MCQs

ANS & Autacoids

• 1. Which one of the following drugs is least likely to cause tachycardia in a patient who has recently undergone heart transplantation?

• a. Isoproterenol b. Epinephrine c. Dobutamine d. Amphetamine

• 2. In very young children, the most dangerous effect of belladonna alkaloids is

• a. Hyperthermia b. Intraventricular Heart Block c. Hypertension d. Hallucinations

• 3. Which of the following is the first & only FDA approved Non-peptide arginine vasopressin antagonist?

• a. Tolvaptan b. Conivaptan c. Mozavaptan d. Lixivaptan

• 4. Which of the following statements is FALSE?• a. There are three isoforms of nitric oxide

synthase.• b. The primary endogenous substrate for nitric

oxide synthase is arginine.• c. NΨ-Monomethyl-L-Arginine is a competitive

nonselective NOS inhibitor.• d. NΨ-Monomethyl-L-Arginine is a non

competitive selective NOS inhibitor.

• 5. The most common adverse effect of nesiritide is

• a. Rise in serum transaminases• b. Fatal renal damage• c. Stomatitis• d. Excessive hypotension

• 6. Which of the following statements is FALSE?• a. Omapatrilat is a vasopeptidase inhibitor.• b. Vasopeptidase inhibitors increase the levels

of natriuretic peptides.• c. Icatibant is an endothelin receptor

antagonist.• d. Nesiritide is administered by constant

intravenous infusion.

• 7. Which of the following statements about bosentan is FALSE?

• a. is a nonselective endothelin receptor blocker.• b. is associated with rise in serum

transaminases.• c. inactive orally.• d. approved for pulmonary artery hypertension.

• 8. Which of the following signs would distinguish between an overdose of a ganglion blocker and a muscarinic blocker?

• a. Tachycardia b. Postural hypotension c. Blurred vision d. Constipation

• 9. Which of the following effects of epinephrine would be blocked by phentolamine but not metoprolol?

• a. Relaxation of uterus• b. Increase of cAMP in fat• c. Contraction of radial smooth muscle in the

iris.• d. Relaxation of bronchial smooth muscle.

• 10. Which of the following agents is a prodrug that is much less toxic in mammals than in insects?

• a. Malathion b. Parathion c. Nicotine d. Pilocarpine

• 11. Which of the following binds covalently to the site specified?

• a. Atenolol: beta receptor• b. Pindolol: beta receptor• c. Phenoxybenzamine: alpha receptor• d. Labetalol: alpha & beta receptors

• 12. Which of the following statements is TRUE?

• a. Esmolol’s pharmacokinetics are compatible with chronic topical use.

• b. Metoprolol blocks beta-2 receptors selectively.

• c. Nadolol lacks beta-2 blocking action.• d. Timolol lacks the local anaesthetic effects of

propanolol.

• 13. A peptide that causes increased capillary permeability & edema is

• a. Ang II b. Bradykinin c. Captopril d. Histamine

• 14. Agents that produce arteriolar vasoconstriction include all EXCEPT

• a. Ang II b. Endothelin-1 c. Substance P d. Serotonin

• 15. Which of the following statements is TRUE?

• a. Ang I is the most potent of the series that includes angiotensinogen & ang II.

• b. Bradykinin is a potent vasodilator with pain & edema-inducing effects.

• c. Atrial & brain natriuretic peptides increase cardiac contractility in heart failure.

• d. Bradykinin is inactivated by the enzyme kallikrein.

• 16. Which of the following statements is FALSE?

• a. Angiotensin converting enzyme (ACE) 2 serves as a receptor for coronaviruses.

• b. ACE 2 doesn’t hydrolyze bradykinin.• c. Tegaserod is a 5HT4 partial antagonist.

• d. Tegaserod is indicated in Irritable bowel syndrome & constipation.

• 17. All of the following statements are true EXCEPT

• a. Zafirlukast is LTD4-receptor antagonist.

• b. Montelukast is LTB4-receptor antagonist.

• c. Nedocromil sodium & cromolyn sodium are stable but highly insoluble salts.

• d. Ciclesonide is a prodrug.

• 18. All of the following statements regarding aprepitant are true EXCEPT

• a. is a highly selective neurokinin-1 receptor agonist.

• b. is used as antiemetic agent.• c. believed to act on area postrema• d. is metabolized by CYP3A4.

• 19. Many H1 blockers have additional nonhistamine-related effects; these are likely to include all of the following EXCEPT

• a. Antimuscarinic reduction in bladder tone• b. Increase in total peripheral resistance• c. Anti-motion sickness effect• d. Local anesthetic effects if the drug is

injected

• 20. Which of the following will result from blockade of H2 receptors?

• a. Decreased cAMP in cardiac muscle• b. Decreased channel opening in enteric

nerves• c. Increased IP3 in gastric mucosa

• d. Increased IP3 in smooth muscle