Menstrual Disorders in AdolescenceUterine myoma Uterine carcinoma. 12/6/2004 19 Other endocrine...
Transcript of Menstrual Disorders in AdolescenceUterine myoma Uterine carcinoma. 12/6/2004 19 Other endocrine...
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Menstrual Disorders in Adolescence
Maureen Kays, M.D.Assistant Clinical Professor of
PediatricsUniversity of Florida
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Jane
Jane, a 15 3/12 year-old girl, visits you for a WCC. Her last check-up was at 12 yo. Jane has always been mildly overweight. She reports that she has not had a menstrual period for 6 months. Menarche occurred at age 12 1/2. She recently saw a cosmetologist for facial hair removal.
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Tamisha
Tamisha is here today for menstrual cramps. She started menarche at age 12, every 28 days, lasting 5-7 days. Cramps the week before, daily. Increased pain with walking. Stays in bed. Some school absences. During period, headache/malaise, but worst is cramping/back pain.
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Sonia
Sonia comes in complaining of menses for 4 weeks. Her first period was 8 months ago and intervals have been irregular with menses lasting 5-7 days.Mother reports she tires easily and appears pale.
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Menstrual Disorders
AmenorheaAbnormal Vaginal BleedingDysmenorrhea
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Amenorrhea
Differential DiagnosisPregnancyHormonal ContraceptionHypothalamic CausesPituitary CausesOvarian CausesOutflow tract relatedAndrogen excess
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Amenorrhea Algorithm
PositivePregnant
Hyper/hypothyroidism,Hyperprolatinemia
PCOD
Increased LHDecreased FSH
Increased Testosterone
Hypothalamic amenorrhea(eating disorder, Female athletic triad)
Decreased FSH/LHnormal testosterone
Ovarian Failure
Increased LH/FSHnormal testosterone
LH/FSH/testosterone
TSH, Prolactin Progestational challenge
Urine Pregnancy test
History and normal PE
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Hypothalamic causes
Chronic or systemic illnessStressAthleticsEating DisorderObesityDrugsTumor
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Pituitary Causes
HypopituitarismTumorInfiltrationInfarction
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Ovarian causes
DysgenesisAgenesisOvarian failureResistant ovary
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Outflow tract related
Imperforate hymenTransverse vaginal septumAgenesis of the vagina, cervix, uterusUterine synechiae
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Androgen excess
Chronic anovulatory hyper-androgenism (PCO)Adrenal tumorAdrenal hyperplasia (classic and nonclassic)Ovarian Tumor
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Abnormal Vaginal Bleeding
Pregnancy RelatedHormonal contraceptionAnovulationOutflow tract relatedEndocrine causesHematological causesInfections
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Pregnancy Complications
Ectopic pregnancyAbortion
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Hormonal Contraception
Oral ContraceptivesLong acting Progestins
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Anovulatory
Immature hypothalamic-pituitary-ovarian axisPCOD
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Outflow tract related
TraumaForeign body/IUDVaginal tumorCervical carcinomaPolypUterine myomaUterine carcinoma
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Other endocrine causes
Thyroid diseaseAdrenal disease
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Blood Dyscrasias
ThrombocytopeniaAbnormalities of clotting factorsAbnormalities of platelet factorsAnticoagulant medications
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Infections
Pelvic inflammatory diseaseCervicitis
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Dysfunctional Uterine Bleeding
EvaluationHistory and Physical
Vital Signs (orthostatic changes)?Pelvic examination
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Dysfunctional Uterine Bleeding
MildModerateSevere
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Outpatient Regimen for Treatment of Abnormal Vaginal Bleeding with Oral
Contraceptives
One pill QID x 4 daysOne pill TID x 3 daysOne pill BID x 7 daysOne pill QD x 7-14 days*Stop all pills for 7 days and then begin cycling on low dose OCP
*length of therapy depends on level of anemia and amount of time required to reach an adequate hemoglobin level for resumption of menstruation
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Initial 3-4 weeks of therapy should be with a monophasic 35 to 50 mcg estrogen containing OC. Monophasicor triphasic OC can be used for cycling once bleeding is controlled.
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Dysmenorrhea
60% 12 – 17 yo girlsCrampy lower abdominal pain with similar regular recurrence within the menstrual cyclePrimarySecondary
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Primary Dysmenorrhea
Ovulatory cyclesFirst 2 – 3 days of mensesPositive family history
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Secondary Dysmenorrhea
InfectionPregnancy relatedEndometriosis
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Medications used to treat Dysmenorrhea
Propionic Acid Group:Ibuprofen 400-600 mg Q 4-6 HNaproxen Sodium 500 mg load, then 275 mg Q 8-12 H
Naproxen 550 mg load, then Q 12 HFenamate Group:
Mefenamic acid 500 mg loading dose, then 250 mg Q 6 H
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Jane
Jane, a 15 3/12 year-old girl, visits you for a WCC. Her last check-up was at 12yo. Jane has always been mildly overweight. She reports that she has not had a menstrual period for 6 months.
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Jane
Menarche occurred at age 12 1/2. She recently saw a cosmetologist for facial hair removal. On physical examination: Height 155.3 cm (10-25th percentile), Weight 83 kg (95th percentile), which represented an 8-kg weight gain over the last year, and that she had excess dark, curly facial hair in the sideburn area and chin.What’s your diagnosis and plan?
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Tamisha
Tamisha is here today for menstrual cramps. She started menarche at age 12, every 28 days, lasting 5-7 days. Cramps the week before, daily. Increased pain with walking. Stays in bed. Some school absences. During period, headache/malaise, but worst is cramping/back pain.
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Tamisha
Past medical hx: h/o exercise induced asthma and allergic rhinitis.ROS: Unremarkable. Mother had bad menstrual cramps. Not sexually active.Medications: Zyrtec, Albuterol MDI PRNLMP: Last Friday of this monthPE unremarkable, no pelvic done.
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Sonia
Sonia comes in complaining of menses for 4 weeks. Her first period was 8 months ago and intervals have been irregular with menses lasting 5-7 days.Mother reports she tires easily and appears pale.
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Sonia
PMH: unremarkablePSH: T and A at 5 yearsFH: Mother had heavy periods, nothing like thisROS: Fatigue, pallor, no bruising, increasing clots and crampsMeds:none HEADSS: no sex!
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Sonia
Pale P 120 BP 110/70 no orthostatic changesPE: unremarkable except for pallor
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Sonia
Labs: Hgb 10HCG negative
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