Medicinal Chemistry ANS - Jawaharlal Nehru Technological ...
Transcript of Medicinal Chemistry ANS - Jawaharlal Nehru Technological ...
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Dr. N. SRIDHAR GOUD (PhD, M. Pharm., MBA)Genius Book Record Holder
Postdoctoral Fellow,
Department of Neuroimaging and Interventional Radiology
National Institute of Mental Health & Neuro Sciences (NIMHANS),
Bengaluru-560 029, India.
Email: [email protected]
For Pharma Graduates & GPAT Aspirants
Date: 11/07/2020
Medicinal ChemistryANS
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Structures of direct acting parasympathomimetics
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Direct acting parasympathomimetics
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Structural Activity Relationship (SAR) of Ach:
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Stereochemistry (conformers) of Ach:
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2. Indirect Acting Parasympathomimetics (Anti-cholinesterases)
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Structures of indirect acting parasympathomimetics
Reversible Agents Irreversible Agents
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NH2
NH2
1. Mechanism of Ach on Hydrolysis process 2. Mechanism of Reversible inhibitor
3. Mechanism of Irreversible inhibitor 4. Reactivating AchE using 2-PAM
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3. Sympathomimetics
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3. Sympatholytics
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