick Children

Vaska Micevski Heart & Stroke Foundation Merit Award, 1st Prize, NursingPeter Papageorgiou HCFO Research Award Scholarship

AHEPA Scholarship New England Hellenic Medical & Dental Society Research Award, Harvard University

Ali Pourdjabbar University of Toronto Open ScholarshipOntario Graduate Scholarship in Science and Technology (OGSST), Dr. Arnie Aberman Award

Sonja Reichert University of Toronto FellowshipTerry Kavanagh Award, University of TorontoThera-Band® Resistive Band Support Award, The Hygenic Corporation

Sheila Riazi Medtronic Travel Award, Cardiovascular Sciences Collaborative ProgramRestracomp, Hospital for Sick Children Research Institute Award

Jennifer Sarjeant Research Training Centre Postdoctoral Fellowship, Hospital for Sick ChildrenMiriam Neveren Memorial Award, Faculty of MedicineElizabeth Arbuthnot Dyson Fellowship, Faculty of Medicine

Research Fellowship, Heart & Stroke Foundation of CanadaClea Senechal University of Toronto Open FellowshipMona Shawky Ontario Graduate Scholarship in Science and Technology (OGSST)Renee Suen Medtronic Travel Award, Cardiovascular Sciences Collaborative Program

Heart & Stroke/Richard Lewar Centre of Excellence FellowshipJack Wallen Medical Research Council/K.M. Hunter Doctoral Research Award

Medtronic Travel Award, Cardiovascular Sciences Collaborative ProgramLorne Phenix Graduate Student Award 2001, Cardiovascular Sciences Collaborative Program

Liz Yang Student Presentation Award, 1st Prize, Canadian Cardiovascular SocietyDoctoral Research Award, Heart & Stroke Foundation of Canada

FACULTY

MembersFaculty are divided into 3 categories (Full, Associate, and Affiliate) depending on their SGS status. Details on faculty research interests and contact information are available on the web site. Departmental affiliations listed are those within the CSCP.

FullName Departmental Affiliation(s) LocationLee Adamson BME/IMS/PSL Mount Sinai HospitalKhosrow Adeli LMP Hospital for Sick ChildrenPeter Backx IMS/Medicine/PSL UofT - HSRLCEMichelle Bendeck LMP/Medicine UofT - MSBDouglas Bradley IMS/Medicine Toronto General HospitalJohn Coles IMS/Surgery Hospital for Sick ChildrenPhilip Connelly LMP/Medicine St. Michael’s HospitalC. Ross Ethier BME UofT – Mechanical EngineeringJohn S. Floras IMS/Medicine Mount Sinai HospitalChristopher Forrest IMS/Surgery Hospital for Sick ChildrenStephen Fremes IMS/Surgery SWCHSC - SunnybrookJack M. Goodman EXS UofT - Physical Ed & HealthAvrum I. Gotlieb LMP Toronto General HospitalAleksander Hinek IMS/LMP Hospital for Sick ChildrenK. Wayne Johnston BME/IMS/Surgery Toronto General HospitalPeter G. Kalman IMS/Surgery CommunityFred Keeley LMP Hospital for Sick ChildrenB. Lowell Langille LMP Toronto General HospitalGary F. Lewis IMS/Medicine Toronto General HospitalRen-Ke Li IMS/LMP/Surgery Toronto General HospitalC-C. Liew IMS/LMP/Medicine UofT – Banting InstitutePeter Liu IMS/Medicine Toronto General HospitalMarius Locke EXS/Public Health UofT – Physical Ed & HealthPeter McLaughlin IMS/Medicine Toronto General HospitalDonald A.G. Mickle LMP/Surgery Toronto General HospitalLynda Mickleborough IMS/Surgery Toronto General Hospital

David Naylor IMS/Medicine/Public Health/Surgery UofT - MSBMatadial Ojha BME/Surgery UofT – Rosebrugh Bldg.Tom Parker IMS/Medicine Toronto General HospitalMargaret Rand IMS/LMP Hospital for Sick ChildrenJean L. Rouleau IMS/Medicine Toronto General HospitalMichael Sefton BME UofT – Wallberg Bldg.Arthur S. Slutsky IMS/Medicine/Surgery Mount Sinai HospitalMichael J. Sole IMS/Medicine/PSL Toronto General HospitalDonna E. Stewart Anesthesia/IMS/Surgery/Medicine Toronto General HospitalDuncan Stewart IMS/LMP/Medicine St. Michael’s HospitalBradley Strauss LMP/Medicine St. Michael’s HospitalScott G. Thomas EXS/PSL UofT – Physical Ed & HealthRichard D. Weisel IMS/Surgery Toronto General HospitalGregory Wilson IMS/LMP/PSL/Surgery Toronto General HospitalCarin Wittnich IMS/PSL/Surgery UofT - MSBGraham Wright MBP SWCHSC - SunnybrookTai-Wing Wu LMP Toronto General HospitalErik L. Yeo IMS/Medicine Toronto General Hospital

AssociateDina Brooks REH UofT – Rehabilitation ScienceDavid Courtman BME/Surgery St. Michael’s HospitalPaul Dorian IMS/Medicine/PCL St. Michael’s HospitalLen S. Goodman EXS Def & Civil Inst Environ MedMansoor Husain IMS/LMP/Medicine Toronto General HospitalJane Irvine Public Health Toronto General HospitalTom Lindsay IMS/Surgery Toronto General HospitalJohn Parker IMS/Medicine Mount Sinai HospitalNisar A. Shaikh LMP CommunityRobert Tsushima IMS/Medicine/PSL UofT - MSBRobert Wald IMS/Medicine Mount Sinai HospitalLori West IMS Hospital for Sick Children

AffiliateJagdish Butany LMP/Medicine Toronto General HospitalChris M. Feindel Surgery Toronto General HospitalJoel Fisher Anaesthesia Toronto General HospitalDavid Mazer Anesthesia St. Michael’s HospitalPatricia Murphy Anaesthesia Toronto General HospitalRichard I. Ogilvie Medicine/PCL Toronto Western HospitalLen Schwartz Medicine Toronto General Hospital RetiredColin E. Bayliss IMS/Medicine/PSL/Surgery UofT – MSBFlavio Coceani PSL Hospital for Sick ChildrenDaniel H. Osmond IMS/Medicine/PSL UofT – MSBGeorge Steiner IMS/Medicine/PSL Toronto General Hospital

New PositionsWe would like to wish the following faculty all the best in their new positions:Davy Cheng, University of Western OntarioMichael Plyley, Brock UniversityMarlene Rabinovitch, Stanford University

Awards and HonorsKhosrow Adeli Simon-Pierre Noel Lectureship Award, Canadian Lipoprotein Award,

presented in October 2001, Digby, Nova ScotiaPaul Dorian Critical Care Best Abstract Award, AHA Annual Meeting, 2001C. Ross Ethier Tier I Canada Research Chair in Computational TechnologyJoseph A. Fisher 3rd Prize: Outstanding Scientific and Educational Exhibit, American

Society of Anesthesiologists Annual Meeting, 2001. “2 ways to save O2;3 ways to isocapnia”

John Floras Lloyd S.D. Fogler Q.C. Award for Research Excellence (Mount Sinai Hospital)President, Canadian Hypertension Society

Mansoor Husain Clinician-Scientist Award, Phase II. CIHR, 2001-2004Avrum I. Gotlieb Award of Merit, 2001, Society for Cardiovascular Pathology, Inc.Ren-Ke Li Premier’s Research Excellence Award, Ontario Ministry of Energy,

Science and Technology, 2001Thomas Lindsay Wightman-Berris Academy – Award for Individual TeachingDavid Naylor Keynote Lecture, OECD Symposium on Measuring Health System

PerformanceVan den Ende Lecturer, University of Cape Town Faculty of Medicine

Margaret L. Rand Chair, Review Committee, Heart & Stroke Foundation of Ontario, Research and Development

Michael J. Sole Robert Beamish Leadership Award, Elected Fellow, AHADonna Stewart Margaret Mead Memorial Lecturer, Sydney, Australia

Robin Hunter Memorial Lecture, University of TorontoDistinguished Member Award and Lecture, American Psychiatric Association, New OrleansMaster Educator Clinical Consultation, American Psychiatric Association, New Orleans

Duncan Stewart Dexter H.C. Man Chair of CardiologyMacDonald Lectureship (Queens) Devornik Lectureship (Edmonton)

Richard D. Weisel Awarded the Charles Tator Surgeon-Scientist Mentoring Award, University of Toronto, Department of Surgery Gallie Day, 2002

Carin Wittnich Carin Wittnich Teaching Assistant of the Year Award, 2001Order of Ontario, 2001Valedictorian, Order of Ontario, 2001Local Hero, Volunteerism, The Barrie Examiner, Barrie, Ontario, 2002

Peer Reviewed FundingAlter D, Naylor CD, Irvine J, Mustard C, Morgan C, Tu J, Wheaton B, Austin P: The Relationship Between Socioeconomic Status, Quality of Care, and Outcomes Following Acute Myocardial Infarction.

Canadian Institutes of Health Research, 2001-2004Bendeck M: Tetracyclines in the Treatment of Vascular Disease.

Heart & Stroke Foundation of Ontario, 2001-2004Bendeck M: Responses of Vascular Smooth Muscle Cells to Extracellular Matrix in Atherosclerosis and Restenosis.

Canadian Institutes of Health Research, 2000-2003Bendeck M: Ministry of Energy Science and Technology Ontario and Department of Laboratory Medicine and Pathobiology.

Premier’s Research Excellence Award, 2000-2005Cernacek P, Rouleau JL, Stewart DJ: Endothelin Blockade in Heart Failure and Hypertrophy: Which Receptor and when?

Medical Research Council of Canada, 2000-2004Cheung AM, Cameron JI, Hyman I, Franche RL, Stewart DE: Predicting Emotional Distress in Family Caregivers: Analysis of the Longitudinal National Population Health Survey Data.

National Health Research and Development Program, 2003Cheung AM, Cameron J, Stewart DE, Coyte PC, Streiner DL, Feldberg GD: When Home Care Ends and Institutional Care Begins: A Longitudinal Study of Stroke Survivors and Their Family Caregivers.

Social Sciences and Humanities Research Council, 2001-2004Cheung A, Liu P, Abramson B, Stewart DE: Clinical Trial of Raloxifene Use in the Heart (RUTH).

Eli Lilly, 1998-2003Cohen J, Ashley MJ, Ferrence R, Stewart DE, Kyle K: Institutional Addiction to Tobacco: Defining Links Between Canadian Universities and Medical Schools.

National Cancer Institute of Canada, 2000-2002Coles JG, G Hannigan: Xenogenic Cardiomyocyte Transplantation.

Heart & Stroke Foundation of Ontario, 2000-2002Coles JG, G. Hannigan: Integrin-Linked Kinase (ILK) Improves Cardiomyocyte Survival.

Canadian Institutes of Health Research, 2002-2005Connelly PW: The Role of Apolipoproteins in Oxidation and Atherosclerosis.

Heart & Stroke Foundation of Ontario, 2002-2005Deber R, Halman M, Millson P, Meyers T, Stewart DE, Urowitz S, Walmsley S, Bauman A: Preferred Role of People with HIV and AIDS in Treatment Decision Making.

Ontario HIV Treatment Network, 1999-2001Demeules M, Stewart DE (PI’s): Canadian Women’s Health Status Report: A Multidimensional Look at the Health of Canadian Women.

Canadian Population Health Initiative, 2001-2003Ethier CR: Computational Hemodynamics

National Science and Engineering Research Council, 2001-2005Ethier CR: The Hydrodynamics of Aqueous Humor Outflow.

National Institutes of Health (subgrant), 1998-2002Ethier CR: Protein Profiling in Human Trabecular Meshwork.

Glaucoma Research Society of Ontario, 2001-2002Ethier CR: Human Anterior Segment Model for Myocilin Perfusion.

Hildegard Dorenhamp-Gerhard Zbinden Foundation, 2000-2001Ethier CR: Factors Controlling Aqueous Outflow Resistance in Glaucoma.

Canadian Institutes of Health Research, 2001-2004Feindel CM: Prolonged Storage of Cardiac Allografts with Shed Donor Blood.

Heart & Stroke Foundation of Ontario, 1999-2001Feindel CM, Borger M: Effect of Vacuum Assist on Cerebral Microemboli During CPB.

The Physicians’ Services Incorporated Foundation, 2000-2001Feindel CM, Rao V: Preservation of Endothelial Function Following Prolonged Storage of Cardiac Allografts with Shed Donor Blood.

Heart & Stroke Foundation of Ontario, 2001-2004Flanagan JG (PI), Ethier CR (Co-Investigator): The Role of Lamina Cribrosa Biomechanics and Ischemia in Glaucomatous Optic Neuropathy.

Canadian Institutes of Health Research, 2001-2005Floras J: Career Investigator Award, CI.

Heart & Stroke Foundation of Ontario, 2001-2006Floras J: Cardiopulmonary Interactions in Health and Disease.

Medical Research Council of Canada, 2000-2005Floras J: Cardiovascular Regulation in Men and Women with Hypertension of Heart Failure.

Heart & Stroke Foundation of Ontario, 1999-2002Floras J: Peptidergic and Purinergic Modulation of the Autonomic Nervous System in

Humans.Medical Research Council of Canada, 1997-2002

Floras J (Co-Investigator): Investigations Concerning the Control and Modulation of Cardiac and Renal Sympathetic Activity in Chronic Heart Failure Heart & Stroke Foundation of Ontario, 2001-2004Floras J (Co-Investigator): Multicentre Trial of Continuous Positive Airway Pressure (CPAP) for Chronic Therapy of Heart Failure.

Medical Research Council of Canada, University-Industry Grant, 1998-2003Floras J (Co-Investigator): Endothelial Dysfunction in SLE: Its Contribution to Abnormalities in Coronary Perfusion and the Role of ACE Inhibition.

Heart & Stroke Foundation of Ontario, 2001-2003Floras J: By What Mechanisms Does Conversion from Conventional Intermittent Dialysis to Nocturnal Hemodialysis Lower Blood Pressure?

Canadian Institutes of Health ResearchFremes SE, Cohen E, Naylor CD, Fradet G, Buller C, Able J, Carrera R, Gelfand E, Tymchak W, Menkis A, Almond D, Myers M, Errett L, Watson R, Yau T, Schwartz L, Rubens F, Higginson L, Carrier M, Cote G, Morin J, Doyle D, Gleeton O: Multi Centre Radial Artery Patency Study.

Medical Research Council, 2001Fremes SE, Multi-Centre Radial Artery Study Participants: Multi-Centre Radial Artery Patenty Study: 5 Year Results.

Canadian Institutes of Health Research, 2006Gotlieb AI: Studies on Valvular Interstitial Cells and Valvular Repair.

Heart & Stroke Foundation of Ontario, 1999-2002

Gotlieb A (PI), Bendeck M (Co-Investigator): Heart Valve Repair: Regulation by Cells and Matrix.Heart & Stroke Foundation of Ontario, 2002-2005

Gotlieb AI, Langille BL (Co-Applicants): The Endothelium in Atherogenesis: Influences of Hemodynamic Stresses.

Canadian Institutes of Health Research, 2001-2006Hebert PC, Multi-Centre Study Participants (including Fremes, SE): Blood Conservation Using Antifibrinolytics: A Randomized Trial in High Risk Cardiac Surgery – The BART Trial.

Canadian Institutes of Health Research, 2005Henkelman M, Bronskill M, Foster S, Plewes DB, Yaffe M, Rowlands J, Wright GA: Medical Imaging for Cancer.

National Cancer Institute of Canada, 2001-2006Hinek A: Elastin Receptor in Pathobiology of Arterial Thickening.

Canadian Institutes of Health Research, 2001-2006Hinek A (Co-Investigator): Pathobiology of Intimal Plaques.

Canadian Institutes of Health Research, Group Grant, 2001-2006Husain M: c-Myb-Dependent Vascular Smooth Muscle Proliferation.

Canadian Institutes of Health Research, 2001-2004Husain M: Conditional Expression of PMCA Isoforms in Arterial Smooth Muscle of Transgenic Mice.

Heart & Stroke Foundation of Ontario, 2000-2003Husain M: Molecular Physiology of Vascular Smooth Muscle.

Ontario Research & Development Challenge Fund New Opportunities Matching Grant, 2000-2003

Husain M: Mouse Models of Vascular Injury.University of Toronto Faculty of Medicine Dean’s Fund, 1999-2002

Husain M: Molecular Physiology of Vascular Smooth Muscle.Canada Foundation for Innovation New Opportunities Award, 1998-2002

Husain M: c-Myb-Dependent Vascular Smooth Muscle Proliferation.Medical Research Council of Canada, 1998-2001

Husain M: Molecular Regulation of Vascular Smooth Muscle Cell Proliferation.Medical Research Council of Canada, 1998-2001

Husain M: c-Myb-Dependent Vascular Smooth Muscle Proliferation.Heart & Stroke Foundation of Ontario, 1998-2001

Husain M: c-Myb-Dependent Vascular Smooth Muscle Proliferation.University of Toronto Connaught Foundation & Department of Medicine New Staff Grant

Hyman I, Stewart DE, Williams J, Ferris L, Cohen M, Maher J: Women’s Health Status in Ontario.

Ontario Ministry of Health, 2001Jenkins DJA (PI), Connelly PW (Co-Investigator)

Heart & Stroke Foundation of Ontario, 2002-2005Katz J, Gagliese L, Snijdelaar D, Stewart DE, Macrae H, Taddio A, Sandler P: Gender Differences in Pain and Analgesic Response to Kappa & Mu Opioids after Surgery.

Medical Research Council, 2000-2003Langille BL (Director), Bendeck M, Cybulsky M, Husain M, Gotlieb A, Marsden P, Stewart D, Strauss B, Ward M (Co-Investigators): Cell Biology of Atherosclerosis.

Heart & Stroke Foundation of Ontario Group Grant, 2000-2005Langille BL (Director), Gotlieb AI (Member): New Frontiers Program in Restenosis after Interventions: Pathobiology, Genetics and Therapeutics.

Canadian Institutes of Health Research, 2001Lesperance F (PI), Dorian P (Co-Investigator): A Randomized Controlled Trial of Interpersonal Psychotherapy and Citalopram for Depression in Coronary Artery Disease.

Canadian Institutes of Health Research, 2001-200.Leytin V, Freedman J, Blanchette VS, Rand ML (Co-Investigator): Enhanced Diagnosis and Characterization of von Willebrand Disease by Testing Platelet Activation and Function Under Shear Rate Conditions

Aventis Behring Canada Research and Education Fund, 2001-2002Li R-K: Career Investigator Award.

Heart & Stroke Foundation of Ontario, 2001Li R-K, Weisel RD: Angiogenesis by Uterine Cell Transplantation.

Heart & Stroke Foundation of Ontario, 2001-2003Li R-K, Weisel RD: Autologous Tissue-Engineered Grafts for Congenital Heart Surgery.

Heart & Stroke Foundation of Ontario, 2001-2003Li R-K, Weisel RD: Cell Transplantation for Cardiovascular Disease.

Heart & Stroke Foundation of Ontario, 2001-2006Li R-K: Cell Transplantation to Improve Heart Function.

Ontario Ministry of Energy, Science and Technology, 2001-2006Li R-K: Prevention of the Progressive Cardiac Failure of Dilated Cardiomyopathy by Gene-Transfected Cell Transplantation.

Canadian Institutes of Health Research, 2001-2004Li R-K: Cell Transplantation for Diabetic Cardiomyopathy.

Canadian Diabetes Association, 2002-2004Lindsay T: Mechanistic Studies in Organ Injury After Ruptured Aortic Aneurysm.

Physicians’ Services Incorporated, 2002Lindsay T: Ruptured Abdominal Aortic Aneurysm: Early Organ Injury Prevention Strategies.

Physicians’ Services Incorporated, 2002Liu P, Backx P, Husain M, Parker T, Rabinovitch M, Rouleau JL, Sole MJ, Stewart DJ: The Determinants of Host Response and Sesceptibility in the Development of Health Network.

Canadian Institutes of Health Research Group Grant, 2001-2004Liu P (Director), Backx P, Parker T, Rabinovitch M, Rouleau JL, Stewart DJ, Husain M: The Determinants of Host Susceptibilities of Heart Failure.

Canadian Institutes of Health Research Group Grant, 2000-2003Magee L, von Dadelszen P, Guyatt G, Koren G, Ross S, Stephenson M, Stewart DE: Measuring Quality of Life in Nausea and Vomiting of Pregnancy (NVP): Assessment of the Measurement of a New Evaluation Questionnaire.

The Vancouver Foundation, 2001-2002Mazer D: The Role of Anemia and Red Blood Cell Substitutes in Traumatic Brain Injury.

Anemia Institute for Research and Education, 2002Mazer D (Co-Investigator): Blood Conservation Using Antifibrinolytics: A Randomized Trial in a Cardiac Surgery Population – The BART Study.

Canadian Institutes of Health Research, 2002

Mazer D (Co-Investigator): A Randomized Trial of a Lung-Open Ventilation Strategy (LOVS) in Acute Lung Injury.

Canadian Institutes of Health Research, 2002-2003Mazer D (Co-Investigator): CABG Surgery in USA, Canada, Germany and the United Kingdom: Comparison of Timelines and Outcomes.

Ischemia Research and Education Foundation, 2001-2002Mazer D (Co-Investigator): Atrial Fibrillation Risk Indices for Patients Undergoing CABG.

Ischemia Research and Education Foundation, 2001-2002Merchant N, Mickleborough LL: Magnetic Resonance Imaging for Ischemic Heart Disease.

Medical Research Council of Canada, 2001-2002Mickleborough LL (for Canada), Multi-Centre Trial across North America: Surgical Treatment for Ischemic Heart (STICH) Failure Trial.

National Institutes of Health U.S., 2001-2004Nag S, Stewart DJ: Regulation of Cerebrovascular Homeostasis and Repair by Angiogenic Factors.

Heart & Stroke Foundation of Canada, 2000-2002Nolan RP (PI), Ruckholm E, Stewart DE (Co-PI’s), (Co-Applicants) Angus J, Rouleau JL, Franche R-L, Rosser W, Alter D, Picard L, Michel I, Crichton T, Haider L, Micevski V, Grace S: Community Outreach and Heart Health Risk Reduction Trials (COHRT).

Heart & Stroke Foundation of Ontario, 2001-2005Osmond D: New Hypertensive System Linked to Blood Coagulation FXII.

Heart & Stroke Foundation of Ontario, 2002Peltier R (PI), Ethier CR (Co-Investigator): PsciNet II Computing Upgrade.

CFI/OIT/Compaq Canada, 2002-2003Plewes DB (PI), Wright GA (Co-Investigator): Centre for Research Using Magnetic Resonance at Sunnybrook and Women’s College Health Sciences Centre

Medical Research Council of Canada, 1999-2002Rabinovitch M (Director), Bruneau B, Hinek A, Husain M, Keely F, Wilson G: Interdisciplinary Program in Cardiovascular Development and Disease.

Canadian Institutes of Health Research Group Grant, 2000-2005Rand ML, Freedman J: The Procoagulant Surface of Activated Platelets: Persistence in vitro and in vivo

Heart & Stroke Foundation of Ontario, 2001-2004Rowlands J, Keep D, Burns P, Chauhan V, Cohen E, Fort S, Foster S, Fremes SE, Stewart D, Wilson B, Wright G: Imaging Research Centre for Cardiac Intervention – IRCCI.

Canada Foundation for Innovation, 2005Roy D (PI), Dorian P (Co-Investigator): AF CHF Trial.

Canadian Institutes of Health Research, 2001Singer P, Cheung A, Deber R, Dickens B, Flood, Lemmens T, Mullen M, Mykitiuk R, Robertson A, Stewart DE, Till J: Canadian Program on Genomics and Global Health: International and Comparative Perspectives on Health Systems and Insurance Implications of New Genetic Testing.

Genome Canada, 2001-2006Stamer WD (PI), Ethier CR (Co-Investigator): Role of Aquaporin-1 in the Permeability of Schlemm’s Canal.

American Health Assistance Foundation, 2001-2002

Slutsky AS: Critical Care Unit for Research Excellence (CCURE) [Group grant including approximately 20 critical care physicians/specialists from southern Ontario].

Canada Foundation for Innovation and Ontario Innovative Trust, 2002-2006Sole M: The Genetics of Hypertrophic Cardiopathy.

Heart & Stroke Foundation of Ontario, 2000-2003Sole M: Molecular Cardiology.

GH Wood Foundation, 2000-2005Sole M: The Determinants of Host Response and Susceptibility in the Development of Heart Failure.

Canadian Institutes of Health Research Group Grant, 2001-2004Sole M (Co-Investigator): The Prevalence of Thiamine Deficiency in Hospital Patients with CHF.

Canadian Foundation for Dietitic Research, 2000-2001Stewart D (PI), Husain M (Co-Investigator): Targeted Overexpression of Inducible NO Synthase: Relevance for the Pathogenesis of Cardiovascular Disease.

Heart & Stroke Foundation of Ontario, 2002-2005Stewart D (PI), Husain M (Co-Investigator): Pathophysiological Relevance of Endothelin-1 Overexpression.

Canadian Institutes of Health Research, 2001-2004Stewart DE, Ahmad F: Popular Health Promotion Strategies Among Chinese and East Indian Immigrant Women.

Social Sciences and Humanities Research Council, 2001-2003Stewart DE, Ahmad F: The Use of Community Newspaper to Promote Breast Cancer Screening Among South Asian Women.

Canadian Breast Cancer Foundation: Ontario Chapter, 2002Stewart DJ: Biological and Therapeutic Potential of Angiopoietins.

Heart & Stroke Foundation of Canada, 2001-2003Stewart DJ: Clinical Relevance of Endothelial Dysfunction.

Medical Research Council of Canada, 1995-2002Stewart DJ, et al: Cardiovascular Gene Therapy Initiative.

Canada Foundation for Innovation, 2001-2004Stewart DJ, et al: Multicentre Randomized Double Blind Placebo Control Clinical Trial of DNA for VEGF165 in the Treatment of Angina Pectoris

Canadian Institutes of Health Research/University/Industry, 2001-2004Stewart DJ, Fitchett DH, Batchelow WB: Controlled Trial of VEGF DNA in Severe Angina.

Heart & Stroke Foundation of Canada, 2001-2003Stewart DJ, Husain M: Pathophysiological Relevance of Endothelin-1 Overexpression.

Canadian Institutes of Health Research, 2001-2005Stewart DJ, Monge JC: Differential Expression of Endothelial Factors in Angiogenesis.

Medical Research Council of Canada, 1996-2001Stewart DJ: New Frontiers Program “Gene and Cell-Based Therapies for Cardio-Respiratory Disorders”.

Heart & Stroke Foundation of Canada/CIHR, 2001-2002Tu J, Chan B, Naylor CD: Quality of Acute Myocardial Infarction Care.

Canadian Institutes of Health Research, 2000-2005Tu J, Fremes SE: Canadian Cardiovascular Outcomes Research Team.

Canadian Institutes of Health Research – Interdisciplinary Health Research Team, 2005Verma S, Weisel RD: Endothelin Antagonism and Cardiac Surgery in Diabetes.

Physicians’ Services Incorporated Foundation, 2001-2002Weisel RD: Protection from Perioperative Ischemia.

Heart & Stroke Foundation of Ontario, 1999-2002Weisel RD: Protection from Perioperative Ischemia.

Heart & Stroke Foundation of Ontario, 2001-2004Weisel RD: Endothelin, Perioperative Ischemia and Diabetes.

Canadian Diabetes Association, 2001-2003Wilson GJ, Backx PH: Ischemic Preconditioning of the Myocardium: Role of Chloride Channels.

Heart & Stroke Foundation of Ontario, 1999-2002Wilson GJ (PI), Courtman DW (Co-Investigator): Acellular Matrix: Tissue Engineering Approaches for Pediatric Cardiovascular Reconstruction.

Canadian Institutes of Health Research, 2000-2003Wittnich C: Chronically Hypoxic Newborn Hearts Response to Stress.

Heart & Stroke Foundation of Ontario, 1999-2002Wittnich C: Impact of Gender on Myocardial Pathology & Ischemia/Reperfusion.

Heart & Stroke Foundation of Ontario, 2001-2004Wright GA: Evaluation of Myocardial Ischemia with MRI.

The Premier’s Research Excellence Award, 1999-2002Wright GA: Magnetic Resonance Imaging for Ischemic Heart Disease.

Medical Research Council of Canada, 2000-2005Wright GA, Burns P, Coates G, Downar E, Fort S, Hendler A, Hu B, McKerlie C, Merchant N, Mickleborough L, Wittnich C: Magnetic Resonance Imaging for Ischemic Heart Disease.

Medical Research Council of Canada, 1999-2003Wright GA, Merchant N, Rubin BB: Magnetic Resonance Imaging for Ischemia.

Medical Research Council of Canada, 2000-2005Wright GA, Prato F: Ontario Consortium for Cardiac Imaging.

Ontario Research and Development Challenge Fund, 2000-2005Yau TM, Weisel RD: Insulin Cardioplegia for Poor Left Ventricular Function.

Heart & Stroke Foundation of Ontario, 2001-2003

PUBLICATIONS

STUDENTSAhmed Z, Ravandi A, Maguire GF, Emili A, Draganov D, La Du BN, Kuksis A, Connelly PW: Multiple substrates for paraoxonase-1 during oxidation of phosphatidylcholine by peroxynitrite. Biochem Biophys Res Comm, 2002;290:391-396.

Ahmed Z, Ravandi A, Maguire GF, Kuksis A, Connelly PW: Aminoguanidine forms Schiff’s base adducts with phosphatidylcholine core aldehydes as part of its antioxidant activity. Clin Chem, 2001;47(6):A54.

Azakie A, Merklinger S, McCrindle BW, Van Arsdell G, Benson LN, Lee K-J, Coles JG, Williams WG: Evolving strategies and improving outcomes of the modified Norwood procedure: A 10-year single-institution experience. Ann Thorac Surg, 2001;72:1349-1353.

Azakie A, Merklinger S, Williams WG, Van Arsdell GS, Coles JG, Adatia I: Improving outcomes of the Fontan operation in children with atrial isomerism and heterotaxy syndromes. Ann Thorac Surg, 2001;72:1636-1640.

Bandali KS, Belanger MP, Wittnich: Is hyperglycemia seen in neonates during cardiopulmonary bypass due to hyperoxia? J Thorac Cardiovasc Surg, 2001;122(4):753-758.

Barolet A, Nili N, Cheema A, O’Blenes S, et al: Arterial elastolytic activity after angioplasty and the effects of elafin, an elastase inhibitor. Arterioscler Thromb Vasc Biol, 2001;21:1269-1274.

Belanger MP, Wittnich C, Torrance SM, Juhasz S: Model of normothermic long-term cardiopulmonary bypass in swine weighing more than eighty kilograms. Comp Med, 2002;52(2):117-121.

Bhagawan K, Merklinger S, Van Arsdell GS, McCrindle BW, Borger MA, Caldarone CA, Coles JG, Williams WG: Extending the usable size range of homografts in the pulmonary circulation: Outcome of bicuspid homografts. Ann Thorac Surg, 2002;73:866-870.

Blais Jr, C, Lapointe N, Rouleau JL, Clement R, Bachvarov DR, Adam A: Effect of captopril and omapatrilat on early post-myocardial infarctions survival and cardiac hemodynamics in rats: Interaction with cardiac cytokine expression. Can J Physiol & Pharmacol, 2002;80:48-58.

Campbell AIM, Zhao Y, Sandhu R, Stewart DJ: Cell-based transfer of VEGF attenuates monocrotaline-induced pulmonary hypertension. Circulation, 2001;104:2242-2248.

Dharmakumar R, Plewes DB, Wright GA: On the parameters affecting the sensitivity of MR measures of pressure with microbubbles. Magnetic Resonance in Medicine, 2002;47:264-273.

Dumont AS, Hyndman ME, Dumont RJ, Fedak PWM, Kassell NF, Sutherland GR, Verma S: Improvement of endothelial function in insulin-resistant carotid arteries treated with pravastatin. J Neurosurg, 2001;95:466-471.

Fedak PWM, Verma S, Weisel RD, Mickle DAG, Li R-K: Angiogenesis: Protein, gene or cell therapy. Heart Surg Forum, 2001;4:301-304.

Gori T, Burstein J, Ahmed S, Miner S, Al-Hesayen A, Parker JD: Folic acid prevents nitroglycerin-induced nitric oxide synthase dysfunction and nitrate tolerance. Circulation, 2001;104(10:1119-1123.

Gori T, Mak SS, Kelly S, Parker JD: Evidence supporting abnormalities in nitric oxide synthase function induced by nitroglycerin in humans. J Am Coll Cardiol, 2001;38(4):1096-1101.

Hinek A, Riazi S: The role of elastin in modulation of cellular proliferation. Mol Biol Cell, 2001;12:65a.

Jurt U, Gori T, Ravandi A, Babaei S, Zeman P, Parker JD: Differential effects of pentaerythritol tetranitrate and nitroglycerin on oxidative stress and nitrate tolerance development. A human in vivo study. J Am Coll Cardiol, 2001;38(3):854-859.

Koirala B, Merklinger SL, Van Arsdell GS, McCrindle BW, Borger MA, Calderone C, Coles JG, Williams WG: Extending the usable size range of homografts in the pulmonary circulation: Outcome of “bicuspid homografts”. Ann Thorac Surg, 2002;73(3):866-869; discussion 869-870.

Lapointe N, Rouleau JL: Activation of vascular tissue angiotensin converting enzyme (ACE) in heart failure: Effects of ACE inhibitors. J Am Coll Cardiol, 2002;39(5):776-779.

Miriuka S, Rao V, Weisel RD, Li SH, Anderson TJ, Maitland A, Fedak PWM, Li R-K, Verma S: Cyclosporin induced endothelial dysfunction: Effects of the nitric oxide cofactor, tetrahydrobiopterin. J Heart Lung Transplant, 2002;21(1):130-131.

Nguyen QT, Cernacek P, Sirois MG, Calderone A, Lapointe N, Stewart DJ, Rouleau JL: Long-term effects of non-selective endothelin A and B receptor antagonism in post-infarction rat: Importance of timing. Circulation, 2001;104:2075-2081.

Parker JD, Gori T: Tolerance to the organic nitrates: New ideas, new mechanisms, continued mystery. Circulation, 2001;104:2263-2265.

Qi X, Varma P, Newman D, Mamalias N, Dorian P: Terikalant, an IK1 and IKr blocker, decreases the area of vulnerability to ventricular fibrillation induction by T wave shocks in dogs. J Cardiovasc Pharmacol, 2002;39(2):242-250.

Riazi S, Chitayat D, Urban Z, Hinek A: The role of elastin in modulation of cellular proliferation. Can J Cardiol, 2001;17(Suppl C):242C.

Shiono L, Rao V, Weisel RD, Kawasaki M, Li R-K, Mickle DAG, Fedak PWM, Tumiati L, Verma S: L-arginine protects human heart cells from low-volume anoxia and reoxygenation. Am J Physiol: Heart Circ Physiol, 2002;282:H805-H815.

Sia YT, Lapointe N, Parker TG, Tsoporis JN, Deschepper CF, Calderone A, Pourdjabbar A, Jasmin JF, Sarrasin JF, Liu P, Adam A, Butany J, Rouleau JL: Beneficial effects of long-term use of the antioxidant probucol in heart failure in the rat. Circulation, 2002;105(21):2549-2555.

Torrance SM, Wittnich C: Post ischemic functional recovery in immature hearts is influenced by performance index and assessment technique. Am J Physiol: Heart & Circ, 2001;281:H2446-H2455.

Urban Z, Riazi S, Seidl TL...Boyd CD, Hinek A: Connection between elastin haploinsufficiency and increased cell proliferation in patients with supravalvular aortic stenosis and Williams-Beuren Syndrome. Am J Hum Genet, 2002;71(1):30-44.

Van Soeren M, Micevski V: Indicators and barriers to successful role implementation for acute care nurse practitioners in 4 Ontario hospitals. AACN Clinical Issues, 2001;12(3):424-437.

Verma S, Li S-H, Badiwala MV, Weisel RD, Fedak PWM, Li R-K, Dhillon B, Mickle DAG: Endothelin antagonism and interleukin-6 inhibition attenuate the proatherogenic effects of c-reactive protein. Circulation, 2002;105(16):1890-1896.

Verma S, Maitland A, Weisel RD, Fedak PWM, Li SH, Mickle DAG, Li R-K, Ko L, Rao V: Increased endothelin-1 production in diabetic patients after cardioplegic arrest and reperfusion impairs coronary vascular reactivity: Reversal by means of endothelin antagonism. J Thorac Cardiovasc Surg, 2002;123(6):1114-1119.

Verma S, Maitland A, Weisel RD, Fedak PWM, Pomroy NC, Li SH, Mickle DAG, Li R-K, Rao V: Novel cardioprotective effects of tetrahydrobiopterin after anoxia and reoxygenation: Identifying cellular targets for pharmacologic manipulation. J Thorac Cardiovasc Surg, 2002;123(6):1074-1083.

Verma S, Maitland A, Weisel RD, Li SH, Fedak PWM, Pomroy NC, Mickle DAG, Li R-K, Ko L, Rao V: Hyperglycemia exaggerates ischemia-reperfusion-induced cardiomyocyte injury: Reversal with endothelin antagonism. J Thorac Cardiovasc Surg, 2002;123(6):1120-1124.

Verma S, Fedak PWM, Weisel RD, Butany J, Rao V, Maitland A, Li R-K, Dhillon B, Yau TM: Fundamentals of reperfusion injury for the clinical cardiologist. Circulation, 2002;105:2332-2336.

Wallen WJ, Belanger MP, Wittnich C: Body weight and food intake profiles are modulated by sex hormones and tamoxifen in chronically hypertensive rats. J Nutrition, 2002;132:1-5.

Wallen WJ, Belanger MP, Wittnich C: Sex hormones and the selective estrogen receptor modulator tamoxifen modulate weekly body weights and food intakes in adolescent and adult rats. J Nutrition, 2001;131:2351-2357.

Wittnich C, Belanger MP, Wallen JW, Torrance SM, Juhasz S: A long-term stable normothermic cardiopulmonary bypass model in neonatal swine. J Surg Res, 2001;101:176-182.

Wong AYH, Kulandavelu S, Whiteley KJ, Qu D, Langille BL, Adamson SL: Maternal cardiovascular changes during pregnancy and postpartum in mice. Am J Physiol: Heart & Circ, 2002;282:H918-H925.

Yang L, Tuan L, Newman ER: Structure of the LRP-regulated serA promoter of E. coli K-12. Mol Microbio, 2002;43(2):323-333.

FACULTYAdeli K, Taghibiglou C, Carpentier A, Lewis GF: Mechanisms of hepatic very low-density lipoprotein overproduction of VLDL in insulin resistance. Trends in Cardiovasc Med, 2001;11(5):170-176.

Afroze T, Husain M: Cell cycle-dependent regulation of intracellular calcium concentration in vascular smooth muscle cells: A potential target for drug therapy. Curr Drug Targets – Cardiovasc & Haematol Dis, 2001;1:23-40

Ahmad F, Gupta H, Rawlins J, Stewart DE: Preferences for gender of family physicians among Canadian European-descent and South Asian immigrant women. Family Practice, 2002;19:146-153.

Ahmed Z, Ravandi A, Maguire GF, Emili A, Draganov D, La Du BN, Kuksis A, Connelly PW: Multiple substrates for paraoxonase-1 during oxidation of phosphatidylcholine by peroxynitrite. Biochem Biophys Res Comm, 2002;290:391-396.

Ahmed Z, Ravandi A, Maguire GF, Kuksis A, Connelly PW: Aminoguanidine forms Schiff’s base adducts with phosphatidylcholine core aldehydes as part of its antioxidant activity. Clin Chem, 2001;47(6):A54.

Al-Sannaa N, Forrest CR, Teebi AS: Trigonomicrocephaly, severe micrognathia, large ears, atrioventricular septal defect, symmetrical cutaneous syndactyly of hands and feet and multiple cafe-au-lait spots: New acrocraniofacial dysostosis syndrome? Am J Med Gen, 2001;101:279-282.

Alter DA, Naylor CD, Austin PC, Tu JV: Factoring socioeconomic status into cardiac performance profiling for hospitals: Does it matter? Medical Care, 2002;40(1):60-67.

Alter DA, Naylor CD, Austin PC, Tu JV: Long-term MI outcomes at hospitals with or without on-site revascularization. JAMA, 2001;285(16):2101-2108.

Atkins DL, Dorian P, Gonzalez ER, et al: Treatment of tachyarrhythmias. Ann Emerg Med, 2001;37(4Pt2):S91-S109.

Austin LA, Ahmad F, McNally MJ, Stewart DE: Breast and cervical cancer screening in Hispanic women: A literature review using health belief model. Women’s Health Issues, 2002;12:122-128.

Azakie A, McCrindle BW, Van Arsdell GS, Benson LN, Coles JG, Hamilton R, Freedom RM, Williams WG: Extracardiac conduit versus lateral tunnel cavopulmonary connections at a single institution: Impact on outcomes. J Thorac Cardiovasc Surg, 2001;122(6):1219-1228.

Azakie A, Merklinger S, McCrindle BW, Van Arsdell G, Benson LN, Lee K-J, Coles JG, Williams WG: Evolving strategies and improving outcomes of the modified Norwood procedure: A 10-year single-institution experience. Ann Thorac Surg, 2001;72:1349-1353.

Azakie A, Merklinger S, Williams WG, Van Arsdell GS, Coles JG, Adatia I: Improving outcomes of the Fontan operation in children with atrial isomerism and heterotaxy syndromes. Ann Thorac Surg, 2001;72:1636-1640.

Azevedo ER, Kubo T, Mak S, Al-Hesayen A, Newton GE, Floras JS, Parker JD: Nonselective versus selective adrenergic receptor blockade in congestive heart failure: Differential effects on sympathetic activity. Circulation, 2001;104:2194-2199.

Azevedo ER, Stewart DJ, Parker JD: Increased extraction of endothelin-1 across the failing human heart. Am J Cardiol, 2001;88(2):180-182.

Bandali K, Belanger MP, Wittnich C: Is hyperglycemia seen in children during cardiopulmonary bypass a result of hyperoxia? J Thorac Cardiovasc Surg, 2001;122(4):753-758.

Barolet AW, Babaei S, Robinson R, Picard P...Stewart DJ, Strauss BJ: Administration of exogenous endothelin-1 following vascular balloon injury: Early and late effects on intimal hyperplasia. Cardiovasc Res, 2001;52(3):468-476.

Belanger MP, Wittnich C, Torrance SM, Juhasz S: Model of normothermic long-term cardiopulmonary bypass in swine weighing more than eighty kilograms. Comp Med, 2002;52(2):117-121.

Bellingham CM, Woodhouse K, Robson P, Rothstein S, Keeley FW: Self-aggregation characteristics of recombinantly expressed human elastin polypeptides. Biochim Biophys Acta, 2001;1550:6-19.

Bendeck M, Nakada M: The β3 integrin antagonist m7E3 reduces matrix metalloproteinase activity and smooth muscle cell migration. J Vasc Res, 2001;38:590-599.

Bendeck MP, Conte M, Zhang M, Nafiseh N, Strauss B, Farwell S: Doxycycline modulates smooth muscle cell growth, migration and matrix remodeling after arterial injury. Am J Path, 2002;160:1089-1095.

Bendeck MP: Matrix metalloproteinases: Are they anti-atherogenic but pro-aneurysmal? Circ Res, 2002;90:836-837.

Bhagawan K, Merklinger S, Van Arsdell GS, McCrindle BW, Borger MA, Caldarone CA, Coles JG, Williams WG: Extending the usable size range of homografts in the pulmonary circulation: Outcome of bicuspid homografts. Ann Thorac Surg, 2002;73:866-870.

Black CE, Huang N, Neligan PC, Levine RH, Lipa JE, Lintlop S, Forrest CR, Pang CY: Effect of nicotine on vasoconstrictor and vasodilator responses in human skin vasculature. Am J Physiol: Regul Integr Comp Physiol, 2001;281:R1097-R1104.

Blais Jr, C, Lapointe N, Rouleau JL, Clement R, Bachvarov DR, Adam A: Effect of captopril and omapatrilat on early post-myocardial infarctions survival and cardiac hemodynamics in rats: Interaction with cardiac cytokine expression. Can J Physiol & Pharmacol, 2002;80:48-58.

Bonetta C, Cheung AM, Stewart DE: Italian-Canadian women’s views of menopause: How culture may affect hormone use. Medscape Women’s Health, 2001;6(5).

Bonn V, Cheung RC, Chen B, Taghibiglou C, Van Iderstine S, Adeli K: Simvastatin, an HMG-CoA reductase inhibitor, induces the synthesis and secretion of apolipoprotein AI in HepG2 cells and primary hamster hepatocytes. Atherosclerosis, 2002;163:59-68.

Borger MA, Feindel CM: Cerebral emboli during cardiopulmonary bypass: Effect of perfusionist interventions and aortic cannulas. J Extra Corpor Technology, 2002;34:29-33.

Bradley TD, Lorenzi-Filho G, Floras JS: Pathophysiological interactions between sleep apnea and the heart. IN: Respiratory-Circulatory Interactions in Health and Disease (Scharf S, Pinsky M, Magder S, eds), Marcel Dekker, New York, 2001:577-611.

Brockhausen I, Lehotay M, Yang J-M, Wenshen Q, Young D, Lucien J, Coles JG, Paulsen H: Glycoprotein biosynthesis in porcine aortic endothelial cells and changes in the apoptotic cell population. Glycobiology, 2002;12:33-45.

Brown AL, Farhat W, Merguerian PA, Wilson GJ, Khoury AE, Woodhouse KA: 22 week assessment of bladder acellular matrix as a bladder augmentation material in a porcine model. Biomaterials, 2002;23(10):2179-2190.

Buono C, Come CE, Witztum JL, Maguire GF, Connelly PW, Carroll M, Lichtman AH: The influence of C3 deficiency on atherosclerosis. Circulation, 2002;105:3025-3031.

Butany J, Dias B, Iyengar P, Leask R, Brister S: Acute mitral regurgitation due to a torn porcine bioprosthetic cusp. Circulation, 2002;105(10):e58-e60.

Butany J, Leask R: The failure modes of biological prosthetic heart valves. J Long-Term Effects of Medical Implants, 2001;11:115-135.

Butany J: Pathogenetic heterogeneity of in-stent lesion formation in human peripheral arterial disease. J Vasc Surg, 2002;35(4):820-822.

Cameron JI, Franche RL, Cheung AM, Stewart DE: Lifestyle interference and emotional distress in family caregivers to advanced cancer patients. Cancer, 2002;94:521-527.

Campbell AIM, Zhao Y, Sandhu R, Stewart DJ: Cell-based transfer of VEGF attenuates monocrotaline-induced pulmonary hypertension. Circulation, 2001;104:2242-2248.

Carcao MD, Blanchette VS, Stephens D, He L, Wakefield CD, Butchart S, Christie DJ, Rand ML: Assessment of thrombocytopenic disorders using the Platelet Function Analyzer (PFA-100®). Br J Haematol, 2002;117:961-964.

Carpentier A, Taghibiglou C, Leung N...Buckingham R, Adeli K, Lewis GF: Ameliorated hepatic insulin resistance is associated with normalization of microsomal triglyceride transfer protein expression and reduction in very low density lipoprotein assembly and secretion in the fructose-fed hamster. J Biol Chem, 2002;277(32):28795-28802.

Chan C, Floras JS, Miller JA, Richardson RMA, Pierratos A: Regression of left ventricular hypertrophy after conversion to nocturnal hemodialysis. Kidney International, 2002;61:2235-2239.

Chidambaram M, Duncan JA, Lai VS, Cattran DC, Floras JS, Scholey JW, Miller JA: Variation in the renin angiotensin system throughout the normal menstrual cycle. J Am Soc Nephrology, 2002;13:446-452.

Clark RH, Gerstmann DR, Jobe AH, Moffitt ST, Slutsky AS, Yoder BA: Lung injury in neonates: Causes, strategies for prevention and long-term consequences. J Pediatrics, 2001;139(4):478-484.

Cohen G, Christakis GT, Tamariz M...Rao V, Szalai JP, Fremes SE, Goldman BS: Are stentless valves hemodynamically superior to stented valves? A prospective randomized trial. Ann Thorac Surg, 2001;73:767-778.

Cohen G, Tamariz MG, Sever JY...Abouzahr L, Goldman BS, Fremes SE: The radial artery versus the saphenous vein graft in contemporary CABG: A case-matched study. Ann Thorac Surg, 2001;71:180-186.

Cohen J, Butany J, Leask RL, Desai ND, Lenkei S, Feindel CM: Chronic aortic dissection: 27 years after aortic valve replacement. Can J Cardiol, 2002;18(4):437-438.

Cohen MM, Schei B, Ansara D, Gallop R, Stuckless N, Stewart DE: A history of personal violence and postpartum depression: Is there a link? Archives of Women’s Mental Health, 2002;4:83-92.

Cook D, Laporta D, Skrobik Y, Peters S, Sharpe M, Murphy P, Chin D, Crowther M: Prevention of venous thromboembolism in critically ill surgery patients: A cross-sectional study. J Crit Care, 2001;16(4):161-166.

Cook D, McMullin J, Hodder R, Heule M, Pinilla J, Dodek P, Stewart T, and the Canadian ICU Directors Group: Prevention and diagnosis of venous thromboembolism in critically ill patients: A Canadian survey. Crit Care, 2001;5:336-342.

Cunningham CH, Stainsby JA, Wright GA, Wood ML: Partial Discrete Fourier Transform (PDFT) multiband encoding. Magnetic Resonance in Medicine, 2001;45:118-127.

David TE, Armstrong S, Ivanov J, Feindel CM, Omran A, Webb G: Results of aortic valve-sparing operations. J Thorac Cardiovasc Surg, 2001;122(1):39-46.

David TE, Ivanov J, Eriksson MJ, Bos J, Feindel CM, Rakowski H: Dilation of the sinotubular junction causes aortic insufficiency after aortic valve replacement with the Toronto SPV bioprosthesis. J Thorac Cardiovasc Surg, 2001;122(5):929-934.

De Durante G, Del Turco M, Rustichini L, Cosimini P, Giunta F, Hudson LD, Slutsky AS, Ranieri VM: ARDSNet lower tidal volume ventilatory strategy may generate intrinsic positive end-expiratory pressure in patients with acute respiratory distress syndrome. Am J Resp and Crit Care Med, 2002;165(9):1271-1274.

Degousee N, Stefanski E, Lindsay TF, Rubin BB: p38 MAPK regulates group I1a phospholipase A2 expression in interleukin – 1B stimulated rat neonatal cardiomyocytes. J Biological Chem, 2001;276(47):43842-43849.

Dellgren G, Coles JG: Pediatric heart transplantation: Improving results in high-risk patients. IN: Pediatric Cardiac Surgery Annual 2001 (Coles JG, Williams WG, eds). W.B. Saunders Company, Philadelphia, 2001:103-113.

Dellgren G, Feindel CM, Bos J, Ivanov J, David TE: Aortic valve replacement with the Toronto SPV: Long-term clinical and hemodynamic results. Eur J Cardiothorac Surg, 2002;21(4):698-702.

Dharmakumar R, Plewes DB, Wright GA: On the parameters affecting the sensitivity of MR measures of pressure with microbubbles. Magnetic Resonance in Medicine, 2002;47:264-273.

Dias B, Barolet A, Ralph-Edwards A, Graba J, Mohsen B, Butany J: Left atrial mass. Can J Cardiol, 2002;18(1):82-85.

Dias B, El-Hajj H, Cusimano RJ, Graba J, Velups A, Butany J: Coexisting ventricular septal aneurysms: Congenital and postmyocardial infarction. Can J Cardiol, 2001;17(11):1193-1196.

Dias B, Parker T, Ralph-Edwards A, Velups S, Butany J: Surgical myectomy in hypertrophic cardiomyopathy. Can J Cardiol, 2001;17(10):1087-1089.

Dias B, Sassoon Z, Leask R, Yau T, Persaud J, Butany J: Right atrial mass. Can J Cardiol, 2001;17(12):1299-1304.

Dias B, Scully H, Black R, Iwanochko RM, Graba J, Butany J: Actue bacterial endocarditis on myxomatous mitral valve. Can J Cardiol, 2001;17(9):983-985.

Diaz RJ, Batthish M, Backx PH, Wilson GJ: Chloride channel inihibition does block the protection of ischemic preconditioning in myocardium. J Mol Cell Cardiol, 2001;33(10):1887-1889.

Dorian P, Cass D, Schwartz B, Cooper R, Gelaznikas R, Barr A: A randomized clinical trial of amiodarone versus lidocaine in shock resistant out-of-hospital ventricular fibrillation. N Eng J Med, 2002, March.

Dorian P, Koster RW, Chapman FW, Schmitt PW, O’Grady SG: External cardioversion of atrial fibrillation with biphasic shocks requires less current and cases less pain discomfort. Acad Emerg Med, 2001;8(5):543-544.

dos Santos CC, Zhang H, Slutsky AS: From bench to bedside: Bacterial growth and cytokines (Commentary). Crit Care, 2002;6:4-6.

Durbin AD, Gotlieb AI: Advances towards understanding heart valve response to injury. Cardiovascular Pathology, 2002;11:69-77.

Egri Z, Floras JS: Role of angiotensin II blockade in therapy of heart failure. IN: Harrison’s On-Line (Braunwald E. ed), McGraw-Hill, Doi.1036/1096/7133.edl3037

Emmett L, Iwanochko RM, Barolet A, Freeman M, Lee D, Husain M: Reversible regional wall motion abnormalities on exercise Tc-99m gated cardiac SPECT predict high-grade angiographic stenoses. J Am Coll Cardiol, 2002;39:991-998.

Ethier CR, Chan DW-H: Cationic ferritin changes outflow facility in human eyes while anionic ferritin does not. Investigative Ophthalmology and Visual Sci, 2001;42:1795-1802.

Ethier CR: The inner wall of Schlemm’s canal. Experimental Eye Res, 2002;74:161-172 (Invited Review).

Exercise and Stress Response: The Role of Stress Proteins. (Locke M, Noble EG, co-eds), CRC Press, Boca Raton, Florida, 2002.

Farb RI, McGregor C, Kim JK...Schwartz ML, Stainsby JA, Wright GA: Intracranial arteriovenous malformations: Real-time auto-triggered elliptic centric-ordered 3D gadolinum-enhanced MR angiography – initial assessment. Radiology, 2001;220(1):244-251.

Farkas LG, Katie MJ, Forrest CR, Litsas L: Surface anatomy of the face in Down’s Syndrome: Linear and angular measurements in the craniofacial regions. J Craniofacial Surgery, 2001;12:373-379.

Farkas LG, Katie MJ, Forrest CR: Surface anatomy of the face in Down’s Syndrome: Anthropometric proportion indices in the craniofacial regions. J Craniofacial Surgery 2001;12:519-524.

Fedak PWM, Verma S, Weisel RD, Mickle DAG, Li R-K: Angiogenesis: Protein, gene or cell therapy. Heart Surg Forum, 2001;4:301-304.

Fialkov JA, Holy C, Forrest CR, Phillips JH, Antonyshyn OM: Post-operative infections in craniofacial reconstructive procedures. J Craniofacial Surgery, 2001;12:362-363.

Floras JS, Butler GC, Ando S, Brooks S, Pollard MJ, Picton P: Differential sympathetic nerve and heart rate power spectral responses to lower body negative pressure. Am J Physiol: Regulatory Integrative and Comparative Physiol, 2001;281:R468-R475.

Floras JS: Morning activity and blood pressure-a cause for concern? J Hypertension, 2002;20:809-811 (Invited Editorial).

Floras JS: The ‘unsympathetic’ nervous system of heart failure. Circulation, 2002;105:1753-1755 (Invited Editorial).

Floras JS: Update on the Canadian Hypertension Society: Maintaining our strengths within an evolving environment. Can J Cardiol, 2002;18:589-590 (Invited Editorial).

Floras JS: Vasopeptidase inhibition: A novel approach to cardiovascular therapy. Can J Cardiol, 2002;18:177-182.

Forrest CR, Armstrong DC: Vascular anomalies. IN: Craniofacial Surgery: A Multidisciplinary Approach to Craniofacial Anomalies (Lin K, Ogle R, Jane J, eds). W.B. Saunders Company, Toronto, 2001:382-397.

Franco C, Hou G, Bendeck MP: Collagens, integrins and the discoidin domain receptors in arterial occlusive disease. Trends in Cardiovasc Med, 2002;12:143-148.

Ghali WA, Cornuz J, McAlister FA, Wasserfallen J-B, Devereaux PJ, Naylor CD: Accelerated publication versus usual publication in 2 leading medical journals. CMAJ, 2002;166(9):1137-1143.

Goodman J, Thomas SC: Aging of the cardiorespiratory system: Influences of gender and physical activity. IN: Gender, Physical Activity and Aging (Shephard RJ, ed). CRC Press, 2002.

Goodman JM, Kirwan LD: Exercise-induced myocardial ischemia in women: Factors affecting prevalance. Sports Medicine, 2001;31(4):235-247.

Goodman LS, Mikuliszyn R, Grosman-Rimon L, et al: Effect of carotid sinus pressure clamping during centrifuge Gz transition maneuvers. Aviat Space Environ Med, 2002;73(3):304.

Gori T, Burstein J, Ahmed S, Miner S, Al-Hesayen A, Parker JD: Folic acid prevents nitroglycerin-induced nitric oxide synthase dysfunction and nitrate tolerance. Circulation, 2001;104(10:1119-1123.

Gori T, Mak SS, Kelly S, Parker JD: Evidence supporting abnormalities in nitric oxide synthase function induced by nitroglycerin in humans. J Am Coll Cardiol, 2001;38(4):1096-1101.

Grace SL, Abbey SE, Shnek ZM, Irvine J, France R-L, Stewart DE: Cardiac rehabilitation I: Review of psychosocial factors. General Hospital Psychiatry, 2002;24:121-126.

Grace SL, Abbey SE, Shnek ZM, Irvine J, France R-L, Stewart DE: Cardiac rehabilitation II: Referral and participation. General Hospital Psychiatry, 2002;24:127-134.

Grasso S, Mascia L, Del Tuco M, Malacarne P, Giunta F, Brochard L, Slutsky AS, Ranieri VM: Effects of recruiting maneuvers in patients with acute respiratory distress syndrome ventilated with protective ventilatory strategy. Anesthesiology 2002;96(4):795-802.

Gros R, Van West R, You X, Thorin E, Husain M: Age, gender and blood-pressure-dependent myogenic responses in C57B1/6 mice. Am J Physiol: Heart & Circ Physiol, 2002;282(1):H380-H388.

Gupta A, Kuman A, Stewart DE: Cervical cancer screening among South Asian women: The role of education and acculturation. Health Care for Women International, 2002;23:123-134.

Guttman M, Slaughter PM, Theriault M-E, DeBoer DP, Naylor CD: Parkinsonism in Ontario: Physician Utilization. Can J Neurological Sci, 2002.

Guttman M, Slaughter PM, Theriault M-E, DeBoer DP, Naylor CD: Parkinsonism in Ontario: Increased mortality compared with controls in a large cohort study. Neurology, 2001;57:2278-2282.

Guy RA, Maguire GF, Crandall, Connelly PW, Kain KC: Characterization of peroxynitrite-oxidized low density lipoprotein binding to human CD36. Atherosclerosis, 2001;155:19-28.

Guyatt G, Haynes B, Jaeschke R, Cook D, Greenhalgh T, Meade M, Green L, Naylor CD, Wilson M, McAllister F, Richardson WS: Chapter 2A: Expanded philosophy of evidence-based medicine – parallel but separate goals – evidence-based practitioners and evidence-based care. IN: Users’ Guide to the Medical Literature (Guyatt G, Rennie D, eds). JAMA & Archives Journals, AMA Press, 2002:205-209.

Guyatt G, Haynes B, Jaeschke R, Cook D, Greenhalgh T, Meade M, Green L, Naylor CD, Wilson M, McAllister F, Richardson WS: Chapter 1A: Introduction: The philosophy of evidence based medicine. IN: Users’ Guide to the Medical Literature (Guyatt G, Rennie D, eds). JAMA & Archives Journals, AMA Press, 2002:3-12.

Guyatt G, Naylor CD, Juniper E, Heyland D, Jaeschke R, Cook D: Chapter 2B2: Therapy and understanding the results – quality of life. IN: Users’ Guide to the Medical Literature (Guyatt G, Rennie D, eds). JAMA & Archives Journals, AMA Press, 2002:309-329.

Hanayama N, Christakis GT, Mallidi HR, Joyner CD, Fremes SE, Morgan CD, Mitoff PR, Goldman BS: Patient prosthesis mismatch is rare following aortic valve replacement; vale size may be irrelevant. Ann Thorac Surg, 2001/2002.

Harris SB, Zinman B, Hanley A, Gittelsohn J, Hegele RA, Connelly PW, Shah B, Hux JE: The impact of diabetes on cardiovascular risk factors and outcomes in a native Canadian population. Diab Res Clin Prac, 2002;55:165-173.

Hinek A, Riazi S: The role of elastin in modulation of cellular proliferation. Mol Biol Cell, 2001;12:65a.

Hou G, Vogel WF, Bendeck MP: The tyrosine kinase activity of discoidin domain receptor 1 is necessary for smooth muscle cell migration and matrix metalloproteinase expression. Circ Res, 2002;90:1147-1149.

Humphries KH, Kerr CR, Connolly SJ, Klein G, Boone JA, Green M, Sheldon R, Ralajic M, Dorian P, Newman D: New-onset atrial fibrillation: Sex differences in presentation, treatment and outcome. Circulation, 2001;103:2365-2370.

Hutchison SJ, Sievers RE, Zhu BQ, Sun YP, Stewart DJ, Parmley WW: Secondhand tobacco smoke impairs rabbit pulmonary artery endothelium-dependent relaxation. Chest, 2001;120(6):2004-2012.

Hyman I, Singh M, Ahmad F...Stewart DE: The role of the physician in mammography referral for older Caribbean women in Canada. Medscape Women’s Health, 2001;6(5).

Hyman I, Singh M, Meana M, George U, Wells LM, Stewart DE: Physician-related determinants of cervical cancer screening among Caribbean women in Toronto. Ethnicity and Disease, 2002;12:268-275.

Imaj Y, Nakagawa S, Ito Y, Kawano T, Slutsky AS, Miyasaka K: Comparison of lung protection strategies using conventional and high-frequency oscillatory ventilation. J App Physiol, 2001;91(4):1836-1844.

Jackson ZS, Gotlieb AI, Langille BL: Effects of anastomotic angle on vascular tissue responses at end-to-side arterial grafts. J Vasc Surg, 2001-34:300-307.

Jackson ZS, Gotlieb AI, Langille BL: Wall tissue remodelling regulates longitudinal tension in arteries. Circulation Research, 2002;90:918-925.

Jamieson WR, David TE, Feindel CM, Miyagishima RT, Germann E: Performance of the Carpentier-Edwards SAV and Hancock-II porcine bioprostheses in aortic valve replacement. J Heart Valve Dis, 2002;11(3):424-430.

Jeejeebhoy F, Keight M, Freeman M, Barr A, McCall M, Kurian R, Mazer D, Errett L: Nutritional supplementation with MyoVive® repletes essential cardiac myocyte nutrients and reduces left ventricular size in patients with left ventricular dysfunction. Am Heart J, 2002;143(6):1092-1100.

Jeejeebhoy KN, Sole MJ: Nutrition and the heart. Clin Nutr, 2001;20(suppl):181-185.

Jenkins DJ, Kendall CW, Vidgen E, Augustin LS, van Erk M, Geelen A, Parker T, Falkner D, Vuksan V, Josse RG, Leiter LA, Connelly PW: High-protein diets in hyperlipidemia: Effect of wheat gluten on serum lipids, uric acid, and renal function. Am J Clin Nutr, 2001;74:57-63.

Jenkins DJA, Kendall CWC, Connelly PW, Jackson C-J, Parker T, Falkner D, Vidgen E: Effects of high and low isoflavone (phytoestrogen) soy foods on inflammatory biomarkers and proinflammatory cytokines in hyperlipidemic men and women. Metabolism, 2002;51:919-924.

Ju H, Gros R, You X, Tsang S, Husain M, Rabinovitch M: Conditional and targeted overexpression of vascular chymase in transgenic mice causes hypertension. Proc Natl Acad Sci USA, 2001;98:7469-7474.

Jurt U, Gori T, Ravandi A, Babaei S, Zeman P, Parker JD: Differential effects of pentaerythritol tetranitrate and nitroglycerin on oxidative stress and nitrate tolerance development. A human in vivo study. J Am Coll Cardiol, 2001;38(3):854-859.

Kamel KS, Mazer CD: Effect of NaHCO3 on cardiac energy metabolism and contractile function during hypoxemia. Crit Care Med, 2001;29(2):344-350.

Keeley FW, Bellingham CM, Woodhouse KA: Elastin as a self-organizing biomaterial. Use of recombinantly expressed human elastin polypeptides as a model for investigations of structure and self-assembly of elastin. Philosophical Transactions of the Royal Society B, 2002;357:185-190.

Keith ME, Ball A, Jeejeebhoy KN... Sole MJ: Conditioned nutritional deficiences in the cardiomyopathic hamster heart. Can J Cardiol, 2001;17:449-458.

Kim EJ, Li R-K, Weisel RD, Mickle DAG, Jia Z-Q, Tomita S, Sakai T, Yau TM: Angiogenesis by endothelial cells transplantation. J Thorac Cardiovasc Surg, 2001;122(5):963-971.

Kip KE, Alderman EL, Bourassa MG, Brooks MM, Schwartz L, et al: Differential influence of diabetes melltus on increased jeopardized myocardium after initial angioplasty or bypass surgery: Bypass angioplasty revascularization investigation. Circulation, 2002;105:1914-1920.

Koirala B, Merklinger SL, Van Arsdell GS, McCrindle BW, Borger MA, Calderone C, Coles JG, Williams WG: Extending the usable size range of homografts in the pulmonary circulation: Outcome of “bicuspid homografts”. Ann Thorac Surg, 2002;73(3):866-869; discussion 869-870.

Konstantinov I, Mickleborough LL, Graba J, Merchant N: Intraventricular mitral annuloplasty technique for use with posterior left ventricular aneurysm repair. J Thorac Cardiovasc Surg, 2001;122(6):1244-1247.

Kubo T, Azevedo E, Newton GE, Parker JD, Floras JS: Lack of evidence for peripheral alpha1-adrenoceptor blockade during long-term treatment of heart failure with carvedilol. J Am Coll Cardiol, 2001;38:1463-1469.

Kutryk MJB, Kassam SA, Stewart DJ: Therapeutic angiogenesis for coronary artery disease. IN: Coronary Lesions A Pragmatic Approach. (Dunitz M, ed) Taylor & Francis Group, United Kingdom, 2002:21-42.

Kutryk MJB, Stewart DJ: Cardiac angiogenesis: Part I. An emerging technology for the treatment of CAD. Perspectives in Cardiology, 2001;17(9):47-55.

La Scala GC, Carroll SM, Forrest CR, Zuker RM: Use of a mechanical leech in a reverse-flow radial forearm flap: Case report. J Reconstr Microsurgery, 2001;7:335-340.

Lambert AS, Mazer CD, Duke PC: Survey of the members of the cardiovascular section of the Canadian Anesthesiologists’ Society on the use of perioperative transesophageal echocardiography. Can J Anesth, 2002;49(3):294-296.

Lapointe N, Rouleau JL: Activation of vascular tissue angiotensin converting enzyme (ACE) in heart failure: Effects of ACE inhibitors. J Am Coll Cardiol, 2002;39(5):776-779.

Lee C, Mankani MH, Kellman RM, Forrest CR: Minimally invasive approaches to mandibular fractures. IN: Facial Plastic Surgery Clinics of North America (Thomas JR, ed). W.B. Saunders, Philadelphia, PA, 2001:475-488.

Lee SD, Dorian P, Downar E, Burns M, Yeo E, Gold WL, Paquette M, Lau W, Newman DM: Thrombogenicity of radiofrequency ablation procedures: What factors influence thrombin generation? Europace, 2001;3(3):195-200.

Lee SD, Joseph M, Lambert AS, Mazer CD, Hutchison SJ: Right heart obstruction from a balloon-like sinus of Valsalva aneurysm in a patient with Down’s Syndrome. Can J Cardiol, 2002;18(4):433-436.

Lewis GF, Carpentier A, Adeli K, Giacca A: Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocrine Reviews, 2002;23(2):201-229.

Leytin V, Allen DJ, Mody M, Rand ML, Hannach B, Garvey B, Freedman J: A rabbit model for monitoring human platelet viability of human platelet concentrates using flow cytometry. Transfusion, 2002;42:711-718.

Li GM, Borger MA, Williams WG, Weisel RD, Mickle DAG, Wigle D, Li R-K: Regional overexpression of IGF-1 and TFG-B1 in the myocardium of hypertrophic obstructive cardiomyopathic patients. J Thorac Cardiovasc Surg, 2002;123(1):89-95.

Li R-K, Mickle DAG, Weisel RD, Jia Z-Q, Rao V: Optimal time for cardiomyocyte transplantation to maximize myocardial function after left ventricular necrosis. Ann Thorac Surg, 2001;72:1957-1963.

Lin Y, Callum JL, Coovadia A, Murphy P: Transfusion of ABO-non-identical platelets is not associated with adverse clinical outcomes in cardiovascular surgery patients. Transfusion Medicine, 2002.

Locke M, Celotti C: Cold stress does not induce stress proteins 25 and 72 in rat skeletal muscle. Cryobiology, 2001;43:54-62.

Locke M, Nussbaum E: Continuous and pulsed ultrasound do not increase HSP 72 content. Ultrasound in Medicine and Biology, 2001;27:1413-1419.

Mahinpey N, Ojha M, Trass O: Transient mass and heart transfer in a pipe. Int J Heat & Mass Transfer, 2001;44(20):3919-3930.

Mancini GB, Stewart DJ: Why were the results of the Heart Outcomes Prevention Evaluation (HOPE) trial so astounding? Can J Cardiol (Suppl A), 2001:15A-17A.

Mangaloglu L, Taghibiglou C, Chen B, Van Iderstine S, Cheung RC, Adeli K: Inhibition of HMG-CaA reductase ameliorates hepatic VLDL overproduction in an animal model of insulin resistance, the fructose-fed Syrian golden hamster. Metabolism, 2002;51(4):409-418.

Mascia L, Fedordo L, Stewart DJ, et al: Temporal relationship between endothelin-1 concentrations and cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage. Stroke, 2001;32(5):1185-1190.

McGinn R, Guyatt G, Wyer P, Naylor CD, Stiell I: Chapter 2C: Diagnosis clinical prediction rules. IN: Users’ Guides to the Medical Literature (Guyatt G, Rennie D, eds). JAMA & Archives Journals, AMA Press, 2002:471-483.

Merante F, Altamentova SM, Mickle DAG, Weisel RD...Li R-K: The characterization and purification of a human transcription factor modulating the glutathione peroxidase gene in response to oxygen tension. Mol Cell Biochem, 2002;229:73-83.

Mickleborough LL: Cardiac surgery for heart failure. LV reconstruction for ischemic cardiomyopathy. Seminars in Thorac Cardiovasc Surgery, 2002;14(2):144-149.

Mickleborough LL, Kells C: Revascularization strategies in women with ischemic heart disease. Can J Cardiol, 2001;17(D):53-56.

Moe GW, Stewart DJ: Endothelin receptor antagonism in heart failure. Harrison’s Online, Editorial Related to Chapter 232: Heart Failure, The McGraw-Hill Companies, 2001.

Morsi A, Schwartz L: The risks of percutaneous coronary intervention in recently implanted internal thoracic bypass grafts: A case report and review of the literature. Can J Cardiol, 2002;18(7):749-752.

Mungrue IN, Gros R, You X...Butany J, Stewart DJ, Husain M: Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block, and sudden death. J Clin Invest, 2002;109(6):735-745.

Nakamura T, Lozano PR, Ikeda Y, Iwanaga Y, Hinek A, et al: Fibulin-5/DANCE is essential for elastogenesis in vivo. Nature, 2002;415:171-175.

Naylor CD, Guyatt G: Chapter 2B: Therapy and harm outcomes of health services. IN: Users’ Guide to the Medical Literature (Guyatt G, Rennie D, eds). JAMA & Archives Journals, AMA Press, 2002:233-246.

Naylor CD, Guyatt G: Chapter 2F. IN: Users’ Guides to the Medical Literature (Guyatt G, Rennie D, eds). JAMA & Archives Journals, AMA Press, 2002:645-657.

Naylor CD: Clinical decisions: From art to science and back again. Lancet, 2001;358(9281):523-524.

Naylor CD: Early Toronto experience with new standards for industry-sponsored clinical research: A progress report. CMAJ, 2002;166(4):453-456.

Naylor CD: Humility, perspective and provocation: Reflecting on Codman. J Health Serv Res Policy, 2001;6(4):249-250.

Naylor CD: Public profiling of clinical performance. JAMA, 2002;287(10):1323-1325.

Naylor CD: Putting evidence into practice. Am J Med, 2002.

Naylor CD: The deferiprone controversy: Time to move on. CMAJ, 2002;166(4):452-453.

Naylor CD: Your money and/or your life? CMAJ, 2002;166(11):1416-1417.

Ng DS, Maguire GF, Wylie J, Ravandi A, Xuan W, Ahmed Z, Eskandarian M, Kuksis A, Connelly PW: Oxidative stress is markedly elevated in LCAT-deficient mice and is paradoxically reversed in the apolipoprotein E knockout background in association with a reduction in atherosclerosis. J Biol Chem, 2002;277:11715-11720.

Nguyen QT, Cernacek P, Sirois MG, Calderone A, Lapointe N, Stewart DJ, Rouleau JL: Long-term effects of non-selective endothelin A and B receptor antagonism in post-infarction rat: Importance of timing. Circulation, 2001;104:2075-2081.

Notarius CF, Azevedo ER, Parker JD, Floras JS: Peak oxygen uptake is not determined by cardiac norepinephrine spillover in heart failure. Eur Heart J, 2002;23:800-805.

Notarius CV, Atchison DJ, Rongen GA, Floras JS: Effect of adenosine receptor blockade with caffeine on sympathetic response to handgrip exercise in heart failure. Am J Physiol: Heart Circ Physiol, 2001;281:H1312-H1318.

O’Blenes SB, Feindel CM: Aortic root replacement with anomalous origin of the coronary arteries. Ann Thor Surg, 2002;73(2):647-649.

O’Donovan DA, Yeung I, Zeman V, Neligan PC, Pan CY, Forrest CR: Radiation-induced craniofacial bone growth inhibition: Development of an animal model. J Craniofacial Surgery, 2001;12:533-543.

Ogilvie RI: High altitude illness. N Eng J Med, 2001;345:1279-1280.

Ogilvie RI: The death of a volunteer research subject: Lessons to be learned. CMAJ, 2001;165:1335-1337.

Ojha M, Leask R, Butany J, Johnston KW: Distribution of intimal and medial thickening in the human right coronary artery: A study of 17 RCA’s. Atherosclerosis, 2001;158:147-153.

Okubo M, Benson LN, Nykanen D, Azakie A, Van Arsdell G, Coles JG, Williams WG: Outcomes of intraoperative device closure of muscular ventricular septal defects. Ann Thorac Surg, 2001;72:416-423.

Packham MA, Rand ML, Kinlough-Rathbone RL: Aggregation. IN: Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics (Gresele P, Page CP, Fuster V, Vermeylen J, eds). Cambridge University Press, Cambridge, MA, 2002;338-356.

Paradiso-Hardy FL, Cornish P, Pharand C, Fremes SE: A national survey of antimicrobial prophylaxis in adult cardiac surgery across Canada. Can J Infect Dis, 2002;13:21-27.

Parker JD, Gori T: Tolerance to the organic nitrates: New ideas, new mechanisms, continued mystery. Circulation, 2001;104:2263-2265.

Patterson JM, Llewellyn-Thomas HA, Naylor CD: Using disease risk estimates to guide risk factor interventions: Field test of a patient workbook for self-assessing coronary risk. Health Expectations, 2002;1:3-15.

Petroianu G, Roth C, Beha U, Fisher JA, Bergler W, Rufer R: Pralidoxime and 1-lactate effects in vitro on the inhibition of acetylcholinesterase by Paraoxon. J Appl Toxicol, 2001;21:7-13.

Pinter A, Dorian P, Newman D: Cesium induced Torsades de Pointes ventricular tachycardia. N Engl J Med, 2002;31:346(5):383-384.

Pinter A, Dorian P: Intravenous antiarrhythmic agents (Review). Curr Opin Cardiol, 2001;16(1):17-22.

Plotz FB, Vreugdenhil HAE, Slutsky AS, Zijlstra J, Heijnen CJ, van Vught H: Mechanical ventilation alters the immune response in children without lung pathology. Int Care Med, 2002;28(4):486-492.

Poirier NC, Coles JG: Cardiac transplantation: Surgical considerations. IN: Pediatric Anesthesia: Principles & Practice (Burno Dissonnette, Bernard Dalens, eds). McGraw-Hill, USA, 2001:1291-1298.

Pontrelli L, Parris W, Van Iderstine S, Adeli K, Cheung R: Atorvastatin treatment beneficially alters the lipoprotein profile and increases LDL particle diameter in patients with combined dyslipidemia and impaired fasting glucose/type 2 diabetes. Metabolism, 2002;51(3):334-342.

Porro GA, Lee JH, de Azavedo J...Slutsky AS, Zhang H: Direct and indirect bacterial killing functions of neutrophil defensins in lung explants. Am J Physiol: Lung Cell Mol Physiol, 2001;281(5):L1270-L1247.

Prakash S, Ethier CR: Enhanced error estimator for adaptive finite element analysis of 3D incompressible flow. Computer Methods in App Mechanics and Engineering, 2001;190:5413-5426.

Prat A, Feindel CM, et al: Ross operation for active culture-positive aortic valve endocarditis with extensive paravalvular involvement. Ann Thor Surg, 2001;72(5):1495-1496 (Invited Commentary).

Qi X, Varma P, Newman D, Dorian P: Gap junctional blockers decrease defibrillation thresholds without changes in ventricular refractoriness in isolated rabbit hearts. Circulation, 2001;104(13):1544-1549.

Qi X, Varma P, Newman D, Mamalias N, Dorian P: Terikalant, an IK1 and IKr blocker, decreases the area of vulnerability to ventricular fibrillation induction by T wave shocks in dogs. J Cardiovasc Pharmacol, 2002;39(2):242-250.

Qi XL, Sia YT, Stewart DJ, Wei G...Rouleau JL: Myocardial contractile responsiveness to endothelin-1 in the post-infarction model of heart failure: Effects of chronic quinapril. J Mol Cell Cardiol, 2001;33(1):2023-2035.

Rand ML, Wang H, Mody M, Chu I, Treutiger I, et al: Concurrent measurement of the survival of two populations of rabbit platelets labeled with either two PKH lipophilic dyes or two concentrations of biotin. Cytometry, 2002;47:111-117.

Rao V, Christakis GT, Weisel RD, Ivanov J, Borger MA, Cohen G: The insulin cardioplegia trial: Myocardial protection for urgent coronary artery bypass surgery. J Thorac Cardiovasc Surg, 2002;123:928-935.

Rao V, Feindel CM, Cohen G, Borger MA, Boylen P, Ross HJ: Is profound hypothermia required for storage of cardiac allografts? J Thorac Cardiovasc Surg, 2001;122(3):501-507.

Rashid S, Barrett P, Uffelman K, Watanabe T, Adeli K, Lewis G: Lipolytically-modified triglyceride-enriched HDLs are rapidly cleared from the circulation. Arterioscl Thromb Vas Biol, 2002;22(3):483-487.

Rashid S, Uffelman K, Barrett P, Vicini P, Adeli K, Lewis G: Triglyceride enrichment of HDL does not alter HDL-selective cholesteryl ester clearance in rabbits. J Lipid Res, 2001;42:265-271.

Reynaud D, Hinek A, Pace-Asciak J: The hepoxilin analog PGT-3 inhibits heparin-activated platelet aggregation evoked by ADP. FEBS Lett, 2002;515:58-60.

Riazi S, Chitayat D, Urban Z, Hinek A: The role of elastin in modulation of cellular proliferation. Can J Cardiol, 2001;17(Suppl C):242C.

Richardson WS, Wilson M, Williams J, Moyer V, Naylor CD: Chapter 2C: Diagnosis clinical manifestations of disease. IN: Users’ Guides to the Medical Literature (Guyatt G, Rennie D, eds). JAMA & Archives Journals, AMA Press, 2002:449-459.

Rubens F, Fremes S, Ruel M: A new and simplified method for coronary and graft imaging during CABG. Heart Surgery Forum, 2001.

Sah R, Oudit GY, Nguyen T-TT, Lim HW, Wickenden AD, Wilson GJ, Molkentin JD, Backx PH: Inhibition of calcineurin and sarcolemmal Ca2+ influx protects cardiac morphology and ventricular function in K(v)4.2N transgenic mice. Circulation, 2002;105(15):1850-1856.

Sakai T, Li R-K, Weisel RD, Mickle DAG, Kim EJ, Jai Z-Q, Yau MT: The fate of a tissue engineered cardiac graft in the right ventricular outflow tract. J Thorac Cardiovasc Surg, 2001;121:932-942.

Sasano H, Vesely AE, Iscoe S, Tesler JC, Fisher JA: Simple apparatus for accelerating recovery from vapor anaesthetics. Anesth Analg, 2001;93(5):1188-1191.

Sasano N, Vesely AE, Hayano J...Fisher JA: Direct effect of PaCO2 on respiratory sinus arrhythmia in conscious humans. Am J Physiol: Heart Circ Physiol, 2002;282:H973-H976. First published Nov 15, 2001, 0.1152/ajpheart.00554.2001.

Savelieva I, Paquette M, Dorian P, Luderitz B, Camm AJ: Quality of life in patients with silent atrial fibrillation. Heart, 2001;85(2):216-217.

Schwartz L, Bourassa MG: Evaluation of patients with chest pain and normal coronary angiograms. Arch Intern Med, 2001;151:1825-1833.

Schwartz L, Bourassa MG: Functional chest pain of presumed esophageal origin. Arch Intern Med, 2002;162:365-366 (Letter to the Editor).

Schwartz L, Morsi A: The draw-back stent deployment technique: A strategy for the treatment of coronary ostial branch lesions. J Invas Cardiol, 2002;14:66-71.

Shiono N, Rao V, Weisel RD, Kawasaki M, Li R-K, Mickle DAG, Fedak PWM, et al: L-Arginine protects human heart cells from low-volume anoxia and reoxygenation. Am J Physiol: Heart & Circ Physiol, 2002;282(3):H805-H815.

Sia YT, Lapointe N, Parker TG, Tsoporis JN, Deschepper CF, Calderone A, Pourdjabbar A, Jasmin JF, Sarrasin JF, Liu P, Adam A, Butany J, Rouleau JL: Beneficial effects of long-term use of the antioxidant probucol in heart failure in the rat. Circulation, 2002;105(21):2549-2555.

Slack G, Cohen J, Lenkei-Kerwin S, David T, Leask R, Butany J: Postaortotomy false aneurysm of the ascending aorta. Can J Cardiol, 2002;18(3):312-314.

Slutsky AS: The acute respiratory distress syndrome, mechanical ventilation, and the prone position (Editorial). N Eng J Med, 2001;345(8):610-612.

Slutsky AS: The acute respiratory distress syndrome, mechanical ventilation, and the prone position (Letter to the Editor). N Eng J Med, 2002;346(4):297.

Sole MJ, Jeejeebhoy KN: Conditioned nutritional requirements: Therapeutic relevance to heart failure. Herz, 2002;27:174-178.

Stangeby DK, Ethier CR: Computational analysis of coupled blood-wall arterial LDL transport. ASME J Biomechanical Engineering, 2002;124:1-8.

Stewart DE, Dalfen AK: Authors reply (to letter, Re: Who develops serious and fatal adverse drug reactions to selective serotonin reuptake inhibitors?) Can J Psychiatry, 2002;47:39-40.

Stewart DE, Duft S, Wong F, Melancon CH, Cheung AM: The views of ovarian cancer survivors on its cause, prevention and recurrence. Medscape Women’s Health, 2001;6(5).

Stewart DE, Rondon M, Damiani G, Honikman J: International psychosocial and systemic issues in women’s mental health. Archives of Women’s Mental Health, 2001;4:13-17.

Stewart DE, Rosen B, Irvine J, Ritvo P, et al: The disconnect: Infertility patients’ information and the role they wish to play in decision making. Medscape Women’s Health, 2001;6:1.

Stewart DE, Wong F, Duff S, Melancon CH, Cheung AM: “What doesn’t kill you makes you stronger”: An ovarian cancer survivor survey. Gynecol Oncol, 2001;83:537-542.

Stewart DE: Hepatic adverse reactions to nefazodone. Can J Psychiatry, 2002;47:375-377.

Stewart DE: Women and selective serotonin receptor inhibitor antidepressants in the real world. Medscape Women’s Health, 2001;6:1.

Stewart DJ, Zhao YD: Endothelin-1 and pulmonary hypertension. IN: Handbook of Experimental Pharmacology 152, Endothelin and its Inhibitors. (Warner TD, ed) Springer-Verlag Berlin Heidelberg, New York, 2001.

Suto F, Cahill SA, Wilson GJ, Hamilton RM, Greenwald I, Gross GJ: A novel rabbit model of variably compensated complete heart block. J App Physiol, 2002;92(3):1199-1204.

Taghibiglou C, Chen B, Van Iderstine S, Lewis G, Adeli K: Hepatic very low density lipoprotein-ApoB overproduction is associated with attenuated hepatic insulin signaling and overexpression of protein-tyrosine phosphotase 1B in a fructose-fed hamster model of insulin resistance. J Biol Chem, 2002;277(1):793-803.

Taghibiglou C, Van Iderstine SC, Kulinski A, Rudy D, Adeli K: Intracellular mechanisms mediating the inhibition of apoB-containing lipoprotein synthesis and secretion in HepG2 cells by avasimibe (CI-1011), a novel acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor. Biochem Pharmacol, 2002;63(3):349-360.

Tomita S, Mickle DAG, Weisel RD, Jai Z-Q, Tumiati LC, Allidina Y, Liu P, Li R-K: Improved heart function with myogenesis and angiogenesis after autologous porcine bone marrow stromal cell transplantation. J Thorac Cardiovasc Surg, 2002;123(6):1132-1140.

Torrance SM, Wittnich C: Post ischemic functional recovery in immature hearts is influenced by performance index and assessment technique. Am J Physiol: Heart & Circ, 2001;281:H2446-H2455.

Urban Z, Riazi S, Seidl TL...Boyd CD, Hinek A: Connection between elastin haploinsufficiency and increased cell proliferation in patients with supravalvular aortic stenosis and Williams-Beuren Syndrome. Am J Hum Genet, 2002;71(1):30-44.

Veltman A, Cameron J, Stewart DE: The experience of providing care to relatives with chronic mental illness. J Nervous and Mental Disease, 2002;190:108-114.

Verma A, Geist M, Greenhut S, Laslop J, DeBellis L, Freeman MR, Newman D, Dorian P: Rate control is superior to rhythm regularization in improving left ventricular function in atrial fibrillation. Can J Cardiol, 2001;17(4):437-445.

Verma S, Fedak PWM, Weisel RD, Butany J, Rao V, Maitland A, Li R-K, Dhillon B, Yau TM: Fundamentals of reperfusion injury for the clinical cardiologist. Circulation, 2002;105:2332-2336.

Verma S, Li S-H, Badiwala MV, Weisel RD, Fedak PWM, Li R-K, Dhillon B, Mickle DAG: Endothelin antagonism and interleukin-6 inhibition attenuate the proatherogenic effects of c-reactive protein. Circulation, 2002;105(16):1890-1896.

Verma S, Maitland A, Weisel RD, Fedak PWM, Li SH, Mickle DAG, Li R-K, Ko L, Rao V: Increased endothelin-1 production in diabetic patients after cardioplegic arrest and reperfusion impairs coronary vascular reactivity: Reversal by means of endothelin antagonism. J Thorac Cardiovasc Surg, 2002;123(6):1114-1119.

Verma S, Maitland A, Weisel RD, Fedak PWM, Pomroy NC, Li SH, Mickle DAG, Li R-K, Rao V: Novel cardioprotective effects of tetrahydrobiopterin after anoxia and reoxygenation: Identifying cellular targets for pharmacologic manipulation. J Thorac Cardiovasc Surg, 2002;123(6):1074-1083.

Verma S, Maitland A, Weisel RD, Li SH, Fedak PWM, Pomroy NC, Mickle DAG, Li R-K, Ko L, Rao V: Hyperglycemia exaggerates ischemia-reperfusion-induced cardiomyocyte injury: Reversal with endothelin antagonism. J Thorac Cardiovasc Surg, 2002;123(6):1120-1124.

Vesely A, Sasano H...Fisher JA, Mikulis D: MRI mapping of cerebrovascular reactivity using square wave changes in end tidal PCO2. Magnetic Res in Med (CPA), 2001;45(6):1011-1013.

Vorp DA, Steinman DA, Ethier CR: Computational modelling of arterial biomechanics. Computing in Science and Engineering, 2001;3(5):51-64 (invited).

Wallen WJ, Belanger MP, Wittnich C: Body weight and food intake profiles are modulated by sex hormones and tamoxifen in chronically hypertensive rats. J Nutrition, 2002;132:1-5.

Wallen WJ, Belanger MP, Wittnich C: Sex hormones and the selective estrogen receptor modulator tamoxifen modulate weekly body weights and food intakes in adolescent and adult rats. J Nutrition, 2001;131:2351-2357.

Whitehead T, Slutsky AS: Managing ARDS: Making the best of both old and new therapies. J Resp Dis, 2002;23(5):287-292.

Wigle ED, Schwartz L, Woo A, Rakowski H: To ablate or operate? That is the question. J Am Coll Cardiol, 2001;38:1701-1706.

Wittnich C, Belanger MP, Wallen JW, Torrance SM, Juhasz S: A long-term stable normothermic cardiopulmonary bypass model in neonatal swine. J Surg Res, 2001;101:176-182.

Wong AYH, Kulandavelu S, Whiteley KJ, Qu D, Langille BL, Adamson SL: Maternal cardiovascular changes during pregnancy and postpartum in mice. Am J Physiol: Heart & Circ, 2002;282:H918-H925.

Woo A, Schwartz L, Wigle ED, Ross J, Rakowski H: Myocardial contract echocardiography during septal ethanol ablation for obstructive hypertrophic cardiomyopathy. IN: Ultrasound Contrast Agents (Goldberg, Raichlin, Forsberg, eds) 2nd Edition. Martin Dunitz, London, 2001:197-211.

Wright GM, Keeley FW, Robson P: The unusual cartilaginous tissues of jawless craniates, cephalochordates and invertebrates. Cell and Tissue Res, 2001;304:165-174.

Yau TM, Fung K, Weisel RD, Fujii T, Mickle DAG, Li R-K: Enhanced myocardial angiogenesis by gene transfer using transplanted cells. Circulation, 2001;104(Supp):I218-I222.

Yokomuro H, Li R-K, Mickle DAG, Weisel RD, Yau T: Transplantation of cryo-preserved cardiomyocytes. J Thorac Cardiovasc Surg, 2001;121(1):98-107.

Zaidi SHE, You X, Ciura S, Husain M, Rabinovitch M: Overexpression of the serine elastase inhibitor Elafin protects transgenic mice from hypoxic pulmonary hypertension. Circulation, 2002;105:516-521.

Zhang W, Ethier CR: Method for non-invasive concentration measurement in polymer mixtures: Tests with dextran and cytochrome-C. Chem Engineering Comm, 2002;189:101-113.

(This report is based on information provided by faculty and students.)

ACKNOWLEDGEMENTS:

The Cardiovascular Sciences Collaborative Program would like to thank the following for their generous support:

Industry SponsorsBristol-Myers SquibbMedtronic CanadaMerck Frosst Canada & Co.Solvay Pharma

Individual DonorsDr. Wilfred G. Bigelow, who has so generously supported the Program both morally and financially.

And, the individuals that have given personal donations to support cardiovascular graduate training at the University of Toronto.

- Michael Morassutti- Stephen McDonald