Medical Imaging Resource Center (MIRC)Clinical Trial Applications

Joshua Tan

Division of Radiologic Sciences Wake Forest University School of Medicine

Departments of Radiology and Biomedical EngineeringNovember 28, 2005 - RSNA 2005

Chicago, IL

Overview

Introduction

WFUSM MIRC configuration

WFUSM uses MIRC for multi-center clinical trials

Introduction

WFUSMDr. Jeffrey CarrDr. Kerry LinkDr. Joseph MaldjianDr. Peter SantagoBob EllisonJoshua Tan

UPennDr. Nick Bryan Lisa DesiderioDengfeng Liu

RSNAChris CarrJohn Perry

MIRC collaboration among RSNA, UPenn, and WFUSM was initiated in early 2004.

UPenn and WFUSM MIRC test (WAKEUP)

Images sent from WFUSM research MR scanner to WFUSM MIRC to UPenn MIRC

WFUSM Center for Biomolecular Imaging

Dedicated research modalities

GE Twin Speed 1.5T MR ScannerGE Sigma Excite 3.0T MR Scanner

GE 16-slice Light Speed Pro CT ScannerGE Discovery ST-8 PET/CT Scanner

Bruker 7.0T MicroMR Scanner with a 30cm. bore

Concord MicroPET Scanner

  GE Advance NXi PET Scanner

WFUSM MIRC hardware configuration

Remote CT

Remote MR

WFUSMNetwork

TeraRecon imaging analysis

workstation GE Advantage imaging analysis

workstation

WFUSM NAS WFUSM research DICOM server

External RAID backup system

ExternalUltra SCSI3

WFUSM Firewall

Internet

Internet

WFUSM MIRC in DMZ

MIRC within WFUSM firewall

Remote MIRC FieldCenter

RemoteNetwork

WFUSM MIRC software configuration

MIRC computer MIRC FieldCenter or MIRC v T26 Tomcat v 4.1.29 Java J2SE v 1.4.2_10 SDK

Remote CT

Remote MR

Internet

WFUSM MIRCRemote MIRC FieldCenter

RemoteNetwork

WFUSMNetwork

WFUSM research DICOM server

External RAID backup system

WFUSM NAS

Research DICOM server

Dell PowerEdge 2800 server• Dual 3.0GHz Intel Xeon CPUs• 1GB ECC DDR ram• 3 x 73GB Ultra 320 SCSI hard drives in a RAID5 configuration• Gigabit Network Interface Card• Software on PowerEdge

• Red Hat Linux• Version 9.0• WS 3.0

• MySQL Database• Mallinckrodt CTN software • PHP• HTML and XML

External RAID storage• 8 x 250GB hard drives• Ultra SCSI-3• Raid5 configuration• ~1.7TB of usable space

• WHIMS• CARDIA_XX• CARDIA_XV• CARDIA_PILOT• CARDIA_QC• WHI• WHI_PILOT• WHI_QC• CAMPS• ADNI• CIREN

Application Entity TitlesWFUSMNetwork

WFUSM NAS

WFUSM research DICOM serverTitan: 192.168.1.110: port 104

(0008, 0018) SOP Instance UID(0008, 0020) Study Date(0008, 0030) Study Time(0008, 0050) Accession Number(0008, 0060) Modality(0008, 0090) Referring Physician Name(0010, 0010) Patient Name(0010, 0020) Patient ID(0010, 0030) Birthdate(0010, 0040) Sex(0020, 000D) Study Instance UID(0020, 000E) Series Instance UID(0020, 0010) Study ID(0020, 0011) Series Number(0020, 0013) Instance Number(0028, 0002) Samples Per Pixel(0028, 0010) Rows(0028, 0011) Columns(0028, 0101) Bits Stored(0028, 0103) Pixel Representation

Required DICOM elements for CTN DICOM server

DICOM element must have a value

WFUSM DICOM research imagesLong term storage and archiving

External attached RAIDUltra SCSI-3Raid5 configuration

WFUSMNetwork

WFUSM MIRC receivers

External RAID backup system

WFUSM research DICOM server

WFUSM NAS

NAS (network attached storage)EMCFiber attachedRaid5+1 configuration

WFUSM research archiving server

Exabyte VXA-2 Autoloader (1 x 10)

Sony external DL/DVD±RW drive

Research archiving serverVXA-2 Tape (80/160GB)DVD-R (4.7/8.5GB)

WFUSM MIRC DMZ and B2B VPN connectionsDMZ (demilitarized zone)

Ports 8080, 8443 (internet)Open on WFUSM MIRC to receive via MIRC software

Port 104 (intranet)Only open to the internal WFUSM network on port 104 to DICOM export to WFUSM DICOM research server

NAT (network address translation)

Remote CT

Remote MR

WFUSMNetwork

WFUSM research DICOM server

B2B VPN (branch to branch virtual private network)Remote modality can DICOM export directly to WFUSM MIRCInformation Services from both locations must collaborate for configuration to properly connect and transfer DICOM images

Internet

WFUSM MIRC in DMZ

WFUSM Firewall

RemoteNetwork

Remote MIRC FieldCenter

Internet

MIRC within WFUSM firewall

MIRC software tools

FieldCenterApplication to receive DICOM images from an imaging modalityDICOM export images from remote sites to reading center via internetAnonymize/de-identify/modify DICOM images

DicomEditorModification and correction of DICOM headerPowerful anonymization/de-identification toolBatch modifying application

FileSenderDICOM export corrected images back to workstation/DICOM serverDICOM export images from local media and network drives

MODCD-rom/DVD-romHard driveOther misc media formats

WHIMS Women's Health Initiative Memory Study Import DICOM images

Clinical trials using MIRC

CARDIA Year20 Coronary Artery Risk Development

in Young Adults Import DICOM images

WHI Women's Health Initiative Import DICOM images

CAMPS Carotid Atherosclerosis MRI Progression Export DICOM images

ADNI Alzheimer's Disease Neuroimaging Initiative Export DICOM images to a pc

CIREN (WFUSM internal) Crash Injury Research and Engineering Network Archive and distribute DICOM images

UAB CTUIC CT UMN CTUSF CT

CARDIA year20 data flow

WFUSM DICOM research server

RAID storage

WFUSM firewall #2

Calcium scoringworkstations

Internet

WFUSM firewall #1

MIRC within WFUSM firewallWFUSM firewall #1

WFUSM MIRC in DMZ

Internet

RemoteNetwork

Remote MIRC FieldCenter

UIC CT

USF CT

CARDIA year20 data flow UIC/USF to DMZ WFUSM MIRC

WFUSM DICOM research serverTitan: 192.168.1.110: port 104AE TITLE: CARDIA_XX

RAID storage

WFUSM firewall #2

Remote MIRC FieldCenter

RemoteNetwork

RemoteNetwork

Internet

WFUSM MIRC in DMZMIRC IN: 182.158.1.101: port 8443 (ext)192.158.1.101: port 104,3333,8443 (int)

HTTP import to DICOM export (MIRC IN to Titan)HTTP import on http://182.158.1.101:8443/CARDIA_WFU/import/docDICOM export from CARDIA_WFU@192.158.1.101:3333 to CARDIA_XX (Titan)

MIRCsoftware

WFUSM firewall #1

UAB CT

UMN CT

CARDIA year20 data flow UAB/UMN Branch to Branch VPN to WFUSM

WFUSM DICOM research serverTitan: 192.168.1.110: port 104AE TITLE: CARDIA_XX

RAID storage

DICOM export

Internet

WFUSM firewall #1

MIRC within WFUSM firewallDelta: 192.168.1.101

ports 104,3333,3334,3335,3336,8443

DICOM import to HTTP export (CT Scanner to Delta)DICOM import from CT Scanner to CARDIA_UAB@192.168.1.101:3333 (Delta)DICOM import from CT Scanner to CARDIA_UMN@192.168.1.101:3334 (Delta)HTTP export to http://192.168.1.101:8443/car_uab/import/docHTTP export to http://192.168.1.101:8443/car_umn/import/doc

HTTP import to DICOM export (Delta to Titan)HTTP import on http://192.168.1.101:8443/car_uab/import/docHTTP import on http://192.168.1.101:8443/car_umn/import/docDICOM export from CAR_UAB@192.168.1.101:3335 to CARDIA_XX (Titan) DICOM export from CAR_UMN@192.168.1.101:3336 to CARDIA_XX (Titan)

MIRCsoftware

MIRCsoftware

UPMCUIC UMNUSFWHI data flow

WFUSM DICOM research server

RAID storage

WFUSM firewall #2

CDs sent via from 26 Field Centers

Calcium scoringworkstations

Loaded on WFUSMMIRC receiver

WFUSM MIRC receiver

FileSender

WFUSM firewall #1

WFUSM MIRC in DMZ

Internet

RemoteNetwork

Remote MIRC FieldCenter

UIC CT

USF CT

WHI fieldcenter data flowUAB/UIC/UMN/UPMC/USF to DMZ WFUSM MIRC

UPMC CT

UMN CT

WFUSM DICOM research serverTitan: 192.168.1.110: port 104AE TITLE: WHI

RAID storage

WFUSM FIREWALL #2

Remote MIRC FieldCenter

RemoteNetwork

RemoteNetwork

RemoteNetwork

RemoteNetwork

Internet

WFUSM MIRC in DMZMIRC IN: 182.158.1.101: port 8443 (ext)192.158.1.101: port 104,3334,8443 (int)

HTTP import to DICOM export (MIRC IN to Titan)HTTP import on http://182.158.1.101:8443/WHI/import/docDICOM export from WHI@192.158.1.101:3334 to WHI (Titan)

MIRCsoftware

WFUSM FIREWALL #1

WHI data flowCD/DICOM EXPORT to WFUSM RECEIVER

WFUSM DICOM research serverTitan: 192.168.1.110: port 104AE TITLE: WHI

RAID storage

MIRC with WFUSM firewallDelta: 192.168.1.101: ports 104,3337,3338,8443

DICOM import to HTTP export (CD to Delta)DICOM import from CD to WHI_UPLOAD@192.168.1.101:3337 (Delta)HTTP export to http://192.168.1.101:8443/WHI_EXPORT/import/doc

HTTP import to DICOM export (Delta to Titan)HTTP import on http://192.168.1.101:8443/WHI_EXPORT/import/docDICOM export from WHI_EXPORT@192.168.1.101:3338 to WHI (Titan)

MIRCsoftware

MIRCsoftware

CDs sent via from 26 Field Centers

to WFUSM

WFUSMNetwork

FileSender

WFUSM CT

CAMPS/ADNI/CIREN data flowWFUSM modality to WFUSM MIRC OUT

WFUSM MR

CAMPS MIRCUniversity of Washington

ADNI websiteUCLA

CIRENWFUSM (internal)

Internet

HTTP export DICOM send

WFUSM MIRC OUT

WFUSMNetwork

MIRC software summary

• Secure DICOM image transfer via the Internet • Stable • Open-source• Multi-faceted and versatile• De-identification and modification features• Technicians “love” to use the MIRC software• Easy to configure and use• Web-based interface for effortless examination

of received images

Questions or comments?

Special Thanks to:John Perry (RSNA)

Peter Santago, Ph.D. (WFUSM)J. Jeffrey Carr, M.D., M.S. (WFUSM)

Kerry M. Link, M.D. (WFUSM)Bob Ellison (WFUSM)

Nick Bryan, M.D., Ph.D. (UPenn)Lisa Desiderio (UPenn)DengFeng Liu (UPenn)

Steve Moore (Mallinckrodt)

Acknowledgements:Wake Forest University School of Medicine (Radiology and Biomedical Engineering)

Wake Forest University Health SciencesUniversity of Pennsylvania

Winston-Salem State University