Membrane Membrane receptors. Single-pass membrane receptors membrane.

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membrane Membrane receptors

Transcript of Membrane Membrane receptors. Single-pass membrane receptors membrane.

Page 1: Membrane Membrane receptors. Single-pass membrane receptors membrane.

membrane

Membrane receptors

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Single-pass membrane receptors

membrane

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membrane

Multi-pass membrane receptors

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Ion channel membrane receptors

membranemembrane

+

+

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Ion channel membrane receptors

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Receptor kinases

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Kinase activities associated with receptors

intrinsic tyrosine kinase activity

JAK tyrosine kinase activity

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G-protein-linked receptors

GTP

hormone

membrane

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G-protein-linked receptors

GDP

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G-protein-linked receptors

adapter

adenylate adenylate cyclasecyclase

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Insulin activation of glucose response

IRS-1

PP P P

PP

GLUT

GLUT

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Follicle Stimulating Hormone & Receptor

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FSH subunit mRNAs

Huhtaniemi and Aittomaki (1998) Eur.J.Endo. 138: 473– 481

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FSH subunit polypeptides

Huhtaniemi and Aittomaki (1998) Eur.J.Endo. 138: 473– 481

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FSH

Fox, et al. Mol Endocrinol (2001) 15:378-389

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FSH Receptor

Huhtaniemi and Aittomaki (1998) Eur.J.Endo. 138: 473– 481

mRNA

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FSH Receptor

Huhtaniemi and Aittomaki (1998) Eur.J.Endo. 138: 473– 481

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FSH Receptor

(C, cysteine; S, serine; K, lysine; R, arginine; N, asparagine; A, alanine; D, aspartic acid; F, phenylalanine).

Mann, et al. (2000) Biol. Reprod. 62: 1240-1247

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FSH Receptor

Mann, et al. (2000) Biol. Reprod. 62: 1240-1247

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FSH Receptor

Sohn, et al. (2003) J. Biol. Chem. 278: 47868 –47876

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FSH Receptor

Sohn, et al. (2003) J. Biol. Chem. 278: 47868 –47876

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FSH Receptor

Gay et al. (2006) Nature Reviews Immunology 6: 693-698

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Natural mutations of FSH & Receptor

Huhtaniemi and Aittomaki (1998) Eur.J.Endo. 138: 473– 481