MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast...

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MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue by Sashwati Roy, Savita Khanna, Syed-Rehan A. Hussain, Sabyasachi Biswas, Ali Azad, Cameron Rink, Surya Gnyawali, Shani Shilo, Gerard J. Nuovo, and Chandan K. Sen Cardiovasc Res Volume 82(1):21-29 April 1, 2009 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: [email protected].

Transcript of MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast...

Page 1: MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue by.

MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2

via phosphatase and tensin homologue

by Sashwati Roy, Savita Khanna, Syed-Rehan A. Hussain, Sabyasachi Biswas, Ali Azad, Cameron Rink, Surya Gnyawali, Shani Shilo, Gerard J. Nuovo, and Chandan

K. Sen

Cardiovasc ResVolume 82(1):21-29

April 1, 2009

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: [email protected].

Page 2: MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue by.

miR expression profiling in hearts subjected to ischaemia–reperfusion.

Sashwati Roy et al. Cardiovasc Res 2009;82:21-29

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: [email protected].

Page 3: MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue by.

Induction of miR-21 in the infarct region of ischaemia-reperfused murine heart: a laser-capture microdissection based approach.

Sashwati Roy et al. Cardiovasc Res 2009;82:21-29

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: [email protected].

Page 4: MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue by.

Localization of miR-21 in ischaemia-reperfused mouse heart regions.

Sashwati Roy et al. Cardiovasc Res 2009;82:21-29

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: [email protected].

Page 5: MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue by.

Direct regulation of phosphatase and tensin homologue in cardiac fibroblasts by miR-21.

Sashwati Roy et al. Cardiovasc Res 2009;82:21-29

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: [email protected].

Page 6: MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue by.

miR-21 regulates MMP-2 expression in cardiac fibroblasts via a PTEN-AKT-phosphorylation-dependent pathway.

Sashwati Roy et al. Cardiovasc Res 2009;82:21-29

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: [email protected].

Page 7: MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue by.

Decreased phosphatase and tensin homologue and increased MMP-2 expression in the infarct region of heart.

Sashwati Roy et al. Cardiovasc Res 2009;82:21-29

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: [email protected].