Metabolism ( all the chemical reactions occur in a cell )
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Metabolism
( all the chemical reactions occur in a cell )
Catabolism ( breaking down of molecules )
- usually releases energy
Aanabolism ( synthesis of molecules )
- usually requires energy
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Amino acids may not be linked together but are close distance to each other
Other amino acids for maintaining
the correct globular structure
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E + S ES complex EP complex E + P
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Compare and contrast the “lock and key hypothesis” and
“induce fit hypothesis”
Similarities :
1. Similar reaction sequence : E+S ->ES complex ->EP complex ->E+P
2. Catalytic reaction occurs in active site of enzyme
Differences LKH IFH
1. Initial shape of active site
exactly fit with substrate
may not be exactly right in shape to fit the
substrate2. Flexibility of
enzyme molecule less more
3. Change in shape of active site no yes, induced by the binding of
substrate with active site
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Activator (inorganic )
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A B C
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Rate of enzymatic
reaction
Factor :
pH
Temperature
enzyme Conc
Substrate Conc
Coenzyme Conc
.
.Which is the limiting factor which
controls the rate of reaction ?
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For fixed amount of substrate
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Non competitive inhibitor
Competitive inhibitor
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