There’s nothing we haven’t seen.And it’s because of the 35,000 physicians like you who—together—have theanswers. Join the nation’s largest online physician-only community where youcan exchange clinical observations and get paid for your insights. Register atwww.sermo.com by 12/21/07 and you’ll get a $15 Amazon® gift card to jumpstart your earnings. Type 2SermoKnows in the promotion box.

Could there be a different diagnosis?It might just be a case of peripheral neuropathy, but can you afford to be wrong?

Join Sermo—the largest free online physicians-only community where you can

exchange clinical observations with 35,000 of your colleagues and get paid for

your insights. Register today at www.sermo.com before 12/28/07 and you’ll get

a $15 Amazon® gift card to jumpstart your earnings. Enter promo code DIAGNOSE.

If it’s out there, it’s in here.There’s nothing the 30,000 physicians on Sermo haven’t seen. Join the nation’s largest online physicians-only community where insights are exchanged in real time.You can even get paid for your contributions. Sermo is free and has no advertisingor promotion. Register at www.sermo.com on or before 11/31/07, and get a$15 Amazon® gift card to jumpstart your earnings. Enter promo code SILVERMAN.

Dear Dr. [Insert Physician Last Name],

I am writing to invite you to join thousands of your physician colleagues on Sermo. In the less

than two years since I founded Sermo, we have become the nation’s largest online physicians-only

community with nearly 70,000 members — 10% of the US physician population!

My original vision for Sermo was simple: leverage new online tools to capture and aggregate

early insights from practicing physicians that all of us could use to improve patient care. Basically

the peer review model we were all trained under — with a twist. Sermo’s online platform allows

you to post questions, information or comments and receive instant feedback from your

colleagues around the country; on your terms and at your convenience.

Today, Sermo has grown into something much larger than I could ever have imagined.

Nationwide, patient care is improving based on discourse that takes place among physicians

on Sermo. We’ve captured the attention of government agencies, the investment community

and industry who now pay physicians on Sermo, to inform their decisions. We are even seeing

physicians use Sermo to level the playing field with third-party payors by comparing notes on

billing codes.

The simple truth is Sermo is allowing us to do what we’ve always done as teachers and mentors:

help each other provide the best possible patient care and — at the same time — have a positive

impact on our practices and our profession.

I invite you to join me and nearly 70,000 of your colleagues on www.sermo.com. Our unique

business model guarantees that you will never pay to participate, never be subjected to

advertising of any kind and will encounter numerous opportunities to be compensated for

your insights. If you have any questions or thoughts on how we can improve the experience,

I’m always available to the community. You can private message me on Sermo at dpalestrant.

Daniel Palestrant, MD

Founder and CEO, Sermo

PS: I look forwarded to sending you a $15 Amazon® Gift Card when you register. Consider it a

down payment on the rewarding relationship you’ll enjoy as a part of the Sermo community.

Go to www.sermo.com and enter promo code join146 by 11/10/08.

Sermo, Inc. 215 First Street Cambridge, MA 02142 T: 617 497 1110 F: 617 497 4005 www.sermo.com

July 2, 2008sermo

sermoKnow more. Know earlier.

Dear Clinical Investigator,We know that keeping up with the latest clinical trials and the

process to participate can be daunting. That is why Sermo has

teamed up with leading study sponsors and contract research

organizations (CROs) to streamline the process of finding and

participating in the advancement of innovative therapies.On Sermo you can:Learn about the latest clinical trials in your field

Access online tools to streamline paperwork (coming soon)

Leverage study-specific materials online and prep on your own time

Communicate more easily with study sponsorsBecause Sermo is the largest online community of physicians in

every specialty, CROs and study sponsors come to us to find the

most qualified clinical investigators. Become one of them today.Join at www.sermo.com/clinicaltrials

And Sermo is simplifying the process to make it easier for you to participate.

Sermo is the nation’s largest physician-only community with more than 65,000 of your

colleagues. It’s free to join and always free to participate.

Once you’ve joined, please accept this gift card as our thanks for helping

to further innovative therapies.

*Terms & Conditions apply, see back of card.

Start leveraging the strength and industry connections

your colleagues have already established. 1. Go to www.sermo.com/clinicaltrials2. Type join143 into the promo box 3. Get a $15 Amazon® Gift Card*

15$

*Terms & Conditions apply, see back of card.

sermoKnow more. Know earlier.

You are invited...to participate in the latest clinical trials.

That’s why government agencies, financial services firms and industry look to Sermo

to inform their decisions and pay physicians for their insights. And, through a unique

business model, also fuel many of the opportunities available to our members:

It’s free to join and always free to participate. Shouldn’t you be at the center of it all?Visit www.sermo.com to learn more.

You’re almost there.Go to www.sermo.com before 09/15/08Type join145 into the promo box Get a $15 Amazon® Gift Card

Registration takes just 60 seconds. Before you know it, you’ll be at

the center of the nation’s largest physicians-only online community.

2

3

1

Financial earnings for sharing opinions Thousands of clinical discussions Millions of physician comments Money-saving business techniques Clinical trial opportunities

Free online CME A job board—with no recruiters Access to the FDA and AMA Specialty-specific case conferences And much more

We’re the Sermo community: nearly 70,000 physicianssolving difficult cases, exchanging the latest medical thinking, and working together to shape the future of our profession.

E N T E R H E R E

(to be at the center of it all)

Get a $15 Amazon® Gift Card when you enter.

Overall Conversion Rate:

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Dan TowvimDirector, Physician Acquisition

T: 617 497 1110F: 617 497 4005dtowvim@doctorsunite.org

215 First StreetCambridge, MA 02142

Stand together to protectour patients & our profession.

www.doctorsunite.org

copyright 2008 all rights reserved