Mechanical factors in the initiation and fate of atherosclerotic plaques
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Mechanical factors in the initiation and fate of atherosclerotic plaques Peter D Weinberg Department of Bioengineering Imperial College London
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Mechanical factors in the initiation and fate of atherosclerotic plaques. Peter D Weinberg Department of Bioengineering Imperial College London. Flow. J R A Mitchell, C J Schwartz. Arterial Disease , 1965. Flow. J R A Mitchell, C J Schwartz. Arterial Disease , 1965 - PowerPoint PPT Presentation
Transcript of Mechanical factors in the initiation and fate of atherosclerotic plaques
Mechanical factors in the initiation and fate of atherosclerotic plaques
Peter D Weinberg
Department of Bioengineering
Imperial College London
J R A Mitchell, C J Schwartz. Arterial Disease, 1965
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J R A Mitchell, C J Schwartz. Arterial Disease, 1965
CG Caro et al, Proc R Soc Lond B 1971;177:109-159
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N Anitschkow. In: Arteriosclerosis (E V Cowdry, ed), 1933.
Nicolai Anitschkow (1885-1964)
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J B Somer, C J Schwartz. Atherosclerosis 1971;13:293-304.
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There is a continuous movement of plasma constituents from lumen to adventitia
“Lipoids” in this flow precipitate by interaction with the ground substance of the wall
Lymphocytes or monocytes enter the wall and ingest lipoid, becoming foam cells
Process occurs faster where there is a greater transport across the wall
Insudation theory of Anitschkow
N Anitschkow. In: Arteriosclerosis (E V Cowdry, ed), 1933.
S E Barnes, P D Weinberg. Arterioscler Thromb Vasc Biol 1998;18:300-308
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S E Barnes, P D Weinberg. Arterioscler Thromb Vasc Biol 1999;19:2376-2386.
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Immature Mature
A Sebkhi, P D Weinberg. Atherosclerosis 1994;106:1-8.
H Sinzinger et al. Blood Vessels 1980; 17: 44-52
R C Schroter, unpublished
P D Weinberg Biorheology 2002;39:533-537 Pictures from R C Schroter, G D Sloop, J R A Mitchell & C J Schwartz
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A Sebkhi, P D Weinberg. Arterioscler Thromb Vasc Biol 1996;16:317-327.
B A Forster, P D Weinberg. Arterioscler Thromb Vasc Biol 1997;17:1361-1368.
0
2
4
6
8
10
12
14
16
18
Downstream Upstream
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ty (
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Control
Coarctation
C L Murphy and M J Lever
T J Staughton, M J Lever, P D Weinberg. Am J Physiol 2001;281:H53-H59.
( D
owns
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Al-Musawi, Bishton, Dean, Williams, Cremers, Weinberg. Atherosclerosis 2004;72:79
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.
young mature
*
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A Kazakidi, S J Sherwin, P D Weinberg, unpublished data
Roach MR, Fletcher J. Atherosclerosis. 1976;24:327-33.
control
cuff
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Thubrikar MJ, Baker JW, Nolan SP. Arteriosclerosis. 1988;8:410-20.
control
control
cuff
Cheng, C. et al. Circulation 2006;113:2744-2753
