Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in...
Transcript of Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in...
![Page 1: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/1.jpg)
Mechanical Support in the
Failing Fontan-KreutzerStephanie Fuller MD, MS
Thomas L. Spray Endowed Chair in Congenital Heart SurgeryAssociate Professor, The Perelman School of Medicine at the University of Pennsylvania
Program Director, Congenital Cardiac Surgery, The Children’s Hospital of PhiladelphiaSurgical Director, Philadelphia Adult Congenital Heart Program
![Page 2: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/2.jpg)
Consultant: W.L. Gore
![Page 3: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/3.jpg)
The Failing Fontan- Kreutzer
Mode of Failure:Pump vs. Non Pump
Valente AM, Landzberg MJ, Powell AJ: Adult congenital heart disease.
Edited by Libby P. In Essential Atlas of Cardiovascular Disease. New
York, New York: Springer; 2009:231–246
Fontan-Kreutzer FailureEarly vs. Chronic
![Page 4: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/4.jpg)
The Failing Fontan- Kreutzer
Mode of Failure:Pump
Valente AM, Landzberg MJ, Powell AJ: Adult congenital heart disease.
Edited by Libby P. In Essential Atlas of Cardiovascular Disease. New
York, New York: Springer; 2009:231–246
Fontan-Kreutzer Failure
![Page 5: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/5.jpg)
Indications for Mechanical Support
• Failed maximal medical therapy with no surgical options
• Inability to wean from cardiopulmonary bypass
• Cardiogenic Shock
• Decreased organ perfusion
• Intractable Arrhythmias
Bridge to Transplant or Destination Therapy
![Page 6: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/6.jpg)
Relative Contraindications
• Patient is NOT a Transplant Candidate
– Exception – Pulmonary Hypertension: Appropriate for some patients
• Anatomical Diagnosis
• Neurologic Concern
– Intracranial Hemorrhage, Severe Neurologic Impairment
• Isolated Pulmonary Dysfunction
• Sepsis
• Multisystem Organ Failure
VAD: Surgical Challenges
![Page 7: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/7.jpg)
Mechanical Assist Devices for the Fontan-Kreutzer
Cardiac Dysfunction:1. Severe systolic dysfunction
• Less than 35% by echocardiogram• Less than 30% by MRI
2. Moderately depressed dysfunction when accompanied by >moderate or severe systemic AV valve regurgitation
3. Significant growth derangement or failure to thrive4. Decreasing exercise tolerance by patient report as measured on sequential exercise
testing5. Significant electrophysiologic abnormalities including arrhythmia or aborted sudden
death
Fontan Pathway Dysfunction:1. Symptomatic chronic fluid overload despite increasing diuretic therapy2. Occurrence of chronic ascites or pleural effusion refractory to therapy3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or
symptomatic cyanosis
Lymphatic Dysfunction: PLE or plastic bronchitis requiring multiple admissions in 12 monthsExtracardiac Dysfunction: Hemoptysis, liver disease or chronic kidney disease
![Page 8: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/8.jpg)
![Page 9: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/9.jpg)
![Page 10: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/10.jpg)
Device Position Pulsatile Discharge Destination
ECMO Paracorporeal N N N
Pedimag Paracorporeal N N N
Berlin Paracorporeal Y N N
HeartwareIntracorporeal N Y Y
HM3Thoratec
Intracorporeal N Y Y
Syncardia Intracorporeal Y Y Y
Mechanical Assist Devices Choices at CHOP
![Page 11: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/11.jpg)
Device Position Pulsatile Discharge Destination
ECMO Paracorporeal N N N
Pedimag Paracorporeal N N N
Berlin Paracorporeal Y N N
HeartwareIntracorporeal N Y Y
HM3Thoratec
Intracorporeal N Y Y
Syncardia Intracorporeal Y Y Y
Mechanical Assist Devices Choices at CHOP
![Page 12: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/12.jpg)
Options for Mechanical Support at CHOPPatient Size
![Page 13: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/13.jpg)
Options for Mechanical Support at CHOPPatient Size
Adult Devices
Berlin
Heart
Heartmate 3 or Heartware
![Page 14: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/14.jpg)
VAD: Surgical Challenges
Basic Principles of Mechanical Assistance
– Simple, rapid employment
– Decompression of myocardium
– Maintenance of end-organ perfusion
• Elimination of edema
• Improvement in nutrition
– Long-term reliability
– Portability
• Ability to rehabilitate
Acute
Chronic
![Page 15: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/15.jpg)
• Consideration of chest or abdominal DOMAIN• Chest closure challenging. Need for a bioprosthetic membrane
to approximate chest or abdomen (fascial closure)
• Consider AV valve resection
• Pre-peritoneal vs Intra-abdominal placement
• Make drive line tunnels LONG
• TEE use after insertion is a must!
– No residual PFO, Obstruction of inflow cannula by septum
– Obstruction of Right Atrial Conduit
– Ventricular position
Surgical Challenges – Implantable VAD
![Page 16: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/16.jpg)
VAD: Surgical Challenges – Single Ventricle
![Page 17: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/17.jpg)
VAD: Surgical Challenges – Single Ventricle
![Page 18: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/18.jpg)
Figure 1. The left and right
ventricles were resected leaving
a 5mm residual just distal from
the AV valve annulus.
Creation of a Self-Made Total Artificial Heart
Using Combined Components of Available
Ventricular Assist Devices. Tjan TDT et al.
Thorac Cardiov Surg 2008: 56; 51-9.
VAD: Surgical Challenges – Single Ventricle
![Page 19: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/19.jpg)
Figure 3. The inflow cannula from
the Berlin-Heart EXCOR system
introduced in each atria through the
cuffs.
Creation of a Self-Made Total Artificial Heart
Using Combined Components of Available
Ventricular Assist Devices. Tjan TDT et al.
Thorac Cardiov Surg 2008: 56; 51-9.
VAD: Surgical Challenges – Single Ventricle
![Page 20: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/20.jpg)
Figure 4. Connection of the outflow
conduit from the Thoratec system with
the pulmonary artery and the ascending
aorta.
Creation of a Self-Made Total Artificial Heart Using
Combined Components of Available Ventricular
Assist Devices. Tjan TDT et al. Thorac Cardiov Surg
2008: 56; 51-9.
VAD: Surgical Challenges – Single Ventricle
![Page 21: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/21.jpg)
![Page 22: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/22.jpg)
SynCardia TAH
![Page 23: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/23.jpg)
TAH Implantation
![Page 24: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/24.jpg)
![Page 25: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/25.jpg)
HeartWare
• Long-term device
• Centrifugal
• Continuous flow
• 10L/min flow
• BSA as low as 0.5m2
• Discharge to home
• Small
– Pericardial space
HeartWare Systems, Framingham, MA
![Page 26: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/26.jpg)
![Page 27: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/27.jpg)
![Page 28: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/28.jpg)
![Page 29: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/29.jpg)
![Page 30: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/30.jpg)
![Page 31: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/31.jpg)
Single Ventricle - Atrium
![Page 32: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/32.jpg)
![Page 33: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/33.jpg)
![Page 34: Mechanical Support in the Failing Fontan-Kreutzer · 3. Major hemodynamic disturbance resulting in symptoms including diastolic failure or symptomatic cyanosis Lymphatic Dysfunction:](https://reader036.fdocuments.net/reader036/viewer/2022062602/5ee35710ad6a402d666d45a0/html5/thumbnails/34.jpg)
THANK YOU