Metabolism of zinc and its clinical significance
-
Upload
rohinisane -
Category
Health & Medicine
-
view
46 -
download
2
Transcript of Metabolism of zinc and its clinical significance
ZincMetabolism
absorption ofdietaryZinc:DUODENUMInhibitorsofabsorptionofdietaryZinc: Copper,Calcium,Cobalt,Iron,PhytatesZinc&Coppercompetitors(ZincusedinWilson’sDiseaseasitdecreasesdietaryCopperabsorptioninduodenum)Zincstorageinhumanbody:LIVER(Metallothionein)
ZincMetabolism
qDailydietaryRequirement-ForAdults:15mgForchildren:10mgqDailydietaryRequirementincreases–PregnancyLactation
ZincMetabolismvCauses ofZinc deficiencya) Nephroticsyndromeb) Hemolyticanemia‘myocardialinfarction’c) Infectiond) Achrodermititis (Zincabsorptiondefective)vSymptomsofZinc deficiencya) Poorwoundhealingb) Lesionsinskin(ofmouth,nose,fingers)c) Spermatogenesisd) Dermatitis/dementia/depressione) Alopecia
Zinctoxicity:causesandsymptomsqZinctoxicity:1. Welders:inhalationofZincoxidefumes2. RatpoisonscontainZinccompounds3. symptomsofZinctoxicity:a) Ulcerb) Pancreatitisc) anemiad) vomitinge) PulmonaryfibrosisqsymptomsofsevereofZinctoxicity:a) Headacheb) Feverc) Leukocytosisd) Anemiae) Plateletaggregationf) Phagocytosis
Functions of ZincqFunctionsofZinc1.for>300enzymesZincisacofactorofenzymes(LDH,Alkalinephosphatase,Carbonicanhydrase,SOD,Carboxypeptidase )2. RNApolymeraserequiresZnforproteinbiosynthesis.3. ExtracellularSuperoxidedismutaseisZndependent.4.Zn–functionsasanantioxidant.5.synthesisofretinolbindingproteinrequireZinc6.Zincrequiredforimmunologicalfunctions.7.Zincsupplementationusefulfortreatingacutediarrhea.8.Zincsupplementationimprovesbirthweightofbabies.9.Zincplaysimportantrolein“Insulin“storageinbetapancreaticcells10.(commercialProtamine=Zincinsulate).11.Gusten –Salivatastesensation
Zinc –asanantioxidant
3ExtracellularSuperoxidedismutaseisZndependent.4. Zn–functionsasanantioxidant.
Zinc andinsulinstorageinbetapancreaticcells
9.Zincplaysimportantrolein“Insulin“storageinbetapancreaticcells10.(commercialProtamin =Zincinsulate).