Metabolic Activation of Enzymes Cannabinoid Receptors ... · CB2 • active in lymphatic system,...
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44% of patients reported increased stress in the past five years, and 15-40% of respondents also had other health issues (i.e. mood, chronic health conditions) 3 share receptor activation As precursors of endocannabinoids, omega-3 fatty acids are required for a healthy ECS. With balanced omega-3 levels, the body produces its own forms of active cannabinoids. If the ECS is out of balance, then an omega-3 deficiency is likely. If omega-3s are depleted or unavailable, dietary support with omega oils can help support omega-3 status. Additionally, dietary phytoactives support the body and direct activation of the CB1/CB2 receptor system. ECS & OMEGA-3 CB2 • active in lymphatic system, immune cells & spleen • immunomodulatory • stress response • shared immunoresolving Endocannabinoids (ECBs) Metabolic Enzymes Omega-6 derived Omega-3 derived 2-AG anandamide ACTIVATION OF THE ENDOCANNABINOID SYSTEM (ECS) phytocannabinoids Memory Sleep Gut function & response Metabolic processes ECS FUNCTIONS Healthy inflammation response Only about 7.8% of adults and 1.1% children in the United States use supplements containing fish oil, omega-3s, and DHA or EPA 2 60% of American adults have underlying issues with inflammation 1 1. RAND Health 2017 2. 2012 National Health Interview Survey 3. American Psychological Association 2010 Stress in America Survey resolvins protectins maresins EPEA DHEA Balanced activation of both receptors is important but CB2 is preferred Activation of Cannabinoid Receptors (CB1, CB2) CB1 • psychoactive stress, mood & brain
Transcript of Metabolic Activation of Enzymes Cannabinoid Receptors ... · CB2 • active in lymphatic system,...
44% of patients reported increased stress in the past five years, and 15-40% of respondents also had other health issues (i.e. mood, chronic health conditions)3
share receptor activation
As precursors of endocannabinoids, omega-3 fatty acids are required for a healthy ECS. With balanced omega-3 levels, the body produces its own forms of active cannabinoids. If the ECS is out of balance, then an omega-3 deficiency is likely. If omega-3s are depleted or unavailable, dietary support with omega oils can help support omega-3 status. Additionally, dietary phytoactives support the body and direct activation of the CB1/CB2 receptor system.
ECS & OMEGA-3
CB2 • active in lymphatic system, immune cells & spleen• immunomodulatory • stress response• shared immunoresolving
Endocannabinoids(ECBs)
Metabolic Enzymes
Omega-6 derived
Omega-3derived
2-AGanandamide
ACTIVATION OF THEENDOCANNABINOID
SYSTEM (ECS)
phytocannabinoids
Memory
Sleep
Gut function & response
Metabolicprocesses
ECS FUNCTIONS
Healthy inflammation
responseOnly about 7.8% of adults and 1.1% children in the United States use supplements containing fish oil, omega-3s, and DHA or EPA2
60% of American adults have underlyingissues with inflammation1
1. RAND Health 2017
2. 2012 National Health Interview Survey
3. American Psychological Association 2010 Stress in America Survey
resolvins protectins maresins
EPEA DHEA
Balanced activation of both receptors is important but CB2 is preferred
Activation of Cannabinoid Receptors
(CB1, CB2)
CB1 • psychoactive stress,
mood & brain
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