Metabolic and Physiologic Effects From Consuming a Hunter-gatherer (Paleolithic)-Type Diet in Type 2...
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About NPG Contact NPG Accessibility statement Help Privacy policy Use of cookies Legal notice Terms Naturejobs Nature Asia Nature Education RSS web feeds Search: go This journal is a member of and subscribes to the principles of the Committee on Publication Ethics. European Journal of Clinical Nutrition ISSN 09543007 EISSN 14765640 ARTICLE TOOLS Send to a friend Export citation Rights and permissions Order commercial reprints SEARCH PUBMED FOR U Masharani P Sherchan M Schloetter S Stratford A Xiao A Sebastian more authors of this article Access To read this article in full you may need to log in, make a payment or gain access through a site license (see right). Original Article European Journal of Clinical Nutrition , (1 April 2015) | doi:10.1038/ejcn.2015.39 Metabolic and physiologic effects from consuming a huntergatherer (Paleolithic)type diet in type 2 diabetes U Masharani, P Sherchan, M Schloetter, S Stratford, A Xiao, A Sebastian, M Nolte Kennedy and L Frassetto Background/Objectives: The contemporary American diet figures centrally in the pathogenesis of numerous chronic diseases– 'diseases of civilization'–such as obesity and diabetes. We investigated in type 2 diabetes whether a diet similar to that consumed by our preagricultural huntergatherer ancestors ('Paleolithic' type diet) confers health benefits. Subjects/Methods: We performed an outpatient, metabolically controlled diet study in type 2 diabetes patients. We compared the findings in 14 participants consuming a Paleo diet comprising lean meat, fruits, vegetables and nuts, and excluding added salt, and nonPaleolithictype foods comprising cereal grains, dairy or legumes, with 10 participants on a diet based on recommendations by the American Diabetes Association (ADA) containing moderate salt intake, lowfat dairy, whole grains and legumes. There were three rampup diets for 7 days, then 14 days of the test diet. Outcomes included the following: mean arterial blood pressure; 24h urine electrolytes; hemoglobin A1c and fructosamine levels; insulin resistance by euglycemic hyperinsulinemic clamp and lipid levels. Results: Both groups had improvements in metabolic measures, but the Paleo diet group had greater benefits on glucose control and lipid profiles. Also, on the Paleo diet, the most insulinresistant subjects had a significant improvement in insulin sensitivity (r=0.40, P=0.02), but no such effect was seen in the most insulinresistant subjects on the ADA diet (r= 0.39, P=0.3). Conclusions: Even shortterm consumption of a Paleolithictype diet improved glucose control and lipid profiles in people with type 2 diabetes compared with a conventional diet containing moderate salt intake, lowfat dairy, whole grains and legumes. To read this article in full you may need to log in, make a payment or gain access through a site license (see right). © 2015 Macmillan Publishers Limited. All Rights Reserved.
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Metabolic and physiologic effects fromconsuming a huntergatherer(Paleolithic)typediet in type 2 diabetes
Transcript of Metabolic and Physiologic Effects From Consuming a Hunter-gatherer (Paleolithic)-Type Diet in Type 2...
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ThisjournalisamemberofandsubscribestotheprinciplesoftheCommitteeon
PublicationEthics.EuropeanJournalofClinicalNutrition ISSN09543007 EISSN14765640
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UMasharaniPSherchanMSchloetterSStratfordAXiaoASebastianmoreauthorsofthis
article
AccessToreadthisarticleinfullyoumayneedtologin,makeapaymentorgainaccessthroughasitelicense(seeright).OriginalArticle
EuropeanJournalofClinicalNutrition,(1April2015)|doi:10.1038/ejcn.2015.39
Metabolicandphysiologiceffectsfromconsumingahuntergatherer(Paleolithic)typedietintype2diabetesUMasharani,PSherchan,MSchloetter,SStratford,AXiao,ASebastian,MNolteKennedyandLFrassetto
Background/Objectives:
ThecontemporaryAmericandietfigurescentrallyinthepathogenesisofnumerouschronicdiseases'diseasesofcivilization'suchasobesityanddiabetes.Weinvestigatedintype2diabeteswhetheradietsimilartothatconsumedbyourpreagriculturalhuntergathererancestors('Paleolithic'typediet)confershealthbenefits.
Subjects/Methods:
Weperformedanoutpatient,metabolicallycontrolleddietstudyintype2diabetespatients.Wecomparedthefindingsin14participantsconsumingaPaleodietcomprisingleanmeat,fruits,vegetablesandnuts,andexcludingaddedsalt,andnonPaleolithictypefoodscomprisingcerealgrains,dairyorlegumes,with10participantsonadietbasedonrecommendationsbytheAmericanDiabetesAssociation(ADA)containingmoderatesaltintake,lowfatdairy,wholegrainsandlegumes.Therewerethreerampupdietsfor7days,then14daysofthetestdiet.Outcomesincludedthefollowing:meanarterialbloodpressure24hurineelectrolyteshemoglobinA1candfructosaminelevelsinsulinresistancebyeuglycemichyperinsulinemicclampandlipidlevels.
Results:
Bothgroupshadimprovementsinmetabolicmeasures,butthePaleodietgrouphadgreaterbenefitsonglucosecontrolandlipidprofiles.Also,onthePaleodiet,themostinsulinresistantsubjectshadasignificantimprovementininsulinsensitivity(r=0.40,P=0.02),butnosucheffectwasseeninthemostinsulinresistantsubjectsontheADAdiet(r=0.39,P=0.3).
Conclusions:
EvenshorttermconsumptionofaPaleolithictypedietimprovedglucosecontrolandlipidprofilesinpeoplewithtype2diabetescomparedwithaconventionaldietcontainingmoderatesaltintake,lowfatdairy,wholegrainsandlegumes.
Toreadthisarticleinfullyoumayneedtologin,makeapaymentorgainaccessthroughasitelicense(seeright).
2015MacmillanPublishersLimited.AllRightsReserved.
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