Methylation Nutrigenomics --HeartFixer

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    .

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    C D ( . . / ) . ,

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    (+/+); ( / . ( / (+/+) , I C (+). I I CB (+), I

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    CB ). C , / , ( , ,

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    5. F , D . A , , . B12 2000 / , M B . M

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    C677 , , A . D ,

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    5 ( ). , 5 , . 5

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    B12. , . B12 (

    ) . B12. B C , , ,

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    , , ,

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    677 , 5 . A1298 5

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    . . (

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    . , ABA. ABA . ABA, , , , ABA

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    CB , , ABA, , . ABA ,

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    C ( ):

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    ( ). H . , . D . . ,), A .

    C , , BH4 , .

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    A. B . $125 (

    I .B. G L E ,

    . E M ( A /H ); $170. M M .

    C. M , $ 250 $ 600. .

    3. H M : M , , ( 10 20 ). M , , ,

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    . ?A. B , ,

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    . ($250) , , I .

    D. , , , . C $ 350.

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    M . M M C ( ) 10 , .

    10. G : M A C , , C, G B , 2 . .

    11. A (D H ) D : D ( D D , CD .

    , ( ). , I , ($35 2 3

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    ( C D , (

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    ( ).

    A , ; . D , , , ,

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    ( )

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    ,

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    E A 1600 /

    . A C G ,

    . H . D

    , , , .

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    O ( O ), ( CB ), / . ,

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    ). I .

    ? I , M C . K ( ) . I

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    +/ +/+ CB +/+ +/ BHM 1 8, CB H ( ) , ( / ),

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    CB /BHM :1. N ( ) , , ( CB A II: F H / C D ,

    . . / /.2. M 4 7 . L (400 400 800 / )

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    , / BH4. C CB

    . ( ( ).

    CB /BHM

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    1. B ..2. C ( ) , 3. M 4 7 ( ) 400 /( ).4. , A A ,

    ( ; GI ). , , , ( ),

    .5. , B6. A HF

    M C 4 / . B M 3 , B 3 / , B12 ( ).

    6. C E 10 100 / , C 500 , ADH .7. A GABA 500 ; GABA

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    10. L F 900 / BHM , CB . L ED A, , , M C

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    , 1 . 1 . C

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    1 . B 3 14.5 D

    B 20 30

    C 8

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    #4A D

    1 / 1 1 1 .

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    B /

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    (D . ) . . . .

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    :30204 * $55 100 :30205 * $55 100 :540 A A ( )*

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    H H :

    G . .

    C A

    C A

    : :

    :

    :

    E #

    C

    C

    K :560 HH ( )*K : A $85 A :K :02041 * HH 600 60 $17.46K :01129 C * HH 100 260 $9.99

    AC9 * EE 2.5 $10.10K :30054 HF * HH D . 6 $29.99 180K :01092 H B12* HH 2000 B12, $28.95K :01082 * HH 75 /3 2 . $12.20

    B 04 B HH 3 100 $6.50

    K :30020 E * HH 400 I $24GABA 7 GABA* EE 500 GABA, 100 $21

    K :01049 ADH* HH 5 , 30 $33.99K :01023 * HH 275 GABA 100 60 $21

    CA 48 C * EE C 500 60 $39.9001226 C 10* EF 100 60 $55

    I * 100 60 $40.0000537 B12* EF 5 60 $32

    ED A* C ED A 1 $30 F * C

    K :01043 * HH 100 60 $39.90

    K :01044 A * HH 50 50 D AE 120 $28.99I H2 * EE 100 $11.19

    I * 12.5 90 $27I D14 E 9 EE 2 . 265 $12.20

    G G EE 750 G 100 $15.60K :01088 * HH 500 B 50 $14.05

    00453 A * EF 200 A 50 $33.75K :02017 F * HH 5 800 , 60 $17.49

    F 17 F A * EE 800 / 60 $11

    F D : 2.8 , 25 5 , & 2 B12C AC D 5 , 2 B12, 500 AC

    00961 G D * EF 90 $28 G * 15 $90 ( 7 ) . /

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    C A

    I G

    E

    F

    E E

    . .

    E B C

    D

    C

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    F

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    ; ).

    , , . , , , .

    . C G E .

    D . ( , ), , , . I C G

    $1,125 C , D . , D . C . I D .

    4 5 .

    , C C . .

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    . I ( ) , 75%

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    , ( C ). A , . , , ,

    . I , D G ( ). ,

    .

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    J C. D FACC8/24/08

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    C 158 H (+/+)

    C H62H H (+/+)C 199

    D B H (+/ )D H (+/ )

    A A 297 H (+/+)ACA 1 02

    HF C677 HF 3 HF A1298C H (+/+)

    A2756G A66G H (+/ ) H595

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    ( ) :A. A , A : A , .B. B 4, .

    . / , , , .

    . .

    , , , .

    +/ B +/ B ( B 23 ). (

    ) , , / ; 800 1200),

    ( ABA A 1 +/+ ; 9/12 ), ( B 4, ). B 4 ( ) A ,

    .

    . A1298 (+/+) B 4 B 2. (+/ ) B 4 , B 4,

    . A ( B B ) , B B 4 / .

    ( ). ( )

    (+/ ) ,

    ( +/ ), 5 ( B6) 5,10 , 5

    5,10 1, A A . B +/1, . B +/

    . , , .

    B +/+ 2 ( ) ( ) . ( ) A

    . ++ , B ( ), , .

    .

    5 B12 , A ( A ), . +/ , B12 B12, , +/+

    , . A +/+, , . , +/+ . A

    , . B12 ( , , B12 , ,

    350A 415 A664A (+/ )

    B 2 B 4 B 8 (+/ )A 1 (+/ )A 2 A 19 (+/ )

    B 699 (+/ )B A360A (+/ )B 212

    1420

    32 50 A

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    B12 , B12

    +/ D ( D B , D ), D ( ), +/+ C ,

    , ; .

    A A . +/+ A A, +/ A B, , .

    AHC A H ( AH), A . B +/ AH , AH , A AH ,

    A . AH ( ).

    1 +/ HD ( , ), . C 1A2 2

    +/+ C 1B1 4 . H , 2/16 2.8, D . 3 C, 2 . D . 16

    ( 16 H +/+ 2 H 2 . B +/+ C

    , +/+ C ), ( ) .

    G G . A (). ( ) (+/

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    I C , D . .

    . I CB , . . D .

    . I D . .

    G G A CB +/ BH +/

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    , ( / ), (

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    9/14), ( ), ( B .

    9/14, . A BH4 ( )

    . B +/+ HF A1298C +/ BH4, BH4 .

    . I ,

    C , +/+ D , +/ G G

    I ,

    D , CB ( ,

    ) ( ), ( D . GA

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    , , ; CB /BH + ). CB C677 A360A (

    ; I A ). .

    ( ) CB , . H , CB

    A . I () A . A CB ( A

    ); A ( A CB /BH .

    A ( ), A CB , . C A + CB

    / ( , CB )?

    ( H) , / / H ( D . ; I

    ). E ( D CB

    )? C , / ( , , ).

    , BH4 ( ) . BH4 ( /

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    A , ( , ) . ,

    , ( , ,

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    C GI , C , , 2 3

    . / C GI ( GI

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    /A ( ), I , , C

    (1/3 ) , . A / .

    , . ; .

    D . CB . A , CB , CB +

    , . , , GABA. H ,

    , . G

    , ;

    ( ; G, ,

    )? /

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    / G ( ) GABA

    CB , ( ( ) . ,

    . H , , E , , B12 .

    A C C E 10 C , + CB

    , ( C / D ) C E 10, C , , AD .

    BH (B H , ) CB . CB BH

    , BH . G ( ) BH , ( C +/+ ).

    ), ( ) ED A ( ), .

    CB BH HF ( ) ( B12) , (

    ). H , , B12, BH4, C ( )

    . 1 2 , . ,

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    .

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    I :1. * ( ) ,

    ( C D . . / /. B , C ,

    .2. C / ( )

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    .3. 3 7 ( ,

    ). 400 ( 800 ( ).

    . C , / 3. ( ), A A

    ( ), , ( C GI

    ). , , , ( ), /A 1000 3000 ( )

    , . , BH4

    , .4. D , 10 ( ), ( ). C D . C , CB ( . . ).

    5. , D . E . / ? A ? I 50 100 / , 500 , B12, ,

    .6. G / .

    . H , , , / . ( ) G . G

    . ; . , CB /BH .

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    7. I ( ), GABA 500 , . I GABA , GABA

    CB . GABA .

    8. , C E 50 500 ( ). ADH 5 / ( AD+ ) . A 5

    ; A .9. A ( I ,

    / BH4 . I B12 . I , I

    .11. I , A D .

    ( ) ). , .

    12. , D . A 4 6 , A AH. H D I ( . .

    A , AH, ( HFD, H). A , D D $155.

    13. B . , , ? A .

    , . C , , . B .

    . A , , (

    * H ? ( )

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    ; . . I

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    A) , .

    ** C / . A D . ) .

    A :A. B ($126). E

    , , I .B. A ($250) . A ,

    , I C. H D ($350) ( )

    ( D H ). I . D . H CD

    . . .

    D. , / . . D . ( . ).

    I A I I IA G A I BE

    ED CE FA E, A IA, G A A E B DE

    G G A C +/+ D +/ +/

    193 196 D . , G B . B C +/+ , , ,

    . , B12 , ,

    D D , ,

    . ( ) .

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    , C +/+ .

    C (C ) ( , , ). C . I C

    , C +/+ C C +/+. C ,

    , 2 , .

    C 1A2 +/+ ( ) 2 , C 1B1 +/ ( ) 4 . D .

    2 2/16 2.8.

    C 1A2 +/+ ( ) , , C , (+/+

    . .

    C +/+ 2 ( ). ; E

    ).

    E , , C C / , C , C

    25% C / ), .

    ( ). C +/+ .

    , , C ,A H ( AH) C . A ( A )

    C , AH. A AH C ( A C ). A AH

    C . H , AH . C , ,

    , D A, . H

    , H C ( ).

    C +/+ ,

    C +/+ . D , D . I D D , , C , . F

    , C +/+ +/ , D +/+ +/ .

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    B12 B12. , B12 , . A C +/+ D +/ .

    B12, B12, B12 I , B12 ,

    , .

    B BH , , / . BH

    ED A BH ED A ( , , GAD, GABA). G

    ( ) BH , ,

    I ( CB ), GABA 500 , 1 2 . ,

    . C , GABA ( GABA ).

    , GABA, , , , GABA

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    ( ) 100 / ( CB / ). ED A BH ED A

    , , GAD, GABA). ED A , , , . ED A

    . ED A CB .

    ( ) . ,

    , . , , .

    , , ( ,

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    D . A , , A , D A . , ( D . ).

    , ( ).

    C +/+ D +/ , +/

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    ).2. 5 ( ) , 24

    8 ..3. BH BH4, ( C ) 900 / . C (

    C ) 900 ( 1 2 / C .

    4. D . , ( BH ) ( ),

    900 1800 .5. , , , , ,

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    7. A ( ).

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    BH (B H ) , A .

    C (C )

    , C A .

    38 50 A

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    A A A1298 +/+

    . A1298 A B 4, B 4 (

    ). , ( ) B 4 .

    B 4, B 4 . A B 4 .

    . A (< 800). B 4

    .

    A +/

    5,10 , A . 5 , .

    A +/

    A +/ +/+ 5 , , 400 ( 800 .

    A A +/

    , B 4. , .

    A A 2 +/+

    , . .

    .

    A A 1 1958A +/+

    158 (+/+) 62 (+/+) 61 ( / )

    158 ( / ) 62 ( / ) 61 (+/+)

    *

    39 50 A

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    , 5,10 / 5,10 ( D1) 5,10 (

    10 , 5,10 5,10 . A 1958 ( >A) .

    C . ( . . $350) A , A , (

    , D, , D ).

    A A A +/+

    A . , . B .

    . A +/+ C , ( , ).

    A A .

    A A

    A C ( ) , , ) :A. A , A A ( , A ,

    ).B. B 4 ( ), C. ( , , , ).

    ( ) B12, ( , , ), C ( A , B 4,

    ) .

    A , A ( )! ,

    ( . . D A ).

    A ? A ? A A : A ?

    A , A ( A ) , A

    ( A ), . A A : A A A .

    , A A . A , , , , , .

    A , A : A , . ; , , ,

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    .

    A. : ( , , ) ( . . ) ( ),

    , CB ( ( A ) (

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    . . , C . A , CB

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    A , . A ( ).

    B , A, , , . . , ,

    A , .

    , . ( . . , , )

    ( , , , .). A

    . A , A , ( . . A ).

    / . +/+ ,

    . +/ 1 1 . , .

    . ( +/ ).

    B. : 1/ 17 , , 6, 1 B , A .

    . B , , , .

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    A ? A ? A ?

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    A .

    B. : A 50% A , A (A ) A .

    A . , A , A ( , , :

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    . , 100% , A A

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    . ( ) , , ( ). , A

    , . , A , . , , B (

    ) B ( A ). A A : A

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    C ( ) 900 2700 / C H .

    D. C . C (C ) , (

    ), ( . . D ) ( A . E , AH A : AH , C .

    A ; AH , C . , A C .

    A ( H HF , , , BH ) . C

    , C . C . C C +.

    A C .

    A )

    1. C 5 / .2. C 900 / , 900 900 .3. 1 / ( , ).4. G D 250 / .

    G G A A AHC +/

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    A

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    .3. , .4. D . ( ,

    ), .).

    C. D FACC FAA F 1/18/15

    A G C

    C 158

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    +/ CB . H ( C ) , (

    / ), ( ), , BH4, .

    ( ) A , . BH4 ,

    , BH4 .

    CB , , ( ). E , B12, , , E .

    5 B12 , A , . +/ HF C677 , 5

    ( ) 5 ( ).

    +/ , B12 B12, B12 . +/+ D , D

    , / C , , . C ,

    ( / / C

    CB ).

    H 5,10 HF, A . 5,10 HF, F .

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    D G C , , 4 / ,

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    . 2C19 ( , , 2C19

    C H62H C 61

    D B D H (+/+)

    A A 297 H (+/+)ACA 102

    HF C677 H (+/ )HF 3 HF A1298C

    A2756G A66G H (+/ ) H595 350A 415

    A664A BH 2 BH 4 BH 8 AHC 1 AHC 2 AHC 19

    CB C699 H (+/ )CB A360A H (+/ )CB 212 H C1420 H (+/ )

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    (C ) II , D ( ( , D B ).

    G G A , A . A (). ( )

    (+/ ). B , I ).

    G G A CB +/

    CB (C B ) 48 53 D . , G B . A . . +/ ( CB ) CB . F

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    ( , / ( ), ( ),

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    ), ( GABA, ). CB C677 A360A

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    .

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    ). C , / ( , ,

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    44 50 A

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    A C E 10 C , + CB , ( C M / D ) C E 10, C , ADH

    C E ; 100 200 / C E G L E .

    BHM (B H M ) , CB . CB BHM ,

    BHM . DMG ( ) MG ( ) BHM ,

    ( C M / D ). BHM ( ), ( ).

    ED A ( ), .

    M CB BHM M HF ( ) M( B12) , (

    ). H , , B12, BH4, ( /

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    H , , B12, BH4 I M C .

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    I :1. M * ( ) ,

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    3. M 3 7 ( , ). 400 (

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    .4. D , 10 ( ), . C D . L C , CB ( . . ).5. F , D . H F , 3 6/ , (

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    6. G / . . H , ,

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    7. I ( ), GABA 500 (GABA 550 200 , ) . I ( C M / D )

    , (C M +) GABA. I . GABA/ , GABA

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    8. I , E , C E ADH .9. ? A CB

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    HF ( ). I . F

    24 / , E . / ,

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    , B12, BH4 (

    11. A C , ** ( ) . I , A D

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    ** C / . . ) . ( I

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    A C / D +/+ , B12 ( ) 5 .

    ? B12 , ,

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    / , B12 . I CB , ,

    B12 ( ) .

    A C / D +/+, D . B

    , , A , ( ). , , D,

    B BH , , / . A , D AE, , . F BH .

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    ).

    I ( CB GABA (GABA + ). A C / D +/+,

    . H , , , GABA ( GABA GABA ,

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    3. F 900 ( ) BH( ). A

    , ED A F .4. (GABA ) .5. D 50.6. A , , A 200 / .

    A , A C / +/+ .

    ( ) H . ( ) B 12.

    B12, .

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    D +/+ +/ ( ) . C / ( ) . D +/+ C / (

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    48 50 A

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    A

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    .

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