Master's Programme in Neuroscience

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Master's Programme in Neuroscience

Descriptions of courses and study modules included in the

degree structures

Updated 05/2021

STUDY TRACKS

NEU-100: Neuroscience, advanced studies: study track of neuroscience, 60 cp

Validity: 01.01.2017 - Form of study: Advanced studies

Type: Study block/Line

Unit: Master's Programme in Neuroscience

Grading: General scale

Teachers: Juha Voipio

Course language: English Target group Responsible programme: Master’s Programme in Neuroscience. Degree students in the Master's Programme in Neuroscience must choose between the following study tracks: 1) neuroscience, 2) cell and systems physiology or 3) biology teacher. The module is intended for degree students of the Master’s Programme in Neuroscience. Lecture courses are available for students of other programmes. Degree students of the Master’s Programme in Neuroscience are provided priority access to courses where group work may require limiting the maximum number of students. Timing 1st year of Master’s studies, periods I-II (except Master's Thesis and Master's Seminar that are recommended to be completed during the 2nd year or in parallel with the Master's Thesis project) Learning outcomes This module covers the core content in neuroscience that every neuroscience student graduating from the Programme should know. In addition, the module introduces students to various fields within neuroscience, and students get to know the local scientific community. The module includes the Master's thesis. Contents Choose all: . NEU-101: Cellular physiology, 5 cp . NEU-102: Cellular neurobiology, 5 cp . NEU-103: Systems neuroscience, 5 cp . NEU-104: Integrative neurobiology, 5 cp . NEU-105: Methods and trends in neuroscience, 5 cp . NEU-106: Master’s seminar in neuroscience, 5 cp . NEU-110: Master's thesis in neuroscience, 30 cp . NEU-111: Maturity test, 0 cp Responsible person Professor Juha Voipio

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NEU-201: Advanced studies in neuroscience, study track of cell and systems physiology, 65

cp






Course language: English Target group Responsible programme: Master’s Programme in Neuroscience. Degree students in the Master's Programme in Neuroscience must choose between the following study tracks: 1) neuroscience, 2) cell and systems physiology or 3) biology teacher. The module is intended for degree students of the Master’s Programme in Neuroscience. Lecture courses are available for students of other programmes. Degree students of the Master’s Programme in Neuroscience are provided priority access to courses where group work may require limiting the maximum number of students. Timing 1st year of Master’s studies, periods I-IV (except Master's Thesis and Master's Seminar that is recommended to be completed during the 2nd year or in parallel with the Master's Thesis project) Learning outcomes This module covers the core content in cell and systems physiology that every physiology student graduating from the Programme should know. In addition, the module introduces students to various fields within physiology and neuroscience, and students get to know the local scientific community. The module includes the Master's thesis. Contents Choose all: . NEU-101: Cellular physiology, 5 cp . NEU-203: Systems physiology, 5 cp . NEU-207: Regulatory networks in metabolism 5 cp . NEU-205: Methods and trends in physiology and neuroscience 5 cp . NEU-561 Principles of bioscience omics 10 cp . NEU-306: Master’s seminar in cell and systems physiology, 5 cp . NEU-220: Master's thesis in cell and systems physiology, 30 cp . NEU-211: Maturity test, 0 cp Responsible person Reijo Käkelä

NEU-300: Advanced studies in neuroscience, study track of biology teacher, 60 cp






Course language: English

Target group Responsible programme: Master’s Programme in Neuroscience. Degree students in the Master's Programme in Neuroscience must choose between the following study tracks: 1) neuroscience, 2) cell and systems physiology or 3) biology teacher. The module is intended for degree students of the Master’s Programme in Neuroscience. Lecture courses are available for students of other programmes. Degree students of the Master’s Programme in Neuroscience are provided priority access to courses where group work may require limiting the maximum number of students.

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Timing 1st year of Master’s studies, periods I-II (except Master's Thesis and Master's Seminar that is recommended to be completed during the 2nd year or in parallel with the Master's Thesis project) Learning outcomes This module covers the core content in neuroscience or cell and systems physiology that every student graduating from the Programme should know. In addition, the module introduces students to various fields within neuroscience and physiology, and students get to know the local scientific community. Contents Choose one study track NEU-100 or NEU-201 and the courses belonging to the track (except for the Master´s Thesis) together with NEU-310 Master´s Thesis, study track of biology teacher • NEU-100: Advanced studies: study track of neuroscience, 30 cp, (excluding NEU-110 Master’s

thesis) OR

• NEU-201: Advanced studies, study track of cell and systems physiology, 30 cp (excluding NEU-207 and NEU-220 Master’s thesis)

• NEU-310: Master’s thesis in the study track of biology teacher, 30 cp

• NEU-311 Maturity test

• PED100: Education, pedagogical studies for teachers 60 cp

Responsible person Professor Juha Voipio

COURSE DESCRIPTIONS

NEU-101: Cellular physiology, 5 cp


Type: Course



Teachers: Ulla Pirvola

Target group The course is obligatory for students of the Master’s Programme in Neuroscience. The course is also suitable for students from different disciplines, including biology, psychology, physics and biomedical engineering. Timing Period I, organized annually. Degree students of the Master's Programme in Neuroscience are recommended to take this course during the first year of studies. Learning outcomes After completion of the course the student has gained understanding into the key principles of cell biological mechanisms and is able to integrate this information into a functional context. The student has gained understanding into the principles of cell membrane function, intracellular compartments and signaling and dynamics within, and life and death of cells. The student is able to use this knowledge to explain the molecular mechanisms that underlie common cell physiological processes. Contents Lectures of the course include: Intracellular compartments, and protein sorting and trafficking; Cell membrane physiology/biophysics; Cytoskeleton and cell junctions; Cell signaling; Cell cycle and cell death; Cellular reprogramming; Cell biology of inflammation; Analyzing and visualizing cells.

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Study materials and literature Lecture material and scientific publications indicated by lecturers. Applicable parts in Alberts et al., Molecular Biology of the Cell and Sperelakis N., Cell Physiology Sourcebook: Essentials of Membrane Biophysics. Assessment practices and criteria The exam is based on lectures, and on book chapters and articles indicated by lecturers. Final grading (scale 0-5) based on the exam (80%) and other activity during the course (20%).

Completion Contact teaching: lectures (appr. 20 h), group work including presentations by the student (appr. 20 h). Minimum of 70% attendance. In addition, the student needs to study and prepare assignments at own time (appr. 100 h) and pass the final exam. Additional information Degree students of the Masters Programme in Neuroscience will prepare their personal study plan during this course. Relations to other study units Replaces the former course 52097 Solufysiologia 3 cr. Responsible teacher University lecturer Ulla Pirvola

NEU-102: Cellular Neurobiology, 5 cp


Type: Course



Teachers: Sari Lauri, Juha Voipio Target group Graduate and advanced undergraduate students of Neuroscience, Molecular Biosciences and related Life Sciences. Timing Period 1. Degree students of the Master's Programme in Neuroscience are recommended to take this course during the first year of studies. Learning outcomes On completion of the course, the student has gained understanding of the mechanisms underlying fast electrochemical signaling in neurons and is able to integrate this information into a broader physiological context. He/she is able to explain how electrical signals are created, how they propagate in neuronal membranes and how they are transmitted from one neuron to another via chemical synapses. In addition, the student recognizes how cellular and synaptic mechanisms control the function of neuronal networks and link to behavior. Prerequisites Basic knowledge of cell biology and cellular physiology is necessary to obtain good learning outcomes. Contents The course addresses the mechanisms of cellular excitability, electrical signaling and synaptic transmission in neurons. In addition, the students familiarize with the mechanisms by which synaptic transmission can be regulated during physiological activity and how it is affected in various brain diseases. Study materials and literature Relevant parts from neuroscience textbooks complemented with material given in the lectures. The exact study materials will be given in the beginning of the course. Activities and teaching methods in support of learning

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Lectures, homework, group work including student presentations and an exam. The course consists of approximately 35 h of contact teaching and 100 h of independent and group work. Assessment practices and criteria Grade (scale 1-5) is based on assignments and the exam. Relations to other study units The course is obligatory for the Master’s students in Neuroscience and provides useful background for studies of cell and molecular biology and related biosciences. Responsible person Juha Voipio

NEU-103: Systems Neuroscience, 5 cp


Type: Course


Grading: General scale Course language: English

Teachers: Mikael Segerstråle Target group The course is intended primarily for students of the Master’s Programme in Neuroscience. It is compulsory for degree students of the Programme in the Neuroscience study track, but is also suitable for students in the biological, (neuro)psychological and biomedical sciences more generally. Timing Period 2, 1st year of Master’s studies. The course is organized annually. Learning outcomes After completion of the course, the student knows and is able to explain the roles and the organizational principles of the major functional systems of the brain and the nervous system. Prerequisites Successful completion of the course requires basic knowledge in neurobiology (as provided by e.g. the course Cellular neurobiology) Contents Organization of the central nervous system and the neural basis of cognition. Perception: somatosensory and sensory systems. Motor system and the control of movement. Study materials and literature Selected chapters of the textbook E.R. Kandel et al., Principles of Neural Science (5th edition); additional material may be distributed at the lectures Assessment practices and criteria The exam is based on the lectures, and on book chapters and other material indicated by lecturers. Final grading (scale 0-5) based on the exam (60 %) and the assignments (40 %). Completion Contact teaching: lectures (appr. 20 h) and group work (appr. 20 h). Minimum 70 % attendance. In addition, the student needs to study and prepare assignments (appr. 100 h of work) and pass the final exam. Relations to other studies: Part of the lectures of NEU-203 Systems Physiology are shared with the course NEU-103 Systems Neuroscience, and thus both courses cannot be included in the Master’s studies of the student. Responsible person University lecturer Mikael Segerstråle

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NEU-203 Systems Physiology, Systeemifysiologia, Systemfysiologi, 5 cr


Type: Course


Grading: General scale Course language: English

Teachers: Reijo Käkelä

Target group: The course is obligatory for students of the Cell and Systems Physiology study track of the Master’s Programme in Neuroscience. The course is also offered for master and graduate students in any life science field. If in need to limit class size, the students from the organizing master’s programmes and faculty are prioritized. Timing: Period 2 / The course is taught annually. Learning outcomes: Systems physiology integrates life functions at several levels of organization from molecules to functioning organism. After completing the course the student understands at very fundamental level the concepts of life emerging from complexity, and the features of the regulatory systems of life. Students acquire the skills to systematically dissect the processes at different organizational levels, through integrated molecular and cellular mechanisms, which determine the organism’s development, life functions and interactions with the environment. Prerequisites: BSc in any life science field. Contents: The course starts by characterizing the essential properties of biological systems, the emergence of new traits by complexity, and the regulation of the functions by homeostatic or allostatic mechanisms. Next demonstrative examples are presented where molecular and cellular interactions are integrated to form regulated physiological systems of animals. These cases reveal principles of neural and hormonal functions, sensing the environment, energy metabolism, and maintaining water balance, solute concentrations and body temperature. In addition, tissue renewal and repair, and setting the pace for reproduction are addressed. In each of the lectures and exercises the focus is on the principles of the design from molecules to organisms. Study material: Applicable parts of W.F. Boron and E.L. Boulpaep, Medical Physiology, and applicable parts of E.R. Kandel et al., Principles of Neural Science. Additional material (e.g. scientific articles, videos etc.) can be found in the Moodle area of the course. Assessment: The exam is based on the lectures, exercises and book chapters and articles indicated by lecturers. Final course grade (0-5) is based on the exam (60 %) and the assignments (40 %). Completion: Contact teaching is comprised of lectures (appr. 20 h) and group work (appr. 20 h). Minimum 70 % attendance. In addition, the student needs to study and prepare assignments (appr. 100 h of work) and pass the final exam. Relations to other studies: Part of the lectures of NEU-203 Systems Physiology are shared with the course NEU-103 Systems Neuroscience, and thus both courses cannot be included in the Master’s studies of the student. Responsible teachers: Reijo Käkelä

NEU-104: Integrative neurobiology, 5 cp


Type: Course


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Teachers: Kai Kaila Course language: English

Target group Students from different disciplines, including neuroscience, biology, molecular biosciences, psychology, medicine, physics and biomedical engineering. Timing Period II. Recommended to be completed during the first year of studies in the Master’s Programme in Neuroscience. Learning outcomes After completion of the course, the student has comprehensive insight into fundamental brain functions ranging from signaling mechanisms at the cellular level to brain functions governing i.a. behavioral, cognitive, neuroendocrine and metabolic processes and their interrelations within an organism. Special emphasis is put on critical evaluation of diverse techniques and interpretation of data and concepts, as well as on their historical aspects. Prerequisites Courses on Cellular neuroscience and Cellular physiology are recommended before this course. Contents The aim of the course is to give a thorough overview of neurobiology and its relations to other sciences. Neurobiology and its relationships to other fields of science, research methods, history of ideas and ideologies, biophysics of neuronal membranes, neuronal signaling, synaptic function and plasticity, genes and brains, learning and memory, motor system, neuroendocrinology, neuroethology, sensations and perception, brain disorders and neurobiology of consciousness. Study materials and literature Lecture handouts and notes. Selected chapters of relevant neuroscience text books (and review articles) are used as background reading material. Assessment practices and criteria Final examination based on lectures and the additional material (see above). The exam tests the students’ comprehension of major concepts as well as important data-based knowledge in neuroscience. Grading scale of the exam 0-5. Completion The course consists of lectures (appr. 30 h) and independent studying (appr. 100h). To complete the course, the students need to actively participate in lectures (minimum of 70% attendance) and to pass the final exam. Responsible person Professor Kai Kaila

NEU-105: Methods and Trends in Neuroscience, 5 cp


Type: Course


Grading: Pass-fail Course language: English


Target group This course is primarily intended for students of the Master’s Programme in Neuroscience, and compulsory for students choosing the neuroscience study track. It is designed to be studied during the first autumn term in parallel with the courses ”Cellular Physiology” and “Cellular Neurobiology”. Timing: Periods 1 and 2, annually. Learning outcomes

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The aim of this course is to provide students with exposure to current trends and methods in neuroscience, and thereby broaden students’ knowledge beyond what is taught on the lecture courses. In addition, students will learn to know better the local neuroscience community. Prerequisites It is recommended that the courses ”Cellular Physiology” and “Cellular Neurobiology” are taken in parallel (or before) this course. Contents The course consists of thematic days on specific topics. Students will learn to know the local neuroscience community and modern research methods during laboratory visits and excursions, they will be introduced to cutting edge research trends, and they will work on group assignments and presentations. Study materials and literature Material will be defined during the course and provided by the teachers or via Moodle. Assessment practices and criteria Grading scale pass - fail Completion A minimum of 70% attendance and active participation in in-class discussions and assignments including group work and quizzes, as well as completing independent homework assignments on time are required for passing the course. Relations to other study units Personal Study Plan is integrated to this course. Responsible teacher Professor Juha Voipio

NEU-205: Methods and Trends in Physiology and Neuroscience, 5 cp, Fysiologian ja

neurotieteen menetelmiä ja kehityssuuntia, Metoder och trender i fysiologi och

neurovetenskap


Type: Course


Grading: Pass-fail Course language: English

Teachers: Juha Voipio and Reijo Käkelä

Target group This course is primarily intended for students of the Master’s Programme in Neuroscience, and compulsory for students choosing the Cell and Systems Physiology study track. It is designed to be studied during the first autumn term in parallel with the courses ”Cellular Physiology” and “Cellular Neurobiology” (obligatory and optional, respectively, for the Cell and Systems Physiology study track). Timing: Periods 1 and 2, annually. Learning outcomes The aim of this course is to provide students with exposure to current trends and methods in cellular and systems physiology and neuroscience, and thereby broaden students’ knowledge beyond what is taught on the lecture courses. In addition, students will learn to know better the local physiology and neuroscience community. Prerequisites It is recommended that the courses ”Cellular Physiology” (obligatory) and “Cellular Neurobiology” (or other optional course) are taken in parallel (or before) this course. Contents The course consists of thematic days on specific topics. Students will learn to know the local cell and systems physiology and neuroscience community and modern research

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methods during laboratory visits and excursions, they will be introduced to cutting edge research trends, and they will work on group assignments and presentations. Study materials and literature Material will be defined during the course and provided by the teachers or via Moodle. Assessment practices and criteria Grading scale pass - fail Completion A minimum of 70% attendance and active participation in in-class discussions and assignments including group work and quizzes, as well as completing independent homework assignments on time are required for passing the course. Relations to other study units: Personal Study Plan is integrated to this course. Responsible teacher. Professor Juha Voipio and Reijo Käkelä NEU-106: Master’s Seminar in Neuroscience, 5 cp


Type: Course



Teachers: Eva Ruusuvuori, Henna-Kaisa Wigren, Reijo Käkelä

Target group Degree students of the Neuroscience study track of the Master’s Programme in Neuroscience. Timing Periods 1-4, recommended to be taken during the 2nd year of Master’s degree studies. The course is organized annually. Learning outcomes The objective of the seminar is to support the Master’s thesis project of the student. The students acquire the knowledge needed to carry out either an experimental or theoretical research project in accordance with the best procedures and standards of science. Students will practice scientific presentation skills and are trained in scientific dialogue. Students gain experience in reporting their work in the context of relevant literature and with the quality and clarity required for a Master’s thesis. Contents At the seminar, students practice academic writing and citing techniques, and prepare and give oral and poster presentations. They rehearse to present constructive feedback, orally and in writing. They learn how to design and carry out experimental or theoretical scientific projects and develop problem-solving skills and critical thinking. In all individual and group communication, the students are encouraged to provide clearly structured and coherent messages and contents based on independent thinking. Study materials and literature Material is defined during the seminar and provided by the teachers. Assessment practices and criteria Grade (scale 1-5) is based on presentations, assignments and communication. Completion Contact teaching appr. 30 h, assignments prepared at own time appr. 105 h (individual and group work). Participation to 100 % of seminar sessions (possible absences must be agreed upon with teachers in advance) and approved completion of all individual and group assignments and presentations are required in order to pass the course. Relations to other study units Master’s Seminar in Neuroscience and Master’s Seminar in Cell and Systems Physiology have mostly combined teaching and classes. Responsible teacher Eva Ruusuvuori, Henna-Kaisa Wigren, Reijo Käkelä

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NEU-306: Master’s Seminar in Cell and Systems Physiology, 5 cp


Type: Course



Teachers: Eva Ruusuvuori, Henna-Kaisa Wigren, Reijo Käkelä Target group Degree students of the Cell and Systems Physiology study track of the Master’s Programme in Neuroscience. Timing Periods 1-4, recommended to be taken during the 2nd year of Master’s degree studies. The course is organized annually. Learning outcomes The objective of the seminar is to support the Master’s thesis project of the student. The students acquire the knowledge needed to carry out either an experimental or theoretical research project in accordance with the best procedures and standards of science. Students will practice scientific presentation skills and are trained in scientific dialogue. Students gain experience in reporting their work in the context of relevant literature and with the quality and clarity required for a Master’s thesis. Contents At the seminar, students practice academic writing and citing techniques, and prepare and give oral and poster presentations. They rehearse to present constructive feedback, orally and in writing. They learn how to design and carry out experimental or theoretical scientific projects and develop problem-solving skills and critical thinking. In all individual and group communication, the students are encouraged to provide clearly structured and coherent messages and contents based on independent thinking. Study materials and literature Material is defined during the seminar and provided by the teachers. Assessment practices and criteria Grade (scale 1-5) is based on presentations, assignments and communication. Completion Contact teaching appr. 30 h, assignments prepared at own time appr. 105 h (individual and group work). Participation to 100 % of seminar sessions (possible absences must be agreed upon with teachers in advance) and approved completion of all individual and group assignments and presentations are required in order to pass the course. Relations to other study units Master’s Seminar in Cell and Systems Physiology and Master’s Seminar in Neuroscience have mostly combined teaching and classes. Responsible teacher Eva Ruusuvuori, Henna-Kaisa Wigren, Reijo Käkelä

NEU-110: Master's Thesis in Neuroscience, 30 cp


Type: Master's Thesis


Grading: General scale Course language: Finnish, Swedish, English

Target group: Students in Master’s Programme in Neuroscience who have chosen the study track of neuroscience. Timing: Second year of studies (recommendation). Learning outcomes:

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After completing the Master’s thesis the student knows how a research project proceeds, from planning the work and choosing appropriate methods to performing the experiments (or carrying out a theoretical or data-based study), analysing results, and writing a scientific report. The student is capable of scientific thinking and mastering some research methods, and he/she has acquired relevant skills in project management and written scientific communication. Prerequisites: The student should have a good theoretical understanding of the project, its aims and context, the necessary knowledge and skills for collecting and processing data, and skills in scientific writing. Contents: The Master’s thesis is usually based on an experimental research project and critical contemplation of the results in the light of scientific literature on the topic. The thesis may also consist of a theoretical literature study. The Master’s thesis project is carried out under the supervision of an experienced researcher, and it usually consists of four distinct phases: 1. Design and planning of the study (includes reading of relevant literature) 2. Gathering the data (e.g. laboratory work) 3. Analysing the data (e.g. validation/quality control, processing data, statistical analysis, plotting) 4. Interpreting and discussing the results in the light of existing literature, and writing the thesis. The thesis is written as if it were a scientific publication, critically describing, contemplating and discussing the results in the light of previous scientific literature on the topic. Study materials and literature: Mainly international, scientific papers depending on the topic of the Master’s thesis. Assessment practices and criteria: The MSc thesis is graded using the scale 0-5 according the guidelines set by the University and the Faculty. Completion: Before commencing the research work, the student prepares a Master's Thesis Plan together with the supervisor(s), submits it for approval by sending it to the teacher who is in charge of Master's Theses in the Programme, and enrolls to NEU-110 using registration in WebOodi. When the Thesis Plan is approved, registration will be confirmed in WebOodi. The aims of the study and the methods that will be used must be described in sufficient detail in the plan. Approval and grading is based on the written Master’s thesis. The thesis cannot be approved until the student has passed the maturity test. Master's thesis is a written report that presents the background and motivation of the study, materials and methods used as well as the results obtained in the study, and finally discusses the results in light of scientific literature published in the field. The thesis work is carried out under supervision, typically in a research project in which you have a clearly defined and an independent role. The student writes the thesis himself/herself, but the supervisor is supposed to provide feedback and advice on scientific writing. The total workload (30 credits) from designing the project to its completion is approximately 4.5 months (800 hrs, or 20 weeks at 40 hrs/week). For detailed information about the Master’s thesis, see the Faculty’s General Instructions for Master’s Theses as well as the Programme’s own guidelines. Relations to other study units: The Master’s thesis project must not be started before obtaining an approval for the Master’s thesis plan from the director of the Programme (or from the person nominated by the Programme to be in charge of the Master's theses). For further information, see the General Instructions for Master's Theses as well as the Programme’s own guidelines. Each Master’s thesis must have an assigned supervisor (usually a Principal Investigator (PI), professor, university lecturer, or some other specialist in the field). A thesis may have

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additional officially appointed co-supervisors. The primary supervisor must hold at least a doctoral degree or equivalent qualifications. Responsible person: Juha Voipio NEU-220: Master's Thesis in Cell and Systems Physiology, 30 cp




Grading: General scale Course language: Finnish, Swedish, English

Target group: Students in Master’s Programme in Neuroscience who have chosen the study track of cell and systems physiology

Timing: Second year of studies (recommendation). Learning outcomes: After completing the Master’s thesis the student knows how a research project proceeds, from planning the work and choosing appropriate methods to performing the experiments (or carrying out a theoretical or data-based study), analysing results, and writing a scientific report. The student is capable of scientific thinking and mastering some research methods, and he/she has acquired relevant skills in project management and written scientific communication. Prerequisites: The student should have a good theoretical understanding of the project, its aims and context, the necessary knowledge and skills for collecting and processing data, and skills in scientific writing. Contents: The Master’s thesis is usually based on an experimental research project and critical contemplation of the results in the light of scientific literature on the topic. The thesis may also consist of a theoretical literature study. The Master’s thesis project is carried out under the supervision of an experienced researcher, and it usually consists of four distinct phases: 1. Design and planning of the study (includes reading of relevant literature) 2. Gathering the data (e.g. laboratory work) 3. Analysing the data (e.g. validation/quality control, processing data, statistical analysis, plotting) 4. Interpreting and discussing the results in the light of existing literature, and writing the thesis. The thesis is written as if it were a scientific publication, critically describing, contemplating and discussing the results in the light of previous scientific literature on the topic. Study materials and literature: Mainly international, scientific papers depending on the topic of the Master’s thesis. Assessment practices and criteria: The MSc thesis is graded using the scale 0-5 according the guidelines set by the University and the Faculty. Completion: Before commencing the research work, the student prepares a Master's Thesis Plan together with the supervisor(s), submits it for approval by sending it to the teacher who is in charge of Master's Theses in the Programme, and enrolls to NEU-220 using registration in WebOodi. When the Thesis Plan is approved, registration will be confirmed in WebOodi. The aims of the study and the methods that will be used must be described in sufficient detail in the plan. Approval and grading is based on the written Master’s thesis. The thesis cannot be approved until the student has passed the maturity test. Master's thesis is a written report that presents the background and motivation of the study, materials and methods used as well as the results obtained in the study, and finally

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discusses the results in light of scientific literature published in the field. The thesis work is carried out under supervision, typically in a research project in which you have a clearly defined and an independent role. The student writes the thesis himself/herself, but the supervisor is supposed to provide feedback and advice on scientific writing. The total workload (30 credits) from designing the project to its completion is approximately 4.5 months (800 hrs, or 20 weeks at 40 hrs/week). For detailed information about the Master’s thesis, see the Faculty’s General Instructions for Master’s Theses as well as the Programme’s own guidelines. Relations to other study units: The Master’s thesis project must not be started before obtaining an approval for the Master’s thesis plan from the director of the Programme (or from the person nominated by the Programme to be in charge of the Master's theses). For further information, see the General Instructions for Master's Theses as well as the Programme’s own guidelines. Each Master’s thesis must have an assigned supervisor (usually a Principal Investigator (PI), professor, university lecturer, or some other specialist in the field). A thesis may have additional officially appointed co-supervisors. The primary supervisor must hold at least a doctoral degree or equivalent qualifications. Responsible person: Juha Voipio

NEU-310: Master’s thesis in the study track of biology teacher, 30 cp Validity: 01.01.2017 - Form of study: Advanced studies




Course language: Finnish, Swedish, English

Target group: Students in Master’s Programme in Neuroscience who have chosen the study track of biology teacher. Timing: Second year of studies (recommendation). Learning outcomes: After completing the Master’s thesis the student knows how a research project proceeds, from planning the work and choosing appropriate methods to performing the experiments (or carrying out a theoretical or data-based study), analysing results, and writing a scientific report. The student is capable of scientific thinking and mastering some research methods, and he/she has acquired relevant skills in project management and written scientific communication. Prerequisites: The student should have a good theoretical understanding of the project, its aims and context, the necessary knowledge and skills for collecting and processing data, and skills in scientific writing. Contents: The Master’s thesis is usually based on an experimental research project and critical contemplation of the results in the light of scientific literature on the topic. The thesis may also consist of a theoretical literature study. The Master’s thesis project is carried out under the supervision of an experienced researcher, and it usually consists of four distinct phases: 1. Design and planning of the study (includes reading of relevant literature) 2. Gathering the data (e.g. laboratory work) 3. Analysing the data (e.g. validation/quality control, processing data, statistical analysis, plotting) 4. Interpreting and discussing the results in the light of existing literature, and writing the thesis. The thesis is written as if it were a scientific publication, critically describing, contemplating and discussing the results in the light of previous scientific literature on the topic.

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Study materials and literature: Mainly international, scientific papers depending on the topic of the Master’s thesis. Assessment practices and criteria: The MSc thesis is graded using the scale 0-5 according the guidelines set by the University and the Faculty. Completion: Before commencing the research work, the student prepares a Master's Thesis Plan together with the supervisor(s), submits it for approval by sending it to the teacher who is in charge of Master's Theses in the Programme, and enrolls to NEU-310 using registration in WebOodi. When the Thesis Plan is approved, registration will be confirmed in WebOodi. The aims of the study and the methods that will be used must be described in sufficient detail in the plan. Approval and grading is based on the written Master’s thesis. The thesis cannot be approved until the student has passed the maturity test. Master's thesis is a written report that presents the background and motivation of the study, materials and methods used as well as the results obtained in the study, and finally discusses the results in light of scientific literature published in the field. The thesis work is carried out under supervision, typically in a research project in which you have a clearly defined and an independent role. The student writes the thesis himself/herself, but the supervisor is supposed to provide feedback and advice on scientific writing. The total workload (30 credits) from designing the project to its completion is approximately 4.5 months (800 hrs, or 20 weeks at 40 hrs/week). For detailed information about the Master’s thesis, see the Faculty’s General Instructions for Master’s Theses as well as the Programme’s own guidelines. Relations to other study units: The Master’s thesis project must not be started before obtaining an approval for the Master’s thesis plan from the director of the Programme (or from the person nominated by the Programme to be in charge of the Master's theses). Each Master’s thesis must have an assigned supervisor (usually a Principal Investigator (PI), professor, university lecturer, or some other specialist in the field). A thesis may have additional officially appointed co-supervisors. The primary supervisor must hold at least a doctoral degree or equivalent qualifications. Responsible person: Juha Voipio

NEU-111: Maturity test, 0 cp

Form of study: Advanced studies

Type: Course


Grading: Pass - fail Course language: Finnish, Swedish, English

Responsible person: Juha Voipio


Form of study: General studies

Type: Course




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Form of study: General studies

Type: Course




NEU-207 Regulatory Networks in Metabolism, Aineenvaihdunnan säätelyverkot,

Metaboliska regleringsnätverk, 5 cr


Type: Course



Teachers: Reijo Käkelä, Ville Hietakangas

Target group: Primarily for Master students in any life science field. Provided also for graduate students in these fields. If in need to limit class size, the students from the organizing master’s programmes and faculties are prioritized. Timing: Period 2 / The course is taught annually. Learning outcomes: Students get familiar with the principles of regulatory mechanisms controlling metabolic pathway activities, including gene regulation, signaling and systemic control of metabolism by hormones. After the course they recognize that metabolic regulation occurs though integrated control at different organization levels. The students are able to describe central features of the metabolic design of biological systems, name key regulators of metabolism and understand their physiological roles. The students are introduced to the methods of metabolic flux analyses, which ease the way to take advanced modeling courses later during their career. Prerequisites: BSc in any life science field. Contents: The mechanisms of regulating animal metabolism in response to the dietary intake in terms of nutrient quantity and quality are addressed. Lectures deal with the fundamental nutrient-responsive signaling pathways and gene regulatory networks involved. In addition, the role of mitochondrial signaling in adjusting metabolism is studied. The focus is on the principles of the integration of metabolic events, not on the detailed description of the pathways per se. For example, the signaling systems used to integrate metabolism of carbohydrates, lipids, and proteins on cellular and organismal levels are among central themes of the course. The principles are introduced by using examples from vertebrate and invertebrate animal models. The regulation of metabolic fluxes in different conditions are studied by using the systems biology approach, and the methods of performing metabolic flux analysis are demonstrated as one central topic of the exercises. Study material: Selected review articles illuminating the mechanisms of metabolic regulatory networks are studied while preparing the graded assignments. Assessment: Grading 0-5 is based on the final exams and obligatory assignments. Detailed instructions for assignments appear on the Moodle page of the course. Completion: The students need to participate (min 70%) in the obligatory lectures and exercises, submit all assignments, and pass the final exam. The work required on own time is about 90 h.

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Responsible teachers: Reijo Käkelä, Ville Hietakangas Additional information: Master's Programme in Neuroscience organizes the course in collaboration with the Master's Programme in Genetics and Molecular Biosciences (Faculty of Biological and Environmental Sciences).

NEU-231 Mechanisms of regeneration and aging, Uusiutumisen ja vanhenemisen

mekanismit, Regenererandets och åldrandets mekanismer, 5 cr


Type: Course


Grading: General scale Teachers: Ulla Pirvola, Pekka Katajisto

Target group: Primarily for master’s students in any Life science field. Provided also for graduate students in these fields. If in need to limit class size, students from the organizing master’s programmes and faculty are prioritized. Timing: Period 4 / The course is taught annually. Learning outcomes: Students are able to describe the basic mechanisms known to be involved in regeneration and aging. Based on this knowledge gained, they are able to critically evaluate the current and future possibilities to manipulate the regeneration and aging processes of cells and tissues. This provides deep understanding on the functional systems level differences that occur between different organisms and during the life span of an organism. Prerequisites: BSc in any Life science field. Contents: During the first half of the course (1) regeneration mechanisms based on stem cells and functional cell types are explained. The differences in regeneration capacity between animals of different phyla and different ages are addressed. The aim is to understand the molecular and cell biological reasons behind these differences and, specifically, the regeneration barriers of many mammalian cell types. Differences in regeneration and repair mechanisms are explained. Models such as invertebrate Planarians as well as vertebrate muscle, heart, central nervous system and sensory organs are addressed. It is discussed whether the knowledge on the mechanisms of natural regeneration/repair could be brought into therapeutic interventions. Current methods for regeneration research are illuminated. The latter half of the course addresses (2) the mechanistic reasons of aging that eventually reduce tissue function and result in frailty, aging associated diseases, and death. Mechanistic insight is provided to understand how the rate of aging can be influenced and why different organisms age very differently. The multiple types of age-associated alterations and their counteracting repair mechanisms will be detailed to address how levels of tissue renewal by tissue specific stem cells and damage accumulation influence aging. Study material: Lecture material is provided for each session. In addition, selected articles (max 12) illuminating the mechanisms of regeneration and aging are studied while preparing the graded assignments. Assessment: Grading 0-5 is based on the peer assessed final exam (50%) and obligatory presentations and assignments (50%). Detailed instructions for presentations and assignments appear on the Moodle page of the course. Completion: Students need to participate (min 80%) in the sessions, including lectures (about 20 h), group work (about 6 h) and closing symposium with oral presentations (6 h). Students need also to prepare written assignments and pass the final exam. The work required on own time is about 100 h.

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Relations to other studies: Master's Programme in Neuroscience organizes the course in collaboration with the Master's Programme in Genetics and Molecular Biosciences (Faculty of Biological and Environmental Sciences). Responsible teachers: Ulla Pirvola, Pekka Katajisto

NEU-561 Principles of Bioscience Omics, Biotieteellisten omiikkojen perusteet, Grunderna i

biovetenskapliga omiker, 10 cp


Type: Course



Teachers: Reijo Käkelä, Pia Siljander, Marc Baumann

Target group: Primarily for master’s students in any life science field. Provided also for graduate students in these fields. If in need to limit class size, the students from the organizing master’s programmes and faculties are prioritized (especially the students for whom NEU-561 is obligatory). Timing: Periods 3–4 / The course is taught annually. Learning outcomes: The students acquire a general view of the work flow of different systems scale methods of biochemical analyses, known collectively as omics, and the related bioinformatics required for data analysis. After the course, students can design omics-based experimentation and are aware of methodological pitfalls. Students will be able to read and interpret multivariate omics data, which allows them to efficiently utilize data produced by different omics core facilities. They will also be able to integrate results from different omics approaches and platforms, e.g. between genome, proteome and metabolome. Prerequisites: BSc in any life science field. Contents: During the course the principles of genomics, proteomics, metabolomics and lipidomics are studied to the extent which is needed to read and interpret these omics data. Contemporary methodologies in genomics and transcriptomics are demonstrated. The mass spectrometry approaches presented are targeted mass spectrometric analysis of preselected molecules, compositional analysis of metabolites by non-targeted mass spectrometric profiling and mass spectrometric imaging of tissue compound localization. In addition, rehearsals of data integration across different omics approaches and platforms are performed. Students are familiarized with the most frequently used bioinformatics methods, which are used in the context of the demonstrated omics. The course contents are subject to change. Study material: Selected review articles illuminating the principles of omics and related bioinformatics are studied while preparing the graded assignments. Assessment: The students need to participate (min 80%) in the obligatory lectures and exercises (70 h), submit all assignments, and pass all the Moodle quizzes. The work required on own time is about 200 h. Completion: Grading 0-5 is based on the obligatory assignments. In addition, for each course section a Moodle quiz needs to be passed. The points given for each assignment are detailed on the Moodle page of the course. Responsible teachers: Reijo Käkelä, Pia Siljander (Viikki), Marc Baumann (Meilahti) Additional information: Master's Programme in Neuroscience (NEU, Faculty of Biological and Environmental Sciences) organizes the course in collaboration with the Master's Programme in Genetics and Molecular Biosciences (GMB, Faculty of Biological and Environmental Sciences) and the Master's Programme in Translational Medicine (TMED,

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Faculty of Medicine). The course is obligatory in the study tracks of NEU/Cell and Systems Physiology and GMB/Molecular and Analytical Health Biosciences.

NEU-251 Molecular Nutrition, Molekulaarinen ravitsemus, Molekylär näring, 5 cr


Type: Course


Grading: General scale Teachers: Reijo Käkelä, several colleagues and education technology specialists

Target group: Primarily for master’s students in any life science field. Provided also for graduate students in these fields. Timing: Course can be taken annually, and anytime during periods 1–4. Once students register in the Moodle area of the course, they at the same time register to the course. Learning outcomes: Students recognize that differential biological effects of related but structurally slightly different molecules originate from different mechanistic interactions at the levels of digestion, absorption, and metabolism including specific signaling consequences of nutrients. They are able to logically describe organism’s responses to nutrients taking into consideration the transfer and process routes and duration of the biological interaction. When studying cellular events, students are able to use molecular level explanations that include altered signaling and gene expression and specific changes in lipid-protein interactions manifested in altered function. Equally importantly, the students are able to describe consequences at systemic physiology level keeping in mind the crucial role of digestive tract microbiota in processing nutrients. The generic skills trained during this web course include fact-finding and processing, problem solving and analytical mechanistic thinking. Prerequisites: BSc in any life science field. Contents: The course provides profound understanding on the molecular mechanisms of action of nutrients on biological systems. The themes addressed are 1) carbohydrates and gut microbes, 2) nervous system and nutrition, 3) lipids in health and disease, and 4) non-coding RNA in regulating metabolism. Examples from human physiology to animal ecology are used to illustrate the mechanism. The course is implemented as a web course. Study material: All the study material (e.g. scientific articles, videos etc.) can be found in the Moodle and ThingLink areas of the course. Assessment: Grading 3–5 is based on passing the web platform assignments exams. Passing all the obligatory exams provides the grade 3/5. Passing all the assignments exams, obligatory and voluntary, provides the grade 5/5. Completion: Students accomplish in sequence several exams in the Moodle area. The course is passed when all the obligatory exams are passed. The very final obligatory exam is an oral exam in zoom revisiting a few student essay answers typed on the digital platform. Responsible teachers: Reijo Käkelä

NEU-404: Practical training 1, 5-10 cp


Type: Course


Grading: Pass-fail

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Target group: Students of Master’s Programme in Neuroscience Timing: Recommended to be completed during the first or second year, but before the Master’s thesis. Learning outcomes: After the practical training period, the student o has acquired practical experience in a research group or company

o has improved her/his ability to apply and assess her/his own knowledge and skills

o has improved her/his ability for independent work and reporting of results

o has enhanced her/his potential as a future jobseeker in a wider network within the field of study

Contents: Before starting the practical training period, the student will write an internship plan. After the period, the student will write a report that summarized the experience gained. The work itself must be full time and related to student’s field of studies. One month of full time work will give 5 cr. Working life period can be with or without salary (although the latter is not recommended), in a university or outside university. The student must agree beforehand with the responsible teacher, on the suitability of the job description for the practical training period. Assessment practices and criteria: Grading pass / fail. This will be estimated according to the internship plan and report and the statement given by the employer Completion: Practical work in duties related to student’s field of studies. Writing a practical training plan and report according to given instructions at the Student Guide. 1 to 2 months, 1 month of full-time work corresponding 5 cr. In order to be worth 10 credits, the training period must include more diverse tasks and offer a more comprehensive learning experience instead of just lasting twice longer than a 5 cr training period. Responsible person: University lecturer Mikael Segerstråle

NEU-405: Practical training 2, 5 cp


Type: Course


Grading: Pass-fail Teachers: Mikael Segerstråle

Target group: Students of Master’s Programme in Neuroscience Timing: Recommended to be completed during the first or second year, but before the Master’s thesis. Learning outcomes: After the practical training period, the student o has acquired practical experience in a research group or company

o has improved her/his ability to apply and assess her/his own knowledge and skills

o has improved her/his ability for independent work and reporting of results

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o has enhanced her/his potential as a future jobseeker in a wider network within the field of study

Contents: Before starting the practical training period, the student will write an internship plan. After the period, the student will write a report that summarized the experience gained. The work itself must be full time and related to student’s field of studies. One month of full-time work will give 5 cr. Working life period can be with or without salary (although the latter is not recommended), in a university or outside university. The student must agree beforehand with the responsible teacher, on the suitability of the job description for the practical training period. Assessment practices and criteria: Grading pass / fail. This will be estimated according to the internship plan and report and the statement given by the employer Completion: Practical work in duties related to student’s field of studies. Writing a practical training plan and report according to given instructions at the Student Guide. 1 month of full-time work corresponding 5 cr. Responsible person: University lecturer Mikael Segerstråle

NEU-414 Research project, Tutkimusprojekti, Forskningsprojekt, 5 – 10 cp


Type: Course


Grading: pass / fail Course language: English

Target group: Students of Master’s Programme in Neuroscience. Timing: Recommended to be completed during the first or second year, but before the Master’s thesis. Learning outcomes: The student will gain skills in planning, performing and reporting scientific research, as well as in research project management, by carrying out a mini project. Prerequisites: Studying most of the obligatory courses of your study track is recommended before taking the research project. Contents: The mini project includes all steps of a typical scientific research project, from project planning to writing up a manuscript, but in a very concise form. Within about four weeks of full time work you are supposed to accomplish steps including defining a research question, reviewing a few papers that are most relevant to the project, formulating a hypothesis and choosing an appropriate method, designing and performing one or a few experiments to answer the research question, analysing the obtained data, and finally writing a mini paper. The experimental part of the project is done either by participating in a few experiments done by the supervisor, or by doing one or a few experiments yourself under your supervisor’s guidance. All steps will be supervised by a researcher, and it is essential to plan the project so that each step will take no more than a few days. Thus, the manuscript to be written may be based on a single result. The manuscript should have the structure that is typical for papers published in the field of research (e.g., abstract, introduction, materials and methods, results, discussion, references, figure(s) and figure legend(s)), yet it should be very concise (max 2500 words in the whole document).

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Study material: Less that ten published papers recommended by the supervisor of the project. Assessment: Grading pass – fail, based on the written manuscript and the supervisor’s assessment. Completion: The student finds a supervisor, they agree about the project and prepare a brief written proposal that must be accepted by the responsible teacher before the project is commenced. The project may then be carried out as described above. Although supported by the supervisor’s guidance, a significant part of the four weeks full time work is supposed to be the student’s independent work. Completion requires submitting the written manuscript to the responsible teacher, and the supervisors’ assessment. Responsible person: Professor Juha Voipio

NEU-415 Creative scientific thinking, Luova tieteellinen ajattelu, Kreativt vetenskapligt

tänkande, 5 cp

Validity: 01.01.2020 - Form of study: Interdisciplinary studies

Type: Course

Unit: Master's Programme in Neuroscience, Master’s Programme in Genetics and Molecular Biosciences Grading: Pass/fail Teachers: Leonardo Almeida-Souza, Reijo Käkelä, Elina Roine, Eva Ruusuvuori and several session facilitators

Target group: Student’s from any bachelor’s, master’s and doctoral programmes can attend and will be working in heterogeneous groups. Teaching and research staff are also welcome to join the working groups. International partner universities are invited to attend. Timing: Periods 1–4 / The creative activities is taught annually. Learning outcomes: The creative activity will encourage the participants to integrate material and information across subject areas, question their assumptions, and imagine new viewpoints and possibilities. The goal is to promote collaborative and innovative scientific thinking. The open-minded search of new ideas is followed by analytical thinking and employing the scientific method. Participants are encouraged to take advantage of their personal interests and experiences to aid their reasoning in a scientific context. Prerequisites: No prerequisites. Contents: The activity takes place online and is comprised of group work based on the questions and trigger material provided by the facilitators for each case. The questions require creative thinking and do not have one predicted solution. The mind maps produced by groups are discussed in a following session with invited experts. The students are given the possibility to carry out a creative project based on their own innovative idea and utilizing their particular interests. The media that is used to present the work is not restricted, provided that the scientific content remains sufficient. Study material: The trigger materials for the creative group work are provided by the facilitators of each case. Assessment: Students submit their ideas on the case topics to the activity platform after getting familiar with trigger material. They participate in the sessions that include group work, producing and submitting of mind maps, and discussions with invited experts. Completion: Students take part in 6 cases of the creative activity programme, and prepare the different assignments related to them. Alternatively, they can perform their own creative project (enquiries to responsible teachers). Responsible teachers: Reijo Käkelä, Leonardo Almeida-Souza, Elina Roine, Eva Ruusuvuori

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NEU-502: Synaptic Signaling and Plasticity, 5 cp


Type: Course



Teachers: Sari Lauri, Kari Keinänen

Target group Advanced undergraduate, graduate and doctoral students of Neuroscience, Molecular Biosciences and related Life Sciences. Timing Period 3 or 4 Learning outcomes The students will familiarize with the concept, mechanisms and consequences of synaptic signaling and activity–dependent synaptic plasticity in the central nervous system. On completion of the course, the student has gained an understanding of the molecular mechanisms of chemical neurotransmission, can explain how neurotransmitters act on their receptors and induce downstream signals and is able to integrate this information into a physiological context. The student has also obtained practice in critical reading and discussing literature and communicating scientific knowledge. Prerequisites Basic knowledge of neurobiology as well as cell and molecular biology is assumed. Contents The course addresses the mechanisms underlying fast synaptic transmission and activity-dependent synaptic plasticity in the brain. The topics include structure and function of ligand-gated ion channel and G-protein coupled receptors for major neurotransmitters, mechanisms underlying neurotransmitter release as well as induction and expression of Hebbian and homeostatic plasticity. The focus is on the molecular mechanisms mediating glutamatergic transmission, but modulation of these mechanisms in response to physiological signals as well as its relevance for circuit function and behavior will be covered as well. Study materials and literature Reading list covering relevant material from neuroscience textbooks and review and research articles will be given in the beginning of and during the course. Assessment practices and criteria Grade (scale 0-5) is based on attendance and activity in class, presentation and the exam. Completion Lectures, seminars (incl. own oral presentation and written summary) and an exam. Contact teaching approximately 35 h, independent and group work 100 h. Relations to other study units The course provides useful background for studies of neurobiology, pharmacology and cell and molecular biology. Responsible person University lecturer Sari Lauri, Professor Kari Keinänen

NEU-503: Neuronal cell culture workshop, 3 cp


Type: Course


Grading: Pass-fail Teachers: Pirta Hotulainen


Target group Maximum number of students: 10-12, selected based on the student’s degree program and application/motivation letter. • Students of Master’s Programmes in Neuroscience and Doctoral Programme Brain & Mind.

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• Other MSc students and doctoral candidates interested in neuronal cell cultures

Timing Period III Learning outcomes After completion of the course the student will understand • how neurons can be dissociated and cultured

• how to transfect and image cultured neurons and how the images can be analyzed.

• the difference between tissue specific cell lines and primary neurons

• the importance of an in vitro system

Completion methods Lectures, demonstrations, laboratory exercises and presentations by the students. Attendance to the hands on demonstration and 80% attendance to the lectures is necessary. Prerequisites NEU-101 and NEU-102 or similar courses are highly recommended for those planning to attend the course. Contents Aseptic working methods, establishment and maintenance of primary neural cell cultures, transfection, immunofluorescence staining, and live cell imaging. Study materials and literature Study material will be provided during the course. Assessment practices and criteria Presentation and assignment completion based on lectures and study material. Grading scale pass/fail Responsible teachers: Pirta Hotulainen

NEU-511: Systems and Cognitive Neuroscience, 5 cp


Type: Course



Teachers: N.N. Target group 1. Students of Master’s Programme in Neuroscience 2. Students of Master’s Programme in Translational Medicine 3. Students of the Doctoral Programme Brain & Mind 4. Other MSc students and doctoral candidates unless restricted by space limitations Timing Period III or IV Learning outcomes After the course the students should be able to - Understand the concepts and basic mechanisms of different kinds of brain dynamics. - Understand the general concepts in systems and cognitive neuroscience. - Understand the methodology for measuring human-cognition-related brain activity with electrophysiological and magnetic-resonance -imaging (MRI) based approaches - Understand the analysis of hemodynamic activity and analysis of neuronal dynamics from human / animal electrophysiological data. - Understand the basic methods used in analyses of MRI and human/animal electrophysiological data. - Understand how the brain activity and its dynamics are related to (i) cognition and behavior, (ii) emotions and social interactions, and (iii) brain disorders. before this course. Prerequisites Basic courses of neuroscience and neurophysiology are recommended Contents General concepts of different kinds of neuronal dynamics and their underlying mechanisms. - General concepts in systems and cognitive neuroscience. - Methodology for measuring for measuring human-cognition-related brain activity with electrophysiological and magnetic-resonance -imaging (MRI) based approaches

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- Overview of the analysis of hemodynamic activity and analysis of neuronal dynamics from human / animal electrophysiological data. - Overview of the theories and evidence on how the brain/ neuronal activity and dynamics are related to cognition and behavior. - Overview on how the brain activity and its dynamics are related to (i) cognition and behavior, (ii) emotions and social interactions, and (iii) brain disorders. Study materials and literature Literature and reading material will be provided for course participants. Assessment practices and criteria Grading scale 0-5 based on examination. Completion The course consists of lectures, practical exercises, and assignments, and an examination. Lectures and practical exercises 30 h, assignments and independent work 100 h. Responsible person Juha Voipio

NEU-512: Animal models in behavioural neuroscience, 5 cp


Type: Course



Teachers: Vootele Voikar Course language: English

Target group 1. Students of Master’s Programme in Neuroscience and Doctoral Programme Brain & Mind. 2. Other MSc students and doctoral candidates Timing Period III or IV Learning outcomes After the course the students should be able to - describe the general principles and basic concepts of animal models and study design in behavioural neuroscience - understand importance of species-specific characteristics in animal models - critically evaluate the role of genetic background, sex and environmental influences on experimental outcome - indicate appropriate tests for behavioural assessment of animal models for neuropsychiatric and neurodegenerative disorders - describe the animal behaviour in ethological perspective Prerequisites Basic knowledge in neuroscience and laboratory animal science Contents General principles of animal models and study design in behavioural neuroscience; Behavioural phenotyping of animal models for neuropsychiatric and neurodegenerative disorders, learning and memory; Challenges of comprehensive phenotyping – role of environment, standardization of the procedures, genetic background; Ethological perspective Study materials and literature List of recommended literature will be provided for course participants.

Assessment practices and criteria Full attendance at lectures and group works (minimum requirements will be defined in more detail at the beginning of the course), written exam and learning diary. Completion The course consists of lectures (~32 h), individual work (~90 h) and group work (~12 h) followed by examination Responsible person Vootele Voikar

NEU-521: Basic mechanisms of nervous system diseases, 5 cp

Validity: 01.01.2017 -

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Form of study: Advanced studies

Type: Course

Unit: Master's Programme in Neuroscience, Master's Programme in Translational Medicine


Teachers: Henna Tyynismaa, Emil Ylikallio

Course language: Finnish

Target group 1. Students of Master’s Programmes in Neuroscience and Translational Medicine, and Doctoral Programme Brain & Mind. 2. Other MSc students and doctoral candidates interested in mechanisms underlying nervous system diseases Timing Period III Learning outcomes After completion of the course the student: - is familiar with clinical manifestations of selected nervous system diseases - is familiar on the current understanding on the molecular basis and the underlying pathophysiological mechanisms of selected nervous system disorders - has gained understanding into the research paradigms of nervous system disorders - has gained understanding into the treatment paradigms of selected nervous system disorders Prerequisites A prerequisite for successful completion of the course is that the student comprehends the basic concepts in genetics, molecular biology and neurobiology. Contents The lectures of the course include neurodegenerative, ischemic, neuroimmunological, neuropsychiatric and neuromuscular diseases. The lectures are given by both basic researchers and clinicians. Study materials and literature Lecture material and specific scientific review articles indicated by the lecturers (1-2 articles / lecture). Completion Lectures, 26 hours with 80% attendance (1 credit); Lectures and independent reading of literature, 110 hours and passing of the final exam (5 credits). Assessment practices and criteria For 5 credits: Final examination based on lectures and review articles indicated by the lecturers. Grading scale of the exam 0-5. For 1 credit: 80% attendance in the lectures. Pass-fail Responsible person Henna Tyynismaa, Emil Ylikallio

NEU-522: Pre-clinical models of neurological diseases and emerging therapies, 5 cp

Validity: 01.01.2017 -31.7.2021 (will not be organized in 2021-22) Form of study: Advanced studies

Type: Course



Teachers: Anne Panhelainen

Target group 1. Students of Master’s Programmes in Neuroscience and Translational Medicine, and Doctoral Programme Brain & Mind.2. Other MSc students and doctoral candidates interested in mechanisms underlying nervous system diseases Maximum number of participants: 40 Timing Period III/IV Learning outcomes After completion of the course, the student

• knows the most common pre-clinical models of neurological diseases and can evaluate them by their strengths and weaknesses

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• has the current understanding of the mechanisms leading to disease pathology and understands how this knowledge has been achieved from studies using the pre-clinical models of the selected neurological diseases

• knows the basic mechanisms of the current treatments • knows the emerging therapies and basics on how they proceed from research to

clinic Prerequisites Students attending this course should have basic knowledge of neurotransmitter systems and neuropharmacology. It is recommended to have taken the course “Basic mechanisms of nervous system diseases”. Contents Understanding the mechanisms and the progressive pathology of the neurological diseases is the basis for developing new treatments to them. Different research models (in vivo and in vitro) enable us to study these mechanisms and test the effectiveness and safety of the new treatments. Neurological diseases are extremely complex and currently we are mostly only able to treat the symptoms, no cures exist. Many exciting new treatments are emerging, though the path from the pre-clinical research to clinical trials is long and expensive. This course presents the current state of research and drug development for the most common neurological disorders. Study materials and literature Selected scientific reviews and papers on the discussed topics will serve as the study material. Assessment practices and criteria Grading of the course (0-5) is based on evaluation of the group work and presentations (25%) and the final examination based on lectures and indicated review articles (75%). Criteria for evaluation will be available in the Moodle. Completion The course consists of lectures (appr. 15 h), group work on problem-based learning cases and student presentations (appr. 80 h) and independent studying (appr. 40h). To complete the course, the students need to actively take part in lectures and group work (80%), and pass the final exam. Responsible person Anne Panhelainen

NEU-531: Developmental Neuroscience, 5 cp


Type: Course




Target group

Students from different disciplines, including neuroscience, biology, molecular biosciences, psychology, physics, biomedical engineering and medicine Timing: Period III Learning outcomes After completion of the course the student has gained understanding into the development of the central and peripheral nervous system and sensory organs. The student is familiar with the development of neuronal communication. He/she has gained understanding into the current paradigms and methods of developmental neuroscience research. Prerequisites A prerequisite for successful completion of the course is that the student has understanding of the basic concepts in neuroscience and/or developmental biology. Contents Lectures in the course include: Neuronal induction and neurogenesis; Regulation of neuronal fate; Axonal outgrowth and regeneration; Synaptogenesis; Ionic regulation of neuronal development; Development and refinement of neuronal circuits; Gliogenesis and

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myelinization; Development of the peripheral nervous system; Neuronal migration; Neuronal cell death, Development of sensory systems; Developmental brain disorders. Study materials and literature Lecture material and scientific publications indicated by lecturers. Applicable parts in Kandel E. et al. Principles of Neuroscience and Sanes D. et al., Development of the Nervous System. Assessment practices and criteria

The exam is based on lectures and on book chapters and articles indicated by lecturers. Final grading (scale 0-5) based on the exam (70%) and assignments (30%). Completion methods Contact teaching: lectures (appr. 20 h), group work including presentations by the student (appr. 20 h). Minimum of 70% attendance. In addition, the student needs to prepare assignments at own time (appr. 100 h) and pass the final exam. Relations to other studies Replaces the former course 920002 Developmental neuroscience, 3 cr. Responsible teacher University lecturer Ulla Pirvola

NEU-541: Introduction to neurobiophysics, 5 cp


Type: Course




Target group This course is well suited for students of the Master’s Programme in Neuroscience or of related Programmes, as well as for doctoral students. Timing This course runs annually in spring term (period 3 and 4). Learning outcomes After completing the course, students will be able to explain how electrical signals arise at the cellular level using biophysical theories and models. They know and are able to explain, in biophysical terms, structure-function relationships in ion channels, and they have acquainted themselves in detail with some ion channel structures. Prerequisites Students need to have some previous knowledge of molecular and cellular neurobiology in order to be able to achieve good learning outcomes. Contents Basic concepts and principles of ion flux-mediated signalling; the Hodgkin-Huxley model, voltage gated channels, and permeation models; physicochemical principles and molecular mechanisms of ion channel function; structure-function relationships of ion channels including mechanisms of selective permeability, gating and block; types of ion channels and their interplay at the cellular level; electrical signalling in dendrites; synaptic transmission and the origin and analysis of extracellular field potential signals. Study materials and literature The study materials include a major part of the book by Bertil Hille, Ion Channels of Excitable Membranes, 3rd edition, 2001, Sinauer, plus some more recently published review articles and lecture handouts. Assessment practices and criteria: Grading scale 0 – 5. Completion: Weekly written examinations (recommended method of completion) or alternatively a final exam. With weekly exams, passing the course requires passing ≥80 % of the weekly exams, and grading is based on the mean of the separately graded weekly

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exams . The course consists of approximately 20 h of contact teaching and 100 h of independent studying. Relations to other study units This course replaces the previous course 522020 Neurobiophysics 1 (80%) and parts of the course 522021 Neurobiophysics 2 (20%). Responsible person Professor Juha Voipio

NEU-542: Electrophysiological techniques, 5 cp


Type: Course





Target group This course is intended primarily for students of the Master’s Programme in Neuroscience or other students studying the Electrophysiology and Neurobiophysics -module. The course is also suitable for doctoral students. Maximum number of students: 18. Timing This two week course runs annually in spring term (period 3 or 4). If the number of students attending the course is 10 to 18, the second week will run in two shifts (morning and afternoon shifts) and the detailed schedule of the second week will be planned together with the students. Prerequisites Previous knowledge of basic neurobiology is necessary, and some knowledge of elementary physics and electricity is helpful, for achieving good learning outcomes. Learning outcomes Upon completion of the course successful students have gained an in-depth understanding of the implementation of microelectrode recordings in current clamp and voltage clamp modes using either sharp or patch-clamp micropipettes. They are able to explain the sources of error and critical steps in the proper use of electrophysiological equipment. Students will be able to critically read scientific papers where data have been obtained using electrophysiological methods, and they will have the theoretical knowledge that is needed when using electrophysiological methods in a wetlab. Contents 1) The theory part of the course covers the theoretical basis of electrophysiology: Basic principles and concepts of electricity; electrical properties of cells, microelectrodes and amplifiers; equivalent circuit representation; accuracy and sources of error in microelectrode measurements; single and two microelectrode current and voltage clamp techniques; other microelectrode techniques; mechanisms of noise coupling and means for noise reduction; safety in an electrophysiology laboratory. 2) The theoretical knowledge will then be repeated and deepened in hands-on exercises, first using simple circuits and basic recording devices, and then with passive and active model cells and research instruments. Students will learn how to properly use equipment in current and voltage clamp experiments when using one or two microelectrodes, and to evaluate the quality of acquired data. Completion methods Passing the course is based on active participation in laboratory exercises and a written exam. Grading is based on the written exam only. Attending the approximately 50 hours of contact teaching (lectures and laboratory practicals), plus up to 80 hours of independent studying (depending on prior knowledge) may be needed for achieving an excellent grade.

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Study materials Lecture handouts and written instructions for laboratory exercises. Additional supporting literature will be made available during the course. Assessment practices and criteria Grading scale 0 – 5. Grading is based on the written exam where the student is supposed to show comprehension of key concepts and principles, as well as ability to explain proper use and sources of error of the different recording techniques. Responsible person Professor Juha Voipio

NEU-543: Brain slice electrophysiology, 5 cp


Type: Course



Teachers: Svetlana Molchanova

Target group 1. Students of Master’s Programme in Neuroscience and Doctoral Programme Brain & Mind. 2. Other MSc students and doctoral candidates Maximum number of participants for the hands-on part of the course: 9 Selection of participants will be based on the study program, previous studies and motivation letter. Timing Period 3-4 Learning outcomes The goal is to learn widely used methods in electrophysiology (field recordings and patch clamp) and learn how to set up an electrophysiological experiment. After the course the students are aware of the mostly used electrophysiological techniques and are able to apply them in science. Prerequisites Electrophysiological techniques. A strong background in neurophysiology, for example lectures in neurobiology, molecular neurobiology, Purves etc. A letter of motivation is required when applying for the course. Contents During the course, several techniques are discussed and applied in practice (extra- and intracellular recordings; field potentials, patch-clamp, current-clamp. The techniques are applied to answer different physiological questions in different brain preparations. After the course the students also know how to make acute tissue preparations for electrophysiological recordings. Study materials and literature Articles are given at the course. Assessment practices and criteria Course laboratory work, written report. Grading scale: 0-5 Completion The total amount of work 135h Is divided into labwork (80h) and preparation of written reports (55h). Responsible person Svetlana Molchanova

NEU-551: Sensory Biology, 5 cp


Type: Course



Teachers: Kristian Donner

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Target group Primarily for students orienting towards Sensory Biology, but open to all students of the Master’s Program of Neuroscience as well as other programs Timing Taught in period III or IV Learning outcomes After completing the course, the student will have the ability to analyze, qualitatively as well as quantitatively, physical and biological boundary conditions limiting sensory information, understand the principles and mechanisms of information processing in different sensory organs and nervous systems, and analyze structural and functional adaptations of these for performance in different tasks in different environments. This includes understanding the basics of animal communication. Prerequisites Students need to have some previous knowledge of molecular and cellular neurobiology in order to be able to achieve good learning outcomes. Contents All known sensory modalities and their qualities, the major senses familiar from humans as well as “minority senses” of species other than humans, with limiting factors and evolutionary solutions as a pervading theme. Study materials and literature Lecture handouts, plus review articles and original research articles that will be presented during the course and used for exercises (including article presentations by the students). Assessment practices and criteria Grading scale 0-5, based on the mean of the grades of the four “best” exams. For students that pass, the grade may be raised or lowered by 1 depending on the activity at the exercises. Completion Five examinations covering the main topics of the lectures, a final exam, active participation in exercises and article presentations. The course comprises approximately 32 hours of contact teaching and 100 hours of independent studying. Passing the course requires passing at least four of the exams, the final exam and ≥ 80 % participation in the exercises. Responsible person N.N.

NEU-552: Studies of sensory performance in animals and humans, 5 cp


Type: Course



Teachers: Kristian Donner, Ulla Pirvola Target group For students choosing Sensory Biology as their main orientation. The number of participants is limited. Timing Taught in period III or IV Learning outcomes After completing the course the student will be able to start using basic electrophysiological and psychophysical approaches to the study and analysis of sensory information flow from cells to behaviour, and to plan relevant experiments, and will have the theoretical knowledge needed for analysing data quantitatively and reading scientific papers published in the field. Prerequisites To be connected with the lecture course in Sensory Biology Contents Laboratory work and demonstrations including electrophysiology, microspectrophotometry, histology, gross anatomy, human psychophysics and behavioural animal tests, planning and analysis of experiments and seminar work based on research articles. The main emphasis is on vision, hearing and olfaction. Study materials and literature Material presented during the course Assessment practices and criteria Grades 0-5 based on written reports and oral presentations

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Completion Active participation, written reports and oral presentations. The course comprises appr. 35 hours of contact teaching and 100 hours of independent work. Responsible person Ulla Pirvola

NEU-603: Laboratory animal science, 2 - 5 cp


Type: Course



Teachers: Mikael Segerstråle, Eva Ruusuvuori Target group Web-based theoretical studies are suitable to all students interested in research involving animals. The part involving practical work and design exercises are primarily aimed for degree students of the Master's Programme in Neuroscience and of the Doctoral Programme Brain & Mind who aim to carry out procedures on rodents and/or design procedures and projects involving the use of experimental animals. Timing Web-material can be completed year round, and must be successfully finalized before attending hands-on teaching or design exercises. Contact sessions and group-work are organized in Period II and IV 1st or 2nd year of studies. Learning outcome The aim of the course is to provide theoretical and practical training in laboratory animal science in accordance with Finnish and European legislation. Basic theoretical studies (2 credits) provide the obligatory theoretical knowledge for persons carrying out procedures on animals (function A of Article 23, Directive 2010/63/EU), persons designing procedures and projects involving animals (function B) and killing animals (function D). Hands-on exercises (0,5 - 1 credit): Obligatory for functions A and D competence, recommended for those aiming for function B competence. Students will learn to apply their theoretical knowledge in actual hands-on situations under guidance and supervision. Advanced Design Exercises (2 credits): Obligatory for function B competence. Students obtain in depth knowledge on how to design procedures and projects with an emphasis on understanding and implementing good scientific practices. In addition, timely themes and topics related to laboratory animal science will be addressed on one Methods&Trends session, which is an obligatory part of the Advanced Design Exercises. Content The course follows the modular structure outlined in the EU Expert Working Group document (on February 2014) on common education and training framework. It consists of Basic theoretical studies (modules 1-7, and 10), Practical skills: theory (modules 20 -22) and practice (module 8), and Advanced theoretical studies on ethics and design (modules 9 and 11). The basic theoretical studies (2 cr) cover e.g. legislation; ethical aspects; biology and husbandry of laboratory mice and rats; design and conduct of animal experiments; minimally invasive experimental procedures; humane endpoints; and assessment of pain, distress and suffering. The practical hands-on exercises (0,5 - 1 cr) include i) additional theoretical studies on analgesia, anesthesia, and surgical procedures (available in web material), and ii) practical training in appropriate handling of common laboratory rodents (mice and rats), as well as in basic procedures, such as marking animals, blood sampling, injections, induction and maintenance of anesthesia, and humane methods of killing.

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The advanced design exercises (2 cr) cover level II education in implementation of 3Rs in design of procedures and projects; and in the principles of good scientific strategies necessary to achieve robust results; enhance understanding of legal and regulatory framework within which projects are constructed and managed, and of their legal responsibilities; and give training in identifying, understanding and responding appropriately to the ethical and welfare issues raised by the use of animals in scientific procedures. Study material and literature After enrolling to the course, students gain access to “LASDigi” Moodle site. The available web-material consists of lectures, self-study-materials, videos, rehearsals, and quizzes. Additional learning material relevant for contact sessions, and the practical work handouts are also available in Moodle. Assessment practices and criteria Basic theoretical studies (2 credits): Assessment is based on a final exam covering the web material (grading 0-5). Hands-on exercises (0,5 - 1 credit): Assessment (pass/fail) is based on a separate evaluation matrix. Advanced Design Exercises (2 credits): Assessment is based on group work (grading 0 – 5). 5 credits: Grading scale 0-5, based on the exam on web material (60 %); design exercises (40 %); hands-on (pass-fail). Completion methods To pass Basic theoretical studies (2 cr) students need to 1) acceptably complete the relevant web-material (lectures, self-study materials, rehearsals, and quizzes), 2) attend the contact session(s) (100 % attendance), and (3) pass the final exam on the web material. The web-material of Basic theoretical studies has to be successfully completed before participating Hands-on or Advanced Design Exercises. Reserve enough time (appr. 45 hours) for the web-based studies. To pass Hands-on exercises students need to 1) acceptably complete the relevant web-material (lectures, self-study materials, rehearsals, and quizzes), 2) attend practical work sessions (100 % attendance) and 3) demonstrate acquisition of the required skills outlined. To pass Advanced Design Exercises students need to 1) acceptably complete the relevant web-material (lectures, self-study materials, rehearsals, and quizzes), 2) attend contact teaching and group work sessions (100 % attendance), 3) accomplish exercises, presentations and learning diary; and 4) finalize group work (compiling a project application and peer evaluation). Certificates for the separate parts can be obtained by request. Additional information Participants to the hands-on course are selected based on their motivational letter explaining why the candidate needs to complete the practical training part. Those aiming for competence to advanced design exercises are strongly encouraged to attend the hands-on exercises if they don’t have prior experience in working with animals. According to directive 2010/63/EU and Act 497/2013, all persons involved in the usage of laboratory animals are grouped according to the new directive and legislation to functions a-d as follows: (a) persons carrying out procedures on animals (b) persons designing procedures and projects involving animals (c) persons taking care of animals (d) persons euthanizing animals Responsible person Mikael Segerstråle

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NEU-604 Functional Lipidomics Seminar, Lipidit elintoiminnoissa–seminaari, Seminarium i

funktionell lipidomik, 5–10 cp


Type: Course



Target group: Postgraduate and master's level students of any life science field. Timing: Periods 1‒4, every second or third week according to a schedule fixed separately for each term / The course is organized annually. Learning outcomes: Students become aware of the importance of lipids in animal and human physiology and get familiar with the use of lipids and their structural parts as biomarkers in ecology, physiology and biomedicine. Students recognize the applicable methods among the modern techniques of lipid analyses which they could utilize in their projects and get to know experts able to support their work and career development. Prerequisites: BSc degree in any life science field. Contents: Seminars cover lipids and fatty acids as energy storage, structural components and signaling molecules of living organisms. The role of lipids in the pathogenesis of human and animal diseases and in the mechanisms of biochemical adaptation to environmental or physiological stimuli is addressed. Seminars introduce students to the use of cellular and tissue profiles of different fat-soluble substances as markers, which indicate the health of individuals, populations and ecosystems, or give dietary information. Methodological knowledge is gained in various chromatographic and mass spectrometric methods and bioinformatics. The seminar promotes networking of students, post docs and senior experts from different disciplines. Representatives of biomedical companies and independent research institutes are frequently invited to the seminars. Study material: Lecture material and literature delivered by the speakers. Assessment: Grading 0‒5 is based on presentations, assignments and seminar activity of the student. Completion: Participation in the seminar series usually during two or more years is required. To pass, at least one seminar presentation per year is given and several approved written assignments are submitted. When required, the performances are adjusted to give in total either 5 or 10 Cr with additional attendance, presentations or assignments. The rule, 27 h of studying equals to 1 Cr is applied. Relations to other studies: Previously registered credits for 522081 Functional Lipidomics Seminar, 2-6 Cr (Lipidit elintoiminnoissa–seminaari, Seminarium i funktionell lipidomik) can be adjusted to new 5 or 10 cr entities with additional attendance, presentations or assignments. When requested such combined performance of 5 or 10 cr is graded 0‒5. Responsible teachers: Minna Holopainen, Hanna Ruhanen

NEU-606: Neuroscience seminar series, 2 cp


Type: Course


Grading: Pass-fail Target group Students of Master's Programme in Neuroscience and Doctoral Programme Brain & Mind. Available also to other master’s and doctoral students.

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Learning outcomes The objective is to familiarize students with the state-of-the-art international neuroscience research. The students will develop their abilities for scientific reasoning and for understanding the concepts of neuroscience research. Contents Seminar presentations by invited international experts in neuroscience Study materials and literature Optional/recommended reading: selected publications of the seminar speakers. Assessment practices and criteria The signed seminar participation form is returned together with short summaries of seminar presentations to the responsible teacher. Grading scale approved/failed. Completion Participation in seminar series (e.g. Neuroscience seminar, Viikki Biocenter Monday Seminar, Biomedicum Helsinki seminar, Aalto Brain Center seminar): 20 seminar presentations by international experts (~ 20 h) and independent studying (~ 30h). Participation in each seminar presentation is certified by the signature of the host/presenter in the seminar form. For each seminar presentation, a short summary (about 1000 characters) is written by the student. 2 seminar presentations can be replaced by participation in 2 doctoral dissertation defenses (with a short written summary). Responsible person Katri Wegelius,

NEU-601: Book examination in neuroscience, 2 - 10 cp


Type: Course




Target group: Primarily for the students of the Master’s Programme in Neuroscience. Timing: Periods 1–4, on the general examination days of the faculty. Learning outcomes: The aim of book exam is to deepen the student's theoretical knowledge within his/her field of studies. Contents: Specified by the books studied. Study material: The examination is based on exam books as agreed in the personal study plan. Books may be supplemented with review articles. Please consult the responsible and exam assessing teachers about the books at least one week before the exam. Assessment: Grading scale 0–5. Completion: Completed when the exam is passed. Additional information: This course can be taken multiple times for the specified credits. Responsible teachers: Juha Voipio

NEU-602 Book Examination in Cell and Systems Physiology, Solu- ja systeemifysiologian

kirjatentti, Boktentamen i cell- och systemfysiologi, 2–10 cr


Type: Course



Teachers: Reijo Käkelä

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Target group: Primarily for the students of the Master’s Programme in Neuroscience. Timing: Periods 1–4, on the general examination days of the faculty. Learning outcomes: The aim of book exam is to deepen the student's theoretical knowledge within his/her field of studies. Prerequisites: BSc in life sciences, and the examination included in the personal study plan of the student. Contents: Specified by the books studied. Study material: The examination is based on exam books as agreed in the personal study plan. Books may be supplemented with review articles. Please consult the responsible and exam assessing teachers about the books at least one week before the exam. Assessment: Grading scale 0–5. Completion: Completed when the exam is passed. Relations to other studies: Can be used as replacement of the previous course 520002 Book Examination in Physiology and Neuroscience, Fysiologian ja neurotieteen kirjatentti, Boktent i fysiologi och neurovetenskap, 2-12 op. Additional information: This course can be taken multiple times for the specified credits. Responsible teachers: Reijo Käkelä

NEU-771: Other elective studies, 1 - 10 cp

Validity: 01.08.2017 - Form of study: Optional Studies

Type: Course




Course language: Finnish, Swedish, English

Voidaan suorittaa useasti (E): Yes

Target group: Students of the Master’s Programme in Neuroscience Contents: Elective course(s) organized in the University of Helsinki or Aalto University sporadically/once that support the Master’s studies in neuroscience. Assessment practices and criteria: General scale / pass-fail according to the assessment practices and criteria of the course. Completion: Participation and tasks accomplished according to the course description. Responsible person: Professor Juha Voipio, Contact person: [email protected]

ELECTIVE STUDY MODULES

NEU-500: Molecular and cellular neuroscience, 15 cp





Teachers: Sari Lauri Course language: English

Target group

mailto:[email protected]

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Optional module of the Master’s Programme in Neuroscience. The module is available for students of other programmes, but students of the Master’s Programmes in Neuroscience and in Translational Medicine are provided priority access to laboratory courses. The courses can also be included in doctoral studies. Timing First or Second year of Master’s studies Learning outcomes On completion of the module, the student has gained knowledge on the molecular and biochemical basis of brain function with a focus on developmental neurobiology and/or synaptic signaling and plasticity. The student understands the key research methods used to study neurons at molecular and cellular level and is able to critically read research articles in the field. Prerequisites Basic knowledge on neurobiology as well as cell and molecular biology is necessary to obtain good learning outcomes. Contents ≥ 15 cp including at least two of the courses listed below. Other courses or book exam relevant to the field can be included in the module. . PROV-004: Introduction to cell and molecular biology methods, 5 cp . NEU-502: Synaptic Signaling and Plasticity, 5 cp . NEU-543: Brain slice electrophysiology, 5 cp . NEU-531: Developmental Neuroscience, 5 cp Assessment practices and criteria Weighted average of the grades Responsible person Sari Lauri

NEU-510: Systems and cognitive neuroscience, 15 cp





Teachers: Henna-Kaisa Wigren


Target group Master’s Programme in Neuroscience is responsible for the module. The module is optional and it is also available for students of Master’s Programme in Translational Medicine and to other MSc students and doctoral candidates unless restricted by space limitations. Learning outcomes Upon completion of the module, the student has gained a broad general knowledge in systems and cognitive neuroscience. He/she understands how the nervous system and the brain can be described and examined as a dynamic system that is acting and reacting in cognitive and behavioral processes, emotions and social interactions. He /she also understands how brain dynamics, and cognitive and behavioral processes are altered in brain diseases and neuropsychiatric disorders. He/she knows the research methods that are commonly used in the field, and is aware of their applicability and limitations. He/she has gained a sufficient level of knowledge to be able to carry out experimental research work under professional supervision. Prerequisites Basics of neuroscience, neurophysiology and laboratory animal science Contents ≥ 15 cp. Select NEU-511 and optional courses applicable to the module. . NEU-511: Systems and cognitive neuroscience, 5 cp (obligatory) . NEU-512: Animal models in behavioural neuroscience, 5 cp

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. Optional courses or book exams related to the field of systems and cognitive neuroscience can be included in the module. 0-10 cp

. Optional courses, organized by other study programs and/or Aalto University, related to the field of systems and cognitive neuroscience can be included in the module. 0-10 cp.

Assessment practices and criteria Weighted mean of grades. Other information Courses of the module can be included in doctoral studies Responsible person Henna-Kaisa Wigren

NEU-520: Neuroscience in health and disease, 15 cp







Target group Master’s Programme in Neuroscience is responsible for the module. The module is optional and it is also available for students of Master’s Programme in Translational Medicine and other interested MSc/PhD students. Learning outcomes After completion of the module the student: * is familiar with clinical manifestations of selected nervous system diseases * is familiar on the current understanding on the molecular basis and the underlying pathophysiological mechanisms of selected nervous system disorders * knows the most common pre-clinical models of neurological diseases and can evaluate them by their strengths and weaknesses * can describe the components and function of the brain regulatory systems underlying emotional and motivational states and how they are perturbed in various pathological states * knows the basic experimental models used for studying brain disorders resulting from dysfunctional regulatory systems * knows the basic mechanisms of the current treatments and is familiar with some of the emerging therapies and understands the basics on how they proceed from research to clinic Prerequisites A prerequisite for successful completion of the module is that the student comprehends the basic concepts in genetics, molecular biology and neurobiology. Contents ≥ 15 cp. Select NEU-521 and optional courses applicable to the module. . NEU-521: Basic mechanisms of nervous system diseases, 5 cp (obligatory) . NEU-522: Pre-clinical models of neurological diseases and emerging therapies, 5 cp . TMED-406 Translational psychiatry, 5 cp . Optional courses applicable to the module 0-10 cp Assessment practices and criteria Weighted mean of grades Responsible person Henna-Kaisa Wigren

NEU-530: Development and regeneration, 15 cp




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Target group Optional module of the Master’s Programme in Neuroscience. The module is available for students of other programmes, but students of the Master’s Programmes in Neuroscience and in Translational Medicine are provided priority access to laboratory courses. The courses can also be included in doctoral studies. Learning outcomes The student has gained understanding into the key principles of organ development, including stem cell biology. The student has gained knowledge on the principles of development of the nervous system and of neuronal communication. The student is familiar with the modes and mechanisms of cellular regeneration in different animal species and in the current regenerative interventions with a therapeutic focus. The student has knowledge on the current stem cell techniques and clinical aspects of organ transplantation. Prerequisites Basic knowledge on neurobiology and developmental biology is needed for good learning outcomes. Assessment practices and criteria The weighted mean of the grades of the courses Contents ≥ 15 cp. Select NEU-531 and optional courses applicable to the module. . NEU-531: Developmental neuroscience, 5 cp (obligatory) . GMB-305: Stem cells and organogenesis, 5 cp . NEU-231 Mechanisms of regeneration and aging, 5 cp . Optional courses applicable to the module 0-10 cp Responsible person University lecturer Ulla Pirvola

NEU-540: Electrophysiology and neurobiophysics, 15 cp







Target group Optional module of the Master’s Programme in Neuroscience. The module is available for students of other programmes, but students of the Master’s Programme in Neuroscience are provided priority access to laboratory courses. Courses of the module can be included in doctoral studies. Learning outcomes Upon completion of the module, the student will be able to start using microelectrode techniques in an electrophysiology lab, he/she knows and can explain the biophysical and molecular mechanisms underlying electrical signalling at the cellular and subcellular level, and he/she has the theoretical knowledge that is needed when reading scientific papers published in the field. Prerequisites Previous knowledge of molecular and cellular neurobiology is necessary for good learning outcomes.

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Contents ≥ 15 cp. Select obligatory courses NEU-541 and NEU-542. Recommended elective courses: NEU-543. Other courses or book exams related to the field of electrophysiology and neurobiophysics can be included in the module. . NEU-541: Introduction to neurobiophysics, 5 cp (obligatory) . NEU-542: Electrophysiological techniques, 5 cp (obligatory) . NEU-543: Brain slice electrophysiology, 5 cp (recommended) . Optional courses applicable to the module 0-10 cp Assessment practices and criteria Weighted mean of grades. Responsible person Professor Juha Voipio

NEU-550: Sensory biology, 15 cp





Teachers: N.N. Course language: English

Target group Optional module of the Master’s Programme in Neuroscience. The module is available for students of other programmes, but students of the Master’s Programme in Neuroscience are provided priority access to laboratory courses. Courses of the module can be included in doctoral studies. Learning outcomes Upon completion of the module, the student will understand the basic concepts of sensory information and constraining physical and biological factors. He/she will recognize how different evolutionary adaptations determine species-specific sensory environments and sensory trade-offs as well as animal communication, and understand the basics of neural information processing in the major sensory modalities of multicellular animals, especially vertebrates and arthropods. He/she will be able to start using basic electrophysiological and psychophysical approaches to the study and analysis of sensory information flow from cells to behaviour, and to plan relevant experiments, and will have the theoretical knowledge needed for analysing data quantitatively and reading scientific papers published in the field. Prerequisites Previous knowledge of molecular and cellular neurobiology is necessary for good learning outcomes. Contents ≥ 15 cp. Select obligatory courses NEU-551 and NEU-552. Recommended elective courses: NEU-542 and NEU-512. Other courses or book exams related to the field of sensory biology, neurophysiology or e.g. psychology may be included in the module. . NEU-551: Sensory biology, 5 cp (obligatory) . NEU-552: Studies of sensory performance in animals and humans, 5 cp (obligatory) . NEU-542: Electrophysiological techniques, 5 cp . NEU-512: Animal models in behavioural neuroscience, 5 cp . Optional courses applicable to the module 0-10 cp Assessment practices and criteria Weighted mean of grades. Responsible person N.N.

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NEU-560 Omics, Omiikat, Omiker, ≥15 cr





Teachers: Reijo Käkelä, Pia Siljander (Viikki), Marc Baumann (Meilahti) Course language: English

Module status: compulsory or optional: Master’s Programme in Neuroscience (NEU) is responsible for the module, which is organized in collaboration with Master's Programmes in Genetics and Molecular Biosciences (GMB, Faculty of Biological and Environmental Sciences) and Translational Medicine (TMED, Faculty of Medicine). The module can be included as optional studies in any life science field master’s programme. If in need to limit class size, the students from the organizing master’s programmes and faculties are prioritized. Module level: Module level is EQF 7 and the courses can also be included in doctoral studies. Learning outcomes: The students acquire a general view of the work flow of different systems scale methods of biochemical analyses, known collectively as omics, and the related bioinformatics required for data analysis. After the module, students can design omics-based experimentation and are aware of methodological pitfalls. Students will be able to read and interpret multivariate omics data, which allows them to efficiently utilize data produced by different omics core facilities. They will also be able to integrate results from different omics approaches and platforms, e.g. between genome, proteome and metabolome. Prequisites: BSc in any life science field. Contents ≥ 15 cp. Select related additional studies in the fields of biochemistry, genetics, physiology, medicine, omics, bioinformatics or statistics, chosen by the student and approved by a coordinating teacher. . NEU-561: Principles of bioscience omics, 10 cp (obligatory) . Optional courses applicable to the module 0-10 cp Assessment practices and criteria The module is graded according to the weighted mean of the grades of the courses included. Additional information: Master's Programme in Neuroscience organizes the module in collaboration with the Master's Programmes in Genetics and Molecular Biosciences (Faculty of Biological and Environmental Sciences) and Translational Medicine (Faculty of Medicine). Responsible teachers: Reijo Käkelä, Pia Siljander (Viikki), Marc Baumann (Meilahti)

NEU-570 Environmental physiology, Ympäristöfysiologia, Miljöfysiologi, ≥15 cr






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Target group Master’s Programme in Neuroscience is responsible for the module. The module or its courses can be included as optional studies in any bachelor’s or master’s programmes. The courses can be included even in doctoral studies (personal tailoring of contents and assignments). Learning outcomes Student is able to tell how different physical or chemical factors, which vary in the environment in different time scales, affect the body morphology, physiology and biochemistry of animals. The students are able to predict the animal responses to variations in natural conditions as well as the responses to different stressors caused by human activities. Prerequisites No prerequisites. Contents ≥ 15 cp. Select obligatory courses BIO-404 and BIO-405 and related additional studies in the fields of physiology, ecology or environmental science, chosen by the student and approved by a coordinating teacher. . BIO-404: Adapted animal, 5 cp (obligatory) . BIO-405: Exposed animal, 5 cp (obligatory) . Optional courses applicable to the module 0-10 cp Assessment practices and criteria The module is graded (0-5) according to the weighted mean of the grades of the courses included. Responsible person University lecturer Reijo Käkelä

NEU-230 Regeneration and Aging, ≥15 cr

Validity: 01.01.2020 - Form of study: Optional Studies Type: Study block/Line Unit: Master's Programme in Neuroscience Grading: General scale Teachers: Ulla Pirvola Course language: English Module level: Module level is EQF 7.

Module status: compulsory or optional: Master’s Programme in Neuroscience organizes the module in collaboration with the Master's Programmes in Genetics and Molecular Biosciences (Faculty of Biological and Environmental Sciences) and School of Chemical Engineering, Aalto University. The module is optional. Target group Optional module of the Master’s Programme in Neuroscience. The module is available for students of other programmes, but students of the organizing programmes are prioritized. Module learning outcomes: Students gain understanding into the key principles of organ development, including stem cell biology. The student is familiar with the modes and mechanisms of cellular regeneration in different animal species and in the current regenerative interventions with a therapeutic focus. Students learn that the limits of tissue renewal determine lifespan and healthspan. They understand that aging is regulated by accumulation of cellular damage and that conserved signaling pathways govern many aspects of aging. Students get familiar with the potential for cell- and tissue-based engineering, including the choices and materials for scaffolds. Prequisites: No prerequisites. Content: ≥ 15 cp. Select obligatory courses GMB-303, NEU-231 and CHEM-E3225. Related additional studies in the field of developmental biology can be included, chosen by the student and approved by the coordinating teacher.

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. GMB-305 Stem cells and organogenesis 5 cr (obligatory)

. NEU-231 Mechanisms of Regeneration and Aging 5 cr (obligatory)

. Optional courses applicable to the module 5-10 cp Module grading: The module is graded (0–5) according to the weighted mean of the grades of the courses included. Responsible teachers: Ulla Pirvola

NEU-240 Neuroscience from cells to systems (≥15 cr)

Validity: 01.01.2020 - Form of study: Optional Studies Type: Study block/Line Unit: Master's Programme in Neuroscience Grading: General scale Teachers: Juha Voipio, Reijo Käkelä Course language: English Module level: Module level is EQF 7. Scope of module in credits: ≥15 Cr

Module status: compulsory or optional: Master’s Programme in Neuroscience is responsible for the module, which is primarily designed to be an optional module for the Cell and Systems Physiology study track of the programme. Recommended time/stage of studies for completion: No recommendations concerning the stage of studies. Module learning outcomes: Students acquire understanding of the mechanisms underlying fast electrochemical signaling in neurons and are able to integrate this information into a broader physiological context. They learn how cellular and synaptic mechanisms control the function of neuronal networks and recognize the links to behavior. Students get familiar either with common animal models and study designs of behavioral neuroscience or the mechanisms of developing neural diseases. Prequisites: No prerequisites. Content: ≥ 15 cp. Select obligatory course NEU-102 and recommended optional courses NEU-502, NEU-512 or NEU-521. Related additional studies in the field of neuroscience can be included, chosen by the student and approved by a coordinating teacher. . NEU-102 Cellular neurobiology 5 cp, (obligatory) . NEU-502 Synaptic signaling and plasticity 5 cp . NEU-512: Animal models in behavioural neuroscience, 5 cp . NEU-521: Basic mechanisms of nervous system diseases, 5 cp . Optional courses applicable to the module 0-10 cp Module grading: The module is graded (0-5) according to the weighted mean of the grades of the courses included. Responsible teachers: Juha Voipio, Reijo Käkelä

NEU-250 Nutrition and Health, ≥15 cr

Validity: 01.01.2020 - Form of study: Optional Studies Type: Study block/Line Unit: Master's Programme in Neuroscience Grading: General scale Teachers: Reijo Käkelä, Pia Siljander

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Course language: English Module level: Module level is EQF 7. Scope of module in credits: ≥15 Cr

Module status: compulsory or optional: Master’s Programme in Neuroscience organizes the module in collaboration with the Master's Programmes in Genetics and Molecular Biosciences (Faculty of Biological and Environmental Sciences) and Human Nutrition and Food-Related Behaviour (Faculty of Agriculture and Forestry). The module is optional. Module learning outcomes: Students realize that structurally slightly different molecules affect systemic physiology differently due to their different mechanistic interactions at the levels of digestion, absorption and metabolism, including signaling functions. They get familiar with contemporary technologies and commercial and industrial activities in the field of health biosciences. Students also gain insight on how population-based health promotion campaigns and programs are planned and evaluated according to the socio-ecological model of health promotion. Prequisites: No prerequisites. Content: ≥ 15 cp. Select obligatory courses NEU-251, GMB-401 and HBFB-221. Related additional studies in the field of nutrition and health can be included, chosen by the student and approved by a coordinating teacher. . NEU-251 Molecular nutrition 5 cp, (obligatory) . GMB-401 Integrative health biosciences 5 cp, (obligatory) . HNFB-221 Nutrition and society 5 cp, (obligatory) . Optional courses applicable to the module 0-10 cp Module grading: The module is graded (0–5) according to the weighted mean of the grades of the courses included. Responsible teachers: Reijo Käkelä, Pia Siljander

COURSES ORGANIZED BY OTHER STUDY PROGRAMMES

BIO-404 Adapted Animal, Eläinten sopeutuminen, Anpassningar hos djur, 5 cr

Validity: 01.01.2017 - Form of study: Intermediate studies

Type: Course

Unit: Bachelor's Programme in Biology


Teachers: Reijo Käkelä Target group: Master’s, batchelor’s and exchange students in any life science field. Timing: Periods 3–4 / The course is taught every other year (even years), and alternatively can be taken as book exam (also registered as BIO-404) every year. Learning outcomes: Students are able to recognize and describe the morphological, physiological and biochemical adaptations, which allow animals to survive when environmental conditions change either over evolutionary time scales or even daily. For course assignments, students practice information retrieval from scientific sources, and written and oral communication. Prerequisites: No prerequisites. Contents: The topics include adaptations and acclimations of homeothermic and poikilothermic animals when challenged by changes in environmental temperature, oxygen

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level or osmotic conditions. The role of water is addressed e.g. by studying the adaptations needed by mammals living in aquatic versus hot and dry terrestrial habitats. In addition, the importance of adjusting animal physiology to fluctuating environmental conditions by short and long-term biological rhythms is studied. Study material: About 15 scientific review articles chosen and summarized by the students for the whole class are studied for the exam. Alternative book exam (also BIO-404): Somero GN, Lockwood BL and Tomanek L. Biochemical Adaptation — Response to Environmental Challenges from Life’s Origins to the Anthropocene (Sinauer, 1. edition, 2017). Assessment: Grading 0–5 is based on the final exam for which the lectures and presentations given by the teachers or students, and also the student summaries of review articles are studied. The points given for each exam task are detailed on the Moodle page of the course. The alternative book exam is graded 0–5. Completion: The students need to participate (min 70%) in the lectures and group presentations (36 h), write one summary (max 1 page) based on a review article, participate in preparing and presenting of one student group presentation (15 min, when feasible during a Korkeasaari Zoo visit), and pass the final exam. The work required on own time is about 100 h. Alternatively the course is passed by taking the book exam. Relations to other studies: BIO-404 Adapted Animal 5 cr can be used as replacement of the previous course 522047 Eläinten ekofysiologia (Animal Ecophysiology) 6 Cr. Additional information: In English (provided as optional course for master’s, bachelor’s and exchange students) but the exam can be taken also in Finnish or Swedish. Responsible teachers: Reijo Käkelä

BIO-405, Exposed Animal, Eläinten altistuminen, Exponering hos djur, 5 cr

Validity: 01.01.2017 - Form of study: Intermediate studies

Type: Course

Unit: Bachelor's Programme in Biology


Teachers: Reijo Käkelä Target group: Master’s, batchelor’s and exchange students in any life science field. Timing: Periods 3–4 / The course is taught every other year (uneven years), and alternatively can be taken as book exam every year (also registered as BIO-405). Learning outcomes: Students become aware of the different harmful substances released to ecosystems from human activities and are able to predict their physiological effects on cells, organs, and individuals. During the course students practice information retrieval from scientific sources and academic writing. In addition, ethical thinking and the sense of responsibility for global environmental issues is developed. Prerequisites: No prerequisites. Contents: Organismal intake, excretion and accumulation of different xenobiotics, and the abiotic and biotic factors affecting the rates of these processes, are studied. The topics include biotransformations of inorganic and organic pollutants in animals, including humans. The focus is on the physiological effects following exposure to heavy metals or persistent organic pollutants but the radiation-induced tissue and systemic damage is also addressed. In addition an overview of the biomarker methods most frequently used to monitor ecosystem hazard is presented. Study material: Essential parts of the book: Newman MC. Fundamentals of Ecotoxicology (CRC Press, 3. or later edition) are recommended to be studied to support learning. An alternative way to pass the course is by book exam of the whole book (also BIO-405).

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Assessment: Grading 0–5 is based on the final exam (60 %) and the obligatory pre-assignments (40%). The points given for each exam task and the pre-assignments are detailed on the Moodle page of the course. The alternative book exam is graded 0–5. Completion: The students need to participate (min 70%) in the lectures (26 h), prepare pre-assignments for each class (min 70%) to be anonymously graded by class mates, and pass the final exam covering the lectures and literature. The work required on own time is about 110 h. Alternatively the course is passed by taking the book exam (also BIO-405). Relations to other studies: BIO-405 Exposed Animal 5 cr can be used as replacement of the previous course 522047 Fysiologinen ekotoksikologia (Physiological Ecotoxicology) 3 cr. Additional information: In English (provided as optional course for master’s, bachelor’s and exchange students) but the exam can be taken also in Finnish or Swedish. Responsible teachers: Reijo Käkelä

GMB-305: Stem cells and organogenesis, 5 cp


Type: Course

Unit: Master's Programme in Genetics and Molecular Biosciences


MED-TOU11 / NEU-524 An Introduction to Sleep and Circadian Neurobiology, 2.5 op


Type: Online course

Unit: Degree Programme in Medicine & Master’s Programme in Neuroscience


Teachers: Henna-Kaisa Wigren Target group LL/HLL, Psychology, Transmed and Neuroscience students Timing Can be completed at any time of the year Learning outcomes The students will:

• understand the basic principles of sleep and circadian neurobiology, and the impact of

sleep/insufficient sleep to health and well-being.

• be familiar with the most commonly used experimental approaches in sleep research

(EEG, behavioral tracking, imaging, molecular genetics, epidemiology etc.).

• be able to apply the understanding of sleep and circadian neurobiology to other fields of

neuroscience and critically judge new findings.

• be better equipped to take sleep and circadian aspects into consideration in their own

work.

Completion methods Videos 15 h, Video problems 10 h, Examination 1 h, Literature studies 20 h. Studies on the material and preparation for examination 15+6 = 21 h, Altogether 67 h Prerequisites Knowledge on basics of neuroscience and physiology will help with studies. Contents This is a web-based course consisting of 20 videos á 20 min on different aspects of sleep. Each video has section of 10 multiple choice questions and 2-4 articles as part of the educational content.

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Titles of the videos: Definition and structure of sleep, Introduction to measurement of sleep, Neuroanatomy and-chemistry of sleep, Basics of circadian rhythms, Sleep regulation and the 2-process model, REM sleep, Theories on function of sleep, Effects of pharmacological agents on sleep, Adaptation of bodily functions to sleep, Effects of acute and chronic sleep deprivation, Sleep, learning and memory, Genetics of sleep regulation, Hormone secretion and sleep, Thermoregulation and sleep, Sleep at different ages, Gender differences in sleep, Sleep and mental health, Sleep and dreaming, Sleep and consciousness, Jet lag and shift work Study materials and literature 1-4 scientific articles per video announced at the Moodle site after each video. Assessment practices and criteria All tests related to videos and the final examination must be accepted (50% acceptance rate) before course acceptance. Final examination can be participated only after acceptance of the tests related to the videos. Course will be rates as accepted/not accepted. Completion Video course (altogether 20 videos) on Moodle platform. Each video connects to a set of questions that the student must complete before participating the final examination and acceptance of the course. Course will end with an examination at Examinarium. Other information The course language is English. Responsible person Henna-Kaisa Wigren

MED-TOU25 / NEU-525 Interdisciplinary insights into sleep and circadian rhythms, 2.5 cr


Type: Course

Unit: Degree Programme in Medicine & Master’s Programme in Neuroscience


Teachers: Henna-Kaisa Wigren, Tiina Paunio, Tarja Stenberg, Anu-Katriina Pesonen Target group Medicine, Dentistry, Psychology, Logopedics, Translational Medicine and Neuroscience students who have accomplished the course “An Introduction to Sleep and Circadian Neurobiology” (33 medical faculty, 7 neuroscience) Learning outcomes The students will: - Understand the principles of sleep and circadian neurobiology, and the impact of sleep/insufficient sleep to health and well-being -will understand the interdisciplinary nature of sleep, both as research topic and as clinical problem -be familiar with the commonly used experimental approaches in sleep research (EEG, behavioral tracking, imaging, molecular genetics, epidemiology etc.) and is able to critically evaluate the selection of the equipment for specific purposes -be able to apply the understanding of sleep and circadian neurobiology to other fields of neuroscience and critically judge new findings. -be able to take sleep and circadian aspects into consideration in their professional performance -be familiar with common clinical problems of sleep and their treatment Completion methods Video problems 3 h, In-depth lectures 6 h, Small group work 10 h, Hands-on 3h, Literature studies 20 h, Studies on the material and preparation for examination 24 h, Examination 2 h, Altogether 68 h Opetukseen osallistuminen (100, 90 tai 75 %): 90% Prerequisites Course MED-TOU11, “An Introduction to Sleep and Circadian Neurobiology web course” accepted

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Contents The course will consist of lectures by specialists on different topics of sleep- and circadian rhythm-related topics, including clinical and circadian topics, altogether 6 hours. The participants will collect data on their circadian rhythms and sleep using actigraphs and polysomnography, learning the details of data collection and analysis. They will also learn about the methods to assess sleep and circadian rhythms in different species. The participants will prepare in small groups a presentation for the final seminar of the course. Assessment practices and criteria Course will be evaluated as accepted/not accepted. Other information Language of teaching: English Responsible teachers Henna-Kaisa Wigren

PROV-004 Introduction to Cell and Molecular Biology Methods, 5 cr


Type: Course

Unit: Master's Programme in Pharmacy


Teachers: Leena Hanski, Tomi Rantamäki

PROV-502: Neuropharmacology, 5 cp


Type: Course

Unit: Master's Programme in Pharmacy


Teachers: Mikko Airavaara

TMED-202: Regenerative Medicine from Bench to Bedside, 5 cp


Type: Course



Teachers: Esko Kankuri, Kirsi Sainio

TMED-406 / NEU-523 Translational psychiatry, 5 op


Type: Course




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TMED-901: Career Development, 3 cp

Validity: 01.01.2017 - Form of study: Other studies

Type: Course



Teachers: Tiina Immonen, Katri Wegelius


Target group: Students of the Master’s Programme in Translational Medicine and Neuroscience, also other Master’s students in the field of life sciences

PED100: Opettajan pedagogiset opinnot (perus- ja lukio-opetuksen tehtävät),

kasvatustieteen perus- ja aineopinnot 60 op, Pedagogik, pedagogiska studier för lärare 60

sp, Education, pedagogical studies for teachers 60 cp

Voimassaolo: 01.01.2017 - Opiskelumuoto: Aineopinnot Laji: Opintokokonaisuus

Vastuuyksikkö: Kasvatustieteiden osasto

Arvostelu: Yleinen asteikko

VIIKB-100: Studies Accomplished at Another University, 1 - 15 cp

Form of study: Optional Studies

Type: Course

Unit: Faculty of Biological and Environmental Sciences


Can be taken more than once: yes

STUDY MODULES AVAILABLE FOR STUDENTS IN OTHER STUDY PROGRAMMES

NEU-701 Fysiologia ja neurotiede (suppea aineopintotason opintokokonaisuus), 15 op

Voimassaolo: 01.01.2017- Opiskelumuoto: Aineopinnot Laji: Opintokokonaisuus Vastuuyksikkö: Neurotieteen maisteriohjelma Opetuskieli: suomi/englanti Opettaja: Juha Voipio

Kohderyhmä Tämä aineopintotasoinen opintokokonaisuus on tarkoitettu muille kuin Biologian kandiohjelman tai Neurotieteen maisteriohjelman opiskelijoille (soveltuu muiden alojen kuten esim. psykologian opiskelijoille).

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Osaamistavoitteet Opintokokonaisuuden suoritettuaan opiskelijalla on yleiskuva evolutiivisesti kehittyneimpien eläinten, kuten nisäkkäiden (ml. ihminen) toimintojen biologisesta perustasta eri organisaatiotasoilla, molekyyleistä soluihin, kudoksiin ja koko eliön tasolle. Opintokokonaisuuden suorittanut opiskelija osaa tarvittavat biotieteiden ja fysiologian opintojen perusteet jotka antavat riittävät lähtötiedot neurotieteen ja fysiologian syventävien opintojen (NEU-703 tai NEU-704) suorittamiselle. Sisältö Pakolliset opinnot 10 op

• BIO-201 Molekyylit ja solut 3 op • MOLE-103A Mikrobien monimuotoisuus, 2 op • BIO-203 Ihmisen fysiologia 5 op

Vaihtoehtoiset opinnot 5 op, valitse yksi seuraavista 5 op • BIO-403 Yksilönkehitys 5 op • BIO-404 Adapted animal 5 op • BIO-405 Exposed animal 5 op • BIO-207 Kirjallisuus, fysiologia ja neurotiede 5 op (kirjallisuutta sopimuksen

mukaan) Arviointimenetelmät ja -kriteerit Painotettu keskiarvo. Vastuuhenkilö Professori Juha Voipio

NEU-702 Fysiologia ja neurotiede (aineopintotason opintokokonaisuus), 25-35 op

Voimassaolo: 01.01.2017- Opiskelumuoto: Aineopinnot Laji: Opintokokonaisuus Vastuuyksikkö: Neurotieteen maisteriohjelma Opetuskieli: suomi/englanti Opettaja: Juha Voipio

Kohderyhmä Tämä aineopintotasoinen opintokokonaisuus on tarkoitettu muille kuin Biologian kandiohjelman tai Neurotieteen maisteriohjelman opiskelijoille (soveltuu muiden alojen kuten esim. psykologian opiskelijoille). Osaamistavoitteet Opintokokonaisuuden suoritettuaan opiskelijalla on yleiskuva evolutiivisesti kehittyneimpien eläinten, kuten nisäkkäiden (ml. ihminen) toimintojen biologisesta perustasta eri organisaatiotasoilla, molekyyleistä soluihin, kudoksiin ja koko eliön tasolle. Opintokokonaisuuden suorittanut opiskelija osaa tarvittavat biotieteiden ja fysiologian opintojen perusteet jotka antavat riittävät lähtötiedot neurotieteen ja fysiologian syventävien opintojen (NEU-703 tai NEU-704) suorittamiselle. Sisältö Pakolliset opinnot 25 op

• BIO-201 Molekyylit ja solut 3 op • MOLE-103A Mikrobien monimuotoisuus, 2 op • BIO-203 Ihmisen fysiologia 5 op • BIO-409 Eläinfysiologian seminaari 10 op • BIO-410 Eläinfysiologian ryhmätyöt 5 op.

Vaihtoehtoiset opinnot 5-15 op, valitse seuraavista yhteensä 5 -15 op siten että kokonaisuuden laajuudeksi tulee 25-35 op.

• BIO-402 Eläinfysiologian harjoitustyöt 5 op • BIO-403 Yksilönkehitys 5 op • BIO-404 Adapted animal 5 op • BIO-405 Exposed animal 5 op • BIO-207 Kirjallisuus, fysiologia ja neurotiede 5 op (kirjallisuutta sopimuksen

mukaan)

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Arviointimenetelmät ja -kriteerit Painotettu keskiarvo. Vastuuhenkilö Professori Juha Voipio

NEU-703 Neurotiede, opintokokonaisuus, 25-50 op

Voimassaolo: 01.01.2017- Opiskelumuoto: Aineopinnot Laji: Opintokokonaisuus Vastuuyksikkö: Neurotieteen maisteriohjelma Opetuskieli: englanti Opettaja: Juha Voipio

Kohderyhmä Opintokokonaisuus on tarkoitettu ensisijaisesti maisterivaiheen opintoihin muille kuin Neurotieteen maisteriohjelman opiskelijoille (soveltuu muiden alojen kuten esim. psykologian sekä genetiikan ja molekulaaristen biotieteiden maisteriohjelmien opiskelijoille). Osaamistavoitteet Opintojakso antaa varsin kattavat tiedot modernista neurotieteestä neurobiologisella painotuksella. Opintojakson antama osaaminen tukee vahvasti sellaisten muiden alojen opintoja, joissa neurotieteen syvempi tunteminen on tarpeen tai välttämätöntä. Edeltävät opinnot Menestyksellinen opiskelu edellyttää vähintään aiemmin suoritettua NEU-701 Fysiologian ja neurotieteen suppea aineopintotason opintokokonaisuus 15 op tai suositeltavammin NEU-702 Fysiologian ja neurotieteen aineopintotason opintokokonaisuus 25 – 35 op, tai vastaavia esitietoja. Sisältö Pakolliset opinnot 25 op

• NEU-101 Cellular physiology 5 op • NEU-102 Cellular neurobiology 5 op • NEU-103 Systems neuroscience 5 op • NEU-104 Integrative neurobiology 5 op • NEU-601 Book examination in neuroscience 5 op (neurotieteen alan kirjallisuutta

sopimuksen mukaan) Valinnaiset opinnot 0 – 25 op

Valinnaiset opinnot 0 – 25 op · Neurotieteen alan opintojaksoja ensisijaisesti Neurotieteen maisteriohjelmasta 0 – 25 op

Arviointimenetelmät ja -kriteerit Painotettu keskiarvo. Vastuuhenkilö Professori Juha Voipio

NEU-704 Solu- ja systeemifysiologia (syventävien opintojen tasoinen opintokokonaisuus),

25-50 op

Voimassaolo: 01.01.2017- Opiskelumuoto: Aineopinnot Laji: Opintokokonaisuus Vastuuyksikkö: Neurotieteen maisteriohjelma Opetuskieli: englanti Opettaja: Reijo Käkelä

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Kohderyhmä Opintokokonaisuus on tarkoitettu ensisijaisesti maisterivaiheen opintoihin muille kuin Neurotieteen maisteriohjelman opiskelijoille (soveltuu muiden alojen kuten esim. psykologian sekä genetiikan ja molekulaaristen biotieteiden maisteriohjelmien opiskelijoille). Osaamistavoitteet Opintojakso antaa varsin kattavat tiedot fysiologian alalta. Opintojakson antama osaaminen tukee vahvasti sellaisten muiden alojen opintoja, joissa fysiologian syvempi tunteminen on tarpeen tai välttämätöntä.

Edeltävät opinnot Menestyksellinen opiskelu edellyttää vähintään aiemmin suoritettua NEU-701 Fysiologian ja neurotieteen suppea aineopintotason opintokokonaisuus 15 op tai suositeltavammin NEU-702 Fysiologian ja neurotieteen aineopintotason opintokokonaisuus 25 – 35 op, tai vastaavia esitietoja. Sisältö Pakolliset opinnot 20-25 op

• NEU-101 Cellular physiology 5 op • NEU-203 Systems physiology 5 op • NEU-207: Regulatory networks in metabolism 5 cr • NEU-231 Mechanisms of regeneration and aging, 5 cp • NEU-602 Book examination in cell and systems physiology 5 op (fysiologian alan

kirjallisuutta sopimuksen mukaan) Valinnaiset opinnot 0 – 25 op

• Fysiologian tai neurotieteen alan opintojaksoja ensisijaisesti Neurotieteen maisteriohjelmasta 0 – 25 op

Arviointimenetelmät ja -kriteerit Painotettu keskiarvo. Vastuuhenkilö Reijo Käkelä

NEU-705 Neurotiede, opintokokonaisuus, 15-20 op

Voimassaolo: 01.01.2019- Opiskelumuoto: Aineopinnot Laji: Opintokokonaisuus Vastuuyksikkö: Neurotieteen maisteriohjelma Opetuskieli: englanti Opettaja: Juha Voipio

Kohderyhmä Tämä aineopintotasoinen opintokokonaisuus on tarkoitettu muille kuin Biologian kandiohjelman tai Neurotieteen maisteriohjelman opiskelijoille (soveltuu muiden alojen kuten esim. psykologian opiskelijoille). Osaamistavoitteet Opintokokonaisuuden suorittanut opiskelija osaa tarvittavat neurotieteen perusteet jotka antavat riittävät lähtötiedot neurotieteen ja fysiologian syventävien opintojen suorittamiselle. Sisältö Pakolliset opinnot 10 op

• NEU-101 Cellular physiology 5 op • NEU-102 Cellular neurobiology 5 op

Valinnaiset opinnot 5 – 10 op • NEU-104 Integrative neurobiology 5 op • NEU-601 Book examination in neuroscience 5 op (neurotieteen alan kirjallisuutta

sopimuksen mukaan) Arviointimenetelmät ja -kriteerit Painotettu keskiarvo. Vastuuhenkilö Professori Juha Voipio

Master's Programme in Neuroscience

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Transcript of Master's Programme in Neuroscience