Microscope Stages, Tools for Imaging & Biomedical Design · Microscope Stages, Tools for Imaging &...

Piezo Stages, Lens Positioners & Scanners, Steering Mirrors, Actuators

Microscope Stages, Tools for Imaging & Biomedical Design

Microscope Stage, Bio-Medical Catalogp i e z o n a n o p o s i t i o n i n g | w w w. p i . w s

Piezo Stages, Objective Scanners Overview

PInano™ Cost Effective Piezo Stages for SR Microscopy

Z, XY, XYZ, Low Profile, Travel to 200x200x200µm Fast Response, High Speed Version for Particle Tracking Cost-Effective and Very Reliable with PICMA® Technology Compatible w/ Leading Image Acquisition Software Package

PIFOC® Drives: Fastest Z-Steps, for high NA Objectives

Fastest Z-Scanners. Fres to 1100 Hz, Step & Settle <5 msec Long Travel Versions to 1000 µm Capacitive Non-Contact Sensors; Superior Linearity & Stability Quick Lock Adapter for Easy Attachment

PILine® Long Travel XY Piezo Linear-Motor Stages

Closed-Loop; Linear Motors & Encoders: High Speed to 100 mm/s Self-Locking Piezomotor Principle:

Extreme Stability at Rest, No Heat Generation Low Profile Design, Motors Completely Integrated Compatible with PI Piezo Scanning Stages

Piezo Stage for Well Plate Scanning

High-Speed Piezo Motion with Travel Ranges to 500 μm Nanometer Resolution + much Faster than Motorized Stages Large Clear Aperture to Accommodate Specimen Holders Perfect Mechanical Fit to OEM Manual or Motorized Stages


Actuators, Linear Motors, PZT TubesOverview

NEXACT® Piezo Micromanipulator / Nanopositioning Motors

Fast Step & Scan Mode, Replaces Piezo Worm Actuators 30 mm Standard Travel Range, Picometer Resolution Self Locking, with no Heat Dissipation, Nanometer Stability Non-Magnetic and Vacuum-Compatible Working Principle

Ultrasonic Ceramic High Linear Motors for Bio-Automation

Fast: Velocity to 450 mm/sec Travel Ranges to 150 mm Self-Locking at Rest, Non Magnetic Resolution to 0.05 µm

Piezo Tubes and Shear Piezo Actuators

Standard & Custom Sizes, for OEM Applications XYZ-Positioning Sub-Nanometer Resolution For Scanning Microscopy

Miniature Motorized Linear Stages & Linear Slides

Travel Ranges 2 mm to 50 mm Sub-µm Resolution, 2 to 400 mm/sec Velocity DC-Servo, Stepper and Piezo Motor Drives Optional Linear Encoders & Vacuum Versions


Piezo Controllers and Drivers

Overview

Advanced Digital Piezo Controllers

Change Parameters on the Fly Digital Linearization Provides up to 3 Orders Improved Scanning

Accuracy ID Chip Support for Automatic Calibration Real Time Interfaces: PIO, SPI; additional USB, Ethernet, RS-232

Affordable Digital Controllers

Digital Performance for the Cost of Analog Bench-Top and Plug-In Cards I/O, Trigger Functions, Wave Table for User-Defined Curves Extensive Software Support

OEM Controllers and Amplifiers

Low Cost Analog & Optional 24-Bit USB Interfaces For Capacitive and Piezoresistive Strain Gauge Sensors Open-Loop and Closed-Loop Versions

Bench Top Closed-Loop Controllers

Analog & Optional 24-Bit USB Interfaces For Capacitive and Piezoresistive Strain Gauge Sensors Optional Display and Manual Operation 1 to 3 Channels

Microscope Stage, Bio-Medical Catalogp i e z o n a n o p o s i t i o n i n g | w w w. p i . w sMicroscope Stage, Bio-Medical Catalogp i e z o n a n o p o s i t i o n i n g | w w w. p i . w s

Single molecule analysis provides de-

tailed information on chemical char-

acteristics or biological functions, but

the detection of individual molecules

is by no means easy. The extremely

sensitive method of laser-based fluo-

rescence analysis is thus used t o

increase the signal-to-noise ratio.

Confocal microscope with singlemolecule sensitivity

PicoQuant of Berlin, Germany sup-plies the MicroTime 200 confocal,time-resolved fluorescence micro-scope for this task. “This system usesthe time-correlated single photoncount for its data acquisition and canproduce both 2D and 3D images”explains Dr. Felix Koberling, Head ofSystem Development at PicoQuant.This makes it possible to realize avariety of the methods currently usedin fluorescence microscopy such asFCS (Fluorescence Correlation Spec-troscopy) and FRET (FluorescenceResonance Energy Transfer) as wellas so-called fluorescence lifetimeimaging. Here not only the measuredintensity but also the respective fluo-rescence lifetime is used for thevisualization and quantification inorder to analyze intracellular pro-cesses even in living cells. Its modu-

lar design means the fluorescencemicroscope is also very flexible inadjusting to different applications.(www.picoquant.de)

Maximum r epeatability thanks t odynamic digital linearization

The P-733.2CD piezo stage was thescanner system of choice for themicroscope. With a travel range of 100 x 100 µm and sub-nanometerresolution, this high-accuracy nano-positioning system matches the re-quirements of fluorescence micro-scopy perfectly.

Piezo · Nano · Positioningnews

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Moving samples into the spotlight:

Nanopositioning systems in fluorescence microscopy

Issue 39

All pages number cited in this publication make reference to PI’s 530p hardbound catalog. Download yours now at www.pi.ws.


http://www.picoquant.de

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If the sample cannot be moved because it is enclosed in an environ-mental chamber, for example, thesame positioning system can be usedto the microscope objective instead.In all cases, however, the integrateddirect-measuring capacitive sensorsallow the scanner to produce an ac-curate determination of the actualposition value. The first step is typi-cally to record the image of a sampleby scanning an area quickly before in a second step individual points of interest are analyzed in detail. Inorder to return to the exact locationof these points within a few nano-meters, an advanced digital controlalgorithm (DDL) was devised. TheDynamic Digital Linearization algo-rithm improves scanning linearity, i.e. repeatability by up to three ordersof magnitude compared to conven-tional PID (proportional, integral, deri-vative control).

The third dimension: Additionalfocus adjustment

The P-721.CLQ PIFOC® Z-drives areused for three-dimensional images.They provide millisecond responsetimes and their flexure guiding and

capacitive sensors enable very accu-rate positioning, even when the travelranges are relatively large. “PI’s piezo-based nanopositioning systems make

a decisive contribution to the fact that we can achieve very high-qualityresults with our MicroTime 200”, saysKoberling in conclusion.

Single molecule image of a mixture of immobilized Atto665- and Cy5-molecules.The single molecules can be distinguished by the fluorescence lifetime.(Photo: PicoQuant)

Fluorescence intensity image (left) and fluorescence lifetime image of a liver cancercell, stained with the NBD dye to analyze the organization of lipids. In the image onthe right, the lifetime can be used to clearly identify different lipid structures. (Photo: PicoQuant)

The P-733 piezo-based nanoposition-ing system provides a travel range of 100 x 100 µm. The optional Dynamic Digital Linearisation (DDL) features fordigital motion controllers improves the scanning linearity by a factor of to 1000. Tracking error and phase lag arereduced to almost non noticeable values. (Photo: Physik Instrumente (PI))


Communication between PI components is based upon a universal command set (GCS – General Command Set). It decouples hardware and software, and is used for all drive systemss

Controllers PositionersPiezo • Nano • Positioning

For LabView, C++, VB, Matlab, Image Acquisitiong Packages, NI DAC Cards, .....

The high quality of positioningsystems is made apparent indaily operation by PI software.Starting with simple commis-sioning, through convenientoperation with a graphicalinterface, to quick and simpleintegration in customized pro-grams with high performance,PI software covers all aspectsimportant to an application.

Universal Command SetSimplifies Commissioningand Programming

For uniform operation of nanoand micropositioning systems,the universal PI GeneralCommand Set (GCS) is used.GCS operation is independentof the controller or drive princi-ple used, so that several posi-tioning systems can be con-trolled together, or new sys-tems can be introduced with aminimum of programmingeffort. With GCS the develop-ment of custom applicationprograms is simplified and lessprone to errors, because thecommands for all supported

devices are identical in syntaxand function. Through the useof the GCS command set withits convenient functions, theorientation phase and applica-tion development process is

significantly accelerated. TheGCS commands are availableat the controller terminal, inmacros and in the form of auniversal driver set forLabVIEW (VIs), Windows

Supported Operating Systems

Microsoft Windows Vista

Microsoft Windows XP

Microsoft Windows 2000

Linux

Software Updates Online

PI supports users with freeupdates, detailed online helpand well structured manualswhich ease initiation of theinexperienced but still answerthe detailed questions of theprofessional.

Controllers for Piezo Motors

Controllers for PiezoNanopositioning Stages

Controllers for VoiceCoil,Servo & Stepper Motors

Controllers for Complex Multiaxis Systems

Piezo Nanopositioners

Piezo Motor-Driven

Motorized

Hexapod 6-Axis Stages

dynamic link libraries (DLL) andLinux libraries. This facilitatesthe development of custommacros, as well as integrationwith programming languageslike LabVIEW, C++ or MATLAB.

Easy integration in LabView. Quick access to the full functionality

For more information on PI software support, go online or request the PI software brochure

Micropositioners

Actuators & Stages

s

PC/Linux

USB, TCP/IP, Analog,

RS232, GPIB,

software packages such as Andor iQ™, Metamorph™, µManager™,

PI piezo stages & controllers are compatible with all major image acquisition

Slidebook™,Simple PCI™, NIS Elements™, ImagePro™.

PI provides high-level, robust, easy-to-use software tools for fast, seamless integration of motion systems into application control software

SoftwareGCS

Trigger I/O

Platform Independent

Contact PI for our extensive library of software examples!

Software and manuals can be downloaded,from the PI Support server

Software Tools


Long-Range Motion for Sample Positioning

M-545 Microscope Stage

The M-545, 25 x 25 mm micro-scope stage, is designed to pro-vide a stable platform for piezoscanning stages of the P-545 PInano™ series. These high-speed,high-resolution XY / XYZ piezostages allow nanometer-preci-sion adjustment of the specimenholder in up to three dimensionsover 200 µm. The M-545 is alsocompatible with the followingcapacitive-feedback type piezostages: P-733, P-5x7, P-5x8, P-54xand P-56x (s. p. 2-72).The basic M-545 model isequipped with manual microme-ters.

Motorizing forAutomated TasksThe M-545 XY-stage can be sup-plemented with motorized actu-ators M-229 (s. p. 1-44). Theproduct number M-545.USCcomprises the complete packageof two stepper linear actuatorswith controller and joystick.M-545.USG includes two stepperlinear actuators with mountinghardware.

� Stable Platform for P-545 PI nano™Piezo-Nanopositioniersysteme

� Low Profile for Easy Integration: 30 mm� 25 mm x 25 mm Travel Range� Micrometer Screws, Motor Upgrade Available� For Nikon, Zeiss, Leica and Olympus Mikroscopes

Ordering Information

M-545.2MOPI nano™ Manual XY Open-FrameStage, 25 x 25 mm,for Olympus Microscopes

M-545.2MNPI nano™ Manual XY Open-FrameStage, 25 x 25 mm, for NikonMicroscopes

M-545.2MLPI nano™ Manual XY Open-FrameStage, 25 x 25 mm, for LeicaMicroscopes

M-545.2MZPI nano™ Manual XY Open-FrameStage, 25 x 25 mm, for ZeissMicroscopes

Versions for other microscopes onrequest.

Accessories

M-545.USCUpgrade Kit with Stepper-Mikes,Controller and Joystick for M-545PI nano™ Manual XY Open-FrameStage

M-545.USGUpgrade Kit with Stepper-Mikes,for M-545 PI nano™ Manual XYOpen-Frame Stage

M-545.SHPAdapter Plate for Sample Holdersfor M-545 PI nano™ Manual XYOpen-Frame Stage

Accommodates the following PInanopositioning stage series:P-517/518/527/528, P-541/542, P-560PIMars™ and P-545 PI nano™

Adapter available for P-733 nanopo-sitioners:

P-733.AP1Adapter Plate for Mounting ofP-733 Stages on M-545 PI nano™Manual XY Open-Frame Stage

Additional accessories on request.

Ask about custom designs!

M-545.2MO, M-545.2MN dimensions in mm.Mounting adapters for Olympus and Nikon microscopesrespectively included in delivery

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M-545.2ML dimensions in mm

M-545 manual XY microscopy stage


M-545 manual XY microscopy stage with 25 x 25 mmtravel shown with optional PI nano™ piezo nanopositioner(200 µm motion in X, Y und Z) on top. The M-545 stage wasdesigned to provide a stable basis for piezo stages, especiallywhen the highest step-and-settle performance is required

http://www.pi.ws

http://www.pi.ws

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Spacer plates are used to adapt the M-545 stage to the Nikon microscope base.

The proper hardware sizes are shown below.

4x M4x16 Socket Head Screw

Microscope Base

M545E0007 Spacer

4x M5x16Socket Head Screws

M-686K Custom Piezo Motor Microscope StageLow Profile and High Velocity with PILine® Ultrasonic Piezo Motors

� Low 27-mm-profile� Velocity 100 mm/s� Large Clear Aperture to Accomodate Specimen Holders or

P-737 PIFOC® Specimen-Focusing Z-Stage� Travel Range 25 x 25 mm, 130 x 85 mm or 225 x 85 mm� Up to 7 N Force Generation� Direct Metrology Linear Encoder with 0.2 µm Resolution� PILine® Ceramic Motors: Non-Magnetic and Vacuum-

Compatible Working PrincipleCusomized M-686 microscopy

stage with 225 x 85 mm travel and PILine®

ultrasonic piezo motors

� Self Locking at Rest

Mounting Example on Nikon Microscope


The two-channel C-867.260 controller

PInano™ XYZ piezo scanner mounted on a M-545.2U Microscope stage. The XYZ piezo nanopositioning stage provides <1 nm resolution and 200x200x200µm scanning range. The high stability and autolocking feature of M-545 provides significant advan-tages over other microscope stage designs when using fast piezo scan-ning stages.

Preliminary Specs M-545.2U piezomotor stages are mainly designed for automated positioning applications in mi-croscopy. The form factor of the M-545 is optimized for a low profile height of 30 mm only; the mounting pattern is compatible with many PI piezo nanoposition-ing stages.

Space Saving Piezomotors Compared to conventional mo-torized translation stages, the M-545 provides a lower profile and smaller footprint. The com-pact PILine® piezoelectric linear motors and linear encoders make both, the lead screw duct and the flanged, bulky stepper motors

employed in traditional stages obsolete. In addition, the piezo-motors are self-locking at rest and hold the stage in a stable position without generating heat.

Compatibility to PI Nanoposi-tioning and Scanning Stages A number of standard PI piezo flexure stages (PInano™ family, P-736, etc) can be mounted directly on the M-545 stage. Depending on the application, these highly specialized, ul-tra-precise nanopositioning sys-tems are available as fast XYZ scanners (for fluorescence mi-croscopy), as vertical Z position-

ers (3D imaging), or with up to 6 degrees of freedom.

Limit and Reference Switches For the protection of your equip-ment, non-contact Hall-effect limit and reference switches are in-stalled. The direction-sensing reference switch supports ad-vanced automation applications with high precision.

Advantages of PILine® Micro-positioning Systems The ultrasonic piezoceramic drives used in PILine® microposi-tioners have a number of advan-tages over classical drives:

Higher Acceleration, Speed

Smooth Motion, no Vibrations

Small Form Factor

Self-Locking when Powered Down, no Dither, no Energy Consumption

No Shafts, Gears or Other Rotating Parts

Non-Magnetic , Vacuum Compatible Drive Principle

The M-545.2U microscope stage with closed-loop ultrasonic piezo motors provides 25 x 25 mm travel range and very high stability

M-545 XY Microscope Stage with Ultrasonic Linear Drives High Stability, Low Profile, High Speed, Direct Position Measurement

Integrated Closed-Loop Linear Piezomotor Drives Provide Smooth Motion and High Speed to 50 mm/s

Travel Ranges 25 x 25 mm Integrated Linear Encoders with 0.5 µm Resolution Compact Design: 30 mm Profile Height, Mounts Directly to Microscopes Self-Locking at Rest, with no Servo Dither Compatible with PI Piezo Nanopositioning / Scanning

Stages


XY Microscope Stage System with Closed-Loop PILine® Piezomotor Drives, 25 x 25 mm, 0.5 µm Linear Encoder, Includes C-867.260 2 Axis Controller and Joystick. MD5422LOU for Olympus Microscopes MD5422LNU for Nikon Microscopes MD5422LLU for Leica Microscopes MD5422LZU for Zeiss Microscopes Ask about custom designs

Application Examples

Biotechnology Microscopy Scanning microscopy Confocal microscopy Semiconductor testing Handling


Preliminary Specs

Model M-545.2U

Active axes XY

Travel range 25 x 25 mm

Integrated sensor Linear encoder

Sensor resolution 0.5 µm (no dither at rest)

Min. incremental motion 1 µm

Unidirectional repeatability 1 µm

Bidirectional repeatability 2 µm

Max. velocity 50 mm/s

Load Capacity 50*N

Max. push/pull force 5 N

Max. lateral force 4 N

Motor type PILine® U-164

Operating voltage 67 V (RMS)***

Electrical power 10 W / Axis**

Operating temperature range 10 to +30 °C

Material Aluminum (black anodized)

Mass 3.2 kg

Cable length 1.7 m

Connector 2 x MDR connector, 14-pin

Controller/driver C-867.260 2-axis Controller/Driver or 2x C-867.160 1-axis Controller/Driver

M-545 dimensions in mm

* 10 N for max. velocity. ** For drive electronics *** Piezomotor drive voltage; controller requires 12 VDC


Fast, Low Profile and Large Aper ture with Direct Position Measurement

M-686 PILine® XY Ultra-High Stability Piezo Linear-Motor Stage


M-660 ultra low profile (.6", 15mm) rotation stage

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M-686 open-frame piezomotorstages are mainly designed forautomated positioning applica-tions in microscopy . The opti-mized form factor with a lowprofile height of only 32 mmand the standardized mount-ing pattern allows the combi-nation with many PI standardnanopositioning systems.

Space Saving Piezomotors

Compared to conventionalmotorized translation stages,the M-686 provides a lowerprofile and smaller footprint.The compact PILine® piezoelec-tric linear motors and high-res-olution linear encoders makeboth, the lead screw duct andthe flanged, bulky steppermotor employed in traditionalstages obsolete. In addition,the piezomotors are self-lock-ing at rest and hold the stage ina stable position without heat-ing up.

Compatibility to PI Nanopo -sitio ning and Scanning Stages

A number of standard PI piezoflexure stages (150 x 150 mmfootprint) can be mounteddirectly on the M-686 open-

frame stage. Depending on the application, these highlyspecialized, ultra-precise nano -positioning systems are avail-able as fast XY scanners (forfluorescence microscopy), asvertical Z positioners (3D imag-ing), or with up to 6 degrees offreedom.

Limit and Reference Switches

For the protection of yourequipment, non-contact Hall-effect limit and referenceswitches are installed. Thedirection-sensing referenceswitch supports advancedautomation applications withhigh precision.

Advantages of PILine®

Micro positioning Systems

The ultrasonic piezoceramicdrives used in PIline ® micro po-sitioners have a number of advantages over classicaldrives:

� Higher Accelerations, up to 5 g

� Speeds up to 500 mm/s� Small Form Factor� Self-Locking When

Powered Down� No Shafts, Gears or Other

Rotating Parts� Non-Magnetic and Vacuum-

Compatible Drive Principle

Notes

Nanopositioning stages that fitdirectly on the M-686:

P-561 to P-563PIMars™ XYZ Nanoposition-ing systems with up to 300 µm travel

P-541.2 to P-542.2Low-profile microscopy XYscanners

P-541.ZLow-profile Z/tip/tilt piezonanopositioning stages formicroscopy


� Biotechnology

� Microscopy

� Scanning microscopy

� Confocal microscopy

� Semiconductor testing

� Handling


M-686.D64XY Open-Frame Stage with Closed-Loop PILine® PiezomotorDrives, 25 x 25 mm, 7 N, 0.1 µm Linear Encoder


� Integrated Closed-Loop Piezomotor Drives Provide HighSpeed to 100 mm/s

� Travel Ranges 25 x 25 mm � Integrated Linear Encoders with 0.1 µm Resolution� Compact Design:

32 mm Profile Height, 170 x 170 mm Footprint� Clear Aperture 78 x 78 mm, 66 x 66 mm

in Extreme Position� Self-Locking at Rest� Compatible with PI Piezo Nanopositioning /

Scanning Stages

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http://www.pi.ws

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M-686.D64, dimensions in mm. The minimum aperture is 66 x 66 mmwith both axes at the maximum position

0.3 µm steps performed by M-686

M-686 open-frame stage with P-541.2DD piezo scan-ner on top, providing a resolution of 0.1 nm and ascanning range of 30 x 30 µm. The system height of the combination with the P-541 XY (or Z) piezo

scanner is only 48 mm

Download Paper on Stability Test Results!

Customized M-686 stage with a bigger footprint, to sink the piezo Z scanner. The system height together with

the P-541 piezo scanner is reduced to only 33 mm


Cusomized M-686 microscopy stage with 225 x 85 mm travel and PILine®

ultrasonic piezo motors

Technical Data

Model M-686.D64

Active axes XY

Motion and positioning

Travel range 25 x 25 mm

Integrated sensor Linear encoder

Sensor resolution 0.1 µm

Design resolution 0.1 µm

Min. incremental motion 0.3 µm

Bidirectional repeatability 0.3 µm

Pitch / yaw ±50 µrad

Max. velocity 100 mm/s

Mechanical properties

Load Capacity* 50 N

Max. push/pull force 7 N

Max. lateral force 4 N

Drive properties

Motor type 2 x PILine® P-664 per axis

Operating voltage 190 V (Peak-Peak)**67 V (RMS)**

Electrical power 10 W / axis***

Miscellaneous

Operating temperature range -20 to +50 °C

Material Aluminium (black anodized)

Mass 1.2 kg

Cable length 1.5 m

Connector 2 x MDR connector, 14-pin

Recommended controller/driver 2 x C-867.D64 single-axis controller / driver2 x C-185.D64 single-axis drive electronicsfor external servo-controllers (p. 4-116, p. 1-36)

*10 N for max. velocity**The operating voltage or the piezomotor is supplied by the drive electronics which requi-

res 12 VDC***For drive electronics

http://www.bentham.org/cpb/sample/cpb10-5/0008G%5B1%5D.pdf

Low-Profile, Low-Cost Nanopositioning Systems for Super-Resolution Microscopy

P-545 PI nano™ 200µm XY / XYZ Piezo Microscope Stages

Long Travel, Low Profile,Optimized for MicroscopyPI nano™ XY and XYZ low-pro-file piezo scanning stages areoptimized for easy integrationinto high-resolution micro-

scopes. They feature a very lowprofile of 20 mm (0.8") and alarge aperture designed to holdPetri dishes and standard slideholders. The long travel rangesof up to 200 x 200 x 200 µm withnanometer closed-loop resolu-tion are ideal for leading-edge

microscopy and imaging appli-cations.

Cost Effective Design,High Performance

PI nano™ series piezo position-ing stages are designed to pro-vide high performance atminimum cost. For highly-sta-ble, closed loop operation,piezoresistive sensors are ap-plied directly to the movingstructure and precisely meas-ure the displacement of thestage platform. The very highsensitivity of these sensors pro-vides optimum position stabil-ity and responsiveness as wellas nanometer resolution. A pro-prietary servo controller signifi-cantly improves the motionlinearity compared to conven-tional piezoresistive sensorcontrollers.

High Reliability andLong Lifetime

The compact P-545 systems areequipped with preloaded PIC-MA® high-performance piezoactuators which are integratedinto a sophisticated, FEA-mod-eled, flexure guiding system.The PICMA® actuators featurecofired ceramic encapsulationand provide better performanceand reliability than conven-tional piezo actuators. Actua-tors, guidance and sensors aremaintenance-free, not subjectto wear and offer extraordinaryreliability.

� Low Profile for Easy Integration: 20 mm (0.8'')� Up to 200 x 200 x 200 µm Travel Ranges� Large Clear Aperture for 3 x 1'' Slides� Recessed Sample Holders for Maximized Utility Available� Outstanding Lifetime Due to PICMA®Piezo Actuators� Cost-Effective Design due to Piezoresistive Sensors� Compatible w/ Leading Image Acquisition Software Package� Closed-Loop Control for High Repeatability and Accuracy� Millisecond Step Time, Ideal for Super-Resolution Microscopy� 24-Bit Controller w/ USB, Ethernet, RS-232 Interface

and Analog Control� Available Manual Long-Travel Stage with Motor

Upgrade Option


� Super-resolutionmicroscopy

� 3D Imaging

� Laser technology

� Interferometry

� Metrology

� Biotechnology

� Screening

� Micromanipulation

PI nano™series nanopositioning stages feature a very low profile of 20 mm (0.8),a large aperture for 3 x 1'' slides and deliver highly accurate motion with

sub-nanometer resolution in up to 3 axes. Slide / petri dish holders optional


P-545.2R7PI nano™ XY Nanopositioning Sys-tem, Aperture for 3 x 1" MicroscopeSlides, 200 x 200 µm, PiezoresistiveSensors, with USB Controller

P-545.3R7PI nano™ XYZ NanopositioningSystem, Aperture for 3x1" Micro-scope Slides, 200 x 200 x 200 µm,Piezoresistive Sensors, with USBController

Accessories

M-545.2MOPI nano™ Manual XY Open-FrameStage, 25 x 25 mm, for OlympusMicroscopes

M-545.2MNPI nano™ Manual XY Open-FrameStage, 25 x 25 mm, for NikonMicroscopes

M-545.2MLPI nano™ Manual XY Open-FrameStage, 25 x 25 mm, for LeicaMicroscopes

M-545.2MZPI nano™ Manual XY Open-FrameStage, 25 x 25 mm, for ZeissMicroscopes

P-545.PD335mm Petri Dish Holder for P-545PI nano™ XY NanopositioningSystems

P-545.SH325 x 75mm Slide Holder for P-545PI nano™ XY NanopositioningSysteme

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Background: the piezo controlleris included and comes with a 24-bit

resolution USB port as well as ethernet,RS-232 and analog interface.

Foreground: The optional M-545 manualXY stage provides a stable

platform for the PI nano™ piezo stages.Custom stage version shown

P-545.PP3Plain Plate for Accessories for P-545PI nano™ XY NanopositioningSystems


http://www.pi.ws

http://www.pi.ws

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Technical Data

Model P-545.2R7 P-545.3R7 Unit Tolerance

Active axes X, Y X, Y, Z


Integrated sensor piezoresistive piezoresistive

Closed-loop travel 200 x 200 200 x 200 x 200 µm

Closed-loop resolution* 1 1 nm typ.

Linearity ±0.1 ±0.1 % typ.

Repeatability < 5 < 5 nm typ.


Push/pull force capacity 100 / 30 100 / 30 N max.

Load 50 50 N max.

Drive properties

Ceramic type PICMA® P-885 PICMA® P-885

Electrical capacitance 6 6 (X, Y), 12 (Z) µF ±20%

Miscellaneous

Operating temperature range -20 to 80 -20 to 80 °C

Material Aluminum Aluminum

Mass 1 1.2 kg ±5%

Cable length 1.5 1.5 m ±10 mm

Sensor / voltage connection Sub-D, 25 pin Sub-D, 25 pin

Piezo controller (included in delivery) E-545 E-545

* Resolution of PI Piezo Nanopositioners is not limited by friction or stiction. Value given is noise equivalent motion measured with interferometer.

Accessories: Slide holder (above) and Petri dishholder (below), dimensions in mm

P-545 dimensions in mm

High Speed Version for Particle Tracking Available


High Stability and Linearity Optimized for High-Resolution Microscopes The new PInano™ Cap XY and XYZ capacitive sensor piezo stages are optimized for easy integration into high resolution optical microscopes. They feature a very low profile of 0.8” (20 mm), a large aperture, and extremely fast response with subnanometer closed-loop resolution–ideal for leading-edge microscopy and imaging applications. The stage design permits a full slide to be mounted at bottom allowing the turret to be rotated without mov-ing the objective in and out. Lon-gest lifetime is guaranteed by the integrated ceramic encapsulated PICMA® piezo actuators. Due to the significantly higher humidity

resistance, the patented PICMA®

design provides up to 10 times longer life than conventional piezo actuators.

High Performance, Yet Cost Effective PInano™ Cap series piezo stages provide even higher per-formance than their piezoresistive (PR) sensor equipped cousins. Systems consist of the piezo mechanics, an advanced control-ler optimized for capacitive feed-back and software. For the high-est linearity and stability, these stages are based on direct meas-uring, non-contact capacitive sensors, a principle free of John-son noise. RF excitation circuitry in the controller further reduces sensitivity to external noise sources or DC voltage drift of electronic components that can limit the long term stability of DC signal excited sensors such as film and PR strain gauges. The proprietary servo design im-proves the motion linearity com-pared to conventional piezo con-trollers.

Stage Working Principle / Re-liability Flexures optimized with Finite Element Analysis (FEA) are employed to guide the PI nano™ series stages. FEA techniques give the design the highest pos-sible stiffness in, and perpen-dicular to, the direction of motion, and to minimize linear and angu-lar runout. Flexures allow ex-tremely high-precision motion, no matter how minute, as they are completely free of play and fric-tion. The award-winning PICMA® piezo drives are more robust than conventional piezo actuators, featuring superior lifetime and performance in both dynamic and static applications. Because guidance, actuators and sensors are all maintenance-free, these nanopositioning systems achieve outstanding levels of reliability:


P-545.2C7 PInano™ Cap XY Piezo Stage with large Aperture, 200x200μm, Capacitive direct Metrology Sensors, with USB Controller P-545.3C7 PInano™ Cap XYZ Piezo Stage with large Aperture, 200x200x200μm, Capacitive direct Metrology Sensors, with USB Controller


Biotechnology SR-Microscopy Scanning microscopy Confocal microscopy Sample Positioning

Long Travel XY Microscope Tables, 25x25 mm

PI also offers manual and motorized long-travel microscope stages. These high-stability designs are ideal mounting platforms for the fast PInano™ piezo scanning stages. Motorized stages are available for Nikon and Olympus microscopes Manual stages are available for Nikon, Olympus, Zeiss & Leica microscopes

PInano™ series nanopositioning stages feature a very low profile of 0.8” (20mm) and use a full slide mounted a the bottom. They deliver very fast and highly accurate motion to 200µm with sub-nanometer resolution in up to 3 axes. PInano™ systems come complete with a high performance USB controller and software.

Capacitive Direct Metrology Sensors: Higher Linearity,

Stability and Accuracy than PR-Sensor Versions Closed Loop USB Controller (24 Bit Resolution) & Soft-

ware Included Low Profile for Easy Integration: 20 mm (0.8“) Bottom Slide Mount: No Interference with Turret Rotation 200 µm Travel Range per Axis 10X Longer Lifetime with Proprietary Piezo Technology Compatible w/ Leading Image Acquisition Software Sub-Nanometer Resolution and Millisecond Step Time, Ideal for Super-Resolution Microscopy

Optional Long Travel Piezomotor / Manual Stage

P-545 PInano™ Cap Super Stability XY / XYZ Piezo Stages Capacitive Feedback for Highest Stability & Linearity: Ideal for SR-Microscopy

Non-contact capacitive position sensors measure directly and provide higher linearity and long term stability com-pared to piezoresistive or film sensors that infer position information from strain.


Model PInano™ XY PInano™ XYZ Units Tolerance

Active axes X,Y X,Y,Z

Integrated sensor Capacitive Capacitive

Closed-loop travel 200x200 200x200x20 0 µm

*Resolution <1 <1 nm 1 σ

Linearity +/-0.05 +/-0.0 5 % typ.

Repeatability <5 <5 Nm typ.

Push/pull force capacity in motion direction 100 / 30 100 / 30 max.

Max. payload 500 500 g max.

Ceramic type PICMA® PI CMA®

Recommended operating temperature range 20 to 30 20 to 30 °C

Material Aluminum Al uminum

Mass 1 1.2 kg ±5%

Cable length 2 2 m ±10 mm

*Resolution of PI Piezo Nanopositioners is not limited by friction or stiction. Value given is noise equivalent motion measured with interferometer

Accessories: M-545.SH3 Slide holder (above) and M-545.PD3 Petri dish holder (below), dimensions in mm f

P-545, PInano™ piezo stage, dimensions in mm

A powerful 24 bit resolution controller with USB, TCP/IP and analog interfaces and software are included.

Preliminary Specs



PInano™ XYZ piezo scanner mounted on a M-545.2U long travel, ultrasonic motor microscope stage. The XYZ piezo nanopositioning stages provide <1 nm resolution and are available with up to 200µm scanning range. The high stability and autolocking feature of M-545 provides significant advantages over other microscope stage de-signs when using fast piezo scanning stages. Request paper on stability.

P-545 PInano™ Trak High-Speed Piezo Tracking Stage Fastest XYZ Microscope Stage to Enable use of Full Turret Motion

High Speed Long Travel, Low Profile, Ideal for Single Mole-cule Tracking The new PInano™ XY and XYZ high-speed piezo scanning stages are optimized for easy integration into high resolution microscopes. They feature a very low profile of 0.8” (20 mm), a large aperture, and extremely fast response with subnanometer closed-loop resolution– ideal for leading-edge particle tracking and microscopy applications. Longest lifetime is guaranteed by the integrated ceramic encapsulated PICMA® piezo actuators. Due to the significantly higher humidity resistance, the patented PICMA® design provides up to 10 times longer life than conventional piezo actuators.

Cost Effective Design, High Performance PInano™ series piezo positioning systems are designed to provide high performance at minimum cost. The system consists of the mechanics and an advanced controller optimized for the piezo stages. For highly stable, closed loop operation, piezoresistive sensors are applied directly to the moving structure and precisely measure the displacement of the stage platform. The very high sensitivity of these sensors pro-vides optimum position stability and responsiveness as well as sub-nanometer resolution. The proprietary servo controller sig-nificantly improves the motion linearity compared to conven-tional piezoresistive sensor con-trollers.

Working Principle / Reliability Flexures optimized with Finite Element Analysis (FEA) are employed to guide the PInano™ series stages. FEA techniques give the design the highest pos-sible stiffness in, and perpen-dicular to, the direction of motion, and to minimize linear and angu-lar runout. Flexures allow ex-tremely high-precision motion, no matter how minute, as they are completely free of play and fric-tion. The award-winning PICMA® piezo drives are more robust than conventional piezo actuators, featuring superior lifetime and performance in both dynamic and static applications. Because guidance, actuators and sensors are all maintenance-free, these nanopositioning systems achieve outstanding levels of reliability:

Ultra Fast: < 5msec Response Time: Ideal for Tracking Applications

Low Profile for Easy Integration: 20 mm (0.8“) Full Slide Mounted at Bottom:

Turret can Rotate w/o Moving Objective in and out Up to 70 x 70 x 50 μm Travel Range 10X Longer Lifetime due to

Proprietary PICMA® Piezo Technology Cost Effective due to Low-Cost Piezoresistive Sensors Compatible w/ Leading Image Acquisition Software Closed-Loop Control for High Repeatability and Accuracy Sub-Nanometer Resolution and Millisecond Step Time, ideal for Super-Resolution Microscopy High Power Controller Included Optional Long Travel Piezomotor / Manual Stage

PInano™ series nanopositioning stages feature a very low profile of 0.8” (20mm) and use a full slide mounted a the bottom. They deliver very fast and highly accurate motion with sub-nanometer resolution in up to 3 axes.


P-545.2D7 PInano™ Trak XY High-Speed Piezo Tracking Stage with large Aperture, 70x70 μm, Piezoresistive Sensors, with High Power Piezo Controller P-545.3D7 PInano™ Trak XYZ High-Speed Piezo Tracking Stage with large Ap-erture,70x70x50 μm, Piezoresistive, Sensors, with High Power Piezo Controller Ask about custom designs!


Biotechnology Microscopy Scanning microscopy Confocal microscopy Semiconductor testing Handling


Models PInano™ XY PInano™ XYZ Units Tolerance Active axes X,Y X,Y,Z

Integrated sensor Piezoresistive Piezoresistive

Closed-loop travel 70 x70 70 x70x50 µm

*Resolution <1 <1 Nm typ.

Linearity +/-0.1 +/-0.1 % typ.

Repeatability <5 <5 Nm typ.

Push/pull force capacity in motion direction 100 / 30 100 / 30 max.

Max. payload 500 500 g max.

Drive properties

Ceramic type PICMA® PICMA®

Recommended operating temp. range 20 to 30 20 to 30 °C


Mass 1 1.2 kg ±5%


*Resolution of PI Piezo Nanopositioners is not limited by friction or stiction. Value given is noise equivalent motion measured with interferometer

Preliminary Specs

Accessories: M-545.SH3 Slide holder (above) and M-545.PD3 Petri dish holder (below), dimensions in mm f

P-545, PInano™ piezo stage, dimensions in mm

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PInano™ Z, High-Speed Piezo-Z Slide ScannerLow-Profile, Low-Cost, Nanopositioning System for Super Resolution Microscopy

High-Speed, Low Profile,Optimized for Microscopy

The new PInano™ Z low-pro-file piezo Z stages are opti-mized for very fast step andsettle and easy integration intohigh-resolution microscopeapplications. They featurea very low profile of 0.8"(20 mm), a large aperture, andtravel ranges of up to 200 µmwith sub-nanometer closed-loop resolution–ideal for lead-ing-edge microscopy andimaging applications.

Longest lifetime is guaranteedby the integrated ceramic-encapsulated PICMA® piezoactuators. Due to the signifi-cantly higher humidity resist-ance, the patented PICMA®

design provides up to 10 timeslonger life than conventionalpiezo actuators (see latest testresults at www.pi.ws/picma).

Cost Effective Design,High Performance

PInano™ series piezo position-ing stages are designed to pro-vide high performance at mini-mum cost. For highly-stable,closed loop operation, piezore-sistive sensors are applieddirectly to the moving structureand precisely measure the dis-placement of the stage plat-form. The very high sensitivityof these sensors provides opti-mum position stability andresponsiveness as well asnanometer resolution. A pro-prietary servo controller signifi-cantly improves the motion

linearity compared to conven-tional piezoresistive sensorcontrollers.

Excellent Guiding Accuracy

Flexures optimized with FiniteElement Analysis (FEA) areused to guide the stage. FEAtechniques are used to give thedesign the highest possiblestiffness in, and perpendicularto, the direction of motion, andto minimize linear and angularrunout. Flexures allow ex-tremely high-precision motion,no matter how minute, as theyare completely free of play andfriction.

Controller & SoftwareIncluded

The PInano™ Z stage comescomplete with a powerful digi-tal closed-loop controller. Thecontroller features two digitalinterfaces (USB & RS-232) aswell as a high-speed analoginterface and is compatiblewith leading image acquisitionsoftware packages such asMetaMorph etc.The controllers are deliveredincluding software forWindows operating systems.DLLs and LabVIEW drivers areavailable for automated con-trol.The extensive command set isbased on the hardware-inde-

pendent General CommandSet (GCS), which is common toall current PI controllers forboth nano- and microposition-ing systems. GCS reduces theprogramming effort in the faceof complex multi-axis position-ing tasks or when upgrading asystem with a different PI con-troller.

� Extremely Fast Step & Settle, From 5 msec� Low Profile for Easy Integration: 20 mm (0.8'')� 100 and 200 µm Travel Ranges� Proprietary Technology: Outstanding Lifetime Due to PICMA®

Piezo Ceramic Stacks� Cost-Effective Design due to Piezoresistive Sensors� Compatible w/ Leading Image Acquisition Software Package� Closed-Loop Control for High Repeatability and Accuracy� USB Controller & Software Included


� 3D Imaging


� Laser technology

� Interferometry

� Metrology

� Biotechnology



P-736.ZR1SPInano™ Z Piezo Slide ScannerSystem, 100 µm, Slide-SizeAperture, Piezoresistive Sensors,with USB Fully Digital Controller

P-736.ZR2SPInano™ Z Piezo Slide ScannerSystem, 200 µm, Slide-SizeAperture, Piezoresistive Sensors,with USB Fully Digital Controller

Accessories

P-545.PD335mm Petri Dish Holder forP-545 PInano™ Piezo Stages

P-545.SH3Microscope Slide Holderfor PInano™ Piezo Stages

P-736.AP1Adapter Plate P-736 PInano™ PiezoZ to M-545 XY Microscope Stages

PInano™ Z nanopositioning stages (shown with optional slide andPetri dish holder) feature a very low profile of 20 mm (0.8”), a large aperture

and deliver highly accurate motion with sub-nanometer resolution

The PInano™ Z stage can be combined with the M-545 high-stability,long-travel manual /motorized microscope stage (25 x 25 mm)


http://www.pi.ws

http://www.pi.ws

http://www.pi.ws

http://www.pi.ws/picma

Technical Data

Model P-736.ZR1S P-736.ZR2S Units Tolerance

Active axes Z Z


Integrated sensor piezoresistive piezoresistive

Closed-loop travel 100 200 µm

Open-loop resolution 0.2 0.4 nm typ.

Closed-loop resolution 0.4 0.7 nm typ.

Linearity ±0.1 ±0.1 % typ.

Repeatability <4 <5 nm typ.


Settling time (10% step width) 5 7 ms

Load 500 500 g max.

Drive properties


Miscellaneous

Operating temperature range 15 to 40 15 to 40 °C


Mass 550 550 g ±5%

Cable length 1.5 1.5 m ±10 mm

A compact piezo controller with adigital servo, USB, RS-232 and a high–speed

analog interface is includedP-736, dimensions in mm


P-737 piezo Z-stage for high-resolution microscopy


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P-737 PIFOC® Wellplate / Specimen-Focusing Z-StageLow-Profile, Long-Range Piezo Z Nanopositioner for Microscopy Samples

PIFOC® P-737 high-speed verti-cal positioning systems aredesigned for use with XYmicroscopy stages–OEM man-ual stages as well as aftermar-ket motorized stages.

While the XY stage positionsthe sample, the piezo-actuator-based P-737 moves the samplealong the optical axis to quicklyand precisely adjust the focus.Vertical stepping with an accu-racy in the nanometer rangetakes only a few milliseconds.

The large aperture is designedto accommodate a variety ofspecimen holders includingslides or multiwell plates.

High-Speed Z Steps for FastFocus Control and Z StackAcquisition

The immediate response of thesolid-state piezo drives enablesrapid Z-steps with typically10 to 20 times faster step &settle times than classical step-per motor drives. This leads tohigher image acquisition speedand throughput.

Closed-Loop Position Controlfor High-Precision andStability

For high stability and repeata-bility, P-737 stages areequipped with position feed-back. High-resolution, fast-responding, strain gauge sen-sors (SGS) are applied toappropriate locations on thedrive train and provide a high-bandwidth, nanometer-preci-sion position feedback signal tothe controller. The sensors areconnected in a full-bridge con-figuration to eliminate thermaldrift, and assure optimal posi-tion stability in the nanometerrange.

Excellent Guiding Accuracy

Flexures optimized with FiniteElement Analysis (FEA) areused to guide the stage. FEAtechniques are used to give thedesign the highest possiblestiffness in, and perpendicularto, the direction of motion, andto minimize linear and angularrunout. Flexures allow ex-tremely high-precision motion,no matter how minute, as theyare completely free of play andfriction.

Ceramic Insulated PiezoActuators Provide LongLifetime

Highest possible reliability isassured by the use of award-winning PICMA® multilayerpiezo actuators. PICMA® actua-tors are the only actuators onthe market with ceramic-onlyinsulation, which makes themresistant to ambient humidityand leakage-current failures.They are thus far superior toconventional actuators in relia-bility and lifetime.

� High-Speed Piezo Z-Motion with Travel Ranges up to 500 µm� Resolution in the Nanometer Range� Clear Aperture to Accomodate Specimen Holders� Perfect Mechanical Fit with XY OEM Manual or

Motorized Stages� Sub-Millisecond Response Times


� Fluorescence microscopy


� Biotechnology

� Autofocus systems

� 3D Imaging

� Medical technology


P-737.1SLPIFOC® Nanofocusing Z-Stagefor Microscope Sample Holder,100 µm, SGS, LEMO Connector,for Märzhäuser Microscope Stages



Versions with high-resolutioncapacitive sensors on request.Ask about custom designs


http://www.pi.ws

http://www.pi.ws

http://www.pi.ws

The P-737 piezo Z-stage (shown with multiwell plate) is compatible with motorized microscope XY stages like the one shown from Mªrzhªuser


Technical Data

Model P-737.1SL P-737.2SL P-737.5SL Units Tolerance

Active axes Z Z Z


Integrated sensor SGS SGS SGS

Open-loop travel, -20 to +120 V 150 280 550 µm min. (+20 %/-0 %)

Closed-loop travel 100 250 500 µm

Open-loop resolution 0.8 1 1.6 nm typ.

Closed-loop resolution 2.5 4 5 nm typ.

Linearity, closed-loop 0.2 0.5 0.8 % typ.

Repeatability 6 12 15 nm typ.

Rotation around X ±36 ±36 ±36 µrad typ.

Rotation around Y ±36 ±100 ±100 µrad typ.


Unloaded resonant frequency 270 210 120 Hz ±20 %

Resonant frequency @ 100 g 230 180 115 Hz ±20 %


Push/pull force capacity in 50 / 20 50 / 20 50 / 20 N Max.motion direction

Drive properties

Ceramic type PICMA® P-885 PICMA® P-885 PICMA® P-885

Electrical Capacitance 6.3 9.3 13.8 µF ±20 %

Dynamic operating current coefficient 7.9 4.6 3.5 µA/(Hz • µm) ±20 %

Miscellaneous

Operating temperature range -20 to 80 -20 to 80 -20 to 80 °C

Material Aluminum Aluminum Aluminum

Dimensions 220.5 x 138 x 27.3 220.5 x 138 x 27.3 220.5 x 150 x 27.3 mm

Mass 0.7 0.7 0.8 kg ±5 %

Cable length 2 2 2 m ±10 mm

Sensor / voltage connection LEMO LEMO LEMO

System properties

System configuration E-500 System with E-500 System with E-665.SR

E-503 amplifier (6 W) E-503 amplifier (6 W) controller/driver

E-509 servo module E-509 servo module (12 W)

Closed-loop amplifier bandwidth, 60 30 15 Hz typ.small signal

Settling time (10 % step width) 24 30 50 ms typ.

Recommended controller / amplifierSingle-channel: E-610 servo controller / amplifier (p. 2-110), E-625 servo controller, bench-top (p. 2-114), E-665 powerful servo controller, bench-top (p. 2-116)

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With a platform diameter ofonly 10 cm the M-810 Hexapodis the most compact parallel-kinematics micropositioningsystem to date. In addition topositioning all six axes withhigh speed and accuracy, itallows the user to define thecenter of rotation (pivot point)anywhere inside or outside thesystem envelope by one sim-

ple software command. Thismakes it ideal for all complexpositioning tasks with restrict-ed space.

Extremely Compact,Great Freedom of Motion

The M-810.00 with its direct-drive torque motors andActiveDrive™ system withintegrated servo ampifiers pro-vides an increased velocity ofup to 10 mm/s for loads up to5 kg. Small and compact, theHexapod allows a large strokeof up to 40 mm (linear) and 60°(angular).

Hexapod vs. Serial KinematicsSystems

The Hexapod is driven by sixhigh-resolution actuators allconnected directly to the samemoving platform. This designprovides a high system stiff-ness and a large clear aperture.

Because of the low mass of themoving platform, positioningoperations can be performedwith far lower settling timesthan with conventional,

M-810 Miniature Hexapod 6 Axis Stage6 Degrees of Freedom & High Precision in a Small Package

� Most-Compact Hexapod in the PI Portfolio� Travel Ranges 40 x 40 x 13 mm, Rotation to 60 Degrees� Load Capacity to 5 kg� Resolution of a Single Strut 40 nm� Min. Incremental Motion to 200 nm� Repeatability up to ±0.5 µm� Velocity to 10 mm/s


M-810.00Miniature-Hexapod Microrobotwith Controller, Direct Drive

Ask about custom designs

The miniature Hexapod M-810 provides longtravel ranges despite its compact design


� Biotechnology

� Semiconductor technology

� Micromachining


� X-ray diffraction measure-ments

� Tool control

stacked multi-axis systems. Insuch systems, runout, guidingerrors, and the friction andinertia of moving cables allaccumulate to limit accuracyand repeatability-problemswhich do not affect parallelkinematic systems like theHexapod.

User-Defined Pivot Point

For optics and other alignmenttasks, it is important to be ableto define a fixed pivot point.The sophisticated Hexapod-controller allows choosing anypoint in space as the pivotpoint for the rotation axes witha simple software command.The pivot point remains fixedrelative to the platform.

Target positions in 6-space areentered in user-friendly coordi-nates and reached by smoothvectorized motion.Open Architecture

Control of the hexapod is facil-itated by the controller's openinterface architecture, whichprovides a variety of high-levelcommands and includes amacro language for program-ming and storing commandsequences.

M-810 with modified cable exit.

M-810.00, dimensions in mm


http://www.pi.ws

http://www.pi.ws

http://www.pi.ws

Technical Data

M-810.00 Unit

Active axes X, Y, Z, �X, �Y, �Z


*Travel range X, Y ±20 mm

*Travel range Z ±6.5 mm

*Travel range �X, �Y ±11 °

*Travel range �Z ±30 °

Actor drive Brushless DC Motor, ActiveDrive™

Actuator stroke ±7.5 mm

Single-actuator design resolution 0.04 µm

Integrated sensor Rotary encoder

Sensor resolution 12800 Cts./rev.

**Min. incremental motion X, Y 1 µm

**Min. incremental motion Z 0.2 µm

**Min. incremental motion �X, �Y, �Z 3.5 µrad

Repeatability X, Y ±2 µm

Repeatability Z ±0.5 µm

Repeatability �X, �Y, �Z ±5 µrad

Backlash X, Y 2 µm

Backlash Z 0.5 µm

Max. velocity X, Y, Z 10 mm/s

Max. velocity �X, �Y, �Z 250 mrad/s

Typ. velocity X, Y, Z 5 mm/s

Typ. velocity �X, �Y, �Z 120 mrad/s


Stiffness X, Y 0.1 N/µm

Stiffness Z 4 N/µm

Max. load (baseplate horizontal / optional) 5 / 2.5 kg

Miscellaneous

Operating temperature range 0 to +50 °C

Material Stainless steel, aluminum

Mass 1.7 kg* The travel ranges of the individual coordinates ( X, Y, Z, �X, �Y, �Z) are interdependent. The data for each axis in this table

shows its maximum travel, where all other axes are at their zero positions. If the other linear or rotational coordinates are notzero, the available travel may be less.

** Six-axis move. No moving cables (unlike serial-kinematic stacked systems). Eliminates bending, inertia and friction, improvingaccuracy.

Technical data are specified at 20 ±3°C. Data for vacuum versions may differ.

M-824.3DG compact 6-axis Hexapod

The interferometer test shows the Z axis accuracy over the entire travel range of 25 mm and the extremely high repeatability of ±0.046 µm

Interferometer tests show the high repeatability, here with 500 nm steps

M-824 Compact 6-Axis-StagePrecision Micropositioner with Controller, Vacuum Versions

PI Hexapods come with a powerful 6D controller and sophisticated, user-friendly positioning and alignment sofware.

Keypad and display are optional.



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P-721 PIFOCs® are high-speed,piezo-driven microscope objec-tive nanofocusing/scanning

devices, providing a position-ing and scanning range of100 µm with sub-nanometerresolution and very high mo-tion of linearity up to 0.03 %.For applications, such as thetwo-photon spectroscopy wichrequires a particulary high res-olution, there are versions wichallow a free aperture of up to29 mm in diameter.PIFOCs® are also available withup to 460 µm travel (P-725p. 2-28), and for exceptionaldynamic and step performance(models P-726 p. 2-32 andP-725.SDD p. 2-30).

Superior Accuracy With Direct-Metrology Capacitive Sensors

Capacitive position feedback isused in the top-of-the-line

models. PI's proprietary capac-itive sensors measure positiondirectly and without physicalcontact. They are free of fric-tion and hysteresis, a factwhich, in combination with thepositioning resolution of wellunder 1 nm, makes it possibleto achieve very high levels oflinearity. A further advantageof direct metrology with capac-itive sensors is the high phasefidelity and the high bandwidthof up to 10 kHz.Alternatively, strain gauge sen-sor (SGS) models are available.The sensors are connected in abridge configuration to eliminatethermal drift, and assure optimalposition stability in the nanome-ter range.

Open-loop models are availablefor applications where fast res-ponse and very high resolutionare essential. Here, specifying orreporting absolute position val-ues is either not required or ishandled by external sensors,such as interferometers, a visionsystem or photodiode PSD (posi-tion sensitive detector). Thesemodels retain the inherent piezoadvantages such as high resolu-tion and speed.


� 3D-Imaging

� Z Stack Acquisition

� Screening

� Interferometry

� Metrology

� Disc-drive-testing



� Biotechnology


Fast Nanopositioner and Scanner for Microscope Objectives

P-721 PIFOC® Piezo Flexure Objective Scanner

P-721.CLQ piezo objective nanopositioning system withP-721.12Q QuickLock option and objective (adapter and objective not included)

� Scans and Positions Objectives with Sub-nm Resolution� Travel Ranges to 140 µm, Millisecond Settling Time� Significantly Faster Response and Higher Lifetime than

Motorized Z-Stages� Parallel Precision Flexure Guiding for Better Focus Stability� Choice of Position Sensors: Capacitive Direct Metrology

(Higher Performance) or Strain Gauge (Lower Cost)� Compatible with Metamorph™ Imaging Software� Outstanding Lifetime Due to PICMA® Piezo Actuators� QuickLock Adapter for Easy Attachment� Clear Aperture up to 29 mm Ø


P-721.CDQFast PIFOC® Piezo NanofocusingZ-Drive, 100 µm, Direct Metrology,Capacitive Sensor, Sub-D Connector,for Quick Lock Thread Adapters

P-721.CLQFast PIFOC® Piezo NanofocusingZ-Drive, 100 µm, Direct Metrology,Capacitive Sensor, LEMO Connector,for Quick Lock Thread Adapters

P-721.SL2Fast PIFOC® Piezo NanofocusingZ-Drive, 100 µm, SGS-Sensor, LEMOConnector, for Quick Lock ThreadAdapters

P-721.0LQFast PIFOC® Piezo NanofocusingZ-Drive, 100 µm, No Sensor, LEMOConnector, for Quick Lock ThreadAdapters

P-721.CDAFast PIFOC® Piezo NanofocusingZ-Drive, 100 µm, Direct Metrology,Capacitive Sensor, Sub-DConnectors, for Large ApertureQuickLock Thread Adapters

P-721.SDAFast PIFOC® Piezo NanofocusingZ-Drive, 100 µm, SGS Sensor,Sub-D Connectors, for Large Aper-ture QuickLock Thread Adapters

Accessories

QuickLock Thread Adapter, LargeAperture QuickLock Thread Adapters. fig.; Extension Tubes forObjectives s. www.pi.ws

QuickLock Adapter

P-721.xxQ, .SL2 dimensions in mm(adapter to be ordered separately)

P-721.CDA, .SDA, dimensions in mm(adapter to be ordered separately)

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QuickLock P-721.12Qthread adapter exploded view with

microscope objective and PIFOC®

P-721.CLQ (mounting tools areincluded, QuickLock adapter and

objective not included)


Technical Data

Model P-721.CLQ P-721.CDQ P-721.SL2 P-721.0LQ Units ToleranceP-721.CDA P-721.SDA

Active axes Z Z Z Z


Integrated sensor Capacitive Capacitive SGS –

Open-loop travel, -20 to +120 V 140 140 140 140 µm min. (+20 %/-0%)

Closed-loop travel 100 100 100 – µm calibrated

Open-loop resolution 0.5 0.5 0.5 0.5 nm typ.

Closed-loop resolution 0.7 0.7 5 – nm typ.

Linearity, closed-loop 0.03 0.03 0.2 – % typ.

Repeatability ±5 ±5 ±10 – nm typ.

Runout θX, θY 13 13 13 13 µrad typ.

Crosstalk X, Y 100 100 100 100 nm typ.


Stiffness in motion direction 0.3 0.3 0.3 0.3 N/µm ±20 %

Unloaded resonant frequency 580 580 580 550 Hz ±20 %

Resonant frequency @ 120 g 235 235 235 235 Hz ±20 %

Resonant frequency @ 200 g 180 180 180 180 Hz ±20 %

Push/pull force capacity in motion direction 100 / 20 100 / 20 100 / 20 100 / 20 N Max.

Drive properties

Ceramic type PICMA® P-885 PICMA® P-885 PICMA® P-885 PICMA® P-885

Electrical capacitance 3.1 3.1 3.1 3.1 µF ±20 %

Dynamic operating current coefficient 3.9 3.9 3.9 3.9 µA/(Hz•µm) ±20 %

Miscellaneous

Operating temperature range -20 to 80 -20 to 80 -20 to 80 -20 to 80 °C

Material Aluminum Aluminum Aluminum Aluminum

Mass 0.24 0.24 0.22 0.22 kg ±5 %

Max. objective diameter 39 39 39 39 mm

Cable length 1 1 1 1 m ±10 mm

Sensor / voltage connection LEMO Sub-D Special LEMO/Sub-D Special LEMO (no sensor)

Recommended controller / amplifier E-610 servo E-625 servo SL2 version: E-610 servocontroller/amplifier controller, bench E-610 servo controller/amplifier(p. 2-110), modular top (p. 2-114), controller/amplifier,piezo controller E-665 powerful E-625 servosystem E-500 servo controller, controller,(p. 2-142) bench-top bench-top,with amplifier (p. 2-116), E-665 powerfulmodule E-505 Single-channel servo controller,(high performance) digital controller: bench-top(p. 2-147) and E-753 (bench-top) SDA version:E-509 servo (p. 2-108) E-709 single-controller (p. 2-152) E-709 single- channel digital

channel digital controllercontroller

Resolution of PI Piezo Nanopositioners is not limited by friction or stiction. Value given is noise equivalent motion with E-503 amplifier (p. 2-144)

Simple Installation withQuickLock Thread Options

The PIFOC® is mounted be-tween the turret and the objec-tive with the QuickLock threadadapter. After threading theadapter into the turret, theQuickLock is affixed in thedesired position. Because thePIFOC® body need not to berotated, cable wind-up is not anissue.

High Reliability and LongLifetime

The compact PIFOC® systemsare equipped with preloadedPICMA® high-performance pie-zo actuators which are integra-ted into a sophisticated, FEA-modeled, flexure guidingsystem. The PICMA® actuatorsfeature cofired ceramic encap-sulation and thus offer betterperformance and reliability

than conventional piezo actua-tors. Actuators, guidance andsensors are maintenance-freeand not subject to wear, andthus offer an extraordinary reli-ability.

Choice of Controllers

A large choice of analog anddigital piezo controllers as OEM,bench-top and 19-inch-rack-mount versions is available.


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The P-726 PIFOC ® Nano focus -ing system was developed toachieve the fastest possiblestepping time with the heavy ,high-numerical-aperture objec-tives used in many of today’ shigh-resolution microscopyapplications. Its extremely stiffdesign offers excellent settlingtime and scanning frequencyvalues even when objectives ofseveral hundred grams aremoved. High stiffness is

achieved with the rotationallysymmetric arrangement ofmultiple piezo drives and theoptimized design of the flexureand lever elements, whichassure the excellent guidingaccuracy and dynamics.

Furthermore, like other mem-bers of the PIFOC ® family, theP-726 is equipped with directmetrology capacitive positionsensors that allow resolutionsfar below one nanometer.

Direct Metrology withCapacitive Sensors for HighestStability and Accuracy

PI's proprietary capacitive posi-tion sensors measure the actu-al motion of the moving partrelative to the stationary base(direct metrology). Errors in thedrive train, actuator , lever armor in guiding system do notinfluence the measurements.The result is exceptional

motion linearity , higher long-term stability and a stiffer ,more-responsive servo loop,because external influencesare immediately recognized bythe sensor. Due to this sensorprinciple, the P-726 features aresolution of under 0.4 nm inclosed-loop and a linearity of0.02 %.


The PIFOC ® is mounted be -twe en the turret and the objective with the QuickLockthread ad apter. After threadingthe adapter into the turret, theQuickLock is affixed in thedesired position. Because thePIFOC® body need not to berotated, cable wind-up is not anissue.


Highest possible reliability isassured by the use of award-winning PICMA ® multilayerpiezo actuators. PICMA ® actua-tors are the only actuators onthe market with ceramic-only

insulation, which makes themresistant to ambient humidityand leakage-current failures.They are thus far superior toconventional actuators in relia-bility and lifetime.

P-726 PIFOC® High-Dynamics, High Load Objective ScannerHigh-Dynamic Piezo Z Scanner for Heavy Objectives


� 3-D Imaging

� Screening


� Microscopy


� Surface analysis

� Wafer inspection


P-726.1CDHigh-Dynamics PIFOC® PiezoNanofocusing Z-Drive, 100 µm,Capacitive Sensor

QuickLock Thread Adapter asAccessories:

P-726.04P-726 PIFOC® Thread Adapter M28 x 0.75


P-726.06P-726 PIFOC® Thread Adapter M26 x 1/36"


P-726.12P-726 PIFOC® Thread Adapter W0.8 x 1/36"


� High-Dynamics Positioning and Scanning for Large Objectives� 1120 Hz Resonant Frequency, 560 Hz with 210 g Load� Typical Settling Time about 6 ms� Travel Range 100 µm� Direct-Metrology Capacitive Sensors for Best Linearity,

Stability and Control Dynamics� Resolution to 0.3 nm� Frictionless, High-Precision Flexure Guiding System for Better

Focus Stability

High-dynamics P-726 PIFOC®

for large microscope objectives over 60 mm in length

P-726 dimensions in mm with P-726.05 M32 QuickLock adapter

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Technical Data

P-726.1CD Tolerance

Active axes Z


Integrated sensor Capacitive, direct metrology

Closed-loop travel 100 µm calibrated

Closed-loop resolution 0.4 nm typ.

Open-loop resolution 0.3 nm typ.

Linearity, closed-loop 0.02 % typ.

Repeatability ±3 nm typ.

Runout �X, �Y ±5 µrad typ.

Crosstalk X, Y 50 nm typ.


Stiffness in motion direction 3.4 N/µm ±20 %

Unloaded resonant frequency 1120 Hz ±20 %

Resonant frequency under load 560 Hz @ 210 g ±20 %

Resonant frequency under load 480 Hz @ 310 g ±20 %

Push/pull force capacity in motion direction 100 / 50 N Max.

Drive properties

Piezo ceramic type PICMA® P-885

Electrical capacitance 6 µF ±20 %

Dynamic operating current coefficient 7.5 µA/(Hz • µm) ±20 %

Miscellaneous

Operating temperature range -20 to 80 °C

Material Aluminum, steel

Dimensions Diameter: 65 mm, Height: 50.7 mm

Max. objective diameter M32

Mass 575 g ±5 %

Cable length 1.5 m ±10 mm

Sensor / voltage connection Sub-D Special

Recommended controller / amplifier Single-channel digital controller: E-753 (bench-top) (p. 2-108)E-625 bench-top controller (p. 2-114), E-665 high-power bench-top controller (p. 2-116)E-500 modular piezo controller system (p. 2-142)with E-505 high-power amplifier module (p. 2-147)and E-509 servo-controller (p. 2-152)

System properties

System configuration E-500 modular piezo controller system with E-505 high-power amplifier module and E-509 servo-controller 310 g load (objective mass)

Closed-loop amplifier bandwidth, 130 Hzsmall signal, 10 µm

Closed-loop amplifier bandwidth, 70 Hzlarge signal

P-726 QuickLock thread adapter exploded viewwith P-726 PIFOC® (mounting tools included)

P-726 settling time under load

Knurled Ring

Microscope Turret

Turret Ring

PIFOC®

Objective Ring

Objective

High-Precision Positioner / Scanner for Microscope Objectives

P-725 PIFOC® Long-Travel Microscope Objective Scanner

P-725 PIFOC® nanofocus sys-tems are long-travel, high-speed, piezo-driven micro-scope objective nanofocusing/scanning devices. Despite theincreased travel ranges (up to460 µm), they are 20 % shorterthan P-721 units (p. 2-25) whileproviding sub-nanometer reso-lution. The innovative, friction-less, flexure guiding systemprovides enhanced precisionfor superior focus stability withfast response for rapid settlingand scanning.

Fastest Step-and-Settle:25 Milliseconds for 250 Microns

The P-725.2CL can perform a250 µm step to 1 % accuracy inonly 25 ms (E-665.CR controller,no load) and in 50 ms with aload of 150 g.

Superior AccuracyWith Direct-MetrologyCapacitive Sensors

Cpacitive position feedback isused in the top-of-the-line mod-els. PI's proprietary capacitiveposition sensors measure theactual motion of the movingpart relative to the stationarybase (direct metrology). Errorsin the drive train, actuator, leverarm or in guiding system donot influence the measure-ments. The result is exceptionalmotion linearity, higher long-term stability and a stiffer,more-responsive servo loop,because external influences areimmediately recognized by thesensor.

Open-loop models are availablefor applications where fast re-

sponse and very high reso-lution are essential. Here, spec-ifying or reporting absoluteposition values is either not re-quired or is handled by externalsensors, such as interferome-ters, vision system or photodi-ode PSD (position sensitivedetector). These models retainthe inherent piezo advantagesas high resolution and speed.


The PIFOC® is mounted be-tween the turret and the objec-tive with the QuickLock threadadapter. After threading the ad-apter into the turret, the QuickLock is affixed in the desiredposition. Because the PIFOC®

body need not to be rotated,cable wind-up is not an issue.


The compact PIFOC® systemsare equipped with preloadedPICMA® high-performance piezoactuators which are integratedinto a sophisticated, FEA-mod-eled, flexure guiding system.The PICMA® actuators featurecofired ceramic encapsulationand thus offer better perform-ance and reliability than conven-tional piezo actuators. Actuators,guidance and sensors are main-tenance-free and not subject towear, and thus offer an extraor-dinary reliability.

� Travel Ranges to 460 µm� Significantly Faster Response and Higher Lifetime than

Motorized Z-Stages� Scans and Positions Objectives with Sub-nm Resolution� Direct Metrology with Capacitive Sensors for Highest Linearity� Parallel Precision Flexure Guiding for Better Focus Stability� Compatible with Metamorph™ Imaging Software� Outstanding Lifetime Due to PICMA® Piezo Actuators� QuickLock Adapter for Easy Attachment


� 3D-Imaging

� Screening

� Interferometry

� Metrology

� Disc-drive-testing



� Biotechnology



P-725.1CDPIFOC® Piezo NanofocusingZ-Drive for Long Scanning Ranges,100 µm, Capacitive Sensors, Sub-DConnector, for Quick Lock ThreadAdapters

P-725.1CL*PIFOC® Piezo NanofocusingZ-Drive for Long Scanning Ranges,100 µm, Capacitive Sensors, LEMOConnector, for Quick Lock ThreadAdapters





*Also available w/o sensor (open-loop): P-725.10L, P-725.20L andP-725.40L

AccessoriesQuickLock thread adapters and ex-tension tubes for objectives(see p. 2-26)

Top dynamic performance of the P-725.2CL PIFOC®: only 25 ms for a 250 µm step

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P-725.2CD (QuickLock adapterand objective not included)


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Recommended controller / amplifier“CL”-versions:E-610 servo controller / amplifier(p. 2-110); E-500 modular piezocontroller system (p. 2-142) withE-505 high-performance amplifier mo-dule (p. 2-147) and E-509controller (p. 2-152)“CD”-versions:E-621 controller module (p. 2-160),E-625 servo controller, bench-top(p. 2-114), E-665 display servocontroller, with digital interface,bench-top (p. 2-116)Single-channel digital controller:E-753 (bench-top) (p. 2-108)

Technical Data

Model P-725.1CL, P-725.2CL, P-725.4CL, Units ToleranceP-725.1CD P-725.2CD P-725.4CD

Active axes Z Z Z


Integrated sensor Capacitive Capacitive Capacitive

Open-loop travel, -20 to +120 V 150 330 460 µm min. (+20 %/0 %)

Closed-loop travel 100 250 400 µm calibrated

Open-loop resolution 0.3 0.4 0.5 nm typ.

Closed-loop resolution 0.65 0.75 1.25 nm typ.

Linearity, closed-loop 0.03 0.03 0.03 % typ.

Repeatability ±5 ±5 ±5 nm typ.

Runout �X 1 6 10 µrad typ.

Runout �Y 20 45 45 µrad typ.

Crosstalk in X 20 20 60 nm typ.

Crosstalk in Y 20 40 60 nm typ.


Stiffness in motion direction 0.23 0.17 0.12 N/µm ±20 %

Unloaded resonant frequency 470 330 230 Hz ±20 %


Push/pull force capacity 100 / 20 100 / 20 100 / 20 N Max.

in motion direction

Drive properties

Ceramic type PICMA® P-885 PICMA® P-885 PICMA® P-885

Electrical capacitance 4.2 6.2 6.2 µF ±20 %

Dynamic operating current coefficient 5.2 3.1 1.9 µA/(Hz • µm) ±20 %

Miscellaneous

Operating temperature range -20 to 80 -20 to 80 -20 to 80 °C

Material Aluminum Aluminum Aluminum

Max. objective diameter 39 39 39 mm

Mass 0.215 0.23 0.23 kg ±5 %

Sensor / voltage connection CL-version: LEMO CL-version: LEMO CL-version: LEMO

CD-version: CD-version: CD-version:

Sub-D special Sub-D special Sub-D special

P-721.12Q QuickLock threadadapter, exploded view with

microscope objective and PIFOC®

(mounting tools are included,QuickLock adapter

and objective not included)

P-725 dimensions in mm (thread adapter ordered separately)


P-720 PIFOC® Piezo Scanner for Small ObjectivesCompact High-Dynamics Scanner

� Travel Range 100 µm� Rapid Response & Settling Behavior� Scans and Positions Objectives with Sub-nm Resolution� Frictionless, High-Precision Flexure Guiding System� Outstanding Lifetime Due to PICMA® Piezo Actuators

P-721K PIFOC® Nosepiece / Turret NanopositionersFor High-Resolution Microscopy. High-Load Capacity, Capacitive Feedback

� Positioning and Scanning of Microscope Turrets� Direct-Metrology Capacitive Sensors for Highest Linearity,

Stability and Control Dynamics� Frictionless, High-Precision Flexure Guiding System for

Better Focus Stability� Outstanding Lifetime Due to PICMA® Piezo Actuators

NEXACT® 1000 µm Focusing System for MicroscopyIdeal for Two-Photon Microscopy: PiezoWalk® motor enables 1 mm travel & high dynamics

The new PIFOC® drives with NEXACT®

piezo stepping motors are unique

objective nanopositioners.They com-

bine travel ranges of one millimeter

or more with 5-nanometer resolution

and high dynamics. For fast step-

and-settle, the drives have a resonant

frequency of 560 Hz carrying an ob-

Special PIFOC® design with PiezoWalk Linear jective weighing 200 g.Motor drive: 5 nm resolution over 1 mm µm travel


News & Applications

The fastest microscope objective Z-piezo stage

P-726 High-Performance PIFOC®

PI has extended its successful PIFOC®

■ Resonant frequency: 430 Hz line of objective nanopositioners with

(with 300 g), 1100 Hz withouta new, high-power unit. The P-726

®objective

PIFOC can move heavy, high-NAimmersion lenses (>200 g) faster than ■ Closed-loop position noise: <0.4 nm

any other system currently available, ■ Position stability over 100 s: 4 nm with accuracies of 1 nm over a travel

■ Maximum operating frequencyrange of 100 µm.

(amplitude <10 µm): 150 Hz*Here, the convincing performance

■ Maximum operating frequency specifications – achieved with a load

with full travel (100 µm): 60 Hz*of 300 g (11 oz). The E-726 can be operated with a variety of controllers ■ Settling time (10 µm steps): 6 ms**ranging from the economical E-621

■ Settling time (full travel): 15 ms**card, the E-625 controller to a numberof digital controllers for the highestpossible performance. * Amplifier power limited.

Higher performance with E-505, 200 W power module

** Faster settling with smaller load

Settling behavior of the P-726 for a 10 µm step.

10 µm step

Setting time: 5,6 ms

posi

tion

/ µm

time / s

Dispenser for Bio-Handling

Small and fast is not only a require-

independently of each other in orderto dispense liquids into well plates. A single actuator is only 9 millimeterswide to match the standardized sample holder.

The M-664KCEP covers the travelrange of 50 millimeters in less than250 milliseconds and generates forcesof up to 4 N. The resolution of thepositioning sensor is matched to theapplication and amounts to 5 micro-meters.

ment in classical micropositioningtechnology, however. Piezo ultrasonicmotors are also extremely well suitedto applications where the accuracyrequirements are not quite so demand-ing – in the range between 5 and 100 micrometers for example, whichis usually sufficient for industrialautomation and handling tasks.

PI has developed the low cost M-664KCEP dispenser drive withPILine® piezo ultrasonic motors for

Stack of 8 M-664KCEP linear actuators,shown with well plate. The integrated

ceramic piezomotor provides highspeeds of more than 200 mm/sec.this kind of application. Eight or more

of these drives stacked together can move pipettes vertically and

PI is increasingly employing PILine® piezo ultrasonic drives in its positioningstages as an alternative to motor/leadscrew designs – particularly when thestages must be small and fast.They achieve positioning accuracies of up to0.1 µm and speeds of up to several 100 mm/s.



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S-334 Miniature Piezo Laser Scanner Tip/Tilt-Mirror

S-334 Tip/Tilt Mirror System / Scanner ProvidesOptical Deflection Angle up to 120 mrad

Fast Steering Mirror with up to 120 mrad Deflection

S-334 dimensions in mm

� Miniature Design� Optical Beam Deflection to 120 mrad (~ 6.8°)� Coplanar Axes & Fixed Pivot Point;

Eliminate Polarization Rotation� Factory Installed Mirror� Millisecond Response, Resolution to 0.2 µrad� Closed-loop Position Servo-Control for High Accuracy� For Mirrors up to 12.5 mm (0.5”) Diameter� Frictionless, High-Precision Flexure Guiding System� Parallel Kinematics for Enhanced Dynamics and Better

Multi-Axis Accuracy

S-334 piezo tip/tilt mirrors /scanners provide extremelylarge deflection angles in aminiaturized package. Thesefast steering mirror systemsare based on a sophisticatedparallel-kinematics design with

two coplanar, orthogonal axesand a fixed pivot point.

Large Tip/Tilt Ranges withExcellent Motion Characteristics

The novel flexure/lever designwith minimized inertia allows

for the exceptionally large tip/tilt range of 60 mrad (50 mradin closed-loop operation, whichis equivalent to 100 mrad opti-cal beam deflection) and veryfast response in the millisecondrange. These parameters makethe system unique in the mar-ket of piezo driven tip/tilt mirrorsystems.

Sub-Microradian Resolution

In addition to the large anglesand the high dynamics theS-334 provides sub-micro-radian resolution. The integrat-ed high-resolution, full-bridgestrain gauge sensors (SGS)provide absolute position con-trol, excellent repeatability andhigh linearity, typically betterthan 0.05 % over the entire trav-el range.

Differential Drive for ImprovedStability and Dynamics

The S-334 is based on a paral-lel-kinematics design with co-planar axes and a single mov-ing platform. Two pairs of dif-ferentially-driven piezo actua-tors are employed to providethe highest dynamics and posi-tion stability over a wide tem-perature range.

Compared to stacked, (two-stage), piezo or galvo scanners,the single-platform design pro-vides several advantages:smaller package size, identical

dynamic performance in bothaxes, faster response and bet-ter linearity. It also preventspolarization rotation.


The compact S-334 systemsare equipped with preloadedPICMA® high-performance pie-zo actuators which are integrat-ed into a sophisticated, FEA-modeled, flexure guiding sys-tem. The PICMA® actuators fea-ture cofired ceramic encapsula-tion and provide better per-formance and reliability thanconventional piezo actuators.Actuators, guidance and sen-sors are maintenance-free, notsubject to wear and offerextraordinary reliability.


S-334.1SDHigh-Dynamics Piezo Tip/TiltPlatform, 25 mrad, SGS, Sub-DConnector, incl. Mirror

S-334.1SLHigh-Dynamics Piezo Tip/TiltPlatform, 25 mrad, SGS, LEMOConnector, incl. Mirror

S-334.2SDHigh-Dynamics Piezo Tip/TiltPlatform, 50 mrad, SGS, Sub-DConnector, incl. Mirror

S-334.2SLHigh-Dynamics Piezo Tip/TiltPlatform, 50 mrad, SGS, LEMOConnector, incl. Mirror


� Image processing /stablilization

� Interlacing, dithering

� Laser scanning /beam steering

� Optics

� Optical filters / switches


� Beam stabilization

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The E-616 OEM controllerand the S-334 fast steeringmirror system providing atip/tilt range of up to 60 mrad


S-334.2SL cable configuration

Technical Data

Model S-334.1SL S-334.2SL Units ToleranceS-334.1SD S-334.2SD

Active Axes �X, �Y �X, �Y


Integrated sensor SGS SGS

*Open-loop tilt angle at -20 to +120 V 30 60 mrad min. (+20 %/-0 %)

*Closed-loop tilt angle 25 50 mrad

Open-loop resolution 0.2 0.5 µrad typ.

Closed-loop resolution 1 5 µrad typ.

Linearity 0.05 0.05 % typ.

Repeatability 2 5 µrad typ.


Resonant frequency underload 3.0 1.0 kHz ±20 %(with standard mirrors)

Load capacity 0.2 0.2 N Max.

Distance of pivot point to platform surface 6 6 mm ±1 mm

Platform moment of inertia 1530 1530 g • mm² ±20 %

Standard mirror (mounted) diameter: 10 mm, diameter: 10 mm,thickness: 2 mm; thickness: 2 mm;BK7, λ/5, R > 98 % BK7, λ/5, R > 98 %(λ = 500 nm to 2 µm) (λ = 500 nm to 2 µm)

Drive properties


Electrical capacitance per axis 3 3 µF ±20 %

Miscellaneous

Operating temperature range -20 to 80 -20 to 80 °C

Material casing Titanium Titanium

Mass 0.065 0.065 kg ±5 %


Sensor / voltage connection LEMO connector / LEMO connector /

25-pin sub-D connector 25-pin sub-D connector

Recommended controller / amplifierClosed-loop versions with D-sub connector: E-616 controller for tip/tilt mirror systems (p. 2-132);Open-loop versions with LEMO connector: Modular piezo controller system E-500 (p. 2-142) with amplifier module E-503.00S (three channels) (p. 2-146)or 1 x E-505.00S and 2 x E-505 (high speed applications) (p. 2-147) and E-509 servo controller (p. 2-152 / 3-16)Open-loop: E-663 three channel amplifier (p. 2-136)

Resolution of PI piezo tip/tilt platforms is not limited by friction or stiction. Noise equivalent motion with E-503 amplifier, (p. 2-146).

*Mechanical tilt, optical beam deflection is 120 mrad (open loop) and 100 mrad (closed-loop), respectively.

Factory Installed MirrorThe S-334 is equipped with afactory-installed mirror 10 mm

in diameter and 2 mm thick(flatness λ/5, reflectivity >98 %from 500 nm to 2 µm).

� Travel Ranges to 100 x 100 µm in X,Y & to 10 µm in Z� Resolution to 0.1 nm with Capacitive Sensors� High-Speed Versions with Direct Drive� Vacuum and Non-Magnetic Versions� Parallel Kinematics for Better Multi-Axis Accuracy and Dynamics

� Parallel Metrology for Active Trajectory Control� Frictionless, High-Precision Flexure Guiding System� Clear Aperture 50 x 50 mm for Transmitted-Light Applications

� Travel Range 100 µm� Direct Metrology with Capacitive Sensors � Resolution to 0.3 nm, Closed-Loop� Clear Aperture 50 x 50 mm � Versions with Additional Degrees of Freedom Available� XY and XYZ Versions Also Available� Vacuum-Compatible Versions Available

Step response of the P-733.ZCD. Settling time is in the 10 ms range

P-733.Z High-Dynamics Z-Nanopositioner / ScannerDirect Position Metrology and Clear Aper ture

P-733.2 · P-733.3 XY(Z) Piezo-Stage: High Speed for TrackingHigh-Precision XY(Z) Scanner Family

0 to 100 % travel in1.36 msec, withoutovershoot. The P-733.2DD is thefastest, highest preci-sion closed-loop XYscanning stage withlarge aperture cur-rently available.


� Parallel-Kinematics / Metrology forEnhanced Responsiveness / Multi-Axis Precision

� Travel Ranges to 340 x 340 x 340 µm� Capacitive Sensors for Highest Linearity� Frictionless, High-Precision Flexure Guiding System� Excellent Scanning Flatness� High-Dynamics Direct Drive Version Available;

Custom Versions to 6-DOF

� Outstanding Lifetime Due to PICMA® Piezo Actuators� UHV Versions to 10-9 hPa

P-562.3CD (unloaded) step and settle isaster than 10 ms in X, Y and Z

PIMars™ multi-axis, parallel-kinematics nanopositioning stages are avail-able with up to 340 µm travel per axis. Custom versions to 6 DOF are available

PIMars™ XYZ Piezo Stage for Optical TrappingLong Travel, Ultra Stability & Linearity Capacitive Sensors

P-541 Low Profile XY, Z/Tip/Tilt-Stages: High Speed TrackingHigh Speed Tracking Version & Choice of Sensors Available

The P-541/P-542-seriesnanopositioning stages featurea very low profile of 16.5 mm,

a large 80 x 80 mm aperture and deliver highlyM-686 open-frame stage with P-541 piezo scanner on top

makes an ideal combination for microscopy tasks.The system height is only 48 mm

accurate motion with sub-nanometer resolution. Dimensions andhole pattern are the same for all P-541/P-542 stages

� Low Profile 16.5mm; 80x 80mm Aperture

� Up to 200x 200µm XY, 100µm Z-Travel ,1 mrad Tilt30

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� Parallel-Kinematics / Metrology for EnhancedResponsiveness & Multi-Axis Precision

� High-Dynamics Direct-Drive Version� Choice of Sensors: Strain Gauge (Lower Cost) or

Capacitive Sensors (Higher Performance)� Outstanding Lifetime Due to PICMA® Piezo Actuators� Combination with Long Travel Microscopy Stages

time / ms


P-363 PicoCube™ XY(Z) Piezo Scanner for AFM MicroscopesHigh-Dynamics Nanoscanner for Scanning Probe Microscopy

P-363.2CD and .3CD (background)PicoCube™, high-performancepiezo positioning- and scanningsystems or AFM/STM andnanomanipulation. Smart mediacard for size comparison

300 picometersteps (0.3 nm)performed withthe P-363, meas-ured with anexternal high-resolution,capacitive meas-urement system

The P-363 settlesto within 1 nm in1 ms (100 nmstep, X and Ymotion; fasterresponse in Z)

Compact Multi-Axis Piezo System for Nanopositioning and Fiber Alignment

P-611.3 NanoCube® Miniature XYZ Piezo Stage

NanoCube® XYZ-nanopositioningsystem, 100 x 100 x 100 µm closed-loop travel,resolution 1 nm

� Up to 120 x 120 x 120 µm Travel Range� Very Compact: 44 x 44 x 44 mm� Resolution to 0.2 nm, Rapid Response� Frictionless, High-Precision Flexure Guiding System� Outstanding Lifetime Due to PICMA® Piezo Actuators� Fast Multi-Axis Scanning� Version with Integrated Fiber Adapter Interface� Cost-Effective Mechanics/Electronics System Configurations

NanoCube® can be integrated with

� Ultra-High-Performance Closed-Loop Scanner for AFM/SPM � Compact Manipulation Tool for Bio/Nanotechnology� Resonant Frequency 9.8 kHz� Capacitive Sensors for Highest Accuracy� Parallel-Motion Metrology, Automated Guiding Error Compensation

� 50 Picometer Resolution, 5 x 5 x 5 µm Travel Range

� Vacuum-Compatible Versions

motorized M-111 XYZ stages


P-713 XY Piezo Imaging Scanner

Piezo Scanner: Cost-effective design with very small footprint:45x45x6mm

The resonant frequency ofan unloaded P-713 / P-714

scanner is over 2 kHz

Settling time for the P-713/P-714 at 15 µm isin the 2 ms range


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Cost-Effective OEM System with Low Profile

P-713 family piezo scanners andpositioners with travel ranges of15 x 15 µm feature especiallycompact designs. Ideal applica-tions for the P-713 are high-dynamic scanning or trackingtasks such as sub-steppingmethods for enhancing imageresolution. Such tasks involvemoving to specific positions in asmall area (e. g. marked cells orCCD photosites) and from therefollowing or performing motion

with an amplitude of a fewmicrons. The resonant frequen-cy of up to over 2 kHz makes forsettling times of a few millisec-onds, even after a full-rangemove, all with closed-looprepeatability of under 5 nm.A single-axis version with simi-lar footprint is available asP-712 (see p. 2-14) and XY ver-sions with longer travel rangesare available on request.

Flexibility

The basic version of the P-713nanopositioner offers a guidingaccuracy in the motion plane of50 µrad. This value is generallysufficient for dithering andinterlacing tasks in scanningpatterns of a few microns. Formore demanding applications,the P-714 offers higher accuracyof typically < 25 µrad.

Nanometer PositionServo-Control

If servo-control is required andno external position sensor is

available, the P-713.2SL version,equipped with high-resolutionstrain gauge sensors (SGS) canprovide nanometer-range reso-lution.High-resolution, broadband,strain gauge sensors (SGS) areapplied to appropriate locationson the drive train and measurethe displacement of the movingpart of the stage relative to thebase indirectly. The SGS sen-sors assure optimum positionstability in the nanometer rangeand fast response.


Highest possible reliability isassured by the use of award-winning PICMA® multilayerpiezo actuators. PICMA® actua-tors are the only actuators onthe market with ceramic-onlyinsulation, which makes themresistant to ambient humidity

and leakage-current failures.They are thus far superior toconventional actuators in relia-bility and lifetime.See the “Selection Guide” forcomparison with other nanopo-sitioning systems (see p. 2-4 ff ).


� Pixel dithering / sub-step-ping image resolutionenhancement

� Quality assurance testing

� Optical Metrology

� Microscopy

� Imaging

� CCD / CMOS cameratechnology


P-713.20LLow-Profile OEM XY Nanoscanner,20 x 20 µm, No Sensor, LEMOConnector

P-713.2SLLow-Profile OEM XY Nanoscanner,15 x 15 µm, SGS-Sensor, LEMOConnector

P-713 Piezo Scanner

� Ideal for Pixel Sub-Stepping in Image Enhancement� Small Footprint and Low Profile: 45 x 45 x 6 mm with

Clear Aperture� Very Cost-Effective Design� Travel Ranges to 20 x 20 µm� Parallel Kinematics for Better Multi-Axis Accuracy and

Dynamics

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� Frictionless Flexure Guiding System for Straight Motion� IUp to 1000 µm Travel with Integrated Motion Amplifier� High Dynamics, Stiffness, Forces to 400 N, Backlash-free

� Outstanding Lifetime Due to PICMA® Piezo Actuators� Available with Integrated Position Sensor� Custom Designs: Larger Travel, Faster Response, Non Magnetic

� Ideal for Applications in Adaptronics, Biotech, Microfluidics

P-602 linear actuatorfamily featuring travel rangesof 100, 500, and 1000 µm (from left to right). Flexure guides provide straight motion without tip and minimum tilt

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P-603 PiezoMove® Low Cost Flexure Linear ActuatorLong Travel, Compact, for High-Volume Applications

� Low Cost, Ideal for High Volumes� IUp to 500 µm Travel with Integrated Frictionless Motion Amplifier� High Dynamics, Stiffness, Backlash-free

� Outstanding Lifetime Due to PICMA® Piezo Actuators� Available with Integrated Position Sensor� Custom Designs: Larger Travel, Faster Response, Non Magnetic

� Ideal for Applications in Adaptronics, Biotech, Microfluidics

P-603 Flexure design prevents tilt at motion output.Slight offset only.

P-602 PiezoMove® Flexure Actuator: High Stiffness, to 1000 µmIntegrated Guiding System, High Force and Large Travel Ranges

Piezo

Application example: actuator in a micro dispensing valve. Instantaneous response (sub-millisec feasible), high speed, precision and virtually unlimited lifetime.


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The flexure-guided, lever-am-plified PiezoMove™ P-601 actu-ators provide large verticaltravel ranges up to 400 µm, fastresponse and high positioningaccuracy in a very small pack-age. With settling times of only

a few milliseconds and a reso-lution in the sub-nanometerrange they are well suited forboth static and dynamic appli-cations.

P-601 PiezoMove™ lever-ampli-fied actuators cover the rangebetween direct-driven pre-loaded piezo translators, suchas the P-840 series (seep. 1-74) and single-axis nanopo-sitioning stages, like theP-611 series (see p. 2-20). Com-pared to direct-driven piezotranslators, lever-amplified ac-tuators offer larger travelranges and much higher lateralstiffness and guiding precision.Compared to single-axis nano-positioning stages, they offersignificantly smaller sizes.PiezoMove™ lever-amplifiedactuators feature a resolution to0.2 nm and a repeatabilityto 8 nm.

OEM Actuator with IntegratedGuidance

With their highly precise, fric-tionless flexure guidance, avery high stiffness and excel-lent straightness of motion areachieved. Together with theirsmall dimensions and the cost-effective design, the P-601 leveramplified actuators are espe-cially suited for OEM applica-tions. Versions withstrain-gauge sensors (SGS) areequipped with a full bridgecircuit that is insensitive to ther-mal drift. Versions without sen-sors are also available foropen-loop applications such asin high-speed switches andpumps. In addition to the stan-dard steel models, special invarand non-magnetic versions areavailable on request.

Ceramic Insulated Piezo Actua-tors Provide Long Lifetime

Highest possible reliability is as-sured by the use of award-win-ning PICMA® multilayer piezoactuators. PICMA® actuators arethe only actuators on the mar-ket with ceramic-only insula-tion, which makes themresistant to ambient humidityand leakage-current failures.They are thus far superior toconventional actuators in relia-bility and lifetime.

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P-601.1SPiezoMove™ OEM Flexure-Guided,Lever-Amplified Actuator, 100 µm,SGS-Sensor



P-601.1SLPiezoMove™ OEM Flexure-Guided,Lever-Amplified Actuator, 100 µm,SGS-Sensor, LEMO Connector



P-601.10PiezoMove™ OEM Flexure-Guided,Lever-Amplified Actuator, 100 µm,Open-Loop



Flexure-Guided OEM Piezo Actuator with Long Stroke to 400 µm

P-601 PiezoMove™ Z-Actuator

Application Example

� Nanopositioning

� Imaging

� High-speed switching

� Patch clamp

� Micro-dispensing


� Adaptronics / Automation

� Photonics / integratedoptics

� Biotechnology

PiezoMove™ Lever-amplified piezo actuators of the P-601 series

� Flexure Guidance for Frictionless, Ultra-Straight Motion

� Travel Ranges to 400 µm

� Resolution to 0.2 nm

� High Dynamics and Stiffness

� Custom Designs with Longer Travel or Faster Response andNon-Magnetic Versions Feasible

� Outstanding Lifetime Due to PICMA® Piezo Actuators

� Choice of Closed-Loop and Open-Loop Models

� Ideal OEM Actuator for Precision Motion Control in Optics,Medical, Biotech and Microfluidics Applications


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� Wire bonders

� Pneumatic valves

� Fiber optic positioning &switches

� (Laser)- Beam steering

� Micropositioning

� Acceleration sensors

� Nanotechnology


P-871.112PICMA® Multilayer Piezo BenderActuator, 160 µm, 9.6 mm Width,SGS-Sensor




P-871.140PICMA® Multilayer Piezo BenderActuator, 1600 µm, 11 mm Width,SGS-Sensor

Ask about custom designs

Low-Voltage Multilayer Piezo Bender Actuators with Position Sensor

P-871.140, P-871.128, P-871.122 and P-871.112closed-loop bender actuators (from left to right)

� Closed-Loop Operation for Superior Accuracy� Nanometer-Resolution� Displacement to 1.6 mm� Ceramic Encapsulation for Extended Lifetime� Ideal for Scanning Applications� Vacuum-Compatible Versions� Low Operating Voltage� Mounting Hardware Included� Special OEM- and Bench-Top Amplifiers Available

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P-871 transducers are uniqueclosed-loop piezo bendersbased on the open-loop PL 122to PL 140 PICMA® -series multi-layer actuators p. 1-94. Equip -ped with high-resolution posi-tion feedback sensors they pro-vide better linearity , accuracyand repeatability than otherpiezo benders on the market.P-871 bender actuators achievelonger positioning ranges thantypical piezo stack actuators,

up to 1.6 mm, while still pro-viding fast response times inthe millisecond range.

Design

These multilayer piezoelectriccomponents are manufacturedfrom ceramic layers of onlyabout 50 µm thickness. Theyfeature internal silver -palladi-um electrodes and ceramicinsulation applied in a cofiringprocess. Due to the thin layersthe operating voltage is signifi-cantly lower than for classicalparallel bimorph bender ele-ments. For ease of installation,the units come complete withthe mounting hardware, cablesand connectors.

Closed-Loop Position Controlfor Higher Accuracy

P-871s are ideal devices forscanning, positioning andbeam deflection applicationsand provide much better accu-

racy, stability and repeatabilitythan conventional open-loopactuators. The special benderdesign allows the direct appli-cation of a strain gauge sensorto the surface without the needfor a polymer insulation layerin between. The advantagesare faster response, reducedphase lag and precise positioncontrol with non-linearity of<0.5 %. The settling time for asmall-signal step (up to 1 %nominal travel) to an accuracyof better than 1 % is between10 ms (P-871.112) and 30 ms(P-871.140).


Highest possible reliability isassured by the use of award-winning PICMA ® multilayerpiezo actuators. PICMA ® actua-tors are the only actuators onthe market with ceramic-onlyinsulation, which makes themresistant to ambient humidityand leakage-current failures.They are thus far superior toconventional actuators in relia-bility and lifetime.

Optimum UHV Compatibility -Minimum Outgassing

The lack of polymer insulationand the high Curie temperaturemake for optimal ultra-high-

vacuum compatibility (no out-gassing / high bakeout temper-atures, up to 150 °C).

Amplifiers, Drivers &Controllers

PI offers a wide range of stan-dard amplifiers and controllersfor piezo actuators. The E-651.1S and E-651.2S desktopcontrollers and the OEM boardE-614.2BS (see p. 2-123) arespecifically designed to oper -ate P-871 bender actuators.

P-871 PICMA® Piezo Bender Actuators


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M-228 and M-229 series linearactuators provide a travelrange of 10, resp. 25 mm, andare equipped with high-resolu-tion stepper motors. The step-per mikes can push or pullloads up to 80 N, and providespeeds up to 5 mm/s. Modelsfeaturing gearhead /steppermotor combinations offer thesame stroke in a more compactpackage.

Cost-Effective Design,Valuable Features

The cost-effective design offersmany useful features such as anon-rotating tip, limit and ref-erence switches and a mechan-ical position display.

A spherical tip and a 3 m exten-sion cable are included in thedelivery. The more compactgearhead versions include anadditional flat tip.

Non-Rotating Tip

Compared to conventionalrotating-tip micrometer drives,the non-rotating tip designoffers several advantages:

� Elimination of torque-induced positioning errors

� Elimination of sinusoidalmotion errors

� Elimination of wear at thecontact point

� Elimination of tip-angle-dependent wobble

Limit and Reference SwitchesFor the protection of yourequipment, non-contact Hall-effect limit and referenceswitches are installed. Thedirection-sensing referenceswitch supports advancedautomation applications withhigh precision.

Low Cost of OwnershipThe combination of these actu-ators with the networkableC-663 Mercury Step controller(s. p. 4-112) offers high per-formance for a very competi-tive price in both single andmulti-axis configurations.

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M-228 · M-229 Stepper Linear Actuator SeriesHigh-Load, Compact and Highly Cost-Efficient, with Limit Switches

� Highly Cost-Efficient, Compact Design� 10 and 25 mm Travel Range� High Load Capacity to 80 N� Gearhead Version: 46 nm Resolution (with C-663 Controller)� Direct Drive: Max. Velocity 5 mm/s� Non-Rotating Tip� Non-Contact Limit and Reference Switches


M-228.10SStepper-Mike Linear Actuator,10 mm, Stepper Motor,Gearhead, Limit Switches

M-228.11SStepper-Mike Linear Actuator,10 mm, Stepper Motor,Direct Drive, Limit Switches

M-229.25SStepper-Mike Linear Actuator,25 mm, Stepper Motor,Gearhead, Limit Switches

M-229.26SStepper-Mike Linear Actuator,25 mm, Stepper Motor,Direct Drive, Limit Switches


M-228 and M-229 series linear actuators are driven by powerful direct-drivestepper motors, or are equipped with more compact, gearhead stepper motors:

M-229.26S, M-228.11S, M-229.25S, M-228.10S (from left)


� Quality assurance testing

� Testing equipment

� Alignment of secondarymirrors

� Automation

� Metrology

� Precision machining

N-381 piezo stepper linear actuator for samplepositioning and manipulation provides longtravel, high speed and very high resolution

N-310 OEM Piezo Stepper Actuator


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Investigations on interactions and forces at the level of individual molecules

assist in gaining a great deal of information on chemical and mechanical

properties or biological functions. Special techniques have been developed for

this purpose, e.g. atomic force microscopes or so-called optical tweezers.

The latter can grip, guide and manipulate miniscule objects by means of a

laser beam.

Force Measurement in NanoscopicDimensions

Integration of the nanopositioning stage in the NanoTracker(Photo: JPK)

The optical tweez ers consist in

principle of a powerful laser and amicroscope (Fig. 2). A “trap” whichis movable in three dimensions canbe generated by suitably split ting the laser beam. This trap mak es it possible to virtually capture objectswith dimensions in the nanometer ormicrometer range, to hold them andto move them in a predefined waywith respect to other objects, and all

this simply by using light. Since smallpolystyrene beads are easily capturedby the beam, these are attached tothe samples to be manipulated priorto the experiment. When the laserbeam is moved, the bead tries to stayin focus. If it is prevented from doingso by the sample and consequentlymoves out of focus, one can measureand analyz e the forces generatedfrom the resulting deflection of thelaser.

MicroscopynewsIssue 42

Piezo Technology in Optical Tweezers


Optical Tweezers with Laser: Non-Contact and Three-DimensionalMeasurement

Since the tec hnique uses only theradiation pressure of the light, thereis no direct contact with the sample.The main advantage of the opticaltweezers over atomic force micro-scopes is that observations arepossible not only in the direction of the z-axis, but in all three spatialdimensions and experiments can becarried out interactively.

JPK Instruments, of Berlin, Germanyhas brought to market optical tweez -ers ready for series production whichprovide a time-resolved detec tion ofindividual molecules and directly support many of the mathematicallycomplex analytical methods thanksto their extensive software. The Nano -

Figure 1: The NanoTracker enables the user to control and manipulate particlesmeasuring several micrometer s down to 30 nm. The system allows accurate,quantifiable and reproducible measurements of a wide variety of par ticle or cellinteractions (Photo: JPK)

Tracker (Fig. 1) enables the user tocontrol and manipulate par ticlesmeasuring from several micrometersdown to 30 nm. The correspondingsamples, e.g. whole, living cells oralso indi vidual molecules, can beobserved in real-time with nanometerprecision (Fig. 3). The system allowsaccurate, quantifiable and repro-ducible measurements of a wide vari-ety of particle or cell interactions.

Nanopositioning System ImprovesAccuracy and Performance

While measuring the forces, it isbasically possible to only acquire

Figure 2: The optical tweezers consists in principle of a powerful laser and anarrangement of optical lenses. By suitably split ting the laser beam, two traps canbe generated that are movable in three dimensions (Photo: JPK)



data from the trap steering unit, i.e.to evaluate the laser beam deflection. “This is not suf ficient for quite a number of applications, however”explains Dr . Joost van Mameren (Fig. 4), an application scientist at JPK.“If an analysis requires motion at constant speed, for example, we inte-grate a piezo-based three-axis nano -positioning system into our Nano -Tracker. This will prevent smallinterfering signals, which could arisewith pure trap steering due to themotion caused when the optics aredisplaced. Furthermore, the position-ing system pro vides the option ofshifting the focus in the direction ofthe Z-axis, if required, in real-time.One should avoid manipulating theoptics for this purpose, if at all possi-ble, because measuring errors causedby interfering signals would then beinevitable. Moreover, the nanoposi-tioning system enables the calibra-

Figure 3: Samples, e.g. whole cells(BPAE Zelle; FluoCells® Slide #2) or even individual molecules (Alexa 555marked Rad51 protein, image: courtesyof M. Modesti Lab, CNRS Marseilles) can be observed in real-time with nanometer precision. (Photo: JPK)

Figure 4: Dr. Joost van Mameren, application scientist at JPK: “We have integrated apiezo-based nanopositioning system into our NanoTracker to increase the accuracyand the experimental flexibility, e.g. to move at constant speed during an analysis.”

tion of the optical tweezers to providea higher positioning accuracy.” JPKchose the P-561.3CD nanopositioningsystem of the PIMars series from PI.“The parallel kine matics system oper-ates with repeatability in the nanome-ter range at response times belowone milli second, and the travel rangeof 100 x 100 x 100 µm matches therequirements of our application perfectly. Moreover, it proves to bevery reliable and convinces with itslong service life”, Dr. van Mamerencontinues.

Parallel Kinematics and DirectMetrology

The combined use of parallel kine-matics and parallel direct metrologyin the PIMar s system provides themulti-axis nanopositioning systemwith simultaneous determination ofall degrees of freedom with respectto a common fixed reference. An

unintended crosstalk of the motion(e.g. as a result of an external force)into a dif ferent axis can thus bedetected and actively compensatedin real-time. This can k eep the deviation from the trajectory down tounder a few nanometer s, even indynamic operation. “The capacitivesensors integrated in the nanoposi-tioning system make a decisive con-tribution to this effect. They providedirect and contact-free measurementof the position. Neither friction norhysteresis affect the measurement,and this, combined with the positionresolution of far below one nano -meter, means outstanding values forlinearity can be achieved”, explainsDr. van Mameren further.

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The continuing miniaturization in medical engineering places ever in-

creasing demands on the components. Piezo drives are the solution for many

motion control applications; the piezo effect efficiently generates fast

and precise motion while requiring very little space.

Custom piezo disks precisely dose liquidsand gases in the ThinXXS micropump.(source: thinXXS Microtechnology AG)

Efficient Aerosol Generation with

Piezo Elements

The treatment of respiratory diseasesoften involves medications beingadministered directly with atomizers.One method of atomization is togenerate very fine droplets with theaid of ultrasonic piezo ceramics.

Specially shaped piezo disks excite a stainless steel diaphragm withseveral thousand holes to executeultrasonic oscillations at more than100 kilohertz: this produces par-ticularly homogenous aerosols,allowing the medications to be dosedaccurately and administered in amore targeted way.

An annular piezo disk serves as an ultra-sonic transducer to produce the aerosolin the atomizer head of the eFlow® rapidElectronic Nebulizer series.(source: Pari Pharma GmbH)

Piezo elements from PI Ceramic. The broad spectrum of standard products issupplemented by custom engineered products, with the shortest-possible time-to-market

Moreover, the piezo technologyreduces the time required to atomizemedications by up to 50 % comparedto conventional systems increasingthe quality of life for patients withchronic diseases.

Piezo ceramics meet the specialhygiene requirements in medicalengineering; the aerosol generatorscan be sterilized at high tem-peratures, even in autoclaves. Theultrasonic operation is soundless for humans, and the low powerconsumption of the piezo com-ponents allows battery operation.

Piezoelectric Drives in Microfluidics

Piezo-driven microdispensers, i.e.micropumps and microvalves, candose minute volumes down to themicroliter range with very high ac-curacy. Disk-shaped piezo elementsmounted directly onto a metal micro-diaphragm provide the highly dy-namic drive for precision miniatureliquid or gas pumps. Due to theseparation of drive and mediumthrough the diaphragm, interferencewith the pumped media is completelyavoided.

Lab-on-a-chip applications are madepossible by the minute dimensions.

Medical Engineering News:Driven by Piezo

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Load testing of a double crown.

3D position sensing PC(CCD cameras)

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HexMeS block diagram.

Request Information on Hexapods in Spine Surgery

M-850 Hexapod Advances Research in Dental BiomechanicsFrom Christoph Bourauel and Ludger

Keilig–Department for Orthodontics at

the Rheinischen Friedrich-Wilhelms-

Universität, Bonn.

Dental biomechanics deals with theinteractions between dental materi-als, treatment instruments or den-tures and the reaction of teeth, bio-logical tissues, etc. to mechanicalstresses. A wide spectrum of forcesystems occur here with masticatoryforces exerting loads to 380 N andtorques to several Nm.

At the same time, movements of several orders of magnitude areinvolved: orthodontic equipment canchange the position of teeth by up toseveral mm, whereas—during masti-cation—teeth are deflected by lessthan 100 µm and implants by as littleas a few microns or less. These com-binations of small forces with largedeflections, on the one hand, andlarge forces and extremely smalldeflections on the other , represent achallenge with respect to the biome-chanical metrology.

To deal with this challenge, theDental Clinic of the University ofBonn designed the HexMeS (Hexa-pod Measuring System) based on theM-850.50 Hexapod. The ability tomove in 6 degrees of freedom andthe combination of small dimensions,very high stiffness and resolution ofless than 1 µm (1 arcsec) were the keyreasons for choosing the M-850 sys-tem.

HexMeS also features two 6-compo-nent force/torque sensors for theHexapod with measuring ranges of12 N (120 Nmm) and 130 N (10 Nm)respectively and an optical detectionsystem equipped with 3 CCD cam-eras.

Because of its high stiffness (100N/µm), sample deflections can usual-ly be calculated directly from theHexapod motion.

For high-load testing—simulations of mastication in the 100 N range—the optical portion of the HexMeS is used. It resolves sample deflectionsto 0.7 µm / 0.2 arcsec.

The M-850-based HexMeS currentlyrepresents one of the most flexiblemeasuring systems in the field ofdental biomechanics. Its efficiencyand the broad spectrum of its appli-cation have been demonstrated in awhole series of experimental investi-gations into dental implants, tele-scope crowns and orthodontic pros-theses.


http://www.pi.ws

http://www.fraunhofer.de/fhg/archiv/magazin/pflege.zv.fhg.de/english/publications/df/df2001/magazine2_2001_46.pdf

Piezo · Nano · Positioningnews

In medical engineering, modern PILine® ultrasonic piezo motor drives are

opening up applications which were impossible using classic electric motor

leadscrew systems. Due to the piezoelectric effect and the direct creation of

linear motion, PILine® drives are not only faster, lighter and more compact

than conventional motorized drives, but they can also be made non-magnetic.

They achieve resolutions of 20 nm (0.02 µm) and v elocities of up to 1 m/s.

Their travel range is basically unlimited, and they are available in a number of

different integration levels to match the desired (OEM) application. Medical

engineering provides an up-to-date example.

OCT: Piezo Motors in Medical DesignUltrasonic piezo linear drives—new application in non-invasive medical technology

Piezo t echnologyenables fast, com-

pact, high-resolutionOCT scanner

In addition to the clas-sic, invasive, punchbiopsy technique, there

are a number of only par-tially satisfactory non-invasive

procedures in clinical and cos-metic research for properly cate-gorizing skin changes. Those basedon ultrasound do not provide goodresolution, and confocal microscopycannot penetrate sufficiently belowthe epidermis. Now, however, thereis a practical alternative: the newSkinDex scanner – developed by ISISOptronics in Mannheim, Germany –combines the advantages of ultra-sound and confocal microscopy.

Issue 37


http://www.pi.ws

The SkinDex scanner is based on the technology of optical coherencetomography (OCT) and examines thetissue on and under the skin surfacenon-invasively. The results obtainedare extraordinary. The informationcontained in the 2-D and 3-D sectionalimages is comparable to that of a histological examination.

OCT uses the basic transparency ofskin together with the interferencefringes obtainable with white light.The optical paths are made up ofoptical fibers.

Exact positioning for precise results

To enable creation of 2- and 3-dimen-sional images from interferencepatterns, the optical fibers must bemoved both axially and laterallyduring the scan. This task requirespositioners capable of the highestprecision. Ultimately, it is the perfor-mance of the drives which determinethe system resolution and hence thequality of the images.

A PILine® P-661 OEM motor is usedto position the reference-arm mirror(depth parameter). This motor waschosen primarily because of its com-pact design and, considering its size,its high force capacity of 2 newtons(0.5 lbf). Total travel is 2 mm, the po-sition resolution in this application30 nm (0.03 µm, 1.18 micro-inch).

As the images are recorded sequen-tially, the high speed and excellentdynamic response of the drive is agreat advantage. As a result, theSkinDex needs only a few seconds to generate its highly informativeimages. The lateral motions of theoptical fibers in the sensing arm executing the surface scan are alsoperformed by a PI drive.

In this case it is a PIHera® P-622.2CD,

a flexure-guided, 2-axis, piezo nano-

positioning system, which provides

a resolution of 1 nm (0.001 µm, 0.04

µ-inch) and covers an area of 250 x

250 µm. Piezo-motor drives have thus

again contributed to an innovation

from which many people will benefit

in the future.

Integration levels in PILine® ultrasonicpiezo motor technology: from 8-mmdrives, through the successful Rod-Drive linear drive, to integrated multi-axis systems.

The SkinDex scanner based on OCTtechnology for non-invasive but reliableexamination of the tissue on and underthe skin surface (photo ISIS Optronics).

A look under the skin of the ball of thethumb. Even the untrained eye canrecognize the spiral-shaped sweat-gland ducts.

3-D OCT image: Individual laminar and cylindrical structures such as largerblood vessels are visible under therough skin surface.

White-light interferometry is the basis of OCT. Using optical fibers, light isdivided into a sensing and a referencebeam. After being reflected by the target(i.e., a cutaneous structure) and thereference mirror respectively, the beamsare recombined and enter the detector. An interference signal pattern results(photo: ISIS Optronics).

Working principle of an ultrasonicpiezo motor drive.

Mountingplattform

Bearing

Gluedfrictionbar

Friction tip Piezo Actuator(stationary)

exitationelectrodes


nano™ Precision PositioningSystems for Microscopy

PI nano™ series comprising E-545 controller, P-545 piezo system and M-545 manual stage

The P-545 piezo stage provides 200 µmtravel per axis with sub-nanometerresolution. PI nano™ features a largeraperture for 1x3 ‘‘ slides.

Due to their low profile, PI nano™ piezo stages can easily be integratedinto existing microscope setups

Scanning microscopy methodssuch as single molecule fluo-rescence microscopy provide highlateral positioning resolution evenbelow the limitations of the nu-merical aperture. They require correspondingly precise samplepositioning with resolutions in the range of a few nanometers. ThePI nano™ system is designed sothat its performance data andrange of functions correspondexactly to these requirements.

■ Piezo-based XY/XYZ nanposition-ing system with 200 µm travel for planar scanning and verticalfocusing/z-stack acquisition

■ Optional 25 x 25 mm coarse-positioning stage with manual orstepper motor drives, preloadedfor high stability

■ Nanopositioning system withlarge aperture and 20 mm lowprofile for easy integration intothe microscope

■ Mechanical compatibility withinverted microscopes from Zeiss,Nikon, Leica, Olympus

■ Accessories and sample holders

■ Powerful controller with USB andEthernet Interface, and extensivesoftware support

The new PI nano™ positioning sys-

tem from PI was specifically designed

for applications in optical microscopy.

The core component of the PI nano™is an XY or XYZ piezo nano-positioning stage with a low profileof only 20 mm and a large centralaperture for transmitted-light micro-scopy. The stage is equipped withlong-life PILine® piezo actuators andprovides travel ranges of 200 µm withnanometer positioning resolution.It comes with a matched piezo con-troller featuring a 24-bit interface(USB, Ethernet and RS-232) and ahigh-bandwidth analog interface.The contoller is supported by allmajor image acquisition softwarepackages.

An optional, manual XY stage forcoarse sample positioning can beequipped with stepper motor drivesif required. The preloaded XY stagecan be mounted directly onto themicroscope and it provides the stiffness required to carry a highlydynamic piezo nanopositioningsystem.

pi_091227_news40_uk.qxp 19.11.2009 9:13 Uhr Seite 4


Piezo · Nano · PositioningnewsIssue 38

Complex three-dimensional structure:

An Eiffel tower 50 micrometer in heightwas produced using the Nanoscribe 3Dlithography process (Photo: Nanoscribe)

Cell embedded in artificial three-dimensional extra-cellularmatrix. (Photo: Nanoscribe)

3D Structuring in Nanotechnology

A novel 3D laser lithography system based on PI nanopositioning technology is

now available from Nanoscribe GmbH (www.nanoscribe.de).The new system

allows for the first time the fully automated production of complex three-dimen-

sional microstructures and nanostructures using photosensitive materials.

Typical fields of application for thenew technology are, for example, the production of three-dimensionalmatrices for cellular biology, themanufacture of micro-optical com-ponents or photonic crystals and alsoas a rapid-prototyping instrument formicrofluidic and nanofluidic systemsand their production in small batches.The desired structures can be designedand then imported using any CAD soft-ware which supports the DXF format.

Track Widths to 150 nm and Below

The operating principle of the newlithography process, which is suitablefor all commercially available photo-resists, is easily understood: Ultra-short laser pulses are strongly focusedinto the material, which is thenexposed by means of a nonlinearoptical process in the focal point. Likea pen that is moved in three dimen-sions, the laser beam writes on thematerial following arbitrary paths. It is thus possible to achieve trackwidths from several micrometersdown to 150 nm. Two-dimensional 2D structuring or 21/2D structuringwith surface profiles are, of course,also possible and have a resolutionwhich is significantly higher than thatallowed by conventional instrumentsup to now.

The P-563 PIMars™ Piezo Stage is a fast &accurate 3D positioning system based on piezo drives, friction-less flexure guides and non-contacting capacitance sensors.

http://www.physikinstrumente.com/en/products/nanopositioning/nanopositioning_microscopy_selection.php

http://www.nanoscribe.de/en/technology/direct-laser-writing

The P-563.3CD nanopositioning system with its E-761, PC plug-in digital controller(foreground) is ideally suited to the applicationbecause of its high positioning accuracy andtravel range of 300 µm in three axes.

Novel laser lithography system which – for the first time – allows the productionof complex three-dimensional microstructures and nanostructures using photo-sensitive materials. The precise adjustment of object or sample is achieved byusing a P-563 PIMars™, a parallel-kinematics multi-axis piezo nanopositioningsystem (Photo: Nanoscribe)

Nanopositioning in 3D Structuring

The PI nanopositioning system usedby Nanoscribe for its lithographsconsists of a 3-axis P-563 stage andan E-761 digital controller. The P-563.3CD PIMars™ multi-axis nano-positioning stage provides travelranges of up to 300 x 300 x 300 µm

4 nanometer repeatability. Its con-struction as a parallel-kinematics multi-axis system contributes to thehigh positioning accuracy. All piezoactuators act on a central platform so all axes behave with identicaldynamics. One “slower” axis, mostlyunproblematic for linear scans, would

have detrimental effects here. More-over, the high-resolution capacitivesensors can register any deviationfrom the commanded path in 3Dspace in real time. This type of position measurement directly at the moving platform against a fixedreference (parallel metrology) allowsthe immediate determination andactive compensation for axis crosstalkand lateral runout. The PCI-board-based E-761.3CD digital piezo con-troller is matched to the multi-axisparallel-kinematics piezo nanoposi-tioning system and provides the exacttrajectory control necessary for thistask.


http://www.physikinstrumente.com/en/products/prdetail.php?sortnr=600400

http://www.physikinstrumente.com/en/products/prdetail.php?sortnr=201550

http://www.nanoscribe.de/?seo=en/technology/direct-laser-writing&id=421&language=en

PIFOC® Revisited: P-737 Piezo-Z Microscopy Specimen Scanning Stage

PIFOC® P-737 high-speed verticalpositioning systems are designed forintegration into motorized XY micros-copy stages of leading manufacturerssuch as Märzhäuser. While the XYstage positions the sample, the piezoflexure-based P-737 moves thesample along the optical axis to adjustthe focus quickly and precisely.Vertical stepping with nanometer pre-cision takes only a few milliseconds.The large aperture is designed toaccommodate a variety of specimenholders including slides or multiwellplates.

High-speed Z-steps for fast focuscontrol and imaging

The immediate response of the solid-state piezo drives enables rapid Z-steps with typically 10-to-20-times-faster step-and-settle than classicalstepper motor drives. This leads tosignificantly higher image acquisitionspeed and throughput. The P-737 isavailable with travel ranges of 100 or250 µm and offers a choice of feed-back sensors between strain gauge ornon-contact, capacitive positionsensors, depending on the accuracyrequirements.

The P-737 together with the E-625 piezo-controller, offers a cost-effectivesystem for high-speed, high-resolution positioning of microscopyspecimens. The controller features a choice of a 20-bit digital interface ora broadband analog interface for the target position.

The capacitive-sensor-equipped version can also be operated with thesophisticated E-753 digital servo-controller. The main advantage of thiscontroller is its adaptability to changing load conditions on the piezostage. No matter what load is applied, the system can always provide anoptimum combination of speed, settling time and resolution.

Analog or Digital Systems

PIFOC® objective positioners and scannersare available with travel ranges of up to400 µm. QuickLock thread adapters enablefast mounting of the PIFOC® on the micros-cope and flexible replacement of objective

Settling time is in the 10 ms range –here, 1 µm steps

PI is the inventor of high-speedPiezo-Z objective steppers. Todaythe term PIFOC® is practicallysynonymous with all high-reso-lution vertical drives for micro-scope objectives. Depending onthe application, it can be advan-tageous to adjust the sampleinstead of the objective. While nosample stage can beat the speedof the fastest PIFOC® objectivepositioners (due to the stiffer andmore compact design), the P-737stage allows for convenient Z-stack imaging with multipleobjectives and very high through-put. Im both cases the effectremains the same: the focal planemoves through the sample. Thisis why the P-737 is also marketedunder the PIFOC® trademark.

PI Hexapod: Six-Axis Dental Measurement. Metrology. High Stiffness

News & Applications


World’s First Digital Piezo NanopositioningController on PCI Board

E-761 3-channel digital nanopositioning controller: very advanced control

technology in cost-effective PCI format to control up to three logical axes

duces the world’s first fully digitalpiezoelectric nanopositioning con-troller on a PCI board.

The E-761 digital nanopositioning controller offers very advanced con-trol technology in the cost-effectivePCI-board format. It is able to con-trol nanopositioning systems withup to three logical axes and fourpiezo actuators.

Many of today’s high-tech appli-cations, such as imaging, metrology,scanning microscopy and surfaceanalysis require a combination ofhigh-speed motion control and high-resolution vision. They also requireextremely fast data acquisition andprecise synchronization between the imaging and motion controldevices. Peripheral componentswith PCI bus interface are ideal forthese tasks, because the PCI bus was designed to give high-band-width access to the microprocessorin the PC. With the E-761, PI intro-

The PCI bus allows for very rapidcommunication and easy integra-tion with devices such as framegrabbers – a feature which is veryadvantageous in real-time dataacquisition applications or whenoperating multiple axes or con-trollers simultaneously.

The internal coordinate transfor-mation means it is no problem tooperate complex, multi-axis stages,such as three-axis X-Y-�Z stages or Z-tip-tilt platforms. In systemswith parallel metrology, the E-761can also automatically compensateundesired off-axis motion (active trajectory control), making it pos-sible to attain motion accuracies in the sub-nanometer range.

Of course, this digital controller has the technical refinements youhave come to expect from PI, suchas 32-bit digital filters, 24-bit DAC resolution, multi-stage sensorand electronics linearization, plug &play ID-chip support and an exten-sive software support package.

New E-761 digital piezo controllerin the PCI-board format

P-541.2CD low-profile XY piezo stage with capacitivesensors: a perfect fit for the E-761


News & Applications


Digitally Controlling the Nano-World – in up to 6 Axes

New Multi-Axis Piezo Controller Provides Higher Precision, Flexibility

■ Versatile interfaces: TCP/IP for remote control through the internet;additional USB 2.0 and the classic RS-232. Available high-resolutionanalog inputs for direct control with high-bandwidth analog signals.

■ 20-bit D/A converters make possible sub-nanometer position resolution,even over long travel ranges of >1000 µm, like those of the new P-629PIHera® piezo nanopositioning stages.

■ Available high-power amplifier modules, to supplement the integratedamplifiers for high-frequency scanning / tracking applications.

■ Software – tunable, proportional-integral, digital servo-control with 2 notch filters allows operation of the piezomechanics closer to itsresonant frequency.

■ 600 MHz processor and sensor and servo update rates of up to 50 kHzassure faster updating of the position and control data – especiallyimportant for high-dynamics periodic motion. In addition, optionalDigital Dynamic Linearization, ensures that tracking errors are reducedto the nanometer level even in high-dynamics scanning applications.

■ Internal coordinate transformation for parallel-kinematics systems withuser-friendly position commands in Cartesian coordinates.

Additional advantages:

The new, E-712 multi-axis piezo-con-troller picks up where the successfulE-710 left off. It features a faster pro-cessor, a real-time operating systemand significantly higher servo update

and sensor sampling rates toprovide extremely precisecoordinated motion in up to 6degrees of freedom with nano-meter precision.

Mature operating software with in-tuitive interfaces make operating the system almost child’s play. Noprogramming knowledge is needed,whether commissioning, optimizingsystem parameters, creating newuser-defined motion profiles for theintegrated wave generator, or re-cording data generated during themotion. The comprehensive packageof supporting software, includingLabVIEW drivers and DLLs, ensureseasy integration in a variety of sys-tem environments.

The E-712 controller is available in 3- and 6-channelconfigurations.


News & Applications



News & Applications

Ultra-Low-Noise PicoCube® ControllerReference-Class System for AFM Nanotechnology

The minute P-363 PicoCube®, togetherwith its reference-class, ultra-low-noise E-536 driver/controller, areideally suited for nanotechnologyapplications. They provide signifi-cantly higher dynamics, resolutionand positional stability than pre-vious multi-axis scanning stages.Nano-imprint lithography, scanningmicroscopy and biotechnology bene-fit from the extremely high resolutionof up to 25 picometers over travelranges of 5 µm per axis.

nel are recommended. The E-536.3CHultra-low noise versions are optimizedfor highest positioning accuracy andresolution in the picometer range.

Compact 2-Axis and 3-Axis Stages

The compact PicoCube® is availableas XY and XYZ system. It is based onexceptionally robust, high-stiffnessshear piezo drives and employs non-contact, direct-measuring, parallel-metrology capacitive sensors forposition feedback.

Controllers: Optimized for Highest The low-inertia drives allow for a re-New E-536 controllers enable even Resolution/Bandwidth sonant frequency of 10 kHz, importanthigher resolution and bandwidth Two controller versions are avail- for high speed scanning applications.

able. For high-speed scanning appli- Measuring only 30 x 30 x 26 mm (XYwith the minute P-363 PicoCube®

cations the E-536.3C high-power version), it is easy to integrate in anypiezo stages.

models featuring 100 watts per chan- scanning apparatus.

Piezo nanopositioning systems are sig-nificant investments and PI believes in optimizing the performance of every customer’s system. PI individuallycalibrates every stage and optimizes the dynamic performance for the customer’s application. Furthermore,PI makes significant continuing investments in improved-quality, higher-performance nanometrology equipment so that we can deliver bet-ter value to our customers.

Because a nanomechanism can only be as accurate as the equipment it was tuned and tested with, PI closed-loop stages are calibrated ex-clusively with the prestigious ZygoZMI-2000 and ZMI-1000 interfero-meters. PI’s nanometrology calibra-tion laboratories are seismically, elec-tromagnetically and thermally isolat-ed, with temperatures controlled to better than 0.25 C° / 24hr. We areconfident that our calibration ca-pabilities and procedures are the benchmark for the industry.

Test and Calibration—Why High-QualityNanometrology Equipment Matters

Fully randomized position repeatablity measurement of a direct metrology-equipped 100 µm PIHera™ stage, made with Zygo inter-ferometer. The data show the exceptional precision of these mid-level nanopositioningdevices.

Prestigious Zygo ZMI-2000 and ZMI-1000interferometers are used in PI´s nano-metrology calibration labs. Each stage isindividually calibrated and optimized fordynamic response.

State-of-the-art, room-in-room metrology lab with multiple thermal, acoustic and seismic isolation formeaningful sub-nanometer measurements.

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Nanometrology, Nanopositioning, NanoAutomation®

Ultra-Precision Motion Control Solutions for Optics, Imaging, Photonics

Applications

Today PI delivers Nano-positioning & measuring solutions for all high-techmarkets:

� Microscopy & Optics

� Bio & Nanotechnology

� Semiconductors, Photonics, Telecom

� Life Sciences

� Lasers, Metrology

� Aerospace Engineering

� Medical Technology

� Astronomy

Why Vertical Integration Matters

To provide higher performance and better value to customers To advance the state-of-the-art with leading edge technologies

that are just not commercially available To maintain leadership in proprietary design & manufacture

capabilities of control electronics, sensor/metrology tech-nology and actuators acquired over the years

To provide systems with longer lifetime, higher performance, and more robustness to OEM and scientific customers

Motion Control Technology - Key Technologies Under One30 Years Ahead of its Time Roof: A Plus for Our

CustomersPI has been a world market lea-der in nanopositioning techno- PI has a strategy of verticallogy and ultra-high-precision integration with all key techno-motion-control systems for logies developed and maintai-many years. ned in one company.

PI Headquarters

All pages number cited in this publication make reference to PI’s 530p hardbound catalog. Download yours now at www.pi.ws.All pages number cited in this publication make reference to

PI’s 530p hardbound catalog. Download yours now at www.pi.ws.All pages number cited in this publication make reference to

PI’s 530p hardbound catalog. Download yours now at www.pi.ws.

Program Overview

� Piezo Ceramic Actuators & Motors

� Piezo Nanopositioning Systems and Scanners

� Active Optics / Tip-Tilt Platforms

� Capacitive Nanometrology Sensors

� Piezo Electronics: Amplifiers and Controllers

� Hexapod 6-Axis Positioners / Robots

� Micropositioning Stages & Actuators

� Photonics Alignment Systems, Solutions forTelecommunications

� Motor Controllers

� Ultrasonic Linear Motors

PI Nanopositioning & Piezo ActuatorRequest or download the complete

Catalog

Call or go to: http://www.pi.ws

All pages number cited in this publication make reference to PI’s 530p hardbound catalog. Download yours now at www.pi.ws

GERMANY

Physik Instrumente (PI)GmbH & Co. KGAuf der Römerstr. 1D-76228 Karlsruhe/PalmbachTel: +49 (721) 4846-0 Fax: +49 (721) [email protected] · www.pi.ws

JAPAN

PI Japan Co., Ltd.Akebono-cho 2-38-5Tachikawa-shiJ-Tokyo 190Tel: +81 (42) 526 7300Fax: +81 (42) 526 [email protected]

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CHINA

Physik Instrumente (PI Shanghai) Co., Ltd.Building No. 7-301Longdong Avenue 3000201203 Shanghai, ChinaTel: +86 (21) 687 900 08Fax: +86 (21) 687 900 [email protected]

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