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Transcript of Matthew Todd, The University of Sydney mattoddchem MatToddChemistry [email protected] Open...
Open Source Drug Discovery
Matthew Todd, The University of Sydney
mattoddchem
MatToddChemistry
http://intermolecular.wordpress.com/
Open Science Summit, Mountain View/Sydney, Sometime October 2011
http://www3.imperial.ac.uk/schisto; http://bit.ly/9azFHv
Praziquantel
Africa is Desperate for Praziquantel, Lancet 2010, 376, 496-498
2/20
Enantiopure PZQ for a low, low price
http://bit.ly/913iAm; http://bit.ly/KRdIZ; http://bit.ly/cJF1BW
GOT (10 ¢ g-1)
NEED BAD/BITTER
3/20
Intractable Problem?
When you have a tough problem – ASK SOMEONE!
Effectiveness of Solution
(“ee” in Chemical Terms)
Resources(Person-years)
Required Usefulness
Breaking Point for Academia/Industry
4/20
Wall Street JournalMay 26th 2010
Sharing Data is Step 1
tropicaldisease.orgNature Biotech. 2009, 27, 320-321.
9/20
Companies? Seriously?
http://www.syncom.nl/hr/index.html; http://www.solvay.com/; http://www.intervet.com/; http://www.almacgroup.com/
13/20
Current Solution
Details of Route: PLoS NTD 2011, 5(9): e1260 Full Description of Project: Nature Chemistry 2011, 3, 745-748
14/20
http://bit.ly/dtkwf0, http://bit.ly/aqHWtV, http://bit.ly/bJNZ8N, http://bit.ly/8TrvZ4
Advantages15/20