Mature DC Immature DC Antigen capture PAMP recognition and activation T cell expansion B cell...
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Mature DC
Immature DC
Antigen capture
PAMP recognition and activation
T cell expansion
B cell expansion
Figure 1. DC activation and maturation.Adapted from Wack, A. and Rappuoli, R. Current Opinions in Immunology 2005
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Figure 2. Human DC subsets and lineage origins.
Shortman, K and Y. J. Liu Nature Reviews Immunology 2002
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Figure 3. Within the immune synapse formed between APCs and T cells, three signals are required for antigen-specific T cell activation. Gutcher, I. and Becher, B. Journal of Clinical Investigation 2007
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Figure 4. APC-derived cytokines guide the differentiation of naive T cells into an effector T cell subtypes in mouse. Gutcher, I. and Becher, B. Journal of Clinical Investigation 2007
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Figure 5. Structures of the IL-1R family. Sims, J. et al Current Opinions in Immunology 2007
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Figure 6. TLRs localization and their ligands.Verstak, B. et al Inflammation Research 2007
Table 1. Synthetic and endogenous TLR ligands.Kanzler, H. et al Nature Medicine 2007
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Figure 7. IRF Activation by Cytosolic Pattern-Recognition Systems; Operation of a Positive-Feedback Mechanism.Honda, K. et al Immunity 2006
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Figure 8. Summary of TLR signaling pathways. Dunne, A. and O’Neill, L. FEBS Letters 2005
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Figure 9. Type I IFN positive feedback loop. Adapted from Doyle, S. et al, Immunity 2002
TBK1IKK
TRIFTRIF
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Figure 10. Schematic representation of IRF-3 and IRF-7 activation and dimerization by virus-induced phosphorylation. Lin, R. et al. Cellular and Molecular Biology 1999
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Figure 11. Enhanceosome formation and IFN-β gene transcription. Kenya, H. et al Immunity 2006
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Figure 12. IL-12 family members: composition, receptors and regulatory functions. Adapted from Goriely, S. and Goldman, M. Transplantation 2007
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IL-23
IL-27
Figure 13. Regulatory functions of IL-27.Adapted from Colgan, J. and Rothman, P. Nature Immunology 2006
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Figure 14. The classification and structure of the PKC family of isozymes. Kheifets, V. and Mochly-Rosen, D. Pharmacological Research 2007
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Figure 15. Model of PKCα phosphorylation. Bornancin, F. and Parker, P.J. Journal of Current Biology 1996
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TLR3
IL-12p35IL-27p28
IL-12/23p40IL-23p19
Adapted from
PKC
Figure 16. Schematic of PKC activity in TLR3 and TLR4 signaling pathways. Adapted from Akira, S. and Takeda, K. Nature Reviews Immunology 2004