microangiopathic hemolytic anemia
description
Transcript of microangiopathic hemolytic anemia
microangiopathic hemolytic anemia
microangiopathic hemolytic anemia
TTP
reticulocytes
Polychromasia
Autoimmune hemolytic anemia
Target Cells
•Increased surface to volume ratio
•Actually shaped like a bell (3D)
•Target cells are always hypochromic
•Excess membrane cholesterol and phospholipid
•Decreased osmotic fragility
•Hemoglobin C disease
•Liver disease
•Iron deficiency
•Any hemoglobin abnormality
•Post splenectomy
Target Cells
Target Cells (Codocytes)
Target Cells
10 y/o boy of Italian descent
Diagnosis : Beta thalassemia major Homozygous beta0 thalassemia Comment : beta0 = beta gene producing no beta chains no beta chains and hence no Hb A. untreated he has about 95% Hb F (remainder being Hb A2) Treatment : Transfusion to maintain hemoglobin level; Chelation therapy to remove excess iron present due to hemolysis and transfusions. Bone marrow transplantation is treatment of choice
Case 2
Howell Jolly Body
Sickle cell
Erythroblast
Sickle cells (Drepanocytes)
Sickle CellsSickle Cells
Sickle Cells