Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0...

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Martin R. Broadley Professor of Plant Nutrition

Transcript of Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0...

Page 1: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Martin R. Broadley

Professor of Plant Nutrition

Page 2: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Progress in quantifying mineral

micronutrient deficiencies in Malawi

through Agriculture-Nutrition links

International Food & Nutrition Research Dissemination Conference

Food and Nutrition Security for a Healthier and Productive Nation

‘You are what you eat’

October 26th-27th 2016

Bingu International Conference Centre, Lilongwe, Malawi

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Improving NUE in crop production - formulationsThe Law of the Minimum

http://en.wikipedia.org/wiki/Justus_von_Liebig

Justus von Liebig (1803-1873) Liebig’s Law of the Minimum

http://upload.wikimedia.org/wikipedia/commons/1/1c/Minimum-Tonne.svg

P

N

K

Ca

Zn

Mg

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Essential for animals (but not plants)

Selenium

Many roles in health:

immune function

thyroid function / iodine metabolism

cardiovascular health

fertility

cancer ?

25 selenoprotein genes in mammals

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References

>3200-

7500

>3200-7500 ng/ml toxicity - death/mortality Yang et al 1983, Lech et al

2002

>490-

<640

Selenium related side-effects; no serious toxicity Reid et al 2004

>250 Selenium related side-effects; hair loss, dermatitis Lippman et al 2009

180

160 Protection against some cancers; [increased risk of diabetes, high blood

pressure and hypertension]

Yu et al 1999, [Bleys et al

2007, Laclaustra et al 2009]

140 Protection against some cancers; reduction in total mortality Nomura et al 2000, Combs et

al 2001, Bleys et al 2008, Yu

et al 1999, [Vogt et al 2003]

120 Optimisation of selenoprotein P, protection against some cancers, reduction in

total mortality

Combs et al 2001, Burk 2006,

Hurst 2010, Thompson 2004,

Bleys et al 2008

100

80 Optimisation of glutathione peroxidase Thompson 2004

60 Optimisation of iodothyronine deiodinases Thompson 2004

40

20 < 20-40 ng/ml Se deficiency diseases, Keshan, Kashin-Beck, cretinism (with

iodine deficiency)

Thompson 2004; Shi et al

2010

Serum/

plasma

selenium

(ng/ml)

De

ficie

ncy

Adequacy/’optimal’

> R

eq

uir

em

en

ts, u

p to

to

xic

eff

ects

Selenium biomaker

Fairweather-Tait SJ et al. (2011). Selenium in human health and disease. Antioxidant & Redox Signaling, 14: 1337-83.

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Selenium supply in Malawi: soil and grain surveys (2008-10)

Dr Allan Chilimba

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Selenium supply in Malawi: maize-grain survey (2008-10)

Chilimba ADC, Young SD, Black CR, Rogerson KB, Ander EL, Watts M, Lammel J, Broadley MR

(2011). Maize grain and soil surveys reveal suboptimal dietary selenium intake is widespread in Malawi.

Scientific Reports, 1, 72.

Page 8: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

0.325 mg kg-1

0.021 mg kg-1

Selenium supply in Malawi: maize-grain survey (2008-10)

Chilimba ADC, Young SD, Black CR, Rogerson KB, Ander EL, Watts M, Lammel J, Broadley MR

(2011). Maize grain and soil surveys reveal suboptimal dietary selenium intake is widespread in Malawi.

Scientific Reports, 1, 72.

Page 9: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Selenium supply in Malawi: maize-grain survey (2008-10)

Shire valley

(Eutric Vertisols)

Page 10: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Selenium supply in Malawi: maize-grain survey (2008-10)

Chilimba ADC, Young SD, Black CR, Rogerson KB, Ander EL, Watts M, Lammel J, Broadley MR

(2011). Maize grain and soil surveys reveal suboptimal dietary selenium intake is widespread in Malawi.

Scientific Reports, 1, 72.

Page 11: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Se supply from maize:

90% of popultation <7.5 µg d-1

UK Recommended Intake = 75 µg d-1

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Standing: Edwin Siyame, Allan Chilimba, Max Lowole, Alexander Stein, Agnes Mgomezulu, Michael Watts, Beatrice Mtimuni, Benson Kazembe,

Dalitso Kang’ombe, Scott Young, Louise Ander

Seated: Alexander Kalimbira, John Mussa, Rachel Hurst, Obed Lungu, Ros Gibson, Martin Broadley, Orpah Kabambe

Lilongwe, Malawi, September 2010

Multidisciplinary working (2010-present)

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(b)

(c)

(a)

n=60

n=60

Mrs Miriam Nkhoma (Zombwe)

Bily villages, Mikalango

Selenium intakes and

status in Malawi

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Blood plasma Se (µg L-1

)

0 50 100 150 200 250

0 50 100 150 200

Urinary Se (µg L-1

)

0 20 40 60 80 100

Mozyenti

Moses

Chimkango

Chifundo

Chamwaka

Billy

Yolamu

Yesaya Jere

Ngayiwona

Msekeni

Kenani

Bandawe Tembo

0 20 40 60 80 100

Blood GPx3 activity (nmol min-1

mL-1

)

0 50 100 150 200 250

0 50 100 150 200

Dietary Se intake (mg d-1

)

0.00 0.05 0.10 0.15 0.20

Mozyenti

Moses

Chimkango

Chifundo

Chamwaka

Billy

Yolamu

Yesaya Jere

Ngayiwona

Msekeni

Kenani

Bandawe Tembo

0.0 0.1 0.2

(a) (b)

Hurst R, Siyame E, Young SD et al. (2013)

Hurst R, Siyame E, Young SD et al. (2013)

Soil geochemistry linked to selenium intake…

Page 15: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Blood plasma Se (µg L-1

)

0 50 100 150 200 250

0 50 100 150 200

Urinary Se (µg L-1

)

0 20 40 60 80 100

Mozyenti

Moses

Chimkango

Chifundo

Chamwaka

Billy

Yolamu

Yesaya Jere

Ngayiwona

Msekeni

Kenani

Bandawe Tembo

0 20 40 60 80 100

Blood GPx3 activity (nmol min-1

mL-1

)

0 50 100 150 200 250

0 50 100 150 200

Dietary Se intake (mg d-1

)

0.00 0.05 0.10 0.15 0.20

Mozyenti

Moses

Chimkango

Chifundo

Chamwaka

Billy

Yolamu

Yesaya Jere

Ngayiwona

Msekeni

Kenani

Bandawe Tembo

0.0 0.1 0.2

(a) (b)

Soil geochemistry linked to selenium intake…

…and status

Hurst R, Siyame E, Young SD et al. (2013)

Page 16: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

References

>3200-

7500

>3200-7500 ng/ml toxicity - death/mortality Yang et al 1983, Lech et al

2002

>490-

<640

Selenium related side-effects; no serious toxicity Reid et al 2004

>250 Selenium related side-effects; hair loss, dermatitis Lippman et al 2009

180

160 Protection against some cancers; [increased risk of diabetes, high blood

pressure and hypertension]

Yu et al 1999, [Bleys et al

2007, Laclaustra et al 2009]

140 Protection against some cancers; reduction in total mortality Nomura et al 2000, Combs et

al 2001, Bleys et al 2008, Yu

et al 1999, [Vogt et al 2003]

120 Optimisation of selenoprotein P, protection against some cancers, reduction in

total mortality

Combs et al 2001, Burk 2006,

Hurst 2010, Thompson 2004,

Bleys et al 2008

100

80 Optimisation of glutathione peroxidase Thompson 2004

60 Optimisation of iodothyronine deiodinases Thompson 2004

40

20 < 20-40 ng/ml Se deficiency diseases, Keshan, Kashin-Beck, cretinism (with

iodine deficiency)

Thompson 2004; Shi et al

2010

Serum/

plasma

selenium

(ng/ml)

De

ficie

ncy

Adequacy/’optimal’

> R

eq

uir

em

en

ts, u

p to

to

xic

eff

ects

Selenium status in Malawi

Shire Valley

Most of Malawi ?

Fairweather-Tait SJ et al. (2011). Selenium in human health and disease. Antioxidant & Redox Signaling, 14: 1337-83.

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1. Diet diversification

2. Fortification

3. Agronomy

4. Crop breeding

Improving dietary mineral supplies

Page 18: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Diet Diversification

Page 19: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Edward Joy Lazarus Singano Dr Allan Chilimba

2011-2015

Page 20: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

700 samples (+)

100 edible foods

Joy EJM, Broadley MR, Young SD, Black CR, Chilimba ADC, Ander EL, Barlow TS, Watts MJ (2015). Soil type influences

crop mineral composition in Malawi. Science of the Total Environment, 505, 587-595.

GeoNutrition: geographical variation in selenium supply

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Mineral nutrient supply from surveys (Malawi)

Data from Malawi Third Integrated Household Survey (IHS3)

>12,500 households interviewed in 2010-11

Food consumption module: households asked to recall foods consumed in

past 7 d from 112 items (e.g.‘Maize ufa refined (fine flour)’,‘Dried fish’)

Joy EJM, Kumssa DB, Broadley MR, Watts MJ, Young SD, Chilimba ADC, Ander EL (2015). Dietary mineral supplies in

Malawi: spatial and socioeconomic assessment. BMC Nutrition, 1, 42.

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Mineral nutrient supply from surveys (Malawi)

Page 23: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Selenium supply and deficiency risks in Malawi

Joy EJM, Kumssa DB, Broadley MR, Watts MJ, Young SD, Chilimba ADC, Ander EL (2015). Dietary mineral supplies in

Malawi: spatial and socioeconomic assessment. BMC Nutrition, 1, 42.

Median Se supply = 21.4 μg capita-1 d-1

Estimated Average Requirement = 36.0 μg capita d-1

AME =

adult male

equivalent

74%

Page 24: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Se supply vs socioeconomic factors in Malawi

Se supply as proportion of household requirements (adequacy = 1)

Joy EJM, Kumssa DB, Broadley MR, Watts MJ, Young SD, Chilimba ADC, Ander EL (2015). Dietary mineral supplies in

Malawi: spatial and socioeconomic assessment. BMC Nutrition, 1, 42.

Page 25: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Joy EJM, Kumssa DB, Broadley MR, Watts MJ, Young SD, Chilimba ADC, Ander EL (2015). Dietary mineral supplies in

Malawi: spatial and socioeconomic assessment. BMC Nutrition, 1, 42.

Median I supply = 12.6 μg capita-1 d-1

Estimated Average Requirement = 107.0 μg capita d-1

>99%…but 17% with

iodised salt

Iodine supply and deficiency risks in Malawi

Page 26: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Agronomy

Page 27: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Se-fertilizer experiments in Malawi (2009 & 2010, plots=979)

Dr Allan Chilimba

Mark Meacham

Gertrude Phiri Lemon Nyambe

Charles Gondwe

Lazarus Singano

Page 28: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

January 2009

Se-fertilizer experiments in Malawi (2009 & 2010)

Page 29: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

January 2009

Se-fertilizer experiments in Malawi (2009 & 2010)

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Chilimba ADC et al. (2012). Field Crops Research 125: 118-128

Se application (g Se ha-1

)

0 10 20 30

Gra

in S

e (

mg

Se k

g-1

)

0.0

0.1

0.2

0.3

0.4

0.5

0.6

Liquid drench y = 0.019x + 0.061

CAN+Se (granular) y = 0.015x + 0.085

NPK+Se (granular) y = 0.022x + 0.056

15-22 µg Se kg-1 grain . g-1 Se ha-1

Se-fertilizer experiments Malawi: results summary

Page 31: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Ultra-trace amounts of selenium are required

Flickr, Eamon Curry (CC BY 2.0)

Flickr, Gunilla G (CC BY-SA 2.0)

Page 32: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

1. Do nothing?

2. Change fertilizer policy

[as done in Finland]

Options to alleviate selenium deficiency in Malawi

Page 33: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Alfthan G. et al. (2012). Nationwide supplementation of sodium selenate to commercial fertilizers: history and 25-year results from the

Finnish Selenium Monitoring Programme. In: Thompson B, Amoroso L (eds), Combating micronutrient deficiencies: food-based

approaches. CAB International and Food and Agriculture Organization of the United Nations (FAO), Rome, pp 312-337.

16 / 6 6 / 6 10 / 6

Selenium added to solid multi-nutrient fertilizers (mg kg-1 arable / grass sectors)

Precedent for using selenium fertilisers in Finland

(Malawi)

Page 34: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

1. Do nothing?

2. Change fertilizer policy

[as done in Finland]

3. Extend the evidence base

Options to alleviate selenium deficiency in Malawi

Page 35: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Jellita Gondwe

Felix Phiri

Extend the evidence base

CHSU Labs, Lilongwe, April 18th 2016

Page 36: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

References

>3200-

7500

>3200-7500 ng/ml toxicity - death/mortality Yang et al 1983, Lech et al

2002

>490-

<640

Selenium related side-effects; no serious toxicity Reid et al 2004

>250 Selenium related side-effects; hair loss, dermatitis Lippman et al 2009

180

160 Protection against some cancers; [increased risk of diabetes, high blood

pressure and hypertension]

Yu et al 1999, [Bleys et al

2007, Laclaustra et al 2009]

140 Protection against some cancers; reduction in total mortality Nomura et al 2000, Combs et

al 2001, Bleys et al 2008, Yu

et al 1999, [Vogt et al 2003]

120 Optimisation of selenoprotein P, protection against some cancers, reduction in

total mortality

Combs et al 2001, Burk 2006,

Hurst 2010, Thompson 2004,

Bleys et al 2008

100

80 Optimisation of glutathione peroxidase Thompson 2004

60 Optimisation of iodothyronine deiodinases Thompson 2004

40

20 < 20-40 ng/ml Se deficiency diseases, Keshan, Kashin-Beck, cretinism (with

iodine deficiency)

Thompson 2004; Shi et al

2010

Serum/

plasma

selenium

(ng/ml)

De

ficie

ncy

Adequacy/’optimal’

> R

eq

uir

em

en

ts, u

p to

to

xic

eff

ects

Selenium status in Malawi

400

350

300

250

200

150

100

50

0

400

300

200

100 0

Selen

iu

m co

ncen

tratio

n (u

g/L)

FrequencyB

lo

od

p

lasm

a selen

iu

m (u

g/L)

Page 37: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

1. Do nothing?

2. Change fertilizer policy

[as done in Finland]

3. Extend the evidence base

4. R&D

[intervention studies, single/multiple inputs, long-term health outcomes,

cost-benefit, socio-economic analysis, social sciences, ethics]

Options to alleviate Se deficiency in Malawi

Page 38: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Zinc (Zn) fertiliser use and its

impact on human health

Martin R. BroadleyMunir Zia, Waqar Ahmad, Diriba Kumssa, Edward Joy,

Louise Ander, Michael Watts, Alexander Stein, Scott Young

Page 39: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti
Page 40: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Dietary Zn supply: ~20% are deficient

Kumssa DB, Joy EJM, Ander EL, Watts MJ, Young SD, Walker S, Broadley MR (2015). Dietary calcium and zinc deficiency

risks are decreasing but remain prevalent. Scientific Reports, 5, 10974.

Diriba Kumssa

Page 41: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Zn deficiency risks increased due to phytate-P

in cereal grains and legume seeds

Kumssa DB, Joy EJM, Ander EL, Watts MJ, Young SD, Walker S, Broadley MR (2015). Dietary calcium and zinc deficiency

risks are decreasing but remain prevalent. Scientific Reports, 5, 10974.

Page 42: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Health Economic Analyses

(based on Disability Adjusted Life Years, DALYs)

Joy EJM, Stein AJ, Young SD, EL Ander, MJ Watts, Broadley MR (2015). Zinc-enriched fertilisers as a potential public health intervention in Africa.

Plant and Soil, 389, 1-24.

Intervention Cost per

DALY saved

(US $)

Notes Source

Granular fertiliser 773-6457 sub-Saharan Africa Joy et al., 2015

Foliar fertiliser 81-575 sub-Saharan Africa Joy et al., 2015

Soil + foliar fertiliser 256-549 Pakistan (Punjab, Sindh) Joy et al., 2016

Foliar (w/ pesticide) 41-594 China Wang et al. 2016

Crop breeding 0.7-7.3 India (1.1 billion) Stein et al., 2006

Supplements 65-2758 Prophylactic, 1-4 yrs Fink & Heitner, 2014

Flour fortification 401 Zambia, VA, Fe, Zn Fielder et al., 2013

Joy EJM, Ahmad W, Zia MH, Kumssa DB, Young SD, Watts MJ, Stein AJ, Broadley MR (2016). Valuing increased zinc (Zn) fertiliser-use in Pakistan.

Plant and Soil, doi: 10.1007/s11104-016-2961-7.

Page 43: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

1. Diet diversification2. Food fortification3. Agronomy4. Crop breeding

Improving dietary mineral supplies

Page 44: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Diet Diversification

Page 45: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Zn supply in Malawi

AME = adult

male equivalent

Joy EJM, Kumssa DB, Broadley MR, Watts MJ, Young SD, Chilimba ADC, Ander EL (2015). Dietary mineral supplies in

Malawi: spatial and socioeconomic assessment. BMC Nutrition, 1, 42.

Median Zn supply (per AME) = 10 mg capita-1 d-1

Estimated Average Requirement = ~12 mg capita-1 d-1

57%

Page 46: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Zn supply vs socioeconomic factors in Malawi

Zn supply as proportion of household requirements

Joy EJM, Kumssa DB, Broadley MR, Watts MJ, Young SD, Chilimba ADC, Ander EL (2015). Dietary mineral supplies in

Malawi: spatial and socioeconomic assessment. BMC Nutrition, 1, 42.

Page 47: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Agronomy

Page 48: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Health Economic Analyses

Page 49: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Data from NEPAD/IFDC (2013) Practices and policy options for the improved design and implementation of fertilizer subsidy

programs in sub-Saharan Africa. https://ifdcorg.files.wordpress.com/2015/01/sp-41_rev.pdf [October 2015]

Fertiliser-use in sub-Saharan African countries with subsidies

https://ifdcorg.files.wordpress.com/2015/01/sp-41_rev.pdf
Page 50: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Joy EJM, Stein AJ, Young SD, Ander EL, Watts MJ, Broadley MR (2015). Zinc-enriched fertilisers as a potential public

health intervention in Africa. Plant and Soil, 389, 1-24.

Increases in grain Zn concentration as a result of

Zn fertilisation (literature-survey; Joy et al., 2015)

Page 51: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Foliar Zn fertiliser application to maize on a smallholder farm, Zimbabwe,

2009 (photo, Prof. Florence Mtambanengwe, University of Zimbabwe)

Page 52: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Intervention Cost per

DALY saved

(US $)

Notes Source

Granular fertiliser 773-6457 sub-Saharan Africa Joy et al., 2015

Foliar fertiliser 81-575 sub-Saharan Africa Joy et al., 2015

Soil + foliar fertiliser 256-549 Pakistan (Punjab, Sindh) Joy et al., 2016

Foliar (w/ pesticide) 41-594 China Wang et al. 2016

Crop breeding 0.7-7.3 India (1.1 billion) Stein et al., 2006

Supplements 65-2758 Prophylactic, 1-4 yrs Fink & Heitner, 2014

Flour fortification 401 Zambia, VA, Fe, Zn Fielder et al., 2013

Health Economic Analyses

(based on Disability Adjusted Life Years, DALYs)

Joy EJM, Stein AJ, Young SD, EL Ander, MJ Watts, Broadley MR (2015). Zinc-enriched fertilisers as a potential public health intervention in Africa.

Plant and Soil, 389, 1-24.

Joy EJM, Ahmad W, Zia MH, Kumssa DB, Young SD, Watts MJ, Stein AJ, Broadley MR (2016). Valuing increased zinc (Zn) fertiliser-use in Pakistan.

Plant and Soil, doi: 10.1007/s11104-016-2961-7.

Page 53: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Health AND Yield Economic Analyses

Page 54: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Valuing Zn fertiliser use in Pakistan

Joy EJM, Ahmad W, Zia MH, Kumssa DB, Young SD, Watts MJ, Stein AJ, Broadley MR (2016). Valuing increased zinc (Zn)

fertiliser-use in Pakistan. Plant and Soil, doi: 10.1007/s11104-016-2961-7.

Page 55: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Area Cropped

area, wheat

(Mha)

Wheat production

(Mt)

Wheat yield

(t ha-1)

Punjab 7.5 18.4 2.5

Sindh 1.9 3.5 1.9

Pakistan ~10 ~25 ~2.7

Wheat is the major crop of Punjab and Sindh Provinces

Source. PBS Agriculture Census 2010 (p. 36); N.B. 90/97% of wheat is irrigated in Punjab/Sindh (p.39)

Page 56: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Engro FFC

Engro FFC

Industry estimates of Zn-use in Pakistan

Page 57: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Agricultural Zn-use baselines in Pakistan

Based on rapid farmer surveys

Farmers surveyed in Punjab (n=1193), and Sindh (n=1338) Provinces

Farmers asked about their crop-specific fertiliser-usage and yields

wheat, rice, cotton, sugarcane, maize, ‘other’

Only data for wheat are used in this study

Munir Zia Waqar Ahmad

Page 58: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Area Farmers

surveyed

Punjab 1,193

Sindh 1,338

Combined 2,531

Source. W. Ahmad et al. (2015), unpublished survey data.

Rapid farmer survey in Punjab and Sindh

Page 59: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Rapid farmer survey in Punjab and Sindh

Yield-response of wheat to N (urea) and P2O5 (di-ammonium phosphate, DAP)

Joy EJM, Ahmad W, Zia MH, Kumssa DB, Young SD, Watts MJ, Stein AJ, Broadley MR (2016). Valuing increased zinc (Zn)

fertiliser-use in Pakistan. Plant and Soil, doi: 10.1007/s11104-016-2961-7.

Page 60: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Zn fertilisers are currently used by a proportion of

(progressive) farmers

Area Farmers

surveyed

Using Zn

fertilisers

Using Zn

fertilisers?

(%)

Punjab 1,193 172 14

Sindh 1,338 310 23

Combined 2,531 482 19

Page 61: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Yie

ld (

t h

a-1

)

0

2

4

6

8

Yie

ld (

t h

a-1

)

0

2

4

6

8

Punjab

Sindh

-Zn +Zn

Area -Zn mean

yield

(t ha-1)

+Zn mean

yield

(t ha-1)

% P

Punjab 4.0 4.3 108 <0.001

Sindh 3.1 3.6 114 <0.001

Yield response to Zn fertiliser

Page 62: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Assumptions used to value Zn fertiliser-use:

1. Baseline Zn-use 7.3 kt y-1 at 4.8 kg ha-1 (ZnSO4.H2O eq. @ 33% Zn)

2. Constant granular:foliar ratio of 0.7:0.3

3. Wheat support price: $312 USD t-1

4. Cost of ZnSO4.H2O: $1600 USD t-1

5. Scenario: ↑ Zn fertilisers are distributed to 100% wheat in Punjab, Sindh

6. Benefit:Cost Ratios (BCRs) estimated for ↑ yield

7. Health economic impact of ↓ in DALYs lost, due to an ↑ in grain Zn

concentration from national baseline surveys of wheat

Value of increased Zn fertiliser-use in Pakistan

Page 63: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Assumptions used to value Zn fertiliser-use:

8. 4.8 kg ha-1 soil-Zn, ↑ grain Zn by 19% to 29.6 mg kg-1

9. 4.8 kg ha-1 foliar-Zn, ↑ grain Zn by 63%, to 40.6 mg kg-1

10. Value of 1 DALY = x * Gross National Income-PPP, i.e. x * I$ 5,110 PPP=parity purchasing power: I$ based on 2011 International Comparison Program*

11. BCRs for ↑ yield and ↓ in DALYs lost are additive

12. No discounting

Value of increased Zn fertiliser-use in Pakistan

*http://data.worldbank.org/indicator/NY.GNP.PCAP.PP.CD

http://data.worldbank.org/indicator/NY.GNP.PCAP.PP.CD
Page 64: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Valuing Zn fertiliser use in Pakistan (Zn supply, yield)

↑ 2.1 Mt y−1

↑ 0.6 Mt y−1

Page 65: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Valuing Zn fertiliser use in Pakistan (Zn supply, yield)

Page 66: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Cost per DALY saved:

Punjab = $392-549 USD

Sindh = $256-349 USD

Valuing Zn fertiliser use in Pakistan (yield + DALYs)

Page 67: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Intervention Cost per

DALY saved

(US $)

Notes Source

Granular fertiliser 773-6457 sub-Saharan Africa Joy et al., 2015

Foliar fertiliser 81-575 sub-Saharan Africa Joy et al., 2015

Soil + foliar fertiliser 256-549 Pakistan (Punjab, Sindh) Joy et al., 2016

Foliar (w/ pesticide) 41-594 China Wang et al. 2016

Crop breeding 0.7-7.3 India (1.1 billion) Stein et al., 2006

Supplements 65-2758 Prophylactic, 1-4 yrs Fink & Heitner, 2014

Flour fortification 401 Zambia, VA, Fe, Zn Fielder et al., 2013

Health Economic Analyses

(based on Disability Adjusted Life Years, DALYs)

Joy EJM, Stein AJ, Young SD, EL Ander, MJ Watts, Broadley MR (2015). Zinc-enriched fertilisers as a potential public health intervention in Africa.

Plant and Soil, 389, 1-24.

Joy EJM, Ahmad W, Zia MH, Kumssa DB, Young SD, Watts MJ, Stein AJ, Broadley MR (2016). Valuing increased zinc (Zn) fertiliser-use in Pakistan.

Plant and Soil, doi: 10.1007/s11104-016-2961-7.

Page 68: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Intervention Cost per

DALY saved

(US $)

Notes Source

Granular fertiliser 773-6457 sub-Saharan Africa Joy et al., 2015

Foliar fertiliser 81-575 sub-Saharan Africa Joy et al., 2015

Soil + foliar fertiliser 256-549 Pakistan (Punjab, Sindh) Joy et al., 2016

Foliar (w/ pesticide) 41-594 China Wang et al. 2016

Crop breeding 0.7-7.3 India (1.1 billion) Stein et al., 2006

Supplements 65-2758 Prophylactic, 1-4 yrs Fink & Heitner, 2014

Flour fortification 401 Zambia, VA, Fe, Zn Fielder et al., 2013

Health Economic Analyses

(based on Disability Adjusted Life Years, DALYs)

Joy EJM, Stein AJ, Young SD, EL Ander, MJ Watts, Broadley MR (2015). Zinc-enriched fertilisers as a potential public health intervention in Africa.

Plant and Soil, 389, 1-24.

Joy EJM, Ahmad W, Zia MH, Kumssa DB, Young SD, Watts MJ, Stein AJ, Broadley MR (2016). Valuing increased zinc (Zn) fertiliser-use in Pakistan.

Plant and Soil, doi: 10.1007/s11104-016-2961-7.

Page 69: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Cost per DALY saved:

Punjab = $392-549 USD

Sindh = $256-349 USD

Conservative BCRs

Used 24% Zn deficiency prevalence, likely to be >40%

Zn fertiliser effects can persist for 3-4 subsequent crops

Strong drivers for private and public investment in Zn fertilisers

Valuing Zn fertiliser use in Pakistan (yield + DALYs)

Page 70: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Blending Zn and granular fertiliser in Punjab, Pakistan

(photo, Dr Munir Zia, Fauji Fertiliser Company)

Page 71: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Blending Zn and granular fertiliser in Punjab, Pakistan

(photo, Dr Munir Zia, Fauji Fertiliser Company)

Page 72: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Blending Zn and granular fertiliser in Punjab, Pakistan

(photo, Dr Munir Zia, Fauji Fertiliser Company)

Page 73: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Cost per DALY saved:

Punjab = $392-549 USD

Sindh = $256-349 USD

Conservative BCRs

Used 24% Zn deficiency prevalence, likely to be >40%

Zn fertiliser effects can persist for 3-4 subsequent crops

Strong drivers for private and public investment in Zn fertilisers

Other soil improvements will increase yield further

P, K, and B fertilisers are under-utilised in Pakistan

Many saline/sodic soils

Breeding for increased grain Zn concentration adds further ‘value’

Valuing Zn fertiliser use in Pakistan (yield + DALYs)

Page 74: Martin R. Broadley Professor of Plant Nutritionnadgeyte/crelan/3_Crop Animal...%ORRGSODVPD6H J/-1) 0 50 100 150 200 250 0 50 100 150 200 8ULQDU\6H J/-1) 0 20 40 60 80 100 Mozyenti

Acknowledgements

Colleagues at:

Malawi (DARS, DNHA, CHSU, LUANAR)

Zambia (UNZA, ZARI, CBU)

Zimbabwe (UZ)

University of Nottingham

British Geological Survey

Other institutes (e.g. Rothamsted, LSHTM, CDC, UEA, Otago)

Funders…


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