MEETING PROGRAM - ISACBisacb.org/Data/Sites/1/isacbmeetingprogram2016_web2.pdf · Cardiovascular...

S E P T E M B E R 7 - 1 0 T H

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ALBERTA CANADA

15T H B I E N N I A L M E E T I NG

MEETING PROGRAM

SEPTEMBER 7-10TH, 2016

I N T E R N A T I O N A L S O C I E T Y F O R A P P L I E D C A R D I O V A S C U L A R B I O L O G Y

TRANSFORMING APPROACHES TO CARDIOVASCULAR HEALTH AND DISEASE:

ENABLING BIOLOGY AND ENGINEERING IN

PREVENTION, DIAGNOSIS, THERAPEUTICS AND DEVICES

2 I S A C B . O R G

BRONZE LEVEL

A Special Thank You to:

Catherine Barrett, Vasilka Saydina, Lauren Thorston, Judy Siu, Jennifer Lawtey – University of Calgary

Lisa Bowlin – ISACB

GOLD LEVEL

SESSION SPONSORS

SPONSORS

SILVER LEVEL

At Gore, we have provided creative therapeutic solutions to complex medical problems for more than 40 years. During that time, more than 40 million innovative Gore Medical Devices have been implanted, saving and improving the quality of lives worldwide. We are one of a select few companies to appear on all of the US “100 Best Companies to Work For” lists since the rankings debuted in 1984. For more information, visit www.goremedical.com.

As a global leader in medical technology, services and solutions, Medtronic improves the health and lives of millions of people each year. We believe our deep clinical, therapeutic and economic expertise can help address the complex challenges — such as rising costs, aging populations and the burden of chronic disease — faced by families and healthcare systems today. But no one can do it alone. That’s why we’re committed to partnering in new ways and developing powerful solutions that deliver better patient outcomes. Founded in 1949 as a medical repair company, we’re now among the world’s largest medical technology, services and solutions companies, employing more than 85,000 people worldwide, serving physicians, hospitals and patients in nearly 155+ countries. Join us in our commitment to take healthcare Further, Together. Learn more at Medtronic.eu.

Since 1963, Cook Medical has worked closely with physicians to develop technologies that eliminate the need for open surgery. Today, we are combining medical devices, biologic

materials, and cellular therapies to help the world’s healthcare systems deliver better outcomes more efficiently. We have always remained family owned so that we have the freedom to focus on what we care about: patients, our employees, and our communities.

Canadian Hospital Specialties is a national specialty distributor of medical and surgical products focused on strategic partnerships to enhance the experience of our

customers. Our clinical sales and marketing experience, coupled with our continued commitment to invest in new technologies, brings value to supplier partners and customers alike. Our Interventional Specialties division is devoted to the fields of Endovascular and Peripheral Arterial Disease, Interventional Cardiology, Interventional Radiology and Oncology, Ultrasound and Mammography.

3ISACB’S 15TH BIENNIAL MEETING I PROGRAM I BANFF, CANADA I SEPTEMBER 7-10, 2016

TABLE OF CONTENTS

Letters from the ISACB President and Local Organization Committee Chair .......................................................... 4-5

Committees ......................................................................................................... 6

General Information ........................................................................................... 7

The Banff Centre Map ........................................................................................ 8

Keynote Speakers ............................................................................................... 9

Partnering and Mentoring Interactive Lunch ............................................... 10

In Memoriam ..................................................................................................... 10

Pre-Meeting Workshops ....................................................................................11

ISACB 15th Biennial Meeting at a Glance.......................................................12

Meeting Program .........................................................................................13-24

Poster Presentations ................................................................................... .16-17

Poster Session ...............................................................................................18-21

Notes .................................................................................................................. 25

Past ISACB Biennial Meetings ........................................................................ 27

4 I S A C B . O R G

On behalf of the entire Executive Council of the International Society for Cardiovascular Biology (ISACB) and the local organizers of our 15th Biennial Meeting, welcome to beautiful Banff! We are pleased to be holding this meeting in such a wonderful location. Thanks to Dr. Tina Rinker for proposing this venue to the ISACB Executive Council and for following through as Meeting Chair and Local Organizing Committee Chair, leading her team of volunteers in putting together a great meeting. We owe our gratitude, too, to Dr. Glenn Gaudette for serving as Chair of the Program Committee and, with his team of topical “Leads”, fabricating an excellent, enriching program. We have implemented a lot of fresh, new ideas for the 15th Biennial Meeting that I hope provides you with an overall rewarding experience here in Banff.

I have been honored to serve as the Society’s eighth president and I am very proud of the things that the leadership of the Society has accomplished during my two terms. We have positioned ourselves to remain the go-to, small professional society that encompasses clinical translation of cutting edge cardiovascular science and technology. Reflective of this mission is the theme of this year’s meeting: “Transforming Approaches to Cardiovascular Health and Disease: Enabling Biology and Engineering in Prevention, Diagnosis, Therapeutics and Devices”. I look forward to working with incoming President, Dr. Elena Aikawa, the ISACB Executive Council and the membership in keeping ISACB on a firm trajectory.

We in ISACB have always prided ourselves in effectively facilitating communication among clinicians and academic- and industry-based scientists and engineers, and in providing a forum where trainees at all levels can meaningfully interact with established investigators in the field. I encourage you to use the networking opportunities that have been programmed into the meeting to get to know new colleagues, re-establish ties with old friends, and plant seeds for new collaborations that will lead to yet more discoveries to impact cardiovascular health.

It is altogether fitting that the Alexander Whitehill Clowes, M.D. Endowed Chair in Vascular Surgery Dr. Benjamin Starnes will be giving the “Dr. Alexander Clowes Memorial Lecture” at this meeting. We lost Alec Clowes, a founding ISACB leader and ISACB’s second president last year at a much-too-young age. Those of us who attended the 14th Biennial ISACB Meeting in 2014 will recall the youthful exuberance with which Alec delivered that meeting’s keynote lecture. We also lost Dr. Allan Callow, the Society’s first president, who also addressed the delegates at the 2014 ISACB Meeting. We will remain indebted to both of these gentle giants in our field.

I would like to acknowledge the support of all of our sponsors, particularly our two Gold Sponsors, Gore and Medtronic.

Finally, I want to have in this meeting program an indication of our Society’s deep gratitude to Dr. Steve Schmidt, our outgoing Secretary-Treasurer. I use “outgoing” in the previous sentence with a certain degree of sadness as Steve has been the lifeblood of ISACB for most of its existence. His dedication can be measured in many ways, with numerous stories of personal time and even financial investment. Steve has decided to step down as our long-time Secretary-Treasurer after this meeting, but will still serve on our 2016-2018 Executive Council. Steve, thank you from all of us for your dedication and for keeping the ISACB ship steering true!

Collegially,

David A. Vorp, Ph.D. ISACB President

MESSAGE FROM ISACB


Welcome to Banff and the 15th Biennial Meeting of the International Society for Applied Cardiovascular Biology! We are glad to see you, and know you will enjoy both the conference and the spectacular Canadian Rockies! This is the first time ISACB has come to Canada and we are proud to serve as hosts for this year’s event. The event is held at the Banff Centre, a wonderful place to foster engaging conversations, inspire creativity and relax. It is walking distance to the town of Banff, which offers shopping, recreation and dining. Banff is truly unique in the world and the birthplace of the Canada’s first national park. Be sure to take the time and enjoy all this fantastic setting has to offer. I want to thank David Vorp, the ISACB Program Committee, and the ISACB Executive Committee for their support and help in conference organization. I would also like to thank the Local Organizing Committee, Catherine Barrett and Lisa Bowlin, the host institution the University of Calgary, the Libin Cardiovascular Institute of Alberta, the Centre for Bioengineering Research and Education, and the Biomedical Engineering Graduate Program.

Best wishes,

Tina Rinker Local Organizing Committee Chair

Meeting ObjectivesThis Biennial meeting will fulfill the ISACB mission by sharing advancements in the basic sciences, engineering and clinical practices towards understanding cardiovascular health and disease and highlighting achievements in new tools and approaches for improved cardiovascular wellness worldwide. The objectives of the meeting are to:

1. Facilitate collaboration between clinicians, engineers, and scientists in advancing the treatment of cardiovascular disease

2. Increase interactions between trainees/junior investigators with senior investigators in the field of cardiovascular biology and medicine

3. Facilitate progress in cardiovascular wellness through international collaboration and integration of disciplines

MESSAGE FROM ISACB

6 I S A C B . O R G

Elena Aikawa, MD, PhDBrigham and Women’s Hospital Boston, MA USA [email protected]

Masanori Aikawa, MD, PhDBrigham and Women’s Hospital Boston, MA USA [email protected]

Gary Bowlin, PhDUniversity of Memphis Memphis, TN USA [email protected]

Luke Brewster, MD, PhDEmory University Decatur, GA USA [email protected]

Adrian Chester, MDImperial College, NHLI Harefield Hospital, Heart Science Centre Harefield, England U.K. [email protected]

Arthur Coury, PhDBoston, MA USA [email protected]

Glenn Gaudette, PhDWorcester Polytechnic Institute Worcester, MA USA [email protected]

Cecilia Giachelli, PhDUniversity of Washington Seattle, WA USA [email protected]

Jane Grande-Allen, PhDRice University Houston, TX USA [email protected]

Howard Greisler, MD (Past-President) Portland, OR USA [email protected]

Simon Hoerstrup, MD, PhDUniversity Hospital, Cardiovascular Surgery Zurich, Switzerland [email protected]

David Merryman, PhDVanderbilt University Nashville, TN USA [email protected]

Kristina Rinker, PhDUniversity of Calgary Calgary, Alberta, Canada [email protected]

Steven Schmidt, PhD (Secretary-Treasurer)Akron, OH USA [email protected]

Frederick Schoen, MD, PhD Brigham & Women’s Hospital Boston, MA USA [email protected]

Agneta Simionescu, PhDClemson University Clemson, SC USA [email protected]

Dan Simionescu, PhDClemson University Clemson, SC USA [email protected]

Janice Tsui, MDUniversity College London London, England, UK [email protected]

David Vorp, PhD (President)University of Pittsburgh Pittsburgh, PA USA [email protected]

Michael WolfMedtronic Corporation Minneapolis, MN USA [email protected]

Ajit Yoganathan, PhDGeorgia Institute of Technology Atlanta, GA USA [email protected]

Kristina Rinker, PhD MEETING CHAIR

Elena Di Martino, PhD

Paul Fedak, MD, PhD

Randy Moore, MD

Glenn Gaudette, PhD OVERALL LEAD AND LEAD FOR

INDUSTRY/TRANSLATION

Elena Aikawa, MD, PhDBASIC RESEARCH

Luke Brewster, MD, PhD CLINICAL

Jane Grande-Allen, PhDTRAINEES/EARLY CAREER

Fred Schoen, MD, PhDADVISOR

Julie Philippi, PhDWEBINARS/PODCASTS

EXECUTIVE COUNCIL

LOCAL ORGANIZING COMMITTEE

2016 MEETING PROGRAM COMMITTEE LEADS

COMMITTEES


Venue and Official LanguagePlenary Sessions (Scientific Sessions) and the Poster Session will be held in the Max Bell Building at the Banff Centre. The Gala will be in the Kinnear Centre at the Banff Centre. The official language of the meeting is English.

RegistrationRegistration will take place in the entry area of the Max Bell Building at the Banff Centre, except immediately before the Friday night Gala where the location will be at the Kinnear Centre.

Registration Hours:Wednesday September 7, 2016

12:00 PM - 7:00 PM

Thursday September 8, 2016

7:30 AM - 6:30 PM

Friday September 9, 2016

7:15 AM – 11:30 AM

5:30-6:30 PM (at Kinnear Centre)

Saturday September 10, 2016

7:30 AM - 9:00 AM

Travel Award Winners:Mohamed Elkhodiry

Darren Haskett

Salma Ayoub

Joshua Gershlak

Evan Phillips

Ayeeshik Kole

William Poulson (declined)

Travel Award Sponsors:Dr. and Mrs. David Vorp

The Coury Family Fund

Medtronic, Inc

Steven P. Schmidt, PhD

Friends of ISACB

Abstract reviewers:Glenn Gaudette

Jane Grande-Allen

Elena Aikawa

Luke Brewster

Tina Rinker

Steven Schmidt

Frederick Schoen

Michael Wolf

Howard Greisler

Julie Phillippi

Joshua Hutcheson

Joshua Gershlak

Justin Weinbaum

Awards Committee:Jane Grande-Allen (Chair)

Dan Puperi

Luke Brewster

Frederick Schoen

Julie Phillippi

Elena Aikawa

GENERAL INFORMATION

8 I S A C B . O R G

KINNEAR CENTER FOR CREATIVITY & INNOVATION

MAX BELL BUILDING MAIN FLOOR

THE BANFF CENTRE


Thursday September 8

11:30-12:30

Benjamin W. Starnes, M.D. FACSDr. Starnes is a Professor of Vascular Surgery, Chief of the Division of Vascular Surgery and Vice Chair of the Department of Surgery for UW Medicine. He is recognized nationally and internationally for his work in aortic pathology and vascular trauma, most notably the management of ruptured abdominal aortic aneurysms and acute aortic syndromes. Dr. Starnes received his undergraduate degree at Albright College in Reading, PA, his medical degree at Jefferson Medical College in Philadelphia and completed his surgical training at Walter Reed in Washington, D.C. Prior to accepting his position at the UW, Dr. Starnes spent 15 years in the United States Army serving three combat tours. Dr. Starnes’ current research activities focus on multi-branch and fenestrated endografting for complex aortic disease, vascular trauma and studying factors that influence outcomes for patients presenting with ruptured abdominal aortic aneurysm. He is an Investigator on 32 clinical trials, 10 of which he is the Principal Investigator. He has accepted fifteen national visiting professorships and lectured internationally in thirteen different countries including France, Belgium, Australia, the United Kingdom, Brazil and China. He has over eighty peer-reviewed publications with a quarter as first author and written five book chapters. He is an editor for The Journal of Vascular Surgery, Circulation, New England Journal of Medicine and Lancet. He is current President of the Pacific Northwest Vascular Surgery Society. In addition he served as an Associate Examiner of the American Board of Surgery Vascular Surgery Certifying Examination in 2012 and as an Examiner in 2014.

Gala Keynote Speaker

Friday September 9

Stuart Hutchinson MD, FRCPC, FACC, FAHA, FASE, FSCMRDr. Hutchison is a Clinical Professor of Medicine in the Departments of Cardiac Sciences, Internal Medicine, and Radiology at the University of Calgary, and is a member of the Libin Institute and Stephenson Cardiovascular MRI Center. He was educated in Cardiology at McGill University, acquired further sub-specialty training at the University of Southern California and at vascular physiology / pharmacology research fellowship at the CardioVascular Research Institute of the University of California at San Francisco. He was the Director of Echocardiography at St. Michael’s Hospital at the University of Toronto for a decade before moving to Calgary in 2008. He has written 80 articles, 15 book chapters, 72 abstracts, and 7 books with an 8th book in development, with interests in aortic diseases, pericardial diseases, complications of infarction, and multi-modality cardiac imaging. He has received Provincial Excellence in Teaching awards (PAIRO and PAIRA). An avid sportsman, he has run twenty marathons, cycled through Europe and climbed the tallest peaks in the world across three continents. Having scaled the likes of K2 and having been within a few hundred feet of the summit of Mount Everest on his second expedition there, he points to some of the tallest in North America as his favorites and the scaling of Cho Oyo, the sixth tallest worldwide, as the most satisfying.

KEYNOTE SPEAKERS

10 I S A C B . O R G

IN-MEMORIAM

Dr. Allan CallowWe regret to announce the sad news that our friend and colleague Dr. Allan Callow, MD, PhD, passed away on December 22, 2015.

Allan was key to the inception of ISACB in 1987 and served as the Society’s founding President from 1989-1992. At the April, 2014 ISACB Biennial meeting in Cleveland, he was honored by having the ISACB Young Investigator Awards named after him.

We are indebted to Allan and will miss him greatly.

Dr. Alec ClowesIt is with great sadness that we announce the news that our friend and colleague, Dr. Alexander (Alec) Whitehall Clowes, passed away on July 7, 2015.

Alec was a key contributor to ISACB since its inception in 1987 and served as the Society’s 2nd president from 1992-1994. At the April, 2014 ISACB Biennial Meeting in Cleveland, he was honored as the featured keynote speaker.

We will remain indebted to the vast knowledge left behind by Alec and will greatly miss the amazing human being that he was.

Partnering and Mentoring Interactive Lunch

Thursday September 8 12:30-1:30Vistas Dining Room

Have career related questions or inquiries for conference speakers? Join conference speakers, industry representatives, and members of the ISACB Executive Council to discuss issues facing us today from career startup to constructing a powerful mentoring network to research translation, technology development and commercialization and women in science.

Participating leaders include ISACB President David Vorp (University of Pittsburgh) and President-Elect Elena Aikawa (Brigham and Women’s Hospital), Jane Grande-Allen (Rice), Mike Wolf (Medtronic), Glenn Gaudette (WPI), Fred Schoen (Brigham and Women’s Hospital), Rachael Hagen (Coulter Translational Partnership Emory/GA Tech), Rifat Pamukcu (Midway Pharmaceuticals) and many others.


1:00-3:00

Developing a TEDMED-Style Research Presentation Organizers: Jane Grande-Allen, PhD (Rice University) and Dianna Milewicz, MD, PhD (University of Texas Medical School)

Have you been inspired by the personal, compelling nature of TED and TEDMED talks? Do you wish you could present your work in a way that connects with your audience and distills your work into an uplifting story with lasting impact? Think how helpful this skill would be in explaining your research to your friends, family, potential employers, or a funding agency! The compelling nature of TED and TEDMED talks is not due to the inherent skills of the speaker. These skills are learned, but you have to start somewhere.

In this interactive workshop, trainees will take their presentation / research concepts through a transformation using the principles and instructions given to actual TEDMED and TED speakers, as described in the new book “TED Talks: The Official TED Guide to Public Speaking”. This interactive workshop will cover how to shape your message and how to deliver this message effectively on stage. At the end of the workshop, trainees will have the opportunity to present key aspects of their message.

PRE-MEETING WORKSHOPS

These workshops require separate registration from the regular conference.

3:15-5:45

Genomics and Epigenetics in a Dynamic Environment: Concepts, Techniques and Applications in MedicineSponsored by: The Alberta Epigenetics Network

Chairs: Francois Bernier, Steven Greenway, and Deborah Studer

Presenters: Francois Bernier, MD (University of Calgary), Igor Kovalchuk, MD, PhD (University of Lethbridge), Olga Kovalchuk, MD, PhD (University of Lethbridge), Steven Greenway, MD, MSc (University of Calgary), Richard Leask, PhD (McGill University), and Dianna Milewicz, MD, PhD (University of Texas Medical School)

This workshop brings together a great team of experts to present current concepts, techniques and applications in ‘omics and epigenetics. Current technologies, advanced biomarkers, mechanobiology influences, applications in cancer and cardiovascular systems, and factors important for development of new technologies and successful translation to the clinic will be included, culminating in a presentation by Dianna Milewicz.

Dianna M. Milewicz, M.D. Ph.D., is the President George H.W. Bush Chair of Cardiovascular Medicine, Director of the Division of Medical Genetics and Vice-Chair of the Department of Internal Medicine at the University of Texas Medical School at Houston. She completed her postgraduate training in internal medicine, specialized further in medical genetics, and forged a career in translational studies focused on genetic predisposition to vascular diseases. She has received numerous honors and awards for her research, including the Antoine Marfan Award, the Doris Duke Distinguished Clinical Scientist Award, and the University of Texas Presidential Scholars Award for Excellence in Research. She has been inducted into the American Society of Clinical Investigation and the Association of American Physicians. Dr. Milewicz has been the Director of the M.D./Ph.D. Program offered jointly between the University of Texas Health Science Center at Houston and MD Anderson Cancer Center institutions for over 10 years and is Chair of the GREAT MD/PhD Section Committee.

Wednesday September 7 Max Bell 253 Banff Centre


Wednesday, September 7

10:00–12:30

ISACB Executive Committee Meeting

Executive Committee Members Only

Max Bell 251

1:00–3:00

Pre-Meeting Workshop: Developing a TEDMED-Style Research Presentation, Max Bell 253

3:15–5:45

Pre-Meeting Workshop: Genomics and Epigenetics in a Dynamic Environment: Concepts, Techniques and Applications in Medicine

Max Bell 253

6:00–8:00

Welcome Reception, Max Bell Building

8:00 Dinner on own

Thursday, September 8

6:45–7:45

Breakfast-Vistas Dining Room

7:45–8:10

Introduction to ISACB and the Meeting

8:10–11:30

Arterial Remodeling: Bridging Molecular Mechanisms and Arterial Mechanics

11:30–12:30

Dr. Alexander Clowes Memorial Lecture

Keynote Speaker: Ben Starnes, MD

Alexander Whitehill Clowes, MD Endowed Chair in Vascular Surgery

12:30–1:30

Partnering and Mentoring Interactive Lunch- Vistas Dining Room

1:30–3:20

Technology Translation and Commercialization I

3:40–6:15

Valvular Heart Disease

6:30–7:30

Allan Callow Young Investigator Award Finalists – Rapid Poster Presentations

6:30-8:30

Poster Presentations & Reception

8:30 Dinner on own

Friday, September 9

7:00–8:00


8:00–10:40

Frontiers in Heart Failure, Cardiac Assist and Regeneration

11:15–12:15

Technology Translation and Commercialization II

12:15- Lunch

Vistas Dining Room Bag Lunch for Excursion Registrants, or on own

12:15–6:15

Excursions

6:30–11:00

Gala including Keynote Speaker Stuart Hutchison, MD

Saturday, September 10

7:00–8:00


7:30-8:00

ISACB Members Meeting-All invited

8:00–11:30

Platform Technologies & Biomaterials

11:45–12:00

ISACB Meeting Awards

12:00-1:00:

Panel Discussion: Where do we go from here?

1:00 End of conference

MEETING AT A GLANCE


Wednesday, September 7

10:00-12:30

ISACB Executive Committee Lunch Meeting,

Max Bell 251

(Closed, for Executive Council members only)

1:00-3:00

Workshop: Developing a TEDMED Style Research Presentation

Organizers: Jane Grande-Allen and Dianna Milewicz

Max Bell 253

3:15-5:45

Workshop: Genomics and Epigenetics in a Dynamic Environment: Concepts, Techniques and Applications in Medicine

Chairs: Francois Bernier, Steven Greenway and Deborah Studer

Max Bell 253

Presenters: Francois Bernier, Igor Kovalchuk, Olga Kovalchuck, Steven Greenway, Richard Leask, Dianna Milewicz

6:00-8:00

Welcome Reception

Max Bell Building

Thursday, September 8

7:45-8:10

Welcome to ISACB 2016

Max Bell Auditorium

Kristina Rinker, Ph.D., Local Arrangements Chair

David A. Vorp, Ph.D., ISACB President

Elena Aikawa, M.D., Ph.D., ISACB President-Elect

Arterial Remodeling: Bridging Molecular Mechanisms and Arterial Mechanics Max Bell Auditorium

Chairs: Craig Goergen and Luke Brewster

8:10-8:40

Macrophage Activation in Vascular Disease: Multidisciplinary Target Discovery Research

Masanori Aikawa, MD, PhD Invited Speaker Harvard Medical School/BWH

8:40-8:55

Smad2 – a novel regulator of vascular inflammation

Deborah Studer (University of Calgary), Linda Tamez (University of Calgary), Kenneth Fuh (University of Calgary), Robert Shepherd (University of Calgary), Randy Moore (University of Calgary), Kristina Rinker (University of Calgary)

8:55-9:10

Effect of Ageing on Arterial Stresses Due to Limb Flexion

Anastasia Desyatova (University of Nebraska Medical Center), William Poulson (University of Nebraska Medical Center), Paul Deegan (University of Nebraska Medical Center), Carol Lomneth (University of Nebraska Medical Center), Jason Mactaggart (University of Nebraska Medical Center), Alexey Kamenskiy (University of Nebraska Medical Center)

9:10-9:40

Heat Shock Protein 27: Novel Therapy for Modulating Atherosclerosis

Edward O’Brien, MD Invited Speaker University of Calgary

9:40-9:55

ALLAN CALLOW YOUNG INVESTIGATOR AWARD FINALIST

Sortilin – a Novel Regulator of Microcalcification - Associates with Cardiovascular Risk in Humans

Claudia Goettsch (Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women’s Hospital, Harvard Medical School), Joshua Hutcheson (Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women’s

MEETING PROGRAM

http://programme.exordo.com/isacb2016/delegates/keynote/3/


http://programme.exordo.com/isacb2016/delegates/presentation/39/









Hospital, Harvard Medical School), Sasha Singh (Brigham and Women’s Hospital), Hiroshi Iwata (Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women’s Hospital, Harvard Medical School), Sumihiko Hagita (Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women’s Hospital, Harvard Medical School), Peter Libby (Brigham and Women’s Hospital, Harvard Medical School), Pawel Szulc (University of Lyon), Masanori Aikawa (Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women’s Hospital, Harvard Medical School), Elena Aikawa (Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women’s Hospital, Harvard Medical School)

9:55-10:10

In Vitro And In Vivo Disease Modeling Using Patient-Derived iPSCs To Characterize The Calcification Phenotype In Arterial Calcification Due To Deficiency of CD73 (ACDC)

Cynthia St. Hilaire (University of Pittsburgh), Hui Jin (NHLBI), Yuting Huang (NHLBI), Dan Yang (NHLBI), Natalia Dmitrieva (NHLBI), Alejandra Negro (NHLBI), Danielle Donahue (NHLBI), William Gahl (NHGRI), Guibin Chen (NHLBI), Manfred Boehm (NHLBI)

10:10-10:30 Break

10:30-11:00

Bioengineering and the Vascular Clinician

Randy Moore, MD Invited Speaker University of Calgary; Alberta Health Services

11:00-11:15

Viscoelastic Material Properties of Human Thoracic and Abdominal Aortic Aneurysmal Tissue

Doran Mix (University of Rochester Medical Center), Ibrahima Bah (University of Rochester Medical Center), Sandra Toth (University of Rochester Medical Center), Michael Stoner (University of Rochester Medical Center), Jennifer Ellis (University of Rochester Medical Center), Roan Glocker (University of Rochester Medical Center), Peter Knight (University of Rochester Medical Center), Mark Buckely (University of Rochester Medical Center), Michael Richards (University of Rochester Medical Center)

11:15-11:30


Adipose-derived Mesenchymal Stem Cells Stimulate Elastin Production by Adult Human Smooth Muscle Cells in a 3D Fibrin Scaffold

Kory Blose (University of Pittsburgh), Justin Weinbaum (University of Pittsburgh), David Vorp (University of Pittsburgh)

KEYNOTE SPEAKER

Dr. Alexander Clowes Memorial LectureMax Bell Auditorium Chair: Luke Brewster

11:30-12:30

Innovative Device and Design Solutions for Aortic Pathology and Vascular Trauma

Benjamin Starnes, MD, U of Washington

Alexander Whitehill Clowes, MD Endowed Chair in Vascular Surgery

Partnering and Mentoring LunchVistas Dining Room 12:30-1:30

Technology Translation and Commercialization I Max Bell AuditoriumChairs: Jane Grande-Allen and Dan Simionescu

1:30-2:00

Enhancing the Medical Products Innovation Pipeline: Challenges, Strategies and Implications

Frederick Schoen, MD, PhD Invited Speaker Harvard Medical School

2:00-2:15


Detection of Lipid-Laden Plaques by Intravascular Ultrasound and Photoacoustic Dual-Modality Imaging

Ayeeshik Kole (Indiana University School of Medicine), Yingchun Cao (Purdue University), Jie Hui (Purdue University), Pu Wang (Purdue University), Islam Bolad (Indiana University School of Medicine), Ji-Xin Cheng (Purdue University), Michael Sturek (Indiana University School of Medicine)

MEETING PROGRAM

















2:15-2:30

Gated Volumetric Ultrasound Imaging of Cardiac and Vascular Dynamics

Craig Goergen (Purdue University)

2:30-3:20

Panel: Translating Research Discoveries into Products

Rachael Hagan, Rifat Pamukcu, Shawna Hagen, Rebecca Levit

3:20-3:40 Break

Valvular Heart Disease Chairs: Elena Aikawa and Joshua Hutcheson

Max Bell Auditorium

3:40-4:10

Bicuspid Aortic Valve Aortopathy: Evolution Toward Individualized Surgical Resection Strategies

Paul Fedak, MD, PhD Invited Speaker University of Calgary

4:10-4:25

Bioactive Vascular ECM Hydrogels Improve Endothelial Cell Function

Julie Phillippi (University of Pittsburgh), George Fercana (University of Pittsburgh), Jennifer Hill (University of Pittsburgh), Marie Billaud (University of Pittsburgh), Tara Richards (University of Pittsburgh), Stephen Badylak (University of Pittsburgh), Thomas Gleason (University of Pittsburgh)

4:25-4:40

Regeneration of acellularized porcine pulmonary valve in presence of fucoidan and VEGF: biological prosthesis construction ready for transplantation

Nicolas Marinval (Laboratory for Vascular Translational Science, Inserm U1148, Hôpital Xavier Bichat, Paris, France / Institut Galilée, University Paris 13, Sorbonne Paris Cité, France), Malgorzata Morenc (Bioengineering Laboratory, Heart prosthesis institute, Zabrze, Poland / University of Silesia, Katowice, Poland), Nathalie Charnaux (Laboratory for Vascular Translational Science, Inserm U1148, Hôpital Xavier Bichat, Paris / Institut

Galilée, University Paris 13, Sorbonne Paris Cité / Laboratory of biochemistry, Hôpital Jean Verdier, Bondy, France.), Piotr Wilczek (Bioengineering Laboratory, Heart prosthesis institute, Zabrze, Poland / University of Silesia, Katowice, Poland), Hanna Hlawaty (Laboratory for Vascular Translational Science, Inserm U1148, Hôpital Xavier Bichat, Paris, France / Institut Galilée, University Paris 13, Sorbonne Paris Cité)

4:40-5:00 Break

5:00-5:30

The role of Sox9 in the onset, progression and treatment of Calcific Aortic Valve Disease

Joy Lincoln, PhD Invited Speaker Nationwide Children’s Hospital/ Ohio State University

5:30-5:45

Regenerative Potential of Autologous Stem Cell Seeded, Polyphenol-Stabilized Acellular Valve Scaffolds in the Juvenile Sheep Model

Marius Harpa (University of Medicine and Pharmacy Targu Mures), Ionela Movileanu (University of Medicine and Pharmacy Targu Mures), Leslie Sierad (Aptus Bioreactors Inc), Ovidiu Cotoi (University of Medicine and Pharmacy Targu Mures), Horatiu Suciu (University of Medicine and Pharmacy Targu Mures), Terezia Preda (University of Medicine and Pharmacy Targu Mures), Dan Nistor (University of Medicine and Pharmacy Targu Mures), Klara Branzaniuc (University of Medicine and Pharmacy Targu Mures), Radu Deac (University of Medicine and Pharmacy Targu Mures), Simona Gurzu (University of Medicine and Pharmacy Targu Mures), Lucian Harceaga (University of Medicine and Pharmacy Targu Mures), Loredana Harpa (University of Medicine and Pharmacy Targu Mures), Peter Olah (University of Medicine and Pharmacy Targu Mures), Nicoleta Suciu (University of Medicine and Pharmacy Targu Mures), Carmen Sircuta (University of Medicine and Pharmacy Targu Mures), Aggie Simionescu (Clemson University), Michael Dandel (University of Medicine and Pharmacy Targu Mures), Dan Simionescu (Clemson University)

MEETING PROGRAM















5:45-6:00

Vascular remodeling of a novel absorbable polymeric conduit by endogenous cells: First results in the ovine systemic circulation

Fred Schoen (Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA), Marieke Brugmans (Xeltis BV, Eindhoven), Oleg Svanidze (Xeltis BV, Eindhoven), Martin Cox (Xeltis BV, Eindhoven)

6:00-6:15

In in-situ approach to estimate the layer-specific biophysical state of aortic valve interstitial cells

Michael Sacks (University of Texas at Austin), Rachel Buchanan (University of Texas at Austin)

6:15-6:30 Break

Allan Callow Young Investigator Finalist – Rapid Poster PresentationsChair: Jane Grande-Allen, PhD

Max Bell 253

6:30-6:35 P1

Unraveling the controversy of bisphosphonates as vascular calcification therapy using a nanoanalytical approach, Jessica L Ruiz (Brigham and Women’s Hospital, Harvard Medical School), Joshua D Hutchesson (Brigham and Women’s Hospital, Harvard Medical School), Elena Aikawa (Brigham and Women’s Hospital, Harvard Medical School)

6:35-6:40 P2

Crossing Kingdoms: Exploiting Decellularized Plants as Pre-Vascularized Scaffolds for Tissue Engineering, Joshua Gershlak (WPI), Sarah Hernandez (WPI), Gianluca Fontana (University of Wisconsin), Luke Perreault (WPI), Sara Larson (WPI), Tianhong Yang (Arkansas State University), Tanja Dominko (WPI), K M (WPI), Marsha Rolle (WPI), Pamela Weathers (WPI), Fabricio Medina-Bolivar (Arkansas State University), J F (WPI), Carole Cramer (Arkansas State University), William Murphy (University of Wisconsin), Glenn Gaudette (WPI)

6:40-6:45 P3

Cadherin-11 blocking antibody treatment improves outcomes in mice after myocardial infarction, Alison Schroer (Vanderbilt University), W. David Merryman (Vanderbilt University)

6:45-6:50 P4

Acellular Matrix Biomaterial Promotes Vasculogenesis and Cardiac Repair: Evidence of a Bioinductive FGF-2-dependent Mechanism, Daniyil Svystonyuk (University of Calgary), Holly Mewhort (University of Calgary), Jeannine Turnbull (University of Calgary), Guoqi Teng (University of Calgary), Darrell Belke (University of Calgary), David Guzzardi (University of Calgary), Daniel Park (University of Calgary), Sean Kang (University of Calgary), Paul Fedak (University of Calgary)

6:50-6:55 P5

Linking Layer-Specific Mitral Valve Interstitial Cell Deformation to Biosynthetic Response: Implications for Mitral Valve Repair, Salma Ayoub (The University of Texas at Austin), Chung-hao Lee (The University of Texas at Austin), Kathryn Driesbaugh (University of Pennsylvania), Wanda Anselmo (University of Pennsylvania), Connor Hughes (The University of Texas at Austin), Giovanni Ferrari (University of Pennsylvania), Michael Sacks (The University of Texas at Austin)

6:55-7:00 P6

Nanoparticle localization in blood vessels: the effect of vascular flow, Juliana Gomez (University of Calgary), Amber Doiron (Binghampton University), Bahareh Vafadar (Zymetrix, University of Calgary), David Cramb (University of Calgary), Sarah Childs (University of Calgary), Kristina Rinker (University of Calgary)

7:00-7:05 P7

Absence of a J-wave may be predictive of worse outcomes during therapeutic hypothermia in post cardiac arrest patients, Mohammed Alshehri (Libin Cardiovascular Institute of Alberta), Lisa Semeniuk (Libin Cardiovascular Institute of Alberta), Derek Exner (Libin Cardiovascular Institute of Alberta), Andrew Mardell (Libin Cardiovascular Institute of Alberta), David Zygun (university of alberta), Robert Sheldon (Libin Cardiovascular Institute of Alberta), Shiva Wagle (Libin Cardiovascular Institute of Alberta), Gregory Schnell (Libin Cardiovascular Institute of Alberta), Henry Duff (Libin Cardiovascular Institute of Alberta)

POSTER PRESENTATIONS



























7:05-7:10 P8

Longitudinal visualization of calcification genesis and growth in vivo: novel implications for plaque vulnerability, Joshua Hutcheson (Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women’s Hospital, Harvard Medical School), Claudia Goettsch (Center for Interdisciplinary Cardiovascular Sciences, Brigham and Women’s Hospital, Harvard Medical School), Masanori Aikawa (Brigham and Women’s Hospital), Elena Aikawa (Brigham and Women’s Hospital, Harvard Medical School)

7:10-7:15 P9

Towards a “Same-Day” Autologous Tissue-Engineered Vascular Graft: Seeding and Implantation of an Elastomeric Scaffold with the Stromal Vascular Fraction, Darren Haskett (University of Pittsburgh), Kamiel Saleh (University of Pittsburgh), Jeffrey Krawiec (University of Pittsburgh), Justin Weinbaum (University of Pittsburgh), Antonio D’amore (University of Pittsburgh), William Wagner (University of Pittsburgh), Lauren Kokai (University of Pittsburgh), J. Peter Rubin (University of Pittsburgh), David Vorp (University of Pittsburgh)

7:15-7:20 P10

Cadherin-11 Loss Prevents Contraction in Aortic Valve Interstitial Cells, Meghan Bowler (Vanderbilt University), W. David Merryman (Vanderbilt University)

7:20-7:25 P11

Vessel wall heterogeneity is an important factor in abdominal aortic aneurysm rupture risk prediction, Giampaolo Martufi (University of Calgary), Arianna Forneris (University of Calgary), Samaneh Nobakht (University of Calgary), Randy Moore (University of Calgary), Kristina Rinker (University of Calgary), Elena Di Martino (University of Calgary)

7:25-7:30 P12

Predicting Thrombus Formation in Patients with Internal Carotid Artery Webs, Syedah Salwa Ali (University of Calgary), Elena Di Martino (Zymetrix, University of Calgary), Alim P. Mitha (Libin Cardiovascular Institute of Alberta)

7:30-7:35 P13

Withdrawn

The role of fibroblast-specific canonical TGF-beta signaling in cardiac fibrosis, Hadi Khalil (Cincinnati Children’s Hospital Medical center), Onur Kanisicak (Cincinnati Children’s Hospital Medical center), Ruijie Liu (Cincinnati Children’s Hospital Medical center), Tobias Schips (Cincinnati Children’s Hospital Medical center), Nathan Correll (Cincinnati Children’s Hospital Medical center), Jeffery Molkentin (Cincinnati Children’s Hospital Medical center)

MEETING PROGRAM


















Poster Session

Chair: Glenn Gaudette

Max Bell 252

6:30-8:30

P14. Early development in a murine model of abdominal aortic aneurysms, Evan Phillips (Purdue University), Ryan Grant (Purdue University), Craig Goergen (Purdue University)

P15. Structural modeling of ascending thoracic aortic wall tissue indicates locally elevated biomechanical stresses in regions of collagen fiber disruption, James Thunes (Department of Bioengineering, University of Pittsburgh), Julie Phillippi (Department of Cardiothoracic Surgery, Center for Vascular Remodeling and Regeneration, University of Pittsburgh), Thomas Gleason (Department of Cardiothoracic Surgery, Center for Vascular Remodeling and Regeneration, University of Pittsburgh), David Vorp (Department of Bioengineering, Department of Cardiothoracic Surgery, Center for Vascular Remodeling and Regeneration, University of Pittsburgh), Spandan Maiti (Department of Bioengineering, University of Pittsburgh)

P16. Utility of Stem Cell-Derived Smooth Muscle Cells for Elastin Regenerative Repair in Aortic Aneurysms, Shataakshi Dahal (Cleveland Clinic), Ganesh Swaminathan (Cleveland Clinic), Tom Broekelmann (Washington University at St. Louis), Robert Mecham (Washington University at St. Louis), Anand Ramamurthi (Cleveland Clinic)

P17. Clinical, Computational, and Experimental Studies of Fenestrated Aortic Stent Graft Rotation, Matthew Doyle (University of Toronto), Ryan Sanford (University of Toronto), Sean Crawford (University of Toronto), Cristina Amon (University of Toronto), Thomas Forbes (University of Toronto)

P18. Arterial Remodeling in Cell-free, Fast-degrading Vascular grafts using a Rat Carotid Artery Interposition Model, Keewon Lee (University of Pittsburgh), Liwei Dong (University of Pittsburgh), Piyusha Gade (University of Pittsburgh), Muhammad Nisar (University of Pittsburgh), Kang Kim (University of Pittsburgh), Anne Robertson (University of Pittsburgh), Mario Solari (University of Pittsburgh), Yadong Wang (University of Pittsburgh)

P19. Longitudinal Evaluation of Biomechanical Properties of Neoarteries Formed Through Degrading Tissue Engineered Vascular Grafts, Piyusha Gade (University of Pittsburgh), Keewon Lee (University of Pittsburgh), Liwei Dong (University of Pittsburgh), Yadong Wang (University of Pittsburgh), Anne Robertson (University of Pittsburgh)

P20. Novel PPAR α selective agonist K-877 suppresses pro-inflammatory macrophage activation and arterial lesion formation, Hiroshi Iwata (Brigham and Women’s Hospital, Harvard Medical School), Kentaro Murakami (Brigham and Women’s Hospital, Harvard Medical School), Amitabh Sharma (Brigham and Women’s Hospital, Harvard Medical School), Sasha Singh (Brigham and Women’s Hospital, Harvard Medical School), Elena Aikawa (Brigham and Women’s Hospital, Harvard Medical School), Masanori Aikawa (Brigham and Women’s Hospital)

P21. The Effects Of Circulating Endothelial Progenitor Cell And Platelet Microparticle Administration On Platelet-Endothelial Progenitor Cell Interplay In Atherosclerotic Disease, Nicoleta Alexandru (Institute of Cellular Biology and Pathology ‘Nicolae Simionescu’ of the Romanian Academy, Bucharest, Romania), Eugen Andrei (Institute of Cellular Biology and Pathology ‘Nicolae Simionescu’ of the Romanian Academy, Bucharest, Romania), Emanuel Dragan (Institute of Cellular Biology and Pathology ‘Nicolae Simionescu’ of the Romanian Academy, Bucharest, Romania), Violeta Ristoiu (Faculty of Biology,University of Bucharest, Bucharest, Romania), Adriana Georgescu (Institute of Cellular Biology and Pathology ‘Nicolae Simionescu’ of the Romanian Academy, Bucharest, Romania)

POSTER SESSION





























P22. Circulating endothelial progenitor cells of healthy origins and platelet microparticles of hypertensive-hypercholesterolemic origins play opposite roles in atherosclerosis development, Adriana Georgescu (Institute of Cellular Biology and Pathology ‘Nicolae Simionescu’ of Romanian Academy, Bucharest, Romania), Nicoleta Alexandru (Institute of Cellular Biology and Pathology ‘Nicolae Simionescu’ of Romanian Academy, Bucharest, Romania), Eugen Andrei (Institute of Cellular Biology and Pathology ‘Nicolae Simionescu’ of Romanian Academy, Bucharest, Romania), Emanuel Dragan (Institute of Cellular Biology and Pathology ‘Nicolae Simionescu’ of Romanian Academy, Bucharest, Romania), Sérgio Dias (Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal)

P23. A Role for Thrombospondin-1 in Arterial Remodeling under Altered Wall Shear Stress, Luke Brewster (Emory University), Lucas Timmins (Emory University), Anastassia Pokutta-Paskaleva (Emory University)

P24. Femoropopliteal artery calcification is associated with ageing, diabetes, elastin fiber degradation, and anisotropic stiffening, Austin Reilly (University of Nebraska Medical Center), William Poulson (University of Nebraska Medical Center), Sylvie Sim (University of Nebraska Medical Center), Paul Deegan (University of Nebraska Medical Center), Alexey Kamenskiy (University of Nebraska Medical Center), Jason Mactaggart (University of Nebraska Medical Center)

P25. Role of Aging and Exercise on Arterial Remodeling in Mice, Luke Brewster (Emory University), Andrew Morris (Emory University), Lucas Timmins (Emory University), Anastassia Pokutta-Paskaleva (Emory University)

P26. Constitutive description of human femoropopliteal artery ageing, Alexey Kamenskiy (University of Nebraska Medical Center), Andreas Seas (University of Maryland, Baltimore County), William Poulson (University of Nebraska Medical Center), Paul Deegan (University of Nebraska Medical Center), Sylvie Sim (University of Nebraska Medical Center), Anastasia Desyatova (University of Nebraska Medical Center), Jason Mactaggart (University of Nebraska Medical Center)

P27. Cellular and extracellular modifications induced by diabetic conditions in tissue engineered blood vessels, Aggie Simionescu (Clemson University), Jhilmil Dhulekar (Clemson University), Dan Simionescu (Clemson University)

P28. Reconstruction of Tumor Educated Vascular Network on Gelatin Methacrylate Microfluidic Chips, Shirin Soleimani (University of Calgary), Amir Sanati Nezhad (University of Calgary)

P29. Endothelial Cell Mechanobiology: The role of the glycocalyx in MMP regulation and leukocyte attachment, Karli Mcdonald (McGill University), Scott Cooper (McGill), Alexander Emmott (McGill University), Lisa Danielczak (McGill University), Richard Leask (McGill University)

P30. Fluid Flow Magnitude Impacts Nanoparticle Interactions with Endothelial Cells in Angiogenic Vessels, Christopher Sarsons (University of Calgary), Sean Jiang (University of Calgary), Juliana Gomez (University of Calgary), Hagar Labouta (University of Calgary), Bahareh Vafadar (University of Calgary), David Cramb (University of Calgary), Sarah Childs (University of Calgary), Kristina Rinker (University of Calgary)

P31. 3D vascular system on chip for the study of atherosclerosis, Sultan Khetani (University of Calgary), Amir Sanati Nezhad (University of Calgary)

POSTER SESSION
































P32. Improving the Re-endothelialization of Vascular Substitutes via Peptide-based Endothelial Progenitor Cells Recruitment, Mohamed Elkhodiry (McGill University), Mariève Boulanger (McGill University), Jonathan Brassard (McGill University), Jean-françois Tanguay (Montreal Heart Institute), Gaétan Laroche (Université Laval), Corinne Hoesli (McGill University)

P33. Gene Expression Changes in Human Dermal Fibroblasts Exposed to Fluid Flow, Nikita Zabinyakov (University of Calgary), Deborah Studer (University of Calgary), Robert Shepherd (University of Calgary), Kristina Rinker (University of Calgary)

P34. The influence of cellular and extracellular perturbations on cardiomyocyte contractility, Noortje Bax (Eindhoven University of Technology), Ariane Van Spreeuwel (Eindhoven University of Technology), Carlijn Bouten (Eindhoven University of Technology)

P35. Innovative prevascularization model for improving transplantation of human stem cell derived cardiomyocytes, Xuetao Sun (Toronto General Research Institute, University Health Network), Sara Nunes de Vasconcelos (Toronto General Research Institute, University Health Network; Institute of Biomaterials and Biomedical Engineering, University of Toronto; Heart & Stroke/Richard Lewar Centre of Excellence, University of Toronto)

P36. Towards Improved Understanding and Treatment of Failing Fontan Circulation, Matthew Doyle (University of Toronto), S. Lucy Roche (University of Toronto), Osami Honjo (University of Toronto), Thomas Forbes (University of Toronto), Cristina Amon (University of Toronto)

P37. Design of a Fibrin Microthread Composite Layer for Use in a Modular Cardiac Patch, Megan O’Brien (Worcester Polytechnic Institute), Maria Vratsanos (Worcester Polytechnic Institute), Marianne Kanellias (Worcester Polytechnic Institute), Katrina Hansen (Worcester Polytechnic Institute), Joshua Gershlak (Worcester Polytechnic Institute), Glenn Gaudette (Worcester Polytechnic Institute), George Pins (Worcester Polytechnic Institute)

P38. Surgical Application of a Novel Biomaterial Enhances Post-MI Functional Recovery by Stimulating Vasculogenesis Through an Active Bio-Inductive Mechanism, Holly Mewhort (University of Calgary), Jeannine Turnbull (University of Calgary), Guoqi Teng (University of Calgary), Darrell Belke (University of Calgary), Daniyil Svystonyuk (University of Calgary), David Guzzardi (University of Calgary), Daniel Park (University of Calgary), Sean Kang (University of Calgary), Paul Fedak (University of Calgary)

P39. Minimally Invasive Delivery of Hydrogels to the Heart, Rebecca Levit (Emory University), Peter Campbell (Innovatië LifeSciences), Gautam Kumar (Emory)

P40. Optical Method to Quantify Mechanical Contraction and Calcium Transients of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes, Katrina Hansen (Worcester Polytechnic Institute), John Favreau (Worcester Polytechnic Institute), Dirk Albrecht (Worcester Polytechnic Institute), Michael Laflamme (Torontal General Research Institute, University Health Network), Glenn Gaudette (Worcester Polytechnic Institute)

P41. Expression and Role of Lubricin in the Human Pericardium: Implications as a Therapeutic to Prevent Post-Operative Adhesions, Daniel Park (University of Calgary), Suresh Regmi (University of Calgary), Daniyil Svystonyuk (University of Calgary), Darrell Belke (University of Calgary), Guoqi Teng (University of Calgary), Holly Mewhort (University of Calgary), David Guzzardi (University of Calgary), Sean Kang (University of Calgary), Tannin Schmidt (University of Calgary), Paul Fedak (University of Calgary)

P42. Apoptotic Activity in Valvular Interstitial Cell Aggregates Corresponds to Low Cell Stress, Heather Cirka (Worcester Polytechnic Institute), Vivian Liang (Worcester Polytechnic Institute), Sina Askarinejad (Worcester Polytechnic Institute), Nima Rahbar (Worcester Polytechnic Institute), Kristen Billiar (Worcester Polytechnic Institute)

POSTER SESSION


































P43. Stress fiber contractile behaviors in aortic valve interstitial cells, Michael Sacks (University of Texas at Austin), Yusuke Sakamoto (University of Texas at Austin)

P44. Evidence for Interstitial Cell-Driven Restoration of Homeostasis in Heart Valve Remodeling, Bruno Rego (The University of Texas at Austin), Sarah Wells (Dalhousie University), Michael Sacks (The University of Texas at Austin)

P45. Role of Runx2 in Calcific Aortic Valve Disease: A T2DM Mouse Model with Greatly Increased Aortic Stenosis, Melissa Jackson (University of Washington), Mei Speer (University of Washington), Mu-en Lin (University of Washington), Theodore Chen (University of Washington), Marta Scatena (University of Washington), Cecilia Giachelli (University of Washington)

P46. Multidrug -Resistance in Tuberculosis Infected Children with Human Immunodeficiency Virus in South-East Nigeria, Sr Faustina Osuji (Nnamdi Azikiwe Teaching Hospital; Immaculate Heart Hospital Nkpor Nigeria)

P47. How did an albino patient lose 148 lbs of weight? A case report, Zarnain Shah (Liaquat University of Medical and Health Sciences Jamshoro, Pakistan), Samaneh A. Montanagh (Ankara University School of Medicine), Syed Wajih Rizvi (Robert Wood Johnson University Hospital, New Jersey)

Friday September 9

Frontiers in Heart Failure, Cardiac Assist and Regeneration Chairs: Kareen Coulombe and Robert Tranquillo

Max Bell Auditorium

8:00–8:30

Electrical function of human pluripotent stem cell-derived cardiomyocyte grafts

Michael Laflamme, MD, PhD Invited Speaker University of Toronto

8:30-8:45

Surgical Application of a Novel Biomaterial Attenuates Post-MI Remodeling and Heart Failure: Impact of Intervention Timing Relative to Infarct Stage on Functional Recovery, Holly Mewhort (Univ), Jeannine Turnbull (University of Calgary), Guoqi Teng (University of Calgary), Darrell Belke (University of Calgary), Daniyil Svystonyuk (University of Calgary), David Guzzardi (University of Calgary), Daniel Park (University of Calgary), Sean Kang (University of Calgary), Paul Fedak (University of Calgary)

8:45-9:00

Role of Apelin/Apelin Receptor Axis in Heart Disease: Therapeutic role of Apelin Analogues, Gavin Oudit (University of Alberta, Mazankowski Alberta Heart Institute)

9:00-9:30

Myocardial Recovery from Chronic Heart Failure With Left Ventricular Assist Devices

Emma Birks, MD, PhD Invited Speaker University of Louisville

9:30-9:45 Break

POSTER SESSION/MEETING PROGRAM
























9:45-10:15

Characterization of the Ontogenetic Development of the Extracellular Matrix and its Potential Role in Cardiac Regeneration and Repair

Lauren Black III, PhD Invited Speaker Tufts University School of Engineering and School of Medicine

10:15-10:30


Mechanosensitivity of cardiomyocyte progenitor cells: the strain response in 2D and 3D environments, Noortje Bax (Eindhoven University of Technology), Arianna Mauretti (Eindhoven University of Technology), Mieke Van Marion (Eindhoven University of Technology), Mark Van Turnhout (Eindhoven University of Technology), Daisy Van Der Schaft (Eindhoven University of Technology), Marie Jose Goumans (Leiden University Medical Center), Cecilia Sahlgren (Eindhoven University of Technology), Carlijn Bouten (Eindhoven University of Technology)

10:30-10:45

Preconditioning of Acellular Vascular Regeneration Templates by Neutrophils: Regulation and Potential Consequences

Allison Fetz (University of Memphis), Isaac Rodriguez (University of Memphis), Indira Neeli (University of Tennessee Health Science Center), Marko Radic (University of Tennessee Health Science Center), Gary Bowlin (University of Memphis)

10:45-11:00


Postoperative Atrial Fibrillation is Associated with Inflammatory Factors in the Pericardial Space, Timothy Lancaster (Washington University School of Medicine), David George (University of Alabama at Birmingham), Jason Greenberg (Washington University School of Medicine), Marc Moon (Washington University School of Medicine), James George (University of Alabama at Birmingham), Richard Schuessler (Washington University School of Medicine), Ralph Damiano (Washington University School of Medicine), Spencer Melby (Washington University School of Medicine)

11:00-11:15 Break

Technology Translation and Commercialization II Chairs: Jane Grande-Allen and Dan Simionescu

Max Bell Auditorium

11:15-11:45

Cardiovascular Product Development

Andy Campbell, PE Invited Speaker Edwards Lifesciences

11:45-12:00

ISO 10993-4 Biological evaluation of medical devices: selection of tests for interactions with blood; anticipated changes in the standard based upon the 2016 final draft international standard (FDIS)

Mike Wolf (Medtronic Inc.)

12:00-12:15

Vascularized In vitro Perfusion Module (VIPM™) 3D Bio-printed with the BioAssemblyBot™

Michael Golway (Advanced Solutions Life Sciences, LLC.), James Hoying (Advanced Solutions Life Sciences, LLC.)

12:30-6:15 Excursions

MEETING PROGRAM






















Conference Gala

Kinnear Centre 101

6:30-7:00 Reception

7:00-7:30 Dinner

7:30-7:45 ISACB President David Vorp, PhD

7:45-8:15 Stu Hutchison, MD Keynote Speaker Mountains and Medicine

Introduction by Paul Fedak, MD

8:15-8:45 Randy Moore, MD 50 Years Living with Bears, the Charlie Russell story

8:45-11:00 Entertainment

Saturday September 10th

7:30-8:00

ISACB Members Meeting

Platform Technologies and Biomaterials Chairs: Julie Phillippi, PhD and Carlijn Bouten, PhD

Max Bell Auditorium

8:00-8:30

Platform Technology for Maturation of Stem Cell Derived Cardiomyocytes and Drug Discovery

Milica Radisic, PhD Invited Speaker University of Toronto

8:30-8:45


A Synthetic Macromolecule to Reverse Heparin Anticoagulation and Profibrinolytic Activity without Altering Clot Morphology, Manu Thomas Kalathottukaren (University of British Columbia), Libin Abraham (University of British Columbia), Rajesh Shenoi (University of British Columbia), Federico Rosell (University of British Columbia), Charles Haynes (University of British Columbia), Jayachandran Kizhakkedathu (University of British Columbia)

8:45-9:00

A Hybrid Biomaterials Platform for Neovascularization in Engineered Human iPSC-derived Cardiac Tissue, Fabiola Munarin (Brown University), Kareen Coulombe (Brown University)

9:00-9:30

Mechanisms of aortic wall injury and repair in thoracic aortic disease

Scott LeMaire, MD Invited Speaker Baylor College of Medicine, Texas Heart Institute, and Bayor St. Luke’s Medical Center

9:30-9:45 Break

9:45-10:00

Completely Biological Tubes of Cell-Produced Extracellular Matrix for Vascular Grafts and Tubular Heart Valves, Bob Tranquillo (University of Minnesota, Biomedical Engineering), Zeeshan Syedain (University of Minnesota, Biomedical Engineering), Jay Reimer (University of Minnesota, Biomedical Engineering)

10:00-10:15


Porous electrospun poly(glycerol sebacate)-based vascular grafts demonstrate early cell infiltration in a porcine arteriovenous shunt model, Chelsea Stowell (University of Pittsburgh), Begona Campos-Naciff (University of Cincinnati), Diego Celdran (University of Arizona at Tucson), Richard Hoehn (University of Cincinnati), Peter Jernigan (University of Cincinnati), Robert Allen (University of Pittsburgh), Vhakish Suganthan (University of Pittsburgh), Prabir Roy-Chaudhury (University of Arizona at Tucson), Yadong Wang (University of Pittsburgh)

10:15-10:45

Ultrabithorax-based Biomaterials to Enhance Endothelial Activation and Neovascularization

Kayla Bayless, PhD Invited Speaker Texas A&M

MEETING PROGRAM














10:45-11:00

A new picture of HDL metabolism is unveiled by state-of-the-art mass spectrometry, Sasha Singh (Brigham and Women’s Hospital), Allison Andraski (T.H. Chan Public Health School of Harvard University), Frank Sacks (T.H. Chan Public Health School of Harvard University), Masanori Aikawa (Brigham and Women’s Hospital)

11:00-11:15

Electrospun polyurethane and hydrogel composite scaffolds to study valve cell fibrotic response, Daniel Puperi (Rice University), Alysha Kishan (Texas A&M University), Zoe Punske (Rice University), Elizabeth Cosgriff-hernandez (Texas A&M University), Jennifer West (Duke University), Jane Grande-Allen (Rice University)

11:15-11:30


Cell Seeding of a Novel Electrospun Vascular Graft Prevents Stenosis in a Mouse Model, Takuma Fukunishi (Johns Hopkins University), Cameron Best (Nationwide Children’s Hospital), Tadahisa Sugiura (Nationwide Children’s Hospital), Christopher Breuer (Nationwide Children’s Hospital), Toshiharu Shinoka (Nationwide Children’s Hospital), Jed Johnson (Nanofiber Solutions Inc), Narutoshi Hibino (Johns Hopkins University)

11:30-11:45 Break

11:45-12:00

ISACB Conference Awards

Jane Grande-Allen, PhD

12:00-1:00

Where do we go from here? Interactive Discussion

Moderator: Elena Aikawa, MD, PhD

Presenters: Paul Fedak, MD, PhD, Michael Wolf, Jane Grande-Allen, PhD, Julie Phillippi, PhD











NOTES


Steven P. Schmidt, Ph.D., ISACBc/o 1023 Rambling Way, Akron, OH 44333Phone +1 330-730-3331 • Email [email protected]

The International Society for Applied Cardiovascular Biology consists of members engaged in research endeavors in applied cardiovascular biology and actively solicits new membership applications from those individuals supporting the mission of the Society. Membership in ISACB is inclusive – not exclusive – and ISACB members represent the diversity of interests that make ISACB such a vital organization.

Members may apply for General Membership status that includes Senior, Junior and Laboratory Specialist categories, or institutions (Businesses, Universities, Practice Groups) may apply for Institutional Membership Status in which 4 individuals from a single organization may become ISACB members.

Not a Member of ISACB? Join Today.

• ISACB General Members receive all issues of the ISACB Newsletter entitled the eCirculator in their in box immediately upon publication. Archived issues of the eCirculator can be found in our archives section.

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Benefits of Membership in ISACB


# LOCATION DATE LOCAL ORGANIZERS VENUE

1st Gothenburg, Sweden June 5-7, 1989 Bo Risberg The Swedish Exhibition & Per Ortenwall Congress Centre/Sara Gothia Hotel

2nd Venice, Italy Sept. 17-20, 1990 Roland Fasol Hotel Excelsior Venice Lido

3rd St. Louis, Missouri Nov. 5-8, 1992 Allan Callow Adam’s Mark Hotel

4th Heidelberg, Germany Aug. 30- Sept. 4, 1994 Werner Risau Convention Center Victor VanHinsbergh Stadthalle In association with the VIIIth International Symposium on the Biology of Vascular Cells

5th Manchester, England March 22-24, 1996 Michael Walker Postgraduate Centre at Manchester Royal Infirmary and Medical School

6th Munich, Germany March 5-7, 1998 Teddy Fischlein Wildbad Kreuth Hans Wolf

7th Tucson, Arizona March 9-11, 2000 Stu Williams Westward Look Resort

8th St. Gallen, Switzerland Feb. 27- Mar. 2, 2002 Jeffrey Hubbell Abbey of St. Gall

9th Savannah, Georgia Mar. 10-13, 2004 Bob Nerem Westin Savannah Harbor Golf Resort & Spa

10th LaJolla, California Mar. 8-11, 2006 Ivan Vesely Torrey Pines Mark Torrianni Hilton Hotel

11th Bordeaux, France Sept. 17-20, 2008 Laurence Bordenave Cite Mondiale

12th Boston, Massachusetts Sept. 22-25, 2010 Frederick Schoen Cambridge Marriott

13th London, United Kingdom Sept. 12-15, 2012 George Hamilton University College

14th Cleveland, Ohio April 2-5, 2014 Steve Schmidt Doubletree by Hilton - The Tudor Arms Hotel

HISTORY OF MEETING LOCATIONS & LOCAL ORGANIZERS

PAST BIENNIAL MEETING

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