METABOLISME KARBOHIDRAT - new.ppt

7/23/2019 METABOLISME KARBOHIDRAT - new.ppt

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METABOLISMEKARBOHIDRAT


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DIET BERVARIASI P.U. KARBOHIDRAT >

FUNGSI KARBOHIDRAT TERUTAMA SEBAGAISUMBER ENERGI( DR. GLUKOSA )

MONOSAKARIDA ( HEKSOSA ) HASIL PENCERNA-

AN KARBOHIDRAT TERUTAMA :

* GLUKOSA

* FRUKTOSA

* GALAKTOSA

FRUKTOSA DAN GALAKTOSA DI HATIGLU-

KOSA


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AMILUM

Amilum terdiri dari amilosa danamilopektin

AMILOSA:Rangkaian glukosa rantai lurusdengan ikatan -1,4-glukosidik

Produk : Maltosa sedikit glukosa


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AMILOPEKTIN


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Jal! "#$a%&l'"# 'aa!'a ! '#$


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Cara kerja enzim amilase


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M#$a%&l'"# +ala$&a


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M#$a%&l'"# F!$&a


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Gl&a a!a, "#"a /al! "#$a%&l'"#a!%&,'-

!a$ %#!'$ :

0. Gl'&l'' 1. Gl'&+#2#'

3. HMP S,2$

4. O'a' P'!5a$

6. S'l Aa" S'$!a$

7. S'a '$'"%2 %+ l#"a

Paa 8 #la9a!a2 aa! +l&a a!a,"#

"a /al! "#$a%&l'"# a!%&,'!a$ %#!'$ :

0. Gl'&+#2&l''

1. Gl&2#&+#2#'


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GLIKOLISIS

D'#%$ /+a EMBDEN MEER HOFF PATH;A T#!/a' ' ala" '$&&l

Gl'&l'' : &'a' +l&a #2#!+' ( ATP )

A#!&% A2a#!&%

( aa" 9'!5a$) ( aa" la$a$)

Paa #aaa2 a#!&% :

Ha'l a,'!2


11/49Jal! Gl'&l''


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R#a'1 9 Gl'&l'' 9aa ""2


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*R#a' '2' %#!'@a$ '!!#5#!'%l# ATP %+ &2&!++

@&@a$

1. F!$&a 7-9 F!$&a 07-%'-9

* D'a$al'' &l#, #2'" : F&@&@!$&'2a#

* %#!'@a$ '!!#5#!'%l# * M#!9aa2 #2'" 9#2+#2al' ##9a$a2 al!

+l'&-

l'' ( !a$# l'"'$'2+ #2


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E2#!+'


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Paa Gl'&l'' A2a#!&%:

* Ra2$a' !#9'!a' $'a %#!/ala2

* Ha'l a,'!2


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A2a#!&% Ra2$a' R#9'!a' $a %#!/ala2

NADH = H=


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GLIKOLISIS DI ERITROSIT:

* E!'$!&'$ #aa $'a "#"92


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Jal! B'@&@&+l'#!a$ ala" #!'$!&'$


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M#$a%&l'"# B'@&@&+l'#!a$ ' #!'$!&'$


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OKSIDASI ASAM PIRUVAT

T#!/a' ' ala" "'$&&2!'a

O'a' 0 "&l P'!5a$ 0 "&l A#$'l K&A"#2+,a'la2 3 "&l ATP

R#a'2


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O'a' #a!%&'la' aa"'!5a$


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SINTESIS ASETIL K&A


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GLIKOGENESIS

S'2$#' +l'&+#2 a!' +l&a

T#!/a' ' ala" ,a$' a2 &$&$

R#a' 0 : M+==

Gl&a = ATP Gl&a 7-9 = ADP

Gl&'2a# 8 H#&'2a# R#a' 1 :

Gl&a 7-9 Gl&a 0-9

F&@&+l&"$a# R#a' 3 :

Gl&a 0-9 = UTP UDPG =P'!&@&@a$

UDPG P'!&@&@&!'la#


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E2'" Gl'&+#2 '2$#$a#( '2$a#)

"#"%#2$ 'a$a2 -04 Gl'&''( !a2$a' l!)! +l'&+#2

E2'" P#2a%a2+( B!a2,'2+ E2


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SINTESIS GLIKOGEN


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SINTESIS GLIKOGEN


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Jal! +l'&+#2#' a2


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Gl'&+#2#'

Gl'&+#2&l''


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GLIKOGENOLISIS P! 9#"#a,a2 +l'&+#2

Dala" &$&$ : * $/a22


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E2'" Gl&a 7-@&@a$a#$#!a9a$ ' : ,a$'+'2/ala2 #9'$#l ( $#$a9' $'a $#!a9a$

' &$&$ )

E2'" Gl'&+#2 @&@&!'la# "#"$

'a$a2-04+l'&'' ! +l'&+#2

D#%!a2,'2+ #2


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GLUKONEOGENESIS

P#"%#2$a2 +l&a a!' %a,a2 %a2 a!%&,'!a$ Paa ""al'a $#!$a"a $#!/a' ' : ,a$' a2 +'2/al

S%$!a$ :

0. Aa" la$a$ !. &$&$ #!'$!&'$

1. Gl'#!&l !. ,'!&l'' T!'a'l+l'#!&l l". /a!. l#"a ( a'9&a )

3. Aa" a"'2& +l&+#2'

4. Aa" 9!&9'&2a$ 9 !"'2a2'a

Gl&2#&+#2#' 9#2$'2+ #al' 2$ 9#2


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Ja!'2+a2 9#!l 9a&a2 +l&a &2$'2

#%a+a' "%#! #2#!+' $#!$a"a '$#"a!a@ a2 #!'$!&'$

E2'" %a2$a2:

0.P'!5a$ a!%&'la#

1. F&@&l9'!5a$ a!%&''2a#

3. F!$&a 07 %'@&@a$a#

4. Gl&a 7-@&@a$a#


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Jal! Gl&2#&+#2#'


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Gl&2#&+#2#' a!' aa" a"'2&


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P#!%a,a2 aa" 9!&9'&2a$ "a #/al! +l&2#&+#2#'


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CORI CCLE


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K#< E2


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HMP SHUNT(HEKSOSA MONO PHOSPHAT

SHUNT) D'#%$ /+a : P#2$ P,&9,a$# Pa$,a


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T'a a$'@ ' ala" #l &$&$ F2+' : 0. M#"%#2$ NADPH 2$ '2$#' aa" l# "a $#!&' 1. M#"%#2$ 9#2$&a !'%&a 2$

'2$# ' 2l#&$'a a2 aa" 2l#a$

3. Dala" #!'$!&'$ : M#"%#2$ NADPH2$ "#!#' :

Gl$a$,'&2 !#$a#

Gl$a$,'&2 T#!&'a' Gl$a$,'&2$#!#'( G-S-S-G) ( 1-G-SH)


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1G-SH = H1O1 G-S-S-G = 1H1O

Gl$a$,'&2 9#!&'a#

Gl$a$,'&2 $#!#'"#"%#%aa2 #!'$!&'$ a!' H1O1

9#2'"%2a2 H1O1"#"9#!9#2# "! #!'$!&-

'$

M$a' #2'" +l$a$,'&2 9#!&'a#

H#"&l'' #!'$!&'$ /'a '%#!' &'a2 9$. : 9!'"a'2

A9'!'2 l@&2a"'

R'%&a 6-9


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Jal! HMP S,2$


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PRODUK HMP SHUNT


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METABOLISME GLUKOSA

G OS


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GLUKOSA DARAH Gl&a a9a$ '9aa' &l#, #"a /a!'2+a2 $%,

''"9a2 : * ,a$' a2 &$&$ Gl'&+#2

* /a!'2+a2 l#"a T!'a'l+l'#!&l ( TG )

S"%#! +l&a a!a, :

0. Ka!%&,'!a$ Maa2a2 1. Gl'&+#2&l'' ,#9a!

3. Gl&2#&+#2#'

H&!"&2


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PENGARUH HORMON:

* K#aaa2 aa! +l&a a!a,

"#!a2+a2+ #!#' ,&!"&2 +la+&2

* K#aaa2 aa! +l&a a!a,"#!a2+a2+ #!#' ,&!"&2 '2l'2

* K#aaa2 a!!a$ "#!a2+a2+#!#' ,&!"&2 a!#2al'2


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Glukagon(,a$')

P#"%#2$a2AMP

Epinefin(&$&$)

0. AMP "#2+,a"%a$ Gl'&+#2'2$a-

# "#2+,a"%a$ +l'&+#2#'

1. AMP "#"a @&@&!'la#

"#"a +l'&+#2&l''

INSULIN:

0. M#"a +l'&+#2 '2$a#

1. M#"a @&@&'#$#!a#


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PERU!AHAN ANTAR !AHAN MAKANAN

Maa2 %a2


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Maa2 %a2


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M#$a%&l'"# "aa2a2

METABOLISME KARBOHIDRAT - new.ppt

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