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Network oscillations as a substrate for tACS modulation of learning and plasticity: cellular and quantitative insights from brain slice Gottingen, March 18, 2013. Marom Bikson - PowerPoint PPT Presentation

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Pharmacologic activity (efficacy and safety) is determined by drug concentration at tissue

Marom BiksonLucas Parra, Dennis Truong, Abhishek Datta, Davide Reato, Asif Rahman, Belen Lafon, Thomas Radman, Jacek Dmochowski, Preet Minhas, Yu Huang, Mahtab Alam, Alexander David, Peter Toshev, Ole SeibtDepartment of Biomedical Engineering, The City College of New York, New York, NY$ NIH, NSF, Epilepsy Foundation, Wallace Coulter Foundation, DoD (AFOSR)Network oscillations as a substrate for tACS modulation of learning and plasticity: cellular and quantitative insights from brain sliceGottingen, March 18, 2013 1tACS current flow : alternating direction

2tACS current flow : alternating direction

3tACS current flow : alternating direction

4tACS current flow : alternating direction

5tACS dose: WaveformFrequencyPeak Memrane Polarization++DC (0 Hz)50 Hz500 Hz5 Hz5000 HzMaximum polarization at DC is 0.15 mV per mA current (Bikson et al. J. Physiol. 2004, Radman et al. Brain Stim. 2009)Sensitivity decrease with frequencies >20 Hz (Bikson et al. J. Physiol 2004)Neurons become insensitive transparent to current at >500 Hz (Bikson et al. J. Physiol 2001)6