MASTER_ SC

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MASTER Malignant Solid Tumor Management Program



AVIATE

Assessing Ovarian Cancer Treatment Evolution

Perceptorship Program (OC)

IMPACT

Implement Practice Aspirations in Colon Cancer Treatment

Perceptorship Program (CRC )

LEAD

Lung Cancer Experts’ Advisory Board

Advisory Board ( LC)

MASTER Sub-Scientific Collaborations



Short-To-Mid- Term Objectives: • Educate GCC Oncologists about best clinical practice in the

management of malignant solid tumors to optimize patients’

outcomes. • Address Oncology Practice Gaps in Gulf countries from diagnosis to

treatment and conclude a roadmap for suitable corrective measures . • Gain the Competencies and Skills associated with Clinical Practice

excellence (Patient Communication, Best Model of MTDs ,..etc) Long-Term Objectives: • Prepare our TA leaders for future perspectives in managing

malignancies in correlation to oncology innovation (Pipelines ,Combinations and Bio-markers Integrated Evolution )

• Encourage HCPs to Apply their Learnings through outstanding innovative initiatives that could improve cancer care delivery in

their respective countries .


Overall Objectives of MASTER


AVIATE

Assessing Ovarian Cancer

Treatment Evolution

Perceptorship Program (OC)



Objectives :

• Expose HCPs to a Real-World Academic Practice of managing OC especially risky segments with stage IIIB-IV.

• Resolve HCPs gaps and unmet medical needs in terms of :

Treatment practice in front line and recurrent setting irrespective to platinum sensitivity .

Explore Experts recommendations in OC treatment duration with respect to safety implications .

Outline implication of new innovations in optimizing clinical outcomes

• Communicate Latest clinical collaborative groups’ data and

disseminate pipeline innovations.


AVIATE

(Assessing Ovarian Cancer Treatment Evolution )


Description:

• Knowledge sharing tour for 3-4 days, where the 6-8 Medical Oncologist treating Gynecological Tumors will be leaded through the latest treatment algorithm in an international specialized oncology center.

• It is planned in Q2 2015, and the expected cost per participant is 8 KCHF

• It is planned to be in one of the following venues : MD Anderson Cancer Centre

Houston , USA Assistance Publique Hopitauxde de Paris Paris , France University Clinic Heidelburg

Heidelberg, Germany

Leiden University Medical Centre Leiden , Holland


AVIATE

(Assessing Ovarian Cancer Treatment Evolution )


Suggested Topics: • Ovarian Cancer From Novice To Mastery (Highlight treatment

evolution of OC ) • Diagnosis , Histology , staging , screening and surgery • Patient Management in Neo-adjuvant and adjuvant settings and

latest clinical data . • Optimizing treatment outcomes in metastatic setting in terms of

Proper patient selection . Platinum sensitivity , Treatment options in 1st L and ROC with respect to

clinical outcomes . Evolving innovations and Suggested combinations Adverse Events incidence with respect to Patient

Performance Status. Optimal Treatment Duration Latest Clinical Researches in OC Management

• Treatment options and guidelines


AVIATE

(Assessing Ovarian Cancer Treatment Evolution)


IMPACT

Implementating Practice

Aspirations in Colon Cancer

Treatment

Perceptorship Program (CRC)



Objectives :

• Engage HCPs in a comprehensive educative program to leverage their knowledge and enhance the hands-on experience through interaction with academic oncology clinical practice .

• Resolve HCPs gaps and unmet medical needs in terms of : Implications of Bio-markers evolution era on treatment

decision . H2H trials debate and understanding of clinical trials

outcomes (ORR , OS and HRs ) CT partners , Respectability , Optimal Treatment Duration

and Safety Management .

• Communicate Latest clinical collaborative groups’ data and disseminate pipeline innovations .


IMPACT

Implementating Practice Aspirations in Colon Cancer Treatment


Description: • Knowledge sharing tour for 3-4 days, where the 6-8 Medical

Oncologist treating Colorectal Tumors will be leaded through the latest treatment algorithm in an international specialized cancer center.

• It is planned in Q1 2015, and the expected cost per

participant is 10 KCHF • It is planned to be in one of the following venues :

Gustave Roussy Paris , France

John Hopkins USA German Cancer Research Centre Germany

The Royal Marsden Hospital UK MASTER

Malignant Solid Tumor Management Program

IMPACT

Implementating Practice Aspirations in Colon Cancer Treatment


Suggested Topics: • Change the CRC treatment landscape • Diagnosis , Histology , staging , screening and surgery. • Optimizing treatment outcomes in metastatic setting in terms of

: Consistency of clinical data outcomes of anti-

angiogensis agents vs Anti-EGFRs in 1st L , 2ND L , Maintenance till PD and Continuation beyond PD (TML)

Further highlights on Bevacizumab clinical trials in specific patients’ groups ( AVEX , TRIBE , etc…)

CT Backbone choice as efficacy and safety Impacted Bio-markers role in treatment decision Evolving innovations and Suggested combinations Safety Management in Colorectal Cancer receiving

targeted therapies • Treatment guidelines


IMPACT

Implementating Practice Aspirations in Colon Cancer

Treatment


LEAD

Lung Cancer Experts’ Advisory

Board

Advisory Board ( LC)



Objectives :

• Collaborative interaction with TA leaders , seeking their advice in :

Analyze situation (Needs, Gaps and Opportunities) of treatment Gaps in specifically defined high-risk

patients. Utilize the AB input to effectively manage the unmet

medical need and hence optimize patients ‘ treatment options

Counteracting the Lack of data on anti-angiogenic therapy continuation through treatment lines in NSCLC by local data.

Recommended treatment pathways and therapies .

Adopting Regional treatment guidlines in LC management .


LEAD

(Lung Cancer Experts’ Advisory Board)


Description:

• Half day advisory board, with 10-12 TAEs treating NSCLC to help us in better understanding the unmet medical needs of the HCPs and Patients targeting better planning and execution of our tailored personalized medical plans.

• It is planned in Q2/3 2015 parallel to the Middle East Oncology Summit

• The expected cost will be 20 KCHF.

LEAD




Suggested Topics: • Incidence and Prevalence of NSCLC in Gulf Countries • Re-define the Define high-risk group where rapid responses are

required • State‐of‐the‐art: Standard of care for resectable NSCLC

• 1st line chemotherapy and contribution of bevacizumab and impact of second-line chemotherapy in unselected patients

• Maintenance treatment • Evaluate the upcoming E5580 in mid 2015 and its impact. • Explore advice of Bevacizumab outcomes from the TML

Perspectives • Promising innovating approached in NSCLC and new

combinability options (BEVA +1ST L Erlotinib )

LEAD




CLEAR

Clinical Research Training



Objectives :

• Establish the GCC Investigators ‘ Network with

unique clinical research competencies and skills to have the full capabilities of running clinical researches (Epidemiological, economic , ..etc ) and carrying –out clinical trials

• Invest in the young consultant oncologists to leverage their Good Clinical Practice understanding and implementation .

• The planned course will be Q2/3 2015 in TBD venue and it will cost 1.5-2 CHF per participant


CLEAR

(Clinical Research Training)


Objectives : Day I :

• Definition of clinical trials and phases of clinical researches • Ethics and Ethical issues in clinical researches (Ethical

Principles, process and issues of debate • GCP principles , Protocol Design , Statistics , Efficacy and

Safety Assessment • QA and QC. • Data Handling and Records Keeping . • Glossary and Definitions of various clinical trials terms

Day II: • IRB /IEC • Basics of Ethical Principles and Informed Consent Process • Clinical end Points and data types (Primary and secondary

endpoints ) • Roles and Responsibilities (Investigators , Co-Investigators,…etc

) • Safety (adverse event , adverse reaction , reporting AE……etc)


CLEAR

(Clinical Research Training)

MASTER_ SC

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