Methylation Nutrigenomics --HeartFixer
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7/21/2019 Methylation Nutrigenomics --HeartFixer
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, , . , , ,
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. I , ( ). ,
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I C / D +/+; I , , I ( C ).
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) , .
90% (CB / ). C D , ( . . / )
. , , /
.
: , , (+/+), (+/ ), , . I (+/+) HF C677 . C ( ) ( ) 67
HF . C I 100% HF .
, 5 . I I , ,
I , I , I . I . I
5 , I , , C677 100% . I 100%
(+/ ) C677 ( ), ) (+/+) C677 , (+/+). A ,
, . , F . I , (
). I A66G. A ( ) G ( ) 50% . 50% . I A66G
F . I B12 B12, , , B12 HF . C D
( ) , . I (+/+) ACE D 16. 16 ACE . C .
, D D F .
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, , . I ,
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B (+/+)100% (+/+)
(+/+) B ( / )100% ( / )
( /+ +
F(+/+)
+ +/+ +/+ F ( / / /+ +/+ +/+ / /
(+/+) (+/+)
( / ( / )
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(+/ (+/+) (+/ )
(+/+ +
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C , . A . , , ,
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) . E $200 , . I
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( ). I / , CB /BH , , ( ) . A
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. , , , (CB / BH ) ,
. A , (AHC +/+ +/ ) , CB
. . I , C G
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. D D . ).
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.
2014. A 1D A A A A .
F (+/ ) + +/+ +/ F(+/+)
+ +/+ +/ +/ / + +/+ +/
,1/4 ( / ), (+/ ),
1/ +/+
(+/+) (+/ , +/+),
(+/
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.
C C
CB , . C
90% . CB . CB . H
CB . C699 ( ) A360A
CB . H (+/+) (+/ ) CB . CB ( +)
/ . , ,
, , , A .
CB . CB (+) , , ( +/
D . A , ).
B 10 CB ( , ), ( BH4 ),
( ), ( ). G6 DH . ,
. C 10 C , A .
. CB . A ,
. BH4 ( , , ) . CB , BH4,
, , . D A. CB , , , BH4,
, . A A ,
.
. CB , ( ). .
CB (+/+) (+/ ) . (3 75 B 3 / , E 400 / , B12 2000 / .
, ( ) , . CB ,
, ( ) . ; ( ). ( , , ) .
, / , . ( , , CB ,
, , , , ,
. . D A D , ,
(+), / , / CB / . .
. , ,
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C D ( . . / ) . ,
. . . C ( ) .
, , , .
CB , . , ABA, ,
ABA , (
). , ( .
E ; ) ABA, ABA: 500 , .
A B (B ) CB . B
, CB (+) . A B ,
CB . B ( ED A
ED A), ( ), CB (+) / B (+
.
, CB /B B 4 CB / B ,
. B 4. B 4 C
. (200 / ) B 4 ,
C , (2.5 ) B 4 , . , ,
. ,
, . B 4 , ,
, , , , .
. A , C 10 C , , C . ,
, , , , , . AD , C , C 10, 1 A , CB ,
, , . C ( / ), , ). A
, .
. (+/ ) (+/ ) CB , .
. , CB + , , (
, CB (+) . A C (+). (+/+) F C677 100%
. F ,
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(+/+); ( / . ( / (+/+) , I C (+). I I CB (+), I
CB , (+/+) (+/ ). ( I ) I (+).
CB (+) B H (+) :
1. ( ) 2. , , ( ), A
, ( ; GI ).
3. B6 (B6 CB ; 5 B6 D . HF B6 ). A
/ .4. 3 , B 3 / , E 400 I / (
), B12 2000 / .5. GABA 500 ; GABA 6. ( , C ) ADH 5 , C E 10 100 I 100 , C 500 1000 , 5
, . C E 10, C , I , C ( ) / D (+) .
7. A BH .8. C 7 . 400 / (
) 800 / ( ), ( . C ,
. A .
9. I , , , D , ( ).
10. C G 4 6 , ( . / ),
11. I 8 10 :. .
. C 24 , , C . ,
, . .
G G A CB +/ +/+ / BH +/ +/+
CB (C B ) 48 53 D . , G B . A . . +/+ ( CB ) +/ ( CB )
CB +/+ +/ BH ( CB H ( C )
, ( / ),
), ( ), ( BH4, ).
BH4 ( ) ( ) ,
.
D , CB ,
), ( ). CB C677 A360A
. , C677 , 10 .
.
( H) , / / H . E ( A
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CB ). C , / , ( , ,
, BH4 ( ) . BH4 ( /
BH4, ; , .
A , , .
GABA. H , , , . G ,
; (
)?
CB ( ) ) . CB + . H
, , E , , B12 .
A C C E 1C , + CB , ( C / DE 10, C , ADH .
BH (B H ) , CB . CB BH ,
BH . D G ( ) G ( ) BH , ( C / D ). BH (
), ( ). ED A ( ), .
CB BH HF ( ) ( B12) , (
). H , , B12, BH4, ( /
. 1 2 , B12 ,
. HF / CB /BH .
.
CB +/ +/+ (BH )( HF , , , C , D , )
I :1. * ( ) ,
( C D . . / /.
2. C / ( ) / .
3. 3 7 ( , ). 400 (
800 ( ). . C , /
3. ( ), A A ( ), ,
( GI ). , , ( ), .
.4. D , 10 ( ), . C D . C , CB ( . . ).
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5. F , D . A , , . B12 2000 / , M B . M
B 3 , C M C , 3 ( ), CB . B6, 5 ,
.6. G / .
. H , , , / .
L ( ) G . L G ( L ). **
7. I ( ), GABA 500 (GABA 550 200 , ) . I ( C M / D )
(C M +) GABA. I , GABA
CB . M GABA 8. I , E , C E
, . ADH .
9. CB /BHM / . F
. 24 / , L E . / ,
, , CB .10. A ( I ,
, B12, BH4. .
11. B . , , ? A .
, . C , , . B .
. A , , (
* H ? ( )
M C G . A ,
, ; , .
, . I CB C677 , , ),
( , C , , A A) .
** M C / . . ) . :
A. E ( ) ($170 ; HM
B. B ($126).C. A .D. H D ( ) ( D H ). I
. D . H CD . . .
FI G AL ILL BE ED CE LFA E EA D DEC EA E AMM IA A D GL AMA E
GE E A I
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C677 , , A . D ,
, , , . 5 , 5 . ( ) 5
. (+/+) C677 (10% , ) ,
, , , ! (+/+) (+/ ) ( 20% ),
. , 5 100% C677 , 5 .
5 (800 5 ), (5 2.8 , 5 25 , C AC (5 5.6 , AC 500 , B12 2 ). ,
. C , .
, . A . , , B6, B12,
, . A , . C , ,
. ? ,
, (+/+) (+/ ), A , , 5
. A , , .
, . , , C .
, , , ,
, CB . ( ) , / .
" " ( ) 5 , . ,
. 5,10 ( ). 5,10 , 5 . 5,10
, , 5,10 5 ), D A.
, , 5 ( 5,10 ).
11 50 A
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5 ( ). , 5 , . 5
.
2756 . , 5 , . 12 , , 12 .
( ) , 12 12, .
. , , .
2756 , , 12 . 12. 12 , 12 , 12
. . . :
. 12. . 12.
. , ( ).
. ( ) , , /
12 12 . 12 (+/+) (+/ ), 12 , ,
, .
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B12. , . B12 (
) . B12. B C , , ,
C . C , . (+/+) , . C (+/+)
B12 ( ) , . C ( / ) C
, . C ( / ) (+) / (+) , C ( / ), B12. B12 ,
C , C (+/+), . B12 (
). , (+/ ) C , C . ,
B12, , C . B12 , , .
.
B12. , . B12 .
B . ( )
( ). B C
. ,
B12 , B
( , ,
). B , , B / , CB , C
( ) . :
1. , , 100 , B / , ,
( ). A A, B , , , .
, A A , 2. B ( C (+/+) , ).
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, , ,
A . 158 62 . (+/+) (+/ ) .
(+) ,
. ; . B 4 B , B A1298 . B 4
, . (+) , B 4
B 4 . (+) ,
. ( B12 / ),
. . (+)
. ( ) , , . A , , 61,
. (+) 61 .
* ( ), !
, .
, 90% . , , , . A ( )
, . , . .
, (+) . (+/+) (+/ ) , , .
, (+) ( ) . A , .
.
62 (+/+) 136 (+/+) 61 ( /
62 ( / ) 136 ( / ) 61 (+/+)
*
14 50 A
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677 , 5 . A1298 5
, , 5 , 4.
4, , A1298 4 .
4 2. , , . ,
. 4,
, .
A1298 5 ( , ,
4. , .
4. ( / ), ,
. A A ( / ), .
4 , ( ) A , , . .
,
. / 12, 12,
12 12, .
, .
(+/+) ( / ) ,
.
( / )
(+/+)
, , 12 / .
, , , , .
, , , , , A ( ( / ) ) .
, , A , A , . A A
, , A A .
(+/ ) ( / ) (+/+) (+/ (+/+) ( /
(+/ . .
15 50 A
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. . (
) . ,
B 4. B 4 A , .
298 . . (+)
, , . A
, ( ), , A , (+)
, . A , (
, 5 ). ,
). B 4 ,
.
A (A ) A , , A , , , ,
. A ( ) , A
A , A ( B /B , ). A 16
A , , A A (+) A (+/+); !
. A (+) B
A . , ( ) A
, .
A ( ) (
. A, , A A . A ; A
.
16 50 A
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. , ABA. ABA . ABA, , , , ABA
.
, , , , , . ( C
B6 ( A ), ABA ). A .
CB , , ABA, , . ABA ,
.
ABA , , , , , , ,
.
ABA :
1. A CB /B .2. ( ).
3. ABA4. C ABA , .5. C , .
6. . , ; .
*
, , , , ,
A A , C
( )
C B B / A
/ ABA
( CB (+) ABA
C , ; C (+)
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C ( ):
A , . , ( )
. D A A 297 . A ,
( ). H . , . D . . ,), A .
C , , BH4 , .
ACA ,
B12 . , ACA
A ( A ), , A AHC . (+) AHC CB ,
. E , AHC . , CB , .
/ , . D AHC C , A 1/8 .
D ( D ) F .
( , .) D F .
E ( ) . ( ) (
( ). ( ) , H
, E /A C / .
. . ).
?
1. G A : , ( ) .
: C . C , , . C ,
, C . D A, ,
, . C ( $550 . $100 23 . ). . ,
, D A , , . : ( ) ,
G . . D G G D ( $500) 23 . ( $100
C ).
2. : , ), , , . A , ,
100 ( ) ( , ). F , ,
. :
18 50 A
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A. B . $125 (
I .B. G L E ,
. E M ( A /H ); $170. M M .
C. M , $ 250 $ 600. .
3. H M : M , , ( 10 20 ). M , , ,
, ).
. ?A. B , ,
. H , , B. .
E , $ 136 D . D .C. C . H I
. ($250) , , I .
D. , , , . C $ 350.
H ? :
. : A
) .1. M ED A: A (20 30) 3 I M ED A, B C C. M ED A
A C ( AC , 18 38% 5 / ). I
M ED A 20 ; AC ). L C , ED A , I
B .2. C ED A: C ED A 10 . , I
, I . M ED A C ED A ( ).
3. E D D (EDD): EDD I ( GI ).
4. DM : 25 , L , ED A . , M . ED A M !
DM . M I DM , DM G . C ED A, DM L
5. DM A: A , DM A MC , DM A ED A DM . DM A 500 , 3 , 3
, DM A 500 , 10 , 5 .6. L ED A (D M ): L
. L ED A , ( D D ).
7. M F : M F ED A/ ED A ( . . ). I M F . M M F ( ).
I ).8. B M : , M , D . B . D . B 2 3 :
A. A , 10 2 . ( 1 ) ,B. DF, 8 ( 1 ), &C. C 5 , .
CB , ( , , A DF . D . B M
C ED A.9. M : M . 2,
. M F ), M . M
C , , , L
19 50 A
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M . M M C ( ) 10 , .
10. G : M A C , , C, G B , 2 . .
11. A (D H ) D : D ( D D , CD .
, ( ). , I , ($35 2 3
.
12. M F C : E . MME
! MME . M
13. A H D : A , A , , . A
2 3 1 2 . A , , .
14. F : , . , .
. ( A . ). I , ,
. F .15. G G ( )
( . / ).16. F I (FI ): . (
). , . FI . FI
(FI M , ).17. F M (F M): F M ( ) 1/5
E . E , F M . F M ( .
. . I . D , , I
, , . I , , (
. ? I
, F M, ). I , I . I
(
L . I I . D
, , )
.
B , , F , E , G B , I
, , L C (H , C ) C , A
C , A H ( ) , M , A C (B , B , B , B , C , C , C , E , G ,M , , , , , )
20 50 A
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( C D , (
. . / )
, , . CB , B ,
( ).
A , ; . D , , , ,
, . A , . A
3 4 . , ,
&
B ,
( )
( )
, C , C , A , ,
, , C ( ), B
C
C C
C , A D A D ( C ) , B C,
, C C B BC B C B C C C / C / ;
D A
C C A D
( )A B ( ; , )
D A D B
21 50 A
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( )
: .
:
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, , , .
.
, , ,
:
/ .
.
:
, ,
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,
B :
. ( ) . .
:
, , , . A ( , ), . B .
:
, , . , , .
:
, , . .
.
.
B .
, , . , ,
, , , , A A ,
( )
( )( ) ( )
A A A A B B / /B
( ) A
/ /B B
B ( ) B ( ) B A
A ( ) B
/ A
A
, B , , B , B , B , ,
, ,
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E A 1600 /
. A C G ,
. H . D
, , , .
C : $1,150 , , . ,
.
, / BH H ,
C G $1,150, $10 1,600 / .
? ? 100% ? , ; . H , .
/ A. C ?B. A ( ) ( )?C. ?D. ?
CB / BH
(CB /BH 400 / ); H , CB /BH
B F
D FC F C B H C C /H D / G
/ /C C
C A C( )
G B / D / C , D F F C F
BG ED D C B B CF A F
, 1%, 2%, F , D
C
D C C / C B F / D F CB G F B F A F C C B C A F
CC A ,
, CB C , F , D E A
F A F F , A B A / E F C B
A F
A C A
A
A F A E A F A E A C F /C CF A G / G C
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O ( O ), ( CB ), / . ,
CB /BHM , , . . M / (
). I .
? I , M C . K ( ) . I
, CB /BHM , . , ,
. CB /BHM . M C ( M C $5
. D . A , . . A
, .
A , , ; , , .
A A
M C G (CB BHM ) . D
, . ( ),
! M C M C , . O
. A CB /BHM , .
M C .
O
+/ +/+ CB +/+ +/ BHM 1 8, CB H ( ) , ( / ),
), , BH4 ( , ).
CB /BHM :1. N ( ) , , ( CB A II: F H / C D ,
. . / /.2. M 4 7 . L (400 400 800 / )
BH4 / .3. , A NA, ( ;
GI ), . .
4. M O . H , . E , B , B12 O
CB /BHM O , 5. A ( . ) GABA .6. M B6, CB ; 5 .7. C , C , I , NADH ; 8. A
, / BH4. C CB
. ( ( ).
CB /BHM
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1. B ..2. C ( ) , 3. M 4 7 ( ) 400 /( ).4. , A A ,
( ; GI ). , , , ( ),
.5. , B6. A HF
M C 4 / . B M 3 , B 3 / , B12 ( ).
6. C E 10 100 / , C 500 , ADH .7. A GABA 500 ; GABA
.8. I , D, , (
).9. I ( ) 24
, . I 24 AM / .
10. L F 900 / BHM , CB . L ED A, , , M C
2 . 3 C ( )6 8 C3 . F B2 . F 2 ( ) 1 . C 1 .F G
15
A 2 L. A ( 2 ) 2 F ( ) / 15 30 . 1 14.5
2 15
12 G B
B B 20 /
6 7 1 C
I 6 8 G A / ( )
D B A E ! C C C
2 . 3 C /1 B /1 M C /
, 1 . 1 . C
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1 . B 3 14.5 D
B 20 30
C 8
B
B 5
C C C
1 2 3 / 2 . 1 /1
/2 . 1 . B 1 .
, . B , . . . ,
. A 2 . . , , , . .
. 6
B &
#1 / C
A ( , )1 2 , 1 2
# 2 B C ( )
#3 , , . D . B 350 .
#1 A B C B
#2 A B C
#3 B D
1 15 B1 / 1 . C
B
C B C
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#4A D
1 / 1 1 1 .
C
#5 1 B4 5 1
B /
B @ 350 1 B , 1
3 ( )2 ( )1 ( )1 .
4 3 , 1 C , 1 . , , , , 1/8 ( ) . 15 . .
6 7
.
C C C
2 3 . 2 4 ( )
.A 4 , 1 . C , 1 . ,
, 1 . C B C .C . B 15 20 .
4 .
.
C C C
(D . ) . . . .
. . C C
:30204 * $55 100 :30205 * $55 100 :540 A A ( )*
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H H :
G . .
C A
C A
: :
:
:
E #
C
C
K :560 HH ( )*K : A $85 A :K :02041 * HH 600 60 $17.46K :01129 C * HH 100 260 $9.99
AC9 * EE 2.5 $10.10K :30054 HF * HH D . 6 $29.99 180K :01092 H B12* HH 2000 B12, $28.95K :01082 * HH 75 /3 2 . $12.20
B 04 B HH 3 100 $6.50
K :30020 E * HH 400 I $24GABA 7 GABA* EE 500 GABA, 100 $21
K :01049 ADH* HH 5 , 30 $33.99K :01023 * HH 275 GABA 100 60 $21
CA 48 C * EE C 500 60 $39.9001226 C 10* EF 100 60 $55
I * 100 60 $40.0000537 B12* EF 5 60 $32
ED A* C ED A 1 $30 F * C
K :01043 * HH 100 60 $39.90
K :01044 A * HH 50 50 D AE 120 $28.99I H2 * EE 100 $11.19
I * 12.5 90 $27I D14 E 9 EE 2 . 265 $12.20
G G EE 750 G 100 $15.60K :01088 * HH 500 B 50 $14.05
00453 A * EF 200 A 50 $33.75K :02017 F * HH 5 800 , 60 $17.49
F 17 F A * EE 800 / 60 $11
F D : 2.8 , 25 5 , & 2 B12C AC D 5 , 2 B12, 500 AC
00961 G D * EF 90 $28 G * 15 $90 ( 7 ) . /
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C A
I G
E
F
E E
. .
E B C
D
C
C
F
F
C I
C
E
C
E F
. .
C
C , . C ,
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2 EEC 12 . E 4 .
; ).
, , . , , , .
. C G E .
D . ( , ), , , . I C G
$1,125 C , D . , D . C . I D .
4 5 .
, C C . .
I . . A I . I I
. I ( ) , 75%
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, ( C ). A , . , , ,
. I , D G ( ). ,
.
I , . , , ,
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J C. D FACC8/24/08
A G C I
C 158 H (+/+)
C H62H H (+/+)C 199
D B H (+/ )D H (+/ )
A A 297 H (+/+)ACA 1 02
HF C677 HF 3 HF A1298C H (+/+)
A2756G A66G H (+/ ) H595
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( ) :A. A , A : A , .B. B 4, .
. / , , , .
. .
, , , .
+/ B +/ B ( B 23 ). (
) , , / ; 800 1200),
( ABA A 1 +/+ ; 9/12 ), ( B 4, ). B 4 ( ) A ,
.
. A1298 (+/+) B 4 B 2. (+/ ) B 4 , B 4,
. A ( B B ) , B B 4 / .
( ). ( )
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( +/ ), 5 ( B6) 5,10 , 5
5,10 1, A A . B +/1, . B +/
. , , .
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. ++ , B ( ), , .
.
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, . A +/+, , . , +/+ . A
, . B12 ( , , B12 , ,
350A 415 A664A (+/ )
B 2 B 4 B 8 (+/ )A 1 (+/ )A 2 A 19 (+/ )
B 699 (+/ )B A360A (+/ )B 212
1420
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B12 , B12
+/ D ( D B , D ), D ( ), +/+ C ,
, ; .
A A . +/+ A A, +/ A B, , .
AHC A H ( AH), A . B +/ AH , AH , A AH ,
A . AH ( ).
1 +/ HD ( , ), . C 1A2 2
+/+ C 1B1 4 . H , 2/16 2.8, D . 3 C, 2 . D . 16
( 16 H +/+ 2 H 2 . B +/+ C
, +/+ C ), ( ) .
G G . A (). ( ) (+/
C , ( ).
I C , D . .
. I CB , . . D .
. I D . .
G G A CB +/ BH +/
CB (C B ) 48 53 D . , GB . +/ ( CB ) CB
+/ BH ( CB H ( C )
, ( / ), (
GAD +/ GABA,
9/14), ( ), ( B .
9/14, . A BH4 ( )
. B +/+ HF A1298C +/ BH4, BH4 .
. I ,
C , +/+ D , +/ G G
I ,
D , CB ( ,
) ( ), ( D . GA
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, , ; CB /BH + ). CB C677 A360A (
; I A ). .
( ) CB , . H , CB
A . I () A . A CB ( A
); A ( A CB /BH .
A ( ), A CB , . C A + CB
/ ( , CB )?
( H) , / / H ( D . ; I
). E ( D CB
)? C , / ( , , ).
, BH4 ( ) . BH4 ( /
BH4, ; , .
A , ( , ) . ,
, ( , ,
CB /BH / HF ( , ).
I . G ( , ) , .
CD A (C D A ), (
C GI , C , , 2 3
. / C GI ( GI
C , ). G GI , ; .
/A ( ), I , , C
(1/3 ) , . A / .
, . ; .
D . CB . A , CB , CB +
, . , , GABA. H ,
, . G
, ;
( ; G, ,
)? /
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/ G ( ) GABA
CB , ( ( ) . ,
. H , , E , , B12 .
A C C E 10 C , + CB
, ( C / D ) C E 10, C , , AD .
BH (B H , ) CB . CB BH
, BH . G ( ) BH , ( C +/+ ).
), ( ) ED A ( ), .
CB BH HF ( ) ( B12) , (
). H , , B12, BH4, C ( )
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. HF / CB /BH. . I
.
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. C , / 3. ( ), A A
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5. , D . E . / ? A ? I 50 100 / , 500 , B12, ,
.6. G / .
. H , , , / . ( ) G . G
. ; . , CB /BH .
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7. I ( ), GABA 500 , . I GABA , GABA
CB . GABA .
8. , C E 50 500 ( ). ADH 5 / ( AD+ ) . A 5
; A .9. A ( I ,
/ BH4 . I B12 . I , I
.11. I , A D .
( ) ). , .
12. , D . A 4 6 , A AH. H D I ( . .
A , AH, ( HFD, H). A , D D $155.
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, . C , , . B .
. A , , (
* H ? ( )
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; . . I
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A) , .
** C / . A D . ) .
A :A. B ($126). E
, , I .B. A ($250) . A ,
, I C. H D ($350) ( )
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. . .
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I A I I IA G A I BE
ED CE FA E, A IA, G A A E B DE
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. , B12 , ,
D D , ,
. ( ) .
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, C +/+ .
C (C ) ( , , ). C . I C
, C +/+ C C +/+. C ,
, 2 , .
C 1A2 +/+ ( ) 2 , C 1B1 +/ ( ) 4 . D .
2 2/16 2.8.
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. .
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).
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25% C / ), .
( ). C +/+ .
, , C ,A H ( AH) C . A ( A )
C , AH. A AH C ( A C ). A AH
C . H , AH . C , ,
, D A, . H
, H C ( ).
C +/+ ,
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, C +/+ +/ , D +/+ +/ .
5 B12 . (+/ +/+ )
B12 B12. , B12 , . A C +/+ D +/ .
B12, B12, B12 I , B12 ,
, .
B BH , , / . BH
ED A BH ED A ( , , GAD, GABA). G
( ) BH , ,
I ( CB ), GABA 500 , 1 2 . ,
. C , GABA ( GABA ).
, GABA, , , , GABA
. GABA , , ( GABA , GABA , ,
GABA . GABA
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( ) 100 / ( CB / ). ED A BH ED A
, , GAD, GABA). ED A , , , . ED A
. ED A CB .
( ) . ,
, . , , .
, , ( ,
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, ( ).
C +/+ D +/ , +/
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).2. 5 ( ) , 24
8 ..3. BH BH4, ( C ) 900 / . C (
C ) 900 ( 1 2 / C .
4. D . , ( BH ) ( ),
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7. A ( ).
, / , ), ,
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( ) , ( ).
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BH (B H ) , A .
C (C )
, C A .
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A A A1298 +/+
. A1298 A B 4, B 4 (
). , ( ) B 4 .
B 4, B 4 . A B 4 .
. A (< 800). B 4
.
A +/
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A +/
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A A +/
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, . .
.
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158 (+/+) 62 (+/+) 61 ( / )
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*
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, 5,10 / 5,10 ( D1) 5,10 (
10 , 5,10 5,10 . A 1958 ( >A) .
C . ( . . $350) A , A , (
, D, , D ).
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).B. B 4 ( ), C. ( , , , ).
( ) B12, ( , , ), C ( A , B 4,
) .
A , A ( )! ,
( . . D A ).
A ? A ? A A : A ?
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, A A . A , , , , , .
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.
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, CB ( ( A ) (
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. . , C . A , CB
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A , . A ( ).
B , A, , , . . , ,
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, . ( . . , , )
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. A , A , ( . . A ).
/ . +/+ ,
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. ( +/ ).
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. B , , , .
) ) A .
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A .
B. : A 50% A , A (A ) A .
A . , A , A ( , , :
), A , A . 10 . A ,
. , 100% , A A
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5 / . , ( )
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/ A .
. : A , 30% , . ( )
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. ( ) , , ( ). , A
, . , A , . , , B (
) B ( A ). A A : A
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C ( ) 900 2700 / C H .
D. C . C (C ) , (
), ( . . D ) ( A . E , AH A : AH , C .
A ; AH , C . , A C .
A ( H HF , , , BH ) . C
, C . C . C C +.
A C .
A )
1. C 5 / .2. C 900 / , 900 900 .3. 1 / ( , ).4. G D 250 / .
G G A A AHC +/
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H
A
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, . . H . A
. G . F / (D A D ) , ED A
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.3. , .4. D . ( ,
), .).
C. D FACC FAA F 1/18/15
A G C
C 158
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+/ CB . H ( C ) , (
/ ), ( ), , BH4, .
( ) A , . BH4 ,
, BH4 .
CB , , ( ). E , B12, , , E .
5 B12 , A , . +/ HF C677 , 5
( ) 5 ( ).
+/ , B12 B12, B12 . +/+ D , D
, / C , , . C ,
( / / C
CB ).
H 5,10 HF, A . 5,10 HF, F .
B +/+ A A, , , , , . E , ,
, CB
D G C , , 4 / ,
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. 2C19 ( , , 2C19
C H62H C 61
D B D H (+/+)
A A 297 H (+/+)ACA 102
HF C677 H (+/ )HF 3 HF A1298C
A2756G A66G H (+/ ) H595 350A 415
A664A BH 2 BH 4 BH 8 AHC 1 AHC 2 AHC 19
CB C699 H (+/ )CB A360A H (+/ )CB 212 H C1420 H (+/ )
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(C ) II , D ( ( , D B ).
G G A , A . A (). ( )
(+/ ). B , I ).
G G A CB +/
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/ ( ) BH ( CB ). G C, H ( C ) ,
( , / ( ), ( ),
BH4, ). BH4 ( ( ) ,
.
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), ( GABA, ). CB C677 A360A
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.
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). C , / ( , ,
).
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, , GABA , ,
. G ;
( )?
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, CB + . H , . E , , B12 .
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A C E 10 C , + CB , ( C M / D ) C E 10, C , ADH
C E ; 100 200 / C E G L E .
BHM (B H M ) , CB . CB BHM ,
BHM . DMG ( ) MG ( ) BHM ,
( C M / D ). BHM ( ), ( ).
ED A ( ), .
M CB BHM M HF ( ) M( B12) , (
). H , , B12, BH4, ( /
. 1 2 , B12 ,
. M HF /M CB /BHM .
H , , B12, BH4 I M C .
CB +/
I :1. M * ( ) ,
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2. C / ( ) / .
3. M 3 7 ( , ). 400 (
800 ( ). L . C , /
3. ( ), A A ( ), ,
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.4. D , 10 ( ), . C D . L C , CB ( . . ).5. F , D . H F , 3 6/ , (
). , / , M B . M 3
, C M C , 3 . A B6 ( CB . B6, 5 , B6 .
6. G / . . H , ,
, / . L ( ) G . L G
( L ).
7. I ( ), GABA 500 (GABA 550 200 , ) . I ( C M / D )
, (C M +) GABA. I . GABA/ , GABA
CB . M GA .
8. I , E , C E ADH .9. ? A CB
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HF ( ). I . F
24 / , E . / ,
, , CB .10. A ( I ,
, B12, BH4 (
11. A C , ** ( ) . I , A D
. ). , , . D . H CD
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12. BH4 , ( ). F .
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, . C , , . B .
. A , , (
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; . . I
CB (A360A C677 , , . I , ( , C ,
A) , .
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) ($170 ; HB. B ($126);
.C. A ($250) .D. H D ($350) ( )
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. B C / ( C +/ C +/+
). .
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A C / D +/+ , B12 ( ) 5 .
? B12 , ,
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/ , B12 . I CB , ,
B12 ( ) .
A C / D +/+, D . B
, , A , ( ). , , D,
B BH , , / . A , D AE, , . F BH .
BH ED A ( , GAD, GABA) (
).
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. H , , , GABA ( GABA GABA ,
). GABA ( ) (
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, , . ED A . ED A CB .
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3. F 900 ( ) BH( ). A
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A , A C / +/+ .
( ) H . ( ) B 12.
B12, .
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D +/+ +/ ( ) . C / ( ) . D +/+ C / (
) .
G G A HF C677 +/
H HF 5 . 5 . 5 . (
( . . BH4 ), . ( C)
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A H +/
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).
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G C 158 ( / )C H62H ( / )C 61 (+/+)
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A
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, ,
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.
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D FACC 5/27/08
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