Marc Three - CV - University of Michigan · Web view10/05 “Leukotrienes and the lung: a decade of...

CURRICULUM VITAE

Personal Data

Name: Marc Peters-Golden, M.D.

Education and Training

1967-70 Pennsauken High School, Pennsauken, New Jersey1970-74 Franklin and Marshall College, Lancaster, Pennsylvania; A.B. magna cum laude, honors in

biology and special studies1974-78 Duke University School of Medicine, Durham, North Carolina; M.D. 1978-81 Resident, Internal Medicine, Tufts-New England Medical Center, Boston, Massachusetts 1981-83 Research Fellow, Pulmonary Medicine and Environmental Health Sciences, The Johns

Hopkins University, Baltimore, Maryland1983-84 Clinical Fellow, Pulmonary Medicine, The Johns Hopkins University, Baltimore, Maryland

Certification and Licensure

1984 Medical Licensure, Michigan (No. 47562)1981 Certification, American Board of Internal Medicine 1984 Certification, Subspecialty in Pulmonary Diseases1988-97 Certification, Subspecialty in Critical Care Medicine

Academic, Administrative, and Clinical Appointments

1984-91 Assistant Professor of Internal Medicine, The University of Michigan, Ann Arbor1984-95 Staff Physician, Department of Veterans’ Affairs Medical Center, Ann Arbor1984- Staff Physician, University of Michigan Health System, Ann Arbor1991-96 Associate Professor of Internal Medicine with tenure, The University of Michigan, Ann

Arbor1996- Professor of Internal Medicine with tenure, The University of Michigan, Ann Arbor2002- Faculty Member, Graduate Program in Immunology, University of Michigan Medical School1996-2011 Fellowship Program Director, Division of Pulmonary and Critical Care Medicine,

Department of Internal Medicine, University of Michigan 2011- Associate Fellowship Program Director for Research, Division of Pulmonary and Critical

Care Medicine, Department of Internal Medicine, University of Michigan

Consulting Positions

1992 External Advisory Committee, NIH Program Project Grant, "Lipid Mediators and Lung Injury," D.A. Bass, Principal Investigator, Bowman-Gray School of Medicine, Winston-Salem, N.C.

1996 Zeneca Pharmaceuticals, Abbott Laboratories1996 External Examiner, Faculty of Graduate Studies and Research, McGill University1997- Merck and Company, Inc.1999 Monsanto Company2001 Millennium Pharmaceuticals, Inc.2002 Scientific and Clinical Advisory Boards, Virocell, Inc.

Marc Peters-Golden, MD

2003 Gerson Lehrman Group’s Council of Healthcare Advisors2004 External Examiner, School of Graduate Studies, McMaster University2004 Forest Laboratories, Inc.2004 Advisory Board, University of Tennessee NIEHS Superfund Basic Research Proposal2004-2008 Critical Therapeutics, Inc.2004 LTB4 Sweden AB2004 Pfizer, Inc.2006 Efficas, Inc.2006- External Advisory Committee, NIH Program Project Grant, “Ether lipids, eicosanoids, and

lung cell pathophysiology,” C.C. Leslie, Principal Investigator, National Jewish Medical and Research Center

2007-2011 Adult Respiratory Advisory Board, Merck and Company, Inc.2007-2008 Eli Lilly and Company2007 DeCODE Genetics, Inc.2008- Nycomed/Takeda2008- External Advisory Board, Virginia Commonwealth University School of Medicine, training

grant on “Lipid Signaling and Functional Lipidomics in Cardiovascular and Respiratory Diseases (LCRD)”

2008 Actelion Pharmaceuticals2009 Boehringer Ingelheim2009 Ono Pharmaceuticals2010 Sanofi-Aventis2011 Glaxo SmithKline

Scientific Activities

Grant Review Activities:

1986-90 Member, American Lung Association/American Thoracic Society Research Review Committee

1988 Ad hoc reviewer, Veterans Administration Career Development Program1988-94 Ad hoc reviewer, Veterans Administration Merit Review (Respiratory)1993 Ad hoc reviewer, The Israel Science Foundation1993 Member, Special Review Committee for RFA 92-04 ("Ozone: mechanisms of action"),

National Institute of Environmental Health Sciences/National Heart Lung and Blood Institute1993 Ad hoc reviewer, The Health Effects Institute, Cambridge, MA1993 Ad hoc reviewer, American Federation for Clinical Research Foundation Early Career

Development Award1995 Member, Site Visit and Special Emphasis Panel, "Research Center for Pharmacology and

Drug Toxicology,” Vanderbilt University; National Institutes of General Medical Science1996 Member, American Lung Association Asthma Research Center Review Committee1996 Ad hoc reviewer, Alberta Lung Association1996 Ad hoc reviewer, NATO Advanced Study Institutes1997 Ad hoc reviewer, The Wellcome Trust1999 Member, Special Emphasis Panel, Asthma and Allergic Diseases Research Centers, National

Institute of Allergy and Infectious Disease2000 Member, Special Emphasis Panel, Program Project on “Inflammation, Airways Reactivity,

and Asthma,” National Jewish Medical and Research Center; National Heart, Lung, and Blood Institute

2001 Ad hoc reviewer, Arthritis Research Campaign, United Kingdom2002 Member, Special Emphasis Panel, Respiratory Physiology Ad Hoc Study Section, National

Heart Lung and Blood Institute


2003 Member, Special Emphasis Panel, Program Project on “Activation and Organization of Stress Signaling,” Massachusetts General Hospital; National Institute of General Medical Sciences

2003 Ad hoc reviewer, Jeffress Research Grant Program, Thomas F. Jeffress and Kate Miller Jeffress Memorial Trust

2003 Ad hoc reviewer, British Lung Foundation2004 Study Section Consultant, Oak Ridge Associated Universities/Pennsylvania Department of

Health Lung Research Initiative2004 Ad hoc reviewer, British Lung Foundation2004, 2005 Member, Special Review Committee, Program Project on “Chemical Mediators of Acute

Pulmonary Disorders,” Brigham and Women’s Hospital; National Heart, Lung, and Blood Institute

2005 Ad hoc reviewer, Marsden Fund, New Zealand2005 Ad hoc reviewer, The Israel Science Foundation2006 Member, Special Emphasis Panel, Competing Renewal for Severe Asthma Research

Program, National Heart Lung and Blood Institute2006 Ad hoc reviewer, British Lung Foundation2007 Ad hoc reviewer, Health Research Board of Ireland2009 Ad hoc reviewer, British Lung Foundation2009 Member, Special Emphasis Panel, Program Project on “Impact of Infection in Resolution

Circuits of Inflammation,” Brigham and Women’s Hospital; National Institute of Allergy and Infectious Diseases

2009 Ad hoc reviewer, Austrian Academy of Sciences doctoral fellowships2009 Member, Special Emphasis Panel to review conflict applications from NHLBI study section

members2009 Ad hoc reviewer, Asthma Foundation of Western Australia2010 Ad hoc reviewer, Alberta Heritage Foundation for Medical Research2010 Ad hoc reviewer, Austrian Science Fund research grants2010 Ad hoc reviewer, The Wellcome Trust/DBT India Alliance2011 Ad hoc reviewer, Discovery Grants program, Natural Sciences and Engineering

Research Council of Canada2011 Member, Special Emphasis Panel to review applications for RFA “Counter

Measures Against Chemical Threats”2011 Ad hoc reviewer, United Kingdom Medical Research Council Career

Development Awards 2011, 2012 Ad hoc reviewer, Program for Scientific Research in Biomedicine,

Fondazione Cariplo, Milan, Italy2013 Member, Review Committee for RFA “Phase II Clinical Trials of Novel

Therapies for Lung Diseases”

Editorial Positions:

1992-00 Member, Editorial Board, American Journal of Physiology: Lung Cellular and Molecular Physiology

1996-02 Member, Primary Review Pool, Journal of Immunology


2002-06 Section Editor, Journal of Immunology

2002-08 Section Editor, Biochimica et Biophysica Acta (Molecular and Cell Biology of Lipids)

2007- Member, Editorial Board, Clinical and Translational Science

2010- Member, Editorial Board, Thorax

Conference Organization

2001 Co-organizer, Keystone Symposium on Lipid Mediators, Snowbird, UT

Reviewer for Scientific Journals:

American Journal of PathologyAmerican Journal of Physiology: Cell PhysiologyAmerican Journal of Physiology: Lung Cellular and Molecular PhysiologyAmerican Journal of Respiratory and Critical Care MedicineAmerican Journal of Respiratory Cell and Molecular BiologyAmerican Journal of Veterinary ResearchApoptosisBiochemical JournalBiochemistry and Cell BiologyBiochimica et Biophysica ActaBloodBritish Journal of PharmacologyChestCirculation ResearchClinical and Experimental AllergyClinical Immunology and ImmunopathologyCurrent Drug Targets – Inflammation and AllergyEuropean Respiratory JournalEuropean Journal of ImmunologyExperimental Lung ResearchFASEB JournalInfection and ImmunityJournal of Allergy and Clinical ImmunologyJournal of Applied PhysiologyJournal of Biological ChemistryJournal of Clinical InvestigationJournal of Experimental MedicineJournal of ImmunologyJournal of Laboratory and Clinical MedicineJournal of Leukocyte BiologyJournal of the National Cancer InstituteJournal of Pharmacology and Experimental TherapeuticsLaboratory InvestigationLife SciencesMediators of InflammationMedicinal Chemistry ReviewsMetabolismNature


Proceedings of the American Thoracic SocietyProceedings of the National Academy of SciencesProstaglandinsRespirationRespiratory ResearchSarcoidosis, Vasculitis and Diffuse Lung DiseasesScienceScience SignalingScience Translational MedicineThoraxTranslational ResearchTrends in Biochemical SciencesTrends in Immunology

Grant Support

Current:NIH P50 P50HL107177“Prostanoids, Plasminogen Activation, and Personalized Therapeutics in IPF”Centers for Advanced Diagnostics and Experimental Therapeutics in Lung Diseases (CADET)4/1/11-3/31/13; Principal Investigator, 10% effort$300,000 annual direct costs

NIH R01 HL58897“Eicosanoids and Lung Macrophage Antimicrobial Mechanisms”8/1/09-7/31/13; Principal Investigator, 30% effort$250,000 annual direct costs

NIH R01 HL 94311“Control of Fibroblast Function by Prostaglandin E2 and Plasminogen Activation”8/10/09-8/09/13; Principal Investigator, 30% effort$250,000 annual direct costs

NIH T32 HL00749 “Multidisciplinary Training Program in Lung Disease”7/1/08-6/30/13; Associate Director, 5% effort; Theodore Standiford, Director$730,364 annual direct costs

NIH R01 HL094622“Role of Resident Mesenchymal Stem Cells in Lung Allograft Rejection”8/1/09-5/31/14; Co-Investigator, 5% effort; Principal Investigator, Vibha Lama$250,000 annual direct costs

NIH R01 HD057176“Role of Misoprostol in Clostridium Sordellii Endometritis after Medical Abortion”9/1/08-5/31/13; Co-Investigator, 5% effort; Principal Investigator, David Aronoff$201,960 annual direct costs

NIH 1 K08 HL094657“Epigenetic Regulation of the E Prostanoid 2 Receptor Gene in Lung Fibroblasts”7/1/09-6/30/14; Sponsor for Steven Huang, M.D.$125,000 annual direct costs


American Lung Association“Inhibition of Phagocyte Oxidase in Alveolar Macrophages by

Prostaglandin E2”7/1/11 - 6/30/13; Sponsor for Emilie Bourdonnay, Ph.D.$32,500 annual direct costs

American Lung Association“Role of Eicosanoids in Macrophage Accumulation and Polarization in

Allergic Asthma”7/1/12 - 6/30/14; Sponsor for Zbigniew Zaslona, Ph.D.$32,500 annual direct costs

Recent:

NIH 1 K99 HL103777“Regulation of Toll-Like Receptor-Induced NFB Activation by Gi-Coupled Receptors”8/1/10-7/30/12; Sponsor for Carlos Henrique Serezani, Ph.D.$707,669 total direct costs

NIH R01 AI 065543“PGE2 Regulation of Host Defense post BMT”05/15/07-04/30/12, Co-Investigator, 5% effort, Principal Investigator Bethany Moore$250,000 annual direct costs

NIH R01 HL087846“Herpesvirus Infections Recruit Fibrocytes and Augment Pulmonary Fibrosis”3/1/08-2/28/12, Co-Investigator, 5% effort (.60 calendar months), Principal Investigator, Galen Toews$250,000 direct costs annually

American Lung Association“Protein Kinase A Signaling is Impaired in Fibrotic Lung Fibroblasts and Rescued by Plasminogen Activation”7/1/10 - 6/30/12; Sponsor for Katsuhide Okunishi, M.D., Ph.D.$32,500 annual direct costs

NIH R01 HL085149“Eicosanoid Balance in Lung Transplant Injury and Repair”9/1/06–8/31/11, Co-Investigator, 5% Effort, Principal Investigator, David Pinsky$250,000 annual direct costs

American Heart Association Cardiovascular Medical Research and Education FundIdiopathic Pulmonary Arterial Hypertension Center for Cell Studies“Vascular Cell Contribution to Plexogenic Pulmonary Arteriopathy in Pulmonary Arterial Hypertension”4/1/06-3/30/11; Co-Investigator, 5% effort; Principal Investigator, David Pinsky$250,000 annual direct costs

NIH R01 GM068848-05


“Catalysis by Prostaglandin Endoperoxide H Synthases”9/01/07 - 8/31/11, Co-Investigator, 5% effort; Principal Investigator, William W. Smith$290,611 annual direct costs

NIH R01 HL077417“Regulation of Pulmonary Host Defense by Leptin”12/1/05-11/30/10; Co-Investigator, 5% effort; Principal Investigator, Peter Mancuso$200,000 annual direct costs

NIH U10 HL080371 (Idiopathic Pulmonary Fibrosis Clinical Research Network)“Novel Therapeutic Approaches in IPF” 5/1/05-4/30/10; Co-Investigator on Clinical Core, 5% effort (Principal Investigator, Fernando J. Martinez); Co-Investigator on Clinical Skills Development Core, 5% effort (Principal Investigator, Galen Toews)$550,000 annual direct costs

NIH UL1 RR024986“Michigan Institute for Clinical and Health Research”9/17/07-6/30/10 Participating Investigator, 5% effort, Principal Investigator, Kenneth Pienta$5,712,296, annual direct costs

NIH 1 K08 HL078727Modulation of Lung Innate Immunity by Prostaglandin E2”12/1/04-11/30/09; Sponsor for David Aronoff, M.D.$122,500 annual direct costs

NIH 1 K23 HL077719“Fibroproliferation in Bronchiolitis Obliterans”7/1/04-6/30/09; Co-Sponsor for Vibha Lama, M.D.$125,000 annual direct costs

Hartwell Foundation Fellowship Grant“The Role of prostaglandin E2 in mediating intracellular signaling pathways in neonatal alveolar macrophages”1/1/08 - 12/31/09; Sponsor for Megan Ballinger$50,000 annual direct costs

American Lung Association, RT-78960-N“Modulation of Alveolar Macrophage Antimicrobial Functions by Eicosanoids: Role of Lipid Rafts and Signaling Molecules”7/1/08 - 6/30/09; Sponsor for C. Henrique Serezani$32,500 annual direct costs

Parker B. Francis Fellowship, Francis Families Foundation“Epigenetic Regulation of the E Prostanoid 2 Receptor Gene in Fibrotic Lung Fibroblasts”Period: 7/1/08 - 6/30/09; Sponsor for Steven Huang$50,000 annual direct costs

Certification and Licensure

1984 Medical Licensure, Michigan (No. 47562)Marc Peters-Golden, MD

1981 Certification, American Board of Internal Medicine 1984 Certification, Subspecialty in Pulmonary Diseases1988-97 Certification, Subspecialty in Critical Care Medicine

Honors and Awards

1974 Phi Beta Kappa1974 Rawnsley Science Prize (student most likely to apply scientific knowledge to benefit of

community)1974 Williamson Medal (awarded by faculty vote to one graduating senior for excellence in

scholarship, leadership and character)1980 Outstanding Housestaff Teaching Award from students of Tufts Medical School1983-84 Fellow of The American Lung Association of Maryland1990, 1991 Henry Christian Award for scientific excellence in research, American Federation for

Clinical Research national meeting1990-95 Career Investigator Award, American Lung Association1996 American Society for Clinical Investigation (elected)1996 American Lung Association of Michigan Board Member of the Year2003 Association of American Physicians (elected)2006 Inaugural Outstanding Faculty Award conferred by Pulmonary and Critical Care Medicine

Fellows, University of Michigan Medical Center2007 Recognition Award for Scientific Accomplishment, American Thoracic Society 2011 University of Michigan Medical School League of Research Excellence2011, 2013 Best Doctors in America, Pulmonary Medicine2013 The Harold and Marilyn Menkes Memorial Lecturer, Johns Hopkins University Bloomberg

School of Public Health

Memberships and Offices in Professional Societies

1983- American Thoracic Society1985- American Federation for Medical Research1985- Michigan Thoracic Society; 1991-93, Secretary-Treasurer; 1993-95, Vice President; 1995-

97, President1989- Central Society for Clinical Research1990- American Association for the Advancement of Science1992- American Association of Immunologists

Teaching, University of Michigan

Supervision of Internal Medicine House Officers in Senior Research Projects: Nathalie Brophy, M.D. (1986), Jussi Saukkonen, M.D. (1988), S. Patrick Nana-Sinkam, M. D. (1998), Derek Dimcheff, M.D., Ph.D. (2012)

Graduate Thesis Committees: Megan Ballinger (Immunology, Ph.D. conferred 2007); Kevin Vanella (Immunology, Ph.D. conferred 2009), Ben Cronin (Immunology, Ph.D. conferred 2010), Deepti Nagarkar (Molecular and Integrative Physiology, Ph.D. conferred 2010)

Laboratory Trainees

Trainee (Dates) Training Award Current Position

James Chauncey, MD National ALA Research Grant Private Practice(1985-87)

Peter Sporn, MD National ALA Research Fellow Professor &Marc Peters-Golden, MD

(1985-87) Trudeau Scholar of the National Director of Fellowship ProgramALA Pulmonary Division

Clinical Investigator Award, NIH Northwestern University

Meyer Balter, MD National ALA Research Fellow Professor(1986-88) Ontario Lung Association Grant Pulmonary Division

University of Toronto

Randolph Lipchik, MD ALA of Michigan Research Fellow Professor(1988-90) National Research Service Pulmonary Division

Award, NIH Medical College ofWisconsin

Peter Gray, DVM, PhD Graduate Student Fellowship Research Fellow(1989-90) Michigan State University University of Western

Australia

Gregory Neagos, MD National ALA Research Fellow Private Practice(1990-92)

Michael Coffey, MD Clinical Investigator Award, NIH Associate Professor(1990-93) Pulmonary Division

University of Michigan

Jerome Wilborn, MD ACCP Boehringer Ingelheim Fellow Private Practice(1991-94) NIH Minority Supplement Trainee

Randall Covin, MD National ALA Research Fellow Private Practice(1992-96)

Thomas Brock, PhD NIH Postdoctoral Training Grant Scientist(1993-96) Parker B. Francis Research Cayman Chemical

Fellowship Ann Arbor, MI

Tammy C. Ojo, MD ALA of Michigan Research Fellow Assistant Professor(1994-95) Pulmonary Division


Patricia Tithof, DVM PhD Postdoctoral Fellowship Associate Professor(1994-95) Michigan State University University of Tennessee

College of Veterinary Medicine

Marc Bailie, DVM, PhD NIH Postdoctoral Training Grant Associate Professor(1994-96) Pharmacology and Toxicology

Michigan State University

Peter Mancuso, PhD NIH Postdoctoral Training Grant Associate Professor(1997-99) ALA of Michigan Research Fellow Environmental Health Sciences

School of Public HealthUniversity of Michigan

Marc Jacobs, MD None Private Practice(1998-99)


Vibha Lama, MD None Associate Professor(2000-01) Pulmonary Division


Claudio Cannetti, Ph.D. CNPq Fellowship, Brazil Assistant Professor(2002-04) Biophysics Department

State University of Rio de JaneiroRio de Janeiro, Brazil

David Aronoff, M.D. NIH Postdoctoral Training Grant Associate Professor(2002-04) Parker B. Francis Fellowship Infectious Disease Division


Ryan Charbeneau, M.D. GlaxoSmithKline Pulmonary Private Practice(2003-04) Fellowship Award

Carlos Henrique Serezani, Ph.D. Brazilian Research Foundation Ph.D. Student(2003-04) Department of Immunology

University of Sao Paulo

(2006-12) American Lung Association Senior Assistant Professor Research Training Fellowship Department of Microbiology and

ImmunologyNIH K99/R01 Indiana University

Steven Huang, M.D. NIH Postdoctoral Training Grant Assistant Professor(2005-07) ATS Career Development Award Pulmonary Division

Parker B. Francis Fellowship University of Michigan

Camila Peres Brazilian Research Foundation Research Investigator(2005-06) Dental School

University of Sao Paulo-Bauru

Jooho Chung (2006-07) none MSTP StudentUniversity of Michigan

Megan Ballinger, Ph.D. NIH Postdoctoral Training Grant Lecturer(2007-09) Hartwell Foundation Pulmonary Division


Sang Pyo Lee, M.D. Gachon Univ. School of Medicine Associate Professor(2007-08) Seoul, South Korea Pulmonary Division

Gachon UniversitySeoul, South Korea

Alexandra Medeiros, Ph.D. CNPq Fellowship, Brazil Assistant Professor(2007-09) Department of Immunology

Federal University of Sao Paulo, Araraquara, Brazil

Anna Kovalszki, M.D. none Assistant Professor(2007-08) Allergy Division

Harvard University Marc Peters-Golden, MD

Katsuhide Okunishi, M.D., Ph.D. Uehara Memorial Foundation Associate Professor(2008-12) American Lung Association Gumma University, Japan

Sang-Hoon Kim, M.D. Eulji Univ. School of Medicine Associate Professor(2009-10) Seoul, South Korea Pulmonary Division

Eulji University School of MedicineSeoul, South Korea

Camila Stumm Brazilian Research Foundation Medical Science Liaison(2009-10) Novartis

Brazil

Emilie Bourdonnay, Ph.D. American Lung Association Postdoctoral Research Fellow(2009-) Pulmonary Division


Garth Garrison, M.D. Assistant Professor(2009-11) Pulmonary Division

University of Vermont

Zbigniew Zaslona, Ph.D. German Research Foundation Postdoctoral Research Fellow(2010- ) American Lung Association Pulmonary Division


Jacob Scott, M.D. Pulmonary Fellow(2011- ) University of Michigan

Derek Dimcheff, M.D., Ph.D. Internal Medicine Resident(2012- ) University of Michigan

Raghu Kumar, Ph.D. Postdoctoral Research Fellow(2012- ) University of Michigan

Extramural Invited Presentations

Invited Speaker at Scientific Meetings

05/90 "Role of arachidonic acid metabolites in airway hyperreactivity," American Thoracic Society Meeting, Boston, MA

11/90 "Corticosteroid therapy in asthma -- a critical review with regard to controversies," Connecticut State Chest Conference, Yale University, New Haven, CT

05/91 "Molecular regulation of arachidonate metabolism," American Thoracic Society Meeting, Anaheim, CA

09/91 "Eicosanoids in the pathogenesis of asthma: perspective and pitfalls," National Meeting of the Comparative Respiratory Society, East Lansing, MI:

01/92 "Novel aspects of 5-lipoxygenase regulation in alveolar macrophages,” 1992 Winter Prostaglandin Conference, Keystone, CO

10/92 "Future trends in asthma therapy: the research perspective," American Lung Association of Michigan Conference on The New NIH Guidelines on Asthma, Traverse City, MI

10/93 "Redistribution of 5-lipoxygenase and cytosolic phospholipase A2 to the nuclear fraction of activated macrophages," International Congress on Inflammation, Vienna, Austria


03/94 "Expression and regulation of PLA2s in lung cells," Pulmonary Research Group/Inflammation Research Association-sponsored conference on "Phospholipases and pulmonary function," New York Academy of Sciences

05/94 "The dawning of the nuclear era: the new cell biology of eicosanoid synthesis and action," American Thoracic Society Meeting, Boston, MA

06/94 "Localization of 5-lipoxygenase to the nucleus of resting rat basophilic leukemia cells, " Ninth International Conference on Prostaglandins and Related Compounds, Florence, Italy

04/95 "Intracellular localization of 5-lipoxygenase: implications for enzyme function," Symposium on Lipid Mediators, FASEB meeting, Atlanta, GA

05/96 "Intracellular localization of eicosanoid-forming enzymes: insights and questions," Fourth International Symposium of Jagiellonian Medical Research Centre, Cracow, Poland

05/96 “Inflammatory mechanisms in the lung,” American Thoracic Society Meeting, New Orleans, LA 06/96 “Intracellular localization of 5-lipoxygenase: surprising implications for the cell biology of

eicosanoid synthesis and action,” American Society for Biochemistry and Molecular Biology Meeting, New Orleans, LA

05/97 “The intersection of lipid and polypeptide mediators: from strangers to bedfellows,” American Thoracic Society Meeting, San Francisco, CA

06/97 “Molecular mechanisms of leukotriene synthesis: the evolving paradigm,” William Harvey Research Conference, London, England

06/97 “The nucleus as the intracellular site for 5-lipoxygenase localization and action,” Gordon Research Conference on Lipid Metabolism, Kimball Union Academy, Meriden, NH

09/97 “Anti-leukotriene agents: a new option in asthma therapy,” Michigan Association of Respiratory Care Annual Meeting, Frankenmuth, MI

01/98 “Role of anti-leukotriene agents in the treatment of asthma,” Minnesota Thoracic Society Meeting, St. Paul, MN

04/98 “Alveolar macrophages as mediators of inflammatory lung disease,” Postgraduate course, American Thoracic Society Meeting, Chicago, IL

09/98 “Cell biology of 5-lipoxygenase,” Asthma Club of Sendai Conference, Sendai, Japan09/98 “Anti-leukotriene drugs for asthma,” Kyoto Asthma Forum, Kyoto, Japan10/98 “Utility of anti-leukotriene agents in the treatment of asthma,” Indiana Thoracic Society

Meeting, Indianapolis, IN11/98 “Intracellular compartmentalization of leukotriene biosynthesis,” Symposium on “Leukotrienes

as Targets for Treatment of Asthma and Other Diseases: Current Basic and Clinical Research,” Karolinska Institute, Stockholm Sweden

12/98 “Role of leukotriene receptor antagonists in adult asthmatics: where does it fit into asthma treatment guidelines?” Hong Kong Allergy Convention, Hong Kong

04/99 “Nuclear trafficking of enzymes associated with eicosanoid biosynthesis,” Keystone Symposium Keystone, CO

04/99 “New insights into leukotriene synthesis: the inside story,” American Thoracic Society Meeting, San Diego, CA

06/99 “Novel perspectives on leukotriene biology,” 4th World Congress on Inflammation, Paris, France 07/99 “Inhaled steroids: how much is enough?” Annual Congress of the Malaysian Thoracic Society,

Kuala Lumpur 08/99 “COX-2 and the lung: perpetrator or protector?” Third International Workshop on COX-2, Kona,

Hawaii10/99 “Positioning anti-leukotriene agents in asthma treatment: insights from the perspective of

eicosanoid biology,” Colorado Asthma and Allergy Society, Denver, CO03/00 “Use of montelukast as a primary controller agent in the treatment of asthma,” Asthma

Symposia, Taipei, Kaoshiung, and Taichung, Taiwan04/00 “Evolving role of leukotriene receptor antagonists in the management of asthma,” Asthma

Symposia, Guangzhou, Shanghai, and Beijing, China04/00 “Asthma controller therapy: insights from the perspective of eicosanoid biology.” Puget Sound

Allergy and Asthma Society, Seattle, WA04/00 “Anti-leukotriene agents in asthma management; what have we learned and what must we

learn?” Michigan Thoracic Society Annual Meeting, Novi, MIMarc Peters-Golden, MD

05/00 “Lipid mediators,” American Thoracic Society/National Institute of Environmental Health Sciences Workshop, Toronto, Canada

05/00 “Natural knockouts: acquired eicosanoid deficiencies and susceptibility to lung disease,” American Thoracic Society Meeting, Toronto Canada

06/00 “5-Lipoxygenase and the nucleus: where, when, how, and why?” 11th International Conference on Advances in Prostaglandin and Leukotriene Research: Basic Science and New Clinical Applications, Florence, Italy

08/00 “Role of the 5-lipoxygenase pathway in the antimicrobial activity of phagocytes,” FASEB Research Conference, Saxtons River, VT

10/00 "Regulation of leukotriene synthesis" and "Role of leukotrienes in diseases other than asthma," Merck Air Board Workshop, Hayman Island, Australia

03/01 “New insights into the role of leukotrienes in asthma,” Toronto City-Wide Allergy and Immunology Society, Toronto, Ontario

04/01 “Leukotrienes and antimicrobial defenses,” Keystone Symposium, Snowbird, UT05/01 “Lipid mediators and the inflammatory process,” American Thoracic Society Meeting, San

Francisco, CA 05/01 “Leukotrienes in the pathogenesis of interstitial lung disease,” American Thoracic Society

Meeting, San Francisco, CA05/01 “Research year in review: Allergy, immunology, and inflammation assembly,” American

Thoracic Society Meeting, San Francisco, CA05/01 “What is the anti-inflammatory role of leukotriene modifiers in chronic asthma?” American

Thoracic Society Meeting, San Francisco, CA08/01 “Eicosanoids in asthma and allergic disease: a bench to bedside perspective,” Annual Meeting of

the California Society of Allergy, Asthma, and Immunology, Squaw Valley, CA10/01 “An imbalance between leukotrienes and prostaglandin E2 is a central feature of fibrotic lung

disease,” Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Related Diseases, 7th International Conference, Nashville, TN

10/01 “Importance of leukotrienes in airway inflammation and remodeling,” Singulair Second Anniversary Symposium, Lisbon, Portugal

03/02 “State of the science: biologic actions of leukotrienes in asthma, atopic disease, and airway remodeling,” 12th Congress of Interasthma Japan/North Asia, Saitama, Japan

04/02 “Leukotrienes in asthma and allergic disease: the view from 2002,” Buffalo Allergy Society, Buffalo, NY

05/02 “An imbalance between leukotrienes and prostaglandin E2 is a central feature of fibrotic lung disease,” American Thoracic Society Meeting, Atlanta, GA

05/02 “Studying the mediator and inflammatory mechanisms of leukotrienes,” American Thoracic Society Meeting, Atlanta, GA

05/02 “Lipid mediators,” American Thoracic Society Meeting, Atlanta, GA08/02 “New insights into leukotriene synthesis and action: the view from 2002,” Plenary Lecture,

Annual Meeting of the Brazilian Federation of the Societies for Experimental Biology, Salvador, Brazil

10/02 “Inhibition of transforming growth factor-β-induced myofibroblast differentiation by prostaglandin E2,” Twelfth International Colloquium on Lung Fibrosis, Glion, Switzerland

12/02 “New perspectives on the biology of leukotrienes,” San Diego Allergy Society, San Diego, CA03/03 “Therapeutic targeting in a complex inflammatory milieu,” American Academy of Allergy

Asthma & Immunology Meeting, Denver, CO05/03 “Beyond bronchospasm: eicosanoids as mediators of innate and adaptive immune responses,”

American Thoracic Society Meeting, Seattle, WA09/03 “Eicosanoids: master modulators of innate immune responses,” 8th International Meeting on

Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Related Diseases, Chicago, IL

05/04 “Beyond blueprints and roadmaps: a clinician-scientist’s 3-dimensional view of integrative biomedical research and training,” Joint Medical Research Council/Wellcome Trust Workshop on Integrative Physiology, London, England


10/04 “Leukotrienes: multifunctional mediators of asthma and allergic diseases,” Biannual Meeting of the Philadelphia Allergy Society, Philadelphia, PA

05/05 “Leukotriene modifiers: mediators, mechanisms, remodeling, and more,” American Thoracic Society Meeting, San Diego, CA

10/05 “Leukotrienes and the lung: a decade of insights,” Keynote Address, scientific forum sponsored by Ono Pharmaceuticals to celebrate 10th anniversary of launch of pranlukast, the world’s first leukotriene modifier drug for asthma; Tokyo, Japan

11/05 “Leukotrienes in 2005: emerging science,” American College of Chest Physicians Meeting, Montreal, Quebec, Canada

01/06 “Eicosanoids in pulmonary fibrosis: a tale of two lipids,” plenary speaker, Keystone Symposium, Park City, UT

03/06 “Eicosanoids and pulmonary fibrosis,” American Academy of Allergy Asthma & Immunology Meeting, Miami, FL

07/06 “Eicosanoid biology and respiratory disease,” The University of Michigan John A. Sheldon Allergy Society Triannual Meeting, Boyne Mountain, MI

03/07 “Eicosanoids in inflammation: themes, opportunities, and challenges,” Ninth Annual Winter Eicosanoid Conference, Baltimore, MD

05/07 “Insights from eicosanoid deficiency states: a tale of two lipids,” Recognition for Scientific Accomplishment Award Lecture, American Thoracic Society Meeting, San Francisco, CA

06/07 “Eicosanoids and airway remodeling,” 26th Congress of the European Academy of Allergology and Clinical Immunology, Göteborg, Sweden

11/07 “Understanding responsiveness to leukotriene modifiers,” International Asthma Forum, Barcelona, Spain

02/08 “Eicosanoids in fibroproliferative lung disease: a tale of two lipids,” 11th Annual Meakins-Christie Workshop, Asthma and COPD, Orford-Magog, Quebec, Canada

04/08 “Anti-leukotriene drugs in asthma,” Allergy, Asthma, and Immunology Society of Ontario Annual Meeting, Toronto, Ontario, Canada

05/08 “Unique traits of lung macrophages in obesity: leptin, leukotrienes, and lots more,” Workshop on Obesity and Asthma, American Thoracic Society Meeting, Toronto, Ontario, Canada

06/08 “Understanding responsiveness to leukotriene modifiers in asthma,” Spanish National Congress of Pneumology Annual Meeting, Tenerife, Spain

07/08 “Leukotrienes in lung innate immunity,” IXth World Conference on Clinical Pharmacology and Therapeutics CPT 2008, Quebec City, Quebec, Canada

09/08 “Eicosanoid balance: A critical determinant of innate immune defense,” Highlight Symposium on Lipid Signaling, Joint Summer Retreat of the Graduate Schools of Frankfurt University and Karolinska University

10/08 “Leukotrienes: critical mediators of innate immunity and phagocyte function,” Brazilian Immunology Society Meeting, Ribeirao Preto, Brazil

11/08 “Eicosanoids as mediators of leukocyte innate immune function,” Meeting of the Society for Leukocyte Biology, Denver, CO

03/09 “Understanding responsiveness to leukotriene modifiers in asthma,” Asthma Debate II, Madrid, Spain

04/09 “Why do we have a 5-lipoxygenase pathway? Leukotrienes in innate immune cell activation,” Keystone Symposium on Complex Lipids, Lake Tahoe, CA

02/10 “Knocking your SOCS off: silencing of SOCS1 by leukotriene B4 is required for optimal macrophage MyD99 expression and NFB activation,” Annual Meakins-Christie International Workshop, Bromont, Quebec, Canada

05/10 “Efferocytosis adversely affects lung anti-bacterial function,” American Thoracic Society Meeting, New Orleans, LA

05/10 “The immunology of the 5-lipoxygenase pathway,” Wenner-Gren Foundations International Symposium on Inflammation in Atherosclerosis: Activators & Mediators, Stockholm, Sweden

05/11 “Prostaglandin E2: anti-fibrotic mediator for all reasons,” American Thoracic Society Meeting, Denver, CO


10/11 “The PGE2 axis as a broken brake in lung fibrosis and a candidate for therapeutic targeting,” Brazilian Society of Immunology, Foz do Iguaco, Brazil

03/12 “Prostaglandin E2: unexpected regulator of airway remodeling and pulmonary host defense,” Airway Vista 2012, Asan Medical Center, Seoul, Korea

09/12 “Eicosanoid regulation of macrophage pattern recognition receptor responses,” Innate Immunity of the Lung, Berlin, Germany

12/12 “Dysregulation of the PGE2-EP2 axis in fibrotic lung disease,” British Pharmacological Society Meeting, London, UK

1/13 “Eicosanoid regulation of macrophage pattern recognition receptor responses,” Riken Center for Allergy and Immunology-University of Michigan Medical Center Joint Immunology Workshop, Ann Arbor, MI

Invited Speaker at Other Institutions

02/88 Research Seminar, General Motors Research Laboratories, Warren, MI03/90 Research Seminar, Pulmonary and Critical Care Medicine Division, Jefferson Medical College,

Philadelphia, PA06/90 Research Seminar, Department of Large Animal Sciences, College of Veterinary Medicine,

Michigan State University, East Lansing, MI10/90 Research Seminar, Pediatric Pulmonary Section, Case Western University, Cleveland, OH11/90 Research Seminar, Pulmonary and Critical Care Section, Yale University, New Haven, CT04/91 Research Seminar, Merck Frosst Centre for Therapeutic Research, Pointe Claire-Dorval, Quebec,

Canada02/92 Research Seminar, Department of Pharmacology and Toxicology, Michigan State University,

East Lansing, MI12/93 Research Seminar, Institute for Environmental Medicine, University of Pennsylvania,

Philadelphia, PA06/94 Research Seminar, Vanderbilt University Center for Lung Research, Nashville, TN01/95 Research Seminar, National Institute of Environmental Health Sciences, Research Triangle Park,

NC10/95 Research Seminar, Division of Pulmonary and Critical Care, Temple University School of

Medicine, Philadelphia, PA10/95 Pulmonary Grand Rounds and Research Seminar, Temple University School of Medicine,

Philadelphia, PA10/96 Seminar, Michigan State University School of Veterinary Medicine, East Lansing, MI12/96 Research Seminar, Zeneca Pharmaceuticals, Wilmington, DE03/97 Grand Rounds, Beaumont Hospital, Royal Oak, MI03/97 Pulmonary Grand Rounds, University of Pittsburgh Medical Center, Pittsburgh, PA05/97 Seminar, Blue Cross Blue Shield of Michigan, Southfield, MI05/97 Research Seminar, Division of Pulmonary and Critical Care Medicine, University of Chicago,

Chicago, IL01/98 Medical Grand Rounds, Minneapolis VA Medical Center, Minneapolis, MN03/98 Pulmonary/Allergy Grand Rounds, Detroit Medical Center, Detroit, MI07/98 Pulmonary Research Conference, Northwestern University, Chicago, IL09/98 Research Conference, Department of Biochemistry and Molecular Biology, The University of

Tokyo, Tokyo, Japan09/98 Pulmonary Research Conference, Tohoku University, Sendai, Japan10/98 Pulmonary Research Conference, Indiana University Medical Center, Indianapolis, IN10/98 Pulmonary Research Conference, Henry Ford Hospital, Detroit, MI10/98 Pulmonary Research Conference, Tufts-New England Medical Center, Boston, MA01/99 Pulmonary Research Conference, University of Vermont, Burlington, VT


01/99 Medical Grand Rounds, University of Vermont, Burlington, VT02/99 Internal Medicine Grand Rounds, Grace Hospital, Detroit, MI04/99 Allergy Research Conference, University of Southern California, Los Angeles, CA10/99 Research Seminar, National Jewish Center for Immunology and Respiratory Disease, Denver,

CO11/99 Research Seminar, Monsanto Company, St. Louis, MO11/99 Research Seminar, University of Tennessee College of Veterinary Medicine, Knoxville, TN12/99 Medical Grand Rounds, Medical College of Ohio, Toledo, OH11/99 Pulmonary Medicine Conference, Mayo Clinic, Rochester, MN 05/00 Research Seminar, Meakins-Christie Research Laboratories, McGill University, Montreal,

Quebec05/00 Research Seminar, Inflammation and Rheumatology Research Center, Laval University, Sainte-

Foy, Quebec09/00 Pulmonary Grand Rounds, Cleveland Clinic Foundation, Cleveland, OH09/00 Internal Medicine Grand Rounds, Metro Hospital, Cleveland, OH09/00 Pulmonary Grand Rounds, Case Western Reserve University Hospital, Cleveland, OH09/00 Pulmonary Research Conference, Rainbow Babies and Children's Hospital, Cleveland, OH10/00 Research Seminar, Divisions of Allergy and Immunology and Pulmonary and Critical Care

Medicine, Brigham and Women's Hospital, Boston, MA11/00 Pulmonary Research Conference, McMaster University, Hamilton, Ontario01/01 Pulmonary Research Conference, Louisiana State University Medical Center, New Orleans, LA01/01 Pulmonary Research Conference, Tulane University Medical Center, New Orleans, LA01/01 Allergy and Immunology Research Conference, University of Texas Medical Branch, Galveston,

TX01/01 Internal Medicine Grand Rounds, Baylor Medical College, Houston, TX02/01 Allergy and Immunology Research Conference, Children’s Hospital of Detroit, Detroit, MI02/01 Asthma and Allergy Center Research Conference, Johns Hopkins University Medical Center,

Baltimore, MD02/01 Allergy and Immunology Research Conference, University of Virginia, Charlottesville, VA03/01 Pulmonary Research Conference, Hospital of the University of Pennsylvania, Philadelphia, PA03/01 Pulmonary Research Conference, Hahnemann-Medical College of Pennsylvania Hospitals,

Philadelphia, PA03/01 Pulmonary Grand Rounds, Jefferson Medical College, Philadelphia, PA03/01 Respirology Research Conference, University of Toronto, Toronto, Ontario05/01 Department of Medicine Noon Conference, Winthrop University Hospital, Mineola, NY08/01 Medical Grand Rounds, Indiana University Medical Center, Indianapolis, IN09/01 Pulmonary Grand Rounds, Ohio State University Medical Center, Columbus, OH10/01 Combined Allergy/Pulmonary Research Seminar, University of Texas Southwestern Medical

Center, Dallas, TX11/01 Pulmonary Scholars Program, Duke University/University of North Carolina, Chapel Hill, NC11/01 Research Seminar, Merck Frosst Center for Therapeutic Research, Dorval, Quebec, Canada11/01 Pulmonary Research Conference, Duke University Medical Center, Durham, NC11/01 Pulmonary Research Conference, Northwestern University Medical Center, Chicago, IL11/01 Pulmonary Grand Rounds, Loyola University Medical Center, Chicago, IL02/02 Pulmonary Fellows Conference, Brigham and Women’s Hospital, Boston, MA02/02 Pulmonary Grand Rounds, Massachusetts General Hospital, Boston, MA03/02 Research Seminar, Department of Biochemistry and Molecular Biology, The University of

Tokyo, Tokyo, Japan03/02 Research Seminar, Minase Research Institute, Ono Pharmaceutical Co., Osaka, Japan03/02 Pulmonary Grand Rounds, University of California-San Francisco, San Francisco, CA03/02 Research Seminar, California Regional Primate Center, University of California-Davis, Davis,

CA03/02 Department of Medicine Grand Rounds, Stanford University, Palo Alto, CA


03/02 Pulmonary Grand Rounds, Stanford University, Palo Alto, CA04/02 Department of Medicine Grand Rounds, Buffalo General Hospital, Buffalo, NY04/02 City-Wide Grand Rounds, Buffalo, NY08/02 Department of Immunology, Institute of Biomedical Science, University of Sao Paulo, Sao

Paulo, Brazil08/02 School of Pharmaceutical Science, University of Sao Paulo-Ribeirao Preto, Ribeirao Preto,

Brazil10/02 Research Seminar, Allergy and Immunology Division Conference, Children’s Hospital of

Detroit, Detroit, MI02/03 Research Seminar, Vascular Biology Institute, University of Miami Medical Center, Miami, FL02/03 Invited lecture, University of Tennessee College of Veterinary Medicine, Knoxville, TN02/03 Pulmonary Grand Rounds, Boston University Medical Center04/03 Department of Medicine Grand Rounds, Nassau University Medical Center, East Meadow, NY04/03 Research Seminar, Inflammation Biology Department, Wyeth Research, Cambridge, MA09/03 Department of Medicine Grand Rounds, University of Utah, Salt Lake City, UT09/03 Pulmonary Grand Rounds, Division of Pulmonary and Critical Care Medicine, University of

Utah, Salt Lake City, UT11/03 Research Seminar, Lilly Research Laboratories, Indianapolis, IN03/04 Seminar, Franklin & Marshall College, Lancaster, PA03/04 Department of Medicine Grand Rounds, University of Saskatchewan, Saskatoon, Canada03/04 Respirology Research in Progress Rounds, and Pediatric Respirology Research Rounds,

University of Manitoba, Winnipeg, Canada03/04 Respiratory Divisional Rounds, University of Calgary, Calgary, Canada07/04 Pulmonary Department Research Seminar, Justus Liebig University, Giessen, Germany08/04 Research Seminar, Pfizer, Inc., St. Louis, MO08/04 Research Seminar, Critical Therapeutics, Inc., Lexington, MA09/04 Pulmonary Division Research Conference, University of Pittsburgh, Pittsburgh, PA09/04 Research Seminar, Allergy Conference, Pittsburgh Children’s Hospital and University of

Pittsburgh, Pittsburgh, PA10/04 Research Seminar, A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State

University, Moscow, Russia10/04 Pulmonary Research Conference, Thomas Jefferson University, Philadelphia, PA11/04 Research Seminar, Faculties of Medicine and Pharmacy, University of Sao Paulo Ribeirao Preto,

Ribeirao Preto, Brazil11/04 Pulmonary Division Research Conference, Vanderbilt University, Nashville, TN03/05 Pulmonary Grand Rounds, Stanford University Medical Center, Palo Alto, CA03/05 Research Seminar, Pfizer Research Laboratories, Ann Arbor, MI06/05 Pulmonary Research Seminar, Johns Hopkins University, Baltimore, MD06/05 Pulmonary Research Seminar, University of Virginia, Charlottesville, VA07/05 Pulmonary Research Seminar, University of Cincinnati, Cincinnati, OH10/05 Research Seminar, Tohoku University Medical Society, Sendai, Japan10/05 Pulmonary Grand Rounds, Medical University of South Carolina, Charleston, SC11/05 Pulmonary Research Seminar, Wake Forest University Medical Center, Winston-Salem, NC11/05 Research Seminar, Division of Rheumatology, Immunology, and Allergy, Brigham & Women’s

Hospital, Boston, MA11/05 City-wide Pulmonary Rounds, Baylor College of Medicine, Houston, TX12/05 Research Seminar, Division of Allergy, Pulmonary, Critical Care, and Sleep, University of Texas

Medical Branch, Galveston, TX03/06 Pulmonary Grand Rounds, University of British Columbia, St. Paul’s Hospital, Vancouver, BC,

Canada03/06 Pulmonary Research Conference, University of British Columbia, Vancouver General Hospital,

Vancouver, BC, Canada03/06 Medical Grand Rounds, St. Louis University, St. Louis, MO03/06 Asthma Conference, Divisions of Pulmonary and Critical Care Medicine and Allergy /

Immunology, Washington University, St. Louis, MOMarc Peters-Golden, MD

06/06 Pulmonary Grand Rounds, University of Alabama-Birmingham, Birmingham, AL11/06 Allergy Research Conference, University of Washington, Seattle, WA11/06 Respirology Rounds, University of Alberta, Edmonton, Alberta11/06 Respiratory Clinical Rounds, University of Calgary, Calgary, Alberta12/06 Yale State Chest Conference, Yale University, New Haven, CT12/06 Research Conference, Pulmonary and Critical Care, Yale University, New Haven, CT04/07 1) Clinical Rounds and 2) Research Rounds, Firestone Institute for Respiratory Health,

McMaster University, Hamilton, Ontario04/07 University Health Network Visiting Speaker Rounds, Toronto, Ontario04/07 Respiratory Rounds, Toronto Western Hospital, Toronto, Ontario04/07 Respiratory Rounds, Hotel Dieu, University of Montreal, Montreal, Quebec04/07 Research Seminar, Meakins-Christie Laboratories, McGill University, Montreal, Quebec04/07 Keynote Speaker, Annual Research Day, Respiratory Research Group, Laval University, Quebec

City, Quebec 09/07 Respirology Rounds, St. Joseph’s Hospital, London, Ontario10/07 Pulmonary Grand Rounds, Mt. Sinai Medical Center, New York, NY10/07 Research Seminar, DeCODE Genetics, Brighton, MI11/07 Research Seminar, Immunology Department, University of Sao Paulo, Sao Paulo, Brazil11/07 Research Seminar, College of Pharmacy, University of Sao Paulo-Ribeirao Preto, Ribeirao Preto,

Brazil11/07 Research Seminar, Division of Pulmonary and Allergy, University of Barcelona08/08 Research Seminar, Lilly Research Laboratories, Indianapolis, IN09/08 Research Seminar, Nycomed GmbH, Konstanz, Germany10/08 Medical Grand Rounds and Pulmonary Research Conference, Ohio State University Medical

Center, Columbus, OH11/08 Research Seminar, Division of Allergy, Pulmonary, Critical Care, and Sleep, University of Texas

Medical Branch, Galveston, TX12/08 Speaker, Prostacyclin Basic Science Advisory Forum, Actelion Pharmaceuticals, New York, NY03/09 Speaker, Expert Symposium on Resolution of Inflammation, Boehringer Ingelheim, Inc.,

Biberach, Germany03/09 Department of Medicine Grand Rounds and Pulmonary Research Conference, University of

Illinois-Chicago Medical Center, Chicago, IL06/09 Research Seminar, Wyeth Research, Cambridge, MA07/09 Speaker, University of Giessen Graduate Program in Molecular Biology and Medicine of the

Lung Annual Retreat, Giessen, Germany07/09 Research Seminar, University of Frankfurt, Frankfurt, Germany01/10 Research Seminar, Nycomed GmbH, Konstanz, Germany11/10 Research Seminar, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil11/10 Research Seminar, University of Sao Paulo-Ribeirao Preto, Ribeirao Preto, Brazil11/10 Research Seminar, State University of Sao Paulo-Araraquara, Araraquara, Brazil12/10 Research Seminar, Immuno Inflammation Unit, Sanofi-Aventis, Bridgewater, NJ03/11 Research Seminar, Department of Molecular Microbiology and Immunology, University of

Missouri, Columbia, MO04/11 Research Seminar, Division of Rheumatology, Immunology, and Allergy, Brigham and

Women’s Hospital, Boston, MA10/11 Research Seminar, Division of Pulmonary, Allergy, and Critical Care Medicine, University of

Pittsburgh, Pittsburgh, PA10/11 Research Seminar, Pulmonary Division, University of Sao Paulo Medical School, Sao Paulo,

Brazil10/11 Research Seminar, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil03/12 Special Seminar, Gil Hospital of Gachon Medical School, Seoul, Korea04/12 Research Seminar, Division of Pulmonary and Critical Care, University of Vermont, Burlington,

VT09/12 Research Seminar, Department of Molecular Pharmacology, University of Groningen,

Groningen, NetherlandsMarc Peters-Golden, MD

11/12 Research Seminar, Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN

12/12 Research Seminar, Centre for Inflammation & Tissue Repair, University College London, and the London Matrix Group, London, UK

1/13 The 2013 Harold and Marilyn Menkes Memorial Lecture, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD

Committee and Administrative Services

National:

1991 Program Committee for annual meeting of The American Thoracic Society, Scientific Assembly on Respiratory Cell and Molecular Biology

1995-01 Program Committee for annual meeting of The American Thoracic Society, Scientific Assembly on Allergy, Immunology, and Inflammation; Chair-elect, 1999-2000; Chair, 2000-2001

1997-98 Member of Nominating Committee, scientific assembly on Allergy, Immunology, and Inflammation, American Thoracic Society

1999-02 Member of Planning Committee, scientific assembly on Allergy, Immunology, and Inflammation, American Thoracic Society

2010- Research Advocacy Committee, American Thoracic Society2012- Advisory Board, American Thoracic Society Research Quarterly Newsletter

Community Service:

1993-00 Board of Directors, American Lung Association of Michigan; 1995-1997 Executive Committee1995-01 Chair, Grants and Awards Committee, American Lung Association of Michigan1998-99 Search Committee, Chief Executive Officer, American Lung Association of Michigan

Hospital and Medical School:

1986-90 Research and Development Committee, Ann Arbor Department of Veterans’ Affairs Medical Center; Chairperson, 7/89-6/90

1988-94 Critical Care Committee, Ann Arbor Department of Veterans’ Affairs Medical Center1991-93 Endoscopy Committee, Ann Arbor Department of Veterans’ Affairs Medical Center2003-07 Admissions Committee, University of Michigan Medical School2004-06 Preliminary Examination Committee, Graduate Program in Immunology, University of Michigan

Medical School2007-2010 Scientific Advisory Board, University of Michigan Clinical and Translational Science Award 2007-2010 Scientific Review Committee, University of Michigan Clinical and Translational Science Award

Departmental:

1985-88 House Officer Selection Committee, Department of Internal Medicine, University of Michigan1986 Planning Committee, Advances in Internal Medicine Course, Department of Internal Medicine,

University of Michigan1993 Ad Hoc Committee on Laboratory Safety, Department of Internal Medicine, University of

Michigan1994-96 Advisory Committee for Research, Department of Internal Medicine, University of Michigan1996-02 Promotions Committee, Department of Internal Medicine, University of Michigan; Chair, 1999-

20021999- Member, Department of Internal Medicine Education Committee, University of Michigan2002-05 Member, Department of Internal Medicine Awards Committee, University of Michigan2008 Internal Review Committee, GI SPORE application, Dean Brenner, M.D., Principal Investigator


Patents

6/8/99 U.S. Patent No. 5,909,734. “Administration of products of the 5-lipoxygenase metabolic pathway to enhance antimicrobial defense." Technology licensed in 2002 to Virocell; currently held by LTB4 Sweden AB.

Audiovisual Programs

2001 Program Chairman and Lecturer, “Virtual Asthma-Free Zone,” an educational CD-ROM about anti-leukotriene agents in the treatment of asthma, sponsored by the Postgraduate Institute for Medicine and supported by an unrestricted educational grant from Merck & Co., Inc.

2002 Lecturer, “Straight Talk on Singulair,” an educational CD-ROM about anti-leukotriene agents in the treatment of asthma, produced by Merck & Co., Inc.

2013 Lecturer, “Influence of Eicosanoid Lipid Mediators on Macrophage Innate Immune Functions,” in series on Macrophage Heterogeneity and Function, organized by Professor Siamon Gordon, Henry Stewart Talks, London

Bibliography

1. Rosen JA, Pike CS, Golden ML. Zinc, iron, and chlorophyll metabolism in zinc-toxic corn. Plant Physiol 1977; 59:1085-1087

2. Crapo JD, Peters-Golden M, Marsh-Salin J, Shelburne JJ, Vollmer R. Pathologic changes in the lungs of oxygen-adapted rats -- a morphometric analysis. Lab Invest 1978; 39:640-653, PMID: 7349764

3. Peters-Golden M, Wise RA, Schneider P, Hochberg M, Stevens MB, Wigley F. Clinical and demographic predictors of loss of pulmonary function in systemic sclerosis. Medicine 1984; 63:221-231, PMID: 6738343

4. Peters-Golden M, Bathon J, Flores R, Hirata F, Newcombe DS. Glucocorticoid inhibition of zymosan-induced arachidonic acid release by rat alveolar macrophages. Am Rev Respir Dis 1984; 130:803-809, PMID: 647305

5. Peters-Golden M, Wise RA, Hochberg MC, Stevens MB, Wigley FM. Carbon monoxide diffusing capacity as predictor of outcome in systemic sclerosis. Am J Med 1984; 77:1027-1034, PMID: 6507456

6. Peters-Golden M, Wise RA, Hochberg M, Stevens MB, Wigley FM. Incidence of lung cancer in systemic sclerosis. J Rheumatol 1985; 12:1136-1139, PMID: 4093920

7. Peters-Golden M, Thebert P. Inhibition by methylprednisolone of zymosan-induced leukotriene synthesis in alveolar macrophages. Am Rev Respir Dis 1987; 135:1020-1026, PMID: 3034108

8. Peters-Golden M, Shelly C. Modulation of alveolar macrophage-derived leukotriene synthesis by the sulfhydryl reactant N-ethylmaleimide. J Biol Chem 1987; 262:10594-10600, PMID:3112148

9. Sporn PHS, Peters-Golden M, Simon RH. Hydrogen peroxide-induced arachidonic acid metabolism in the rat alveolar macrophage. Am Rev Respir Dis 1988; 137:49-56, PMID:3122612

10. Chauncey, JB, Peters-Golden M, Simon RH. Arachidonic acid metabolism by rat alveolar epithelial cells. Lab Invest 1988;58:133-140, PMID: 2828765

11. Peters-Golden M, Shelly C. Inhibitory effect of exogenous arachidonic acid on alveolar macrophage 5-lipoxygenase metabolism: role of ATP depletion. J Immunol 1988; 140:1958-1966, PMID: 3126237

12. Gravelyn TR, Brophy N, Siegert C, Peters-Golden M. Hypophosphatemia-associated respiratory muscle weakness in a general inpatient population. Am J Med 1988; 84:870-876, PMID: 3364446

13. Chauncey JB, Simon RH, Peters-Golden M. Rat alveolar macrophages synthesize leukotriene B4 and 12-hydroxyeicosatetraenoic acid from alveolar epithelial cell-derived arachidonic acid. Am Rev Respir Dis 1988; 138:928-935, PMID: 2849344,

14. Sporn PHS, Peters-Golden M. Hydrogen peroxide inhibits alveolar macrophage 5-lipoxygenase metabolism in association with depletion of ATP. J Biol Chem 1988; 263:14776-14783, PMID: 2844785


15. Balter MS, Eschenbacher WL, Peters-Golden M. Arachidonic acid metabolism in cultured alveolar macrophages from normal, atopic, and asthmatic subjects. Am Rev Respir Dis 1988; 138:1134-1142, PMID: 3144211

16. Peters-Golden M, Shelly C. The oral gold compound auranofin triggers macrophage arachidonate release and cyclooxygenase metabolism. Prostaglandins 1988; 36:773-786, PMID: 3244832

17. Balter MS, Toews GB, Peters-Golden M. Different patterns of arachidonate metabolism in autologous human blood monocytes and alveolar macrophages. J Immunol 1989; 142:602-608, PMID: 2536058

18. Peters-Golden M, Shelly C. Inhibition of alveolar macrophage 5-lipoxygenase metabolism by auranofin. Biochem Pharmacol 1989; 38:1589-1595, PMID: 2499339

19. Peters-Golden M, Shelly C, Morganroth M. Inhibition of rat lung glutathione synthesis attenuates hypoxic pulmonary vasoconstriction and the associated leukotriene C4 production. Am Rev Respir Dis 1989; 140:1210-1215, PMID: 2817583

20. Balter MS, Toews GB, Peters-Golden M. Multiple defects in arachidonate metabolism in alveolar macrophages from young asymptomatic smokers. J Lab Clin Med 1989; 114:662-673, PMID: 2512364

21. Sporn PHS, Murphy T, Peters-Golden M. Complex effects of in vitro hyperoxia on alveolar macrophage arachidonic acid metabolism. Am J Respir Cell Mol Biol 1990; 2:81-90, PMID: 2155014

22. Peters-Golden M, McNish RW, Hyzy R, Shelly C, Toews GB. Alterations in the pattern of arachidonate metabolism accompany rat macrophage differentiation in the lung. J Immunol 1990; 144:263-270, PMID:2104888

23. Peters-Golden M, McNish RW, Brieland JK, Fantone JC. Diminished protein kinase C-activated arachidonate metabolism accompanies rat macrophage differentiation in the lung. J Immunol 1990; 144:4320-6, PMID: 2160499

24. Sporn PHS, Murphy T, Peters-Golden M. Glucocorticoids fail to inhibit hydrogen peroxide-induced arachidonic acid metabolism in the alveolar macrophage. J Leukocyte Biol 1990; 48:81-88, PMID: 2358752

25. Lipchik RJ, Chauncey J, Paine R, Simon RH, Peters-Golden M. Arachidonate metabolism increases as rat alveolar type II cells differentiate in vitro. Am J Physiol (Lung Cell Mol Physiol) 1990; 259:L73-L80, PMID: 1696434

26. Sporn PHS, Marshall TM, Peters-Golden M. Differential dependence on protein kinase C of arachidonic acid stimulated by hydrogen peroxide and by zymosan in the alveolar macrophage. Biochem Biophys Acta 1990; 1047:187-191, PMID: 2123406

27. Peters-Golden M, McNish RW, Marshall TM, Sporn PHS, Balazovich K. Basal activation of protein kinase C in rat alveolar macrophages: implications for arachidonate metabolism. Am J Physiol (Lung Cell Mol Physiol) 1991; 261:L462-L47, PMID: 1662919

28. Gray PR, Derksen FJ, Robinson NE, Slocombe RF, Peters-Golden ML. Epithelial strips: an alternative technique for examining arachidonate metabolism in equine tracheal epithelium. Am J Respir Cell Mol Biol 1992; 6:29-36, PMID: 1728292

29. Coffey M, Peters-Golden M, Fantone JC, Sporn PHS. Membrane association of active 5-lipoxygenase in resting cells: evidence for novel regulation of the enzyme in the rat alveolar macrophage. J Biol Chem 1992; 267:570-576, PMID: 1309754

30. Gray PR, Derksen FJ, Broadstone R, Robinson NE, Peters-Golden M. Decreased airway mucosal PGE2 production during airway obstruction in an animal model of asthma. Am Rev Respir Dis 1992; 146:586-591, PMID: 1519833

31. Peters-Golden M, Coburn K, Chauncey JB. Protein kinase C activation modulates arachidonic acid metabolism in cultured alveolar epithelial cells. Exp Lung Res 1992; 18:535-551, PMID: 1516571

32. Sporn PHS, Marshall TM, Peters-Golden M. Hydrogen peroxide increases the availability of arachidonic acid for oxidative metabolism by inhibiting acylation into phospholipids in the alveolar macrophage. Am J Respir Cell Mol Biol 1992; 7:307-316, PMID: 1520493

33. Atluru D, Peters-Golden M, Keane WF. Effects of immunosuppressive agents, cyclosporin A, FK-506 and genistein, on the synthesis of 5-lipoxygenase metabolites of arachidonic acid by human mononuclear cells. Biochem Archives 1992; 8:151-160,

34. Neagos GR, Feyssa A, Peters-Golden M. Phospholipase A2 in alveolar type II epithelial cells: biochemical and immunologic characterization. Am J Physiol (Lung Cell Mol Physiol 8) 1993; 264: L261-L268, PMID: 8460714


35. Peters-Golden M, Feyssa A. Transcellular eicosanoid synthesis in co-cultures of alveolar epithelial cells and macrophages. Am J Physiol (Lung Cell Mol Physiol 8) 1993; 264:L438-L447, PMID: 8498522

36. Peters-Golden M, McNish RW. Redistribution of 5-lipoxygenase and cytosolic phospholipase A2 to the nuclear fraction upon macrophage activation. Biochem Biophys Res Commun 1993; 196:147-153, PMID: 8216286

37. Coffey MJ, Gyetko M, Peters-Golden M. 1,25-Dihydroxyvitamin D3 upregulates 5-lipoxygenase metabolism and 5-lipoxygenase activating protein in peripheral blood monocytes as they differentiate into mature macrophages. J Lipid Mediators 1993; 6:43-51, PMID: 8358002

38. Peters-Golden M, Feyssa A. Augmented expression of cytosolic phospholipase A2 during phenotypic transformation of cultured type II pneumocytes. Am J Physiol (Cell Physiol 35) 1994; 266:C382-C390, PMID: 8141252

39. Coffey MJ, Wilcoxen SE, Peters-Golden M. Increases in 5-lipoxygenase activating protein expression account for enhanced capacity for 5-lipoxygenase metabolism which accompanies differentiation of peripheral blood monocytes into alveolar macrophages. Am J Respir Cell Mol Biol, 1994; 11:153-158, PMID: 8049076

40. Brock TG, Paine R III, Peters-Golden M. Localization of 5-lipoxygenase to the nucleus of unstimulated rat basophilic leukemia cells. J Biol Chem 1994; 269:22059-22066, PMID: 8071328

41. Coffey MJ, Wilcoxen SE, Simpson RU, Gyetko MR, Peters-Golden M. Reduced 5-lipoxygenase metabolism in macrophages from 1,25-dihydroxyvitamin D3-deficient rats. Prostaglandins 1994; 48:313-329, PMID: 7855310

42. Wilborn J, DeWitt DL, Peters-Golden M. Expression and role of cyclooxygenase isoforms in alveolar and peritoneal macrophages. Am J Physiol (Lung Cell Mol Physiol 12) 1995; 268:L294-L301, PMID: 7864149

43. Wilborn J, Crofford LJ, Burdick MD, Kunkel SL, Strieter RM, Peters-Golden M. Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2. J Clin Invest 1995; 95:1861-1868, PMID: 7706493

44. Woods JW, Coffey MJ, Brock, TJ, Singer II, Peters-Golden M. 5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation. J Clin Invest 1995; 95:2035-2046, PMID: 7738170

45. Bailie MB, Dahm LJ, Peters-Golden M, Harris RR, Carter GW, Roth RA. Leukotrienes and a-naphthylisothiocyanate-induced liver injury. Toxicology 1995; 100:139-149, PMID: 7624871

46. Brock TG, McNish R, Peters-Golden M. Translocation and leukotriene synthetic capacity of nuclear 5-lipoxygenase in rat basophilic leukemia cells and alveolar macrophages. J Biol Chem 1995; 270:21652-21658, PMID: 7665580

47. Tithof PK, Schiamberg E, Peters-Golden M, Ganey PE. Phospholipase A2 is involved in the mechanism of activation of neutrophils by polychlorinated biphenyls. Env Health Perspect 1996; 104:2-7, PMID: 8834862

48. Brock TG, McNish RW, Coffey M, Ojo TC, Phare SM, Peters-Golden M. Effects of granulocyte-macrophage colony-stimulating factor on eicosanoid production by mononuclear phagocytes. J Immunol 1996; 156:2522-2527, PMID: 8786314

49. Wilborn J, Bailie M, Coffey M, Burdick M, Strieter R, Peters-Golden M. Constitutive activation of 5-lipoxygenase in the lungs of patients with idiopathic pulmonary fibrosis. J Clin Invest 1996; 97:1827-1836, PMCID: PMC507250

50. Coffey MJ, Phare S, Kazanjian P, Peters-Golden M. 5-lipoxygenase metabolism in alveolar macrophages from subjects infected with the human immunodeficiency virus. J Immunol 1996; 157:393-399, PMID: 8683143

51. Peters-Golden M, Song K, Marshall T. Translocation of cytosolic phospholipase A2 to the nuclear envelope elicits topographically localized phospholipid hydrolysis. Biochem J 1996; 318:797-803, PMCID: PMC1217689

52. Lu M-C, Peters-Golden M, Hostetler DE, Robinson NE, Derksen FJ. Age-related enhancement of 5-lipoxygenase metabolic capacity in cattle alveolar macrophages. Am J Physiol (Lung Cell Mol Physiol 15) 1996; 271:L547-554, PMID: 8897901


53. Peters-Golden M, McNish RW, Davis JA, Brock TG. Colchicine inhibits arachidonate release and 5-lipoxygenase action in alveolar macrophages. Am J Physiol (Lung Cell Mol Physiol 15) 1996; 271:L1004-1013, PMID: 8997272

54. Bailie MB, Standiford TJ, Laichalk LL, Coffey MJ, Strieter R, Peters-Golden M. Leukotriene-deficient mice manifest enhanced lethality from Klebsiella pneumonia in association with decreased alveolar macrophage phagocytic and bactericidal activities. J Immunol 1996; 157:5221-5224, PMID: 8955165

55. Coffey MJ, Wheeler CS, Gross KB, Eschenbacher WL, Sporn PHS, Peters-Golden M. Increased 5-lipoxygenase metabolism in alveolar macrophages obtained from subjects exposed in vivo to ozone. Toxicology 1996; 114:187-197, PMID: 8980708

56. Brock TG, McNish RW, Bailie MB, Peters-Golden M. Rapid import of cytosolic 5-lipoxygenase into the nucleus of neutrophils following in vivo recruitment and in vitro adherence. J Biol Chem 1997; 272:8276-8280, PMID: 9079648

57. Ruffin MT, Krishnan K, Rock CL, Normolle D, Vaerten MA, Crowell J, Kelloff G, Boland CR, Peters-Golden M, Brenner DE. Suppression of human colorectal mucosal prostaglandins: determining thelowest effective aspirin dose. J Natl Cancer Inst 1997; 89:1152-1160, PMID: 9262254

58. Tithof PK, Peters-Golden M, Ganey PE. Distinct phospholipase A2s regulate the release of arachidonic acid for eicosanoid production and superoxide anion generation in neutrophils. J Immunol 1998; 160:953-960, PMID: 9551934

59. Brock TG, McNish RW, Peters-Golden M. Capacity for repeatable leukotriene generation following transient stimulation of mast cell and macrophages. Biochem J 1998; 329:519-525, PMCID: PMC1219072

60. Coffey MJ, Phare SM, George S, Peters-Golden M, Kazanjian PH. Granulocyte colony-stimulating factor administration to HIV-infected subjects augments reduced leukotriene synthesis and anticryptococcal activity in neutrophils. J Clin Invest 1998; 102:663-670, PMCID: PMC508927

61. Covin RB, Brock TG, Bailie MB, Peters-Golden M. Altered expression and localization of 5-lipoxygenase accompany macrophage differentiation in the lung. Am J Physiol (Lung Cell Mol Physiol 19) 1998; 275: L303-L310, PMID: 97000091

62. Mancuso P, Standiford TJ, Marshall T, Peters-Golden M. 5-Lipoxygenase reaction products modulate alveolar macrophage phagocytosis of Klebsiella pneumoniae. Infect Immun 1998; 66:5140-5146. , PMCID: PMC108641

63. Phare SM, Peters-Golden M, Coffey MF. Alveolar lining fluid regulates mononuclear phagocyte 5-lipoxygenase metabolism. Eur Respir J 1998; 12:1141-1146, PMID: 9864011

64. Coffey MJ, Wilcoxen SE, Sporn PH, Peters-Golden. Regulation of 5-lipoxygenase activity in mononuclear phagocytes: characterization of an endogenous cytosolic inhibitor. Prostaglandins 1998; 56:103-117, PMID: 9785381

65. Peters-Golden M. Cell biology of the 5-lipoxygenase pathway. Am J Respir Crit Care Med 1998; 157:5227-5232, PMID: 9620944

66. Peters-Golden M. Molecular mechanisms of leukotriene synthesis: The changing paradigm. Clin Exp Allergy 1998; 28:1059-1065, PMID: 9761008

67. Peters-Golden M, Coffey M. Role of leukotrienes in antimicrobial defense of the lung. J Lab Clin Med 1998; 132:251-257, PMID: 9794695Peters-Golden M. Pulmonary diseases other than asthma as potential argets for antileukotrine therapy. Clin Rev Allery Immunol 1999; 17(1-2):247-60 Review. 1043687010436870, PMID: 10436870

68. Brock TG, Anderson JA, Fries FP, Peters-Golden M, Sporn PHS. Decreased leukotriene C4 synthesis accompanies adherence-dependent nuclear import of 5-lipoxygenase in human blood eosinophils. J Immunol 1999 162:1669-1676, PMID: 9973428

69. Brock TG, McNish RW, Peters-Golden M. Arachidonic acid is preferentially metabolized by cyclooxygenase-2 to prostacyclin and prostaglandin E2. J Biol Chem 1999; 274:11660-11666, PMID: 10206978

70. Bae J, Peters-Golden M, Loch-Caruso R. Stimulation of pregnant rat uterine contraction by the polychlorinated biphenyl (PCB) mixture aroclor 1242 may be mediated by arachidonic acid release through activation of phospholipase A2 enzymes. J Pharmacol Exp Ther 1999; 289:1112-1120, PMID: 10215694


71. Healy AM, Peters-Golden M, Yao JP, Brock TG. Identification of a bipartite nuclear localization sequence necessary for nuclear import of 5-lipoxygenase. J Biol Chem 1999; 274:29812-29818, PMID: 10514459

72. Coffey MJ, Phare SM, Cinti S, Peters-Golden M, Kazanjian PH. Granulocyte-macrophage colony–stimulating factor upregulates reduced 5-lipoxygenase metabolism in peripheral blood monocytes and neutrophils in acquired immunodeficiency syndrome. Blood 1999; 94:3897-3905, PMID: 10572106

73. Coffey MJ, Phare SM, Peters-Golden M, Huffnagle GB. Regulation of 5-lipoxygenase metabolism in mononuclear phagocytes by CD4 T lymphocytes. Exp Lung Res 1999; 25:617-629, PMID: 10598321

74. Moore BB, Coffey M, Christensen P, Sitterding S, Ngan R, McDonald R, Phare S, Peters-Golden M, Paine R, Toews GB. GM-CSF regulates bleomycin-induced pulmonary fibrosis via a prostaglandin-dependent mechanism. J Immunol 2000; 165:4032-4039, PMID: 11034414

75. Coffey MJ, Phare SM, Peters-Golden M. Prolonged exposure to lipopolysaccharide inhibits macrophage 5-lipoxygenase metabolism via induction of nitric oxide synthesis. J Immunol 2000; 165:3592-3598, PMID: 11034360

76. Mancuso P, Peters-Golden M. Modulation of alveolar macrophage phagocytosis by leukotrienes is Fc receptor-mediated and protein kinase C-dependent. Am J Respir Cell Mol Biol 2000; 23:727-733, PMID: 11104724

77. Peters-Golden M, Brock TG. Intracellular compartmentalization of leukotriene biosynthesis. Am J Respir Crit Care Med 2000; 161:536-540, PMID: 11163352

78. Peters-Golden M. Playing “telephone”: bioactive lipids as mediators of intercompartmental communication in the alveolus. Commentary. J Clin Invest 2000; 105:857-858, PMCID: PMC377491

79. Peters-Golden M, Brock TG. Intracellular compartmentalization of leukotriene synthesis: unexpected nuclear secrets. FEBS Letters 2001; 487:323-326, PMID: 10673224, PMID: 11163352

80. Mancuso P, Nana-Sinkam P, Peters-Golden M. Leukotriine B4 augments neutrophil phagocytosis of Klebsiella pneumoniae. Infect Immun 2001; 69:2011-2016, PMCID: PMC98124

81. Stichtenoth DO, Thoren S, Bian H, Peters-Golden M, Jakobsson P-J, Crofford LJ. Microsomal prostaglandin E synthase is regulated by pro-inflammatory cytokines and glucocorticoids in primary rheumatoid synovial cells. J Immunol 2001; 167:469-474, PMID: 11418684

82. Krishnan K, Ruffin MT, Normolle D, Shureiqi I, Burney K, Bailey J, Peters-Golden M, Rock CL, Boland CR, Brenner DE. Colonoic mucosal prostaglandin E2 and cyclooxygenase expression before and after low aspirin doses in high-risk and normal-risk subjects for colorectal cancer: surrogate endpoint markers of drug effect. Cancer Epidemiol Biomarkers Prev 2001; 10:447-453, PMID: 11352853

83. Reddy RC, Chen GH, Tateda K, Tsai WC, Phare SM, Mancuso P, Peters-Golden M, Standiford TJ. Selective inhibition of COX-2 improves early survival in murine endotoxemia but not in bacterial peritonitis. Am J Physiol Lung Cell Mol Physiol 2001; 281:L537-43, PMID: 11504678

84. Uz T, Dwiredi Y, Quele A, Peters-Golden M, Pandey G, Manev H. Glucocorticoid receptors are required for upregulation of neuronal 5-lipoxygenase (5LOX) expression by dexamethasone. FASEB J 2001; 15:1792-4, PMID: 11481232

85. Peters-Golden M. Regulation of the leukotriene biosynthetic pathway. Clin Exp Allergy Rev 2001; 1:128-132

86. Peters-Golden M. Potential role of leukotrienes in other disease states. Clin Exp Allergy Rev 2001; 1:178-182

87. Brock TG, Maydanski E, McNish RW, Peters-Golden M. Co-localization of leukotriene A4 hydrolase with 5-lipoxygenase in nuclei of alveolar macrophages and rat basophilic leukemia cells but not neutrophils. J Biol Chem 2001; 276:35071-35077, PMID: 11451962

88. Mancuso P, McNish RW, Peters-Golden M, Brock TG. Evaluation of phagocytosis and arachidonate metabolism by alveolar macrophages and recruited neutrophils from F344xBN rates of different ages. Mech Ageing Dev 2001; 122(15):1899-1913, PMID: 11557288

89. Coffey MJ, Phare SM, Peters-Golden M. Peroxynitrite-induced nitrotyrosination of proteins blocked by the direct 5-lipoxygenase inhibitor zileuton. J Pharmacol Exp Ther 2001; 299:198-203, PMID: 11561080

90. Sud’ina GF, Brock TG, Pushkareva MA, Galkina SI, Turutin DV, Peters-Golden M, Ullrich V. Sulfatides trigger polymorphonuclear granulocyte attachment to collagen-coated surfaces and inhibit subsequent activation of 5-lipoxygenase. Biochem J 2001; 359:621-629, PMCID: PMC1222184


91. Wang C-T, Peters-Golden M, Loch-Caruso R. A calcium-independent phospholipase activity insensitive to bromoenol lactone mediates arachidonic acid release by lindane in rat myometrial cells. Life Sci 2001; 70:453-470, PMID: 11798014

92. Peters-Golden M, Bailie M, Marshall T, Wilke C, Phan SH, Toews GB, Moore BB. Protection from pulmonary fibrosis in leukotriene-deficient mice. Am J Respir Crit Care Med 2002; 165:229-235, PMID: 11790660

93. Mancuso P, Gottschalk A, Phare SM, Peters-Golden M, Lukacs NW, Huffnagle GB. Leptin-deficient mice exhibit impaired host defense in gram-negative pneumonia. J Immunol 2002; 168:4018-4024, PMID: 11937559

94. Peters-Golden M. Open mind, open airways: broadening the paradigm of prostaglandins and allergic airway inflammation. Editorial. Am J Respir Crit Care Med 2002; 165:1035-1036, PMID: 11956040

95. Peters-Golden M. “Good” lipids for asthma. Nat Med 2002; 8:931-932. , PMID: 1220545096. Tithof PK, Elgayyar M, Cho Y, Guan W, Fisher AB, Peters-Golden M. Polycyclic aromatic

hydrocarbons present in cigarette smoke cause endothelial cell apoptosis by a phospholipase A2-dependent mechanism. FASEB J 2002 16(11): 1463-4, PMID: 12205049

97. Jones SM, Luo M, Healy AM, Peters-Golden M, Brock TG. Structural and functional criteria reveal a new nuclear import sequence on the 5-lipoxygenase protein. J Biol Chem 2002; 11:277(41):38550-6, PMID: 124140292

98. Coffey MJ, Phare SM, Peters-Golden M. Interaction between nitric oxide, reactive oxygen intermediates, and peroxynitrite in the regulation of 5-lipoxygenase metabolism. Biochim Biophys Acta 2002; 1584:81-90, PMID: 12385890

99. Lama V, Moore BB, Christensen P, Toews GB, Peters-Golden M. Prostaglandin E2 synthesis and suppression of fibroblast proliferation by alveolar epithelial cells is cyclooxygenase-2-dependent. Am J Respir Cell Mol Biol 2002; 27:752-758, PMID: 12444036

100. Peters-Golden M, Sampson AP. Cysteinyl leukotriene interactions with other mediators and with glucocorticosteroids during airway inflammation. J Allergy Clin Immunol 2003; 111(1 Suppl)S37-42 discussion S34-6, PMID: 12532085

101. Holgate ST, Peters-Golden M. Introduction: the anti-inflammatory role of cysteinyl leukotriene receptor antagonists in asthma. J Allergy Clin Immunol. 2003; 111(1Suppl):S1-4 , PMID: 12532082

102. Holgate ST, Peters-Golden M, Panettieri RA, Henderson WR Jr. Roles of cysteinyl leukotrienes in airway inflammation, smooth muscle function, and remodeling. J Allergy Clin Immunol 2003; 111(1Suppl)S18-S36. PMID: 12532084

103. Coffey MJ, Peters-Golden M. Extending the understanding of leukotrienes in asthma. Curr Opin Allergy Clin Immunol 2003;3(1):57-63, PMID: 12582316

104. Moore BB, Peters-Golden M, Christensen PJ, Lama V, Kuziel WA, Paine R III, Toews GB. Alveolar epithelial cell inhibition of fibroblast proliferation is regulated by MCP-1/CCR2 and mediated by PGE2. Am J Physiol: Lung Cell Mol Physiol 2003; 284:(2)L342-L349, PMID: 12388376

105. Jones SM, Luo M, Peters-Golden M, Brock, TG. Identification of two novel nuclear import sequences on the 5-lipoxygenase protein. J Biol Chem 2003; 21:278(12):10257-63, PMID: 1252477

106. Brock TG, Peters-Golden M. 5-Lipoxygenase and FLAP. Prostaglandins Leukot Essent Fatty Acids 2003; 69:99-109, PMID: 12895592

107. Charbeneau RP, Christensen PJ, Chrisman CJ, Paine R III, Toews GB, Peters-Golden M, Moore BB. Impaired synthesis of prostaglandin E2 by lung fibroblasts and alveolar epithelial cells from GM-CSF-/-

mice: implications for fibroproliferation. Am J Physiol: Lung Cell Mol Physiol 2003; 284(6):L1103-L1111, PMID: 12598228

108. Peters-Golden M. Do anti-leukotriene agents inhibit asthmatic inflammation? Clin Exp Allergy 2003; (6)33:721-724, PMID: 12801303

109. Brock TG, McNish RW, Mancuso P, Coffey M, Peters-Golden M. Prolonged lipopolysaccharide inhibits leukotriene synthesis in peritoneal macrophages: mediation by nitric oxide and prostaglandins. Prostaglandins Other Lipid Mediators 2003; 71(3-4):131-145, PMID: 14518557

110. Canetti CA, Hu B, Curtis JL, Peters-Golden M. Syk activation is a leukotriene B 4-regulated event in Fc receptor- but not phosphatidylserine receptor-mediated phagocytosis in macrophages. Blood 2003; 102(5):1877-1883, PMID: 12730109


111. Kolodsick J, Peters-Golden M, Larios J, Toews GB, Thannickal V Moore BB. PGE2 inhibits myofibroblast differentiation via EP2 signaling and cAMP elevation. Am J Respir Cell Mol Biol 2003; 29(5):537-544, PMID: 12738687

112. Luo M, Jones SM, Peters-Golden M, Brock TG. Nuclear localization of 5-lipoxygenase as a determinant of leukotriene B4 synthetic capacity. Proc Natl Acad Sci USA 2003; 100(21):12165-12170, PMCID: PMC218730

113. Peters-Golden M. When defenses against fibroproliferation fail: spotlight on an axis of prophylaxis. Editorial. Am J Respir Crit Care Med 2003; 168(10):1141-1142, PMID: 1467817

114. Peters-Golden M. The alveolar macrophage: the forgotten cell in asthma. Perspective. Am J Respir Cell Mol Biol 2004; 31(1):3-7, PMID: 15208096

115. Aronoff DM, Canetti C, Peters-Golden M. Prostaglandin E2 inhibits alveolar macrophage phagocytosis through an EP2 receptor-mediated increase in cyclic AMP. J Immunol 2004; 173(1):559-565, PMID: 15210817

116. Coffey MJ, Phare SM, Peters-Golden M. Role of leukotrienes in killing of Mycobacterium bovis by neutrophils. Prostaglandins Leukot Essent Fatty Acids 2004; 71(3):185-90, PMID: 15253889

117. Coffey MJ, Phare SM, Peters-Golden M. Induction of iNOS by LPS/interferon gamma and sepsis downregulates 5-lipoxygenase metabolism in murine alveolar macrophages. Exp Lung Res 2004; 30(7):615-633, PMID: 15371096

118. Mancuso P, Gottschalk A, Marshall T, Peters-Golden M. Leptin augments alveolar macrophage leukotriene synthesis by increasing phospholipase activity and enhancing group IVC iPLA2 (cPLA2protein expression. Am J Physiol Lung Cell Mol Physiol 2004; 287(3):L497-502, PMID: 15145787

119. Luo M, Jones SM, Phare SM, Coffey MJ, Peters-Golden M, Brock TG. Protein kinase A inhibits leukotriene synthesis by phosphorylation of 5-lipoxygenase on serine 523. J Biol Chem 2004; 279(40):41512-41520, PMID: 1580375

120. Aronoff DM, Canetti C, Serezani CH, Luo M, Peters-Golden M. Cutting edge: macrophage inhibition by cAMP: differential roles of protein kinase A and exchange protein activated by cAMP-1. J Immunol 2005; 174(2):595-599, PMID: 15634874

121. Peters-Golden M, Canetti C, Mancuso P, Coffey MJ. Leukotrienes: underappreciated mediators of innate immune responses. J Immunol 2005; 174(2):589-594, PMID: 15634873

122. Benjamim C, Canetti C, Cunha FQ, Kunkel SL, Peters-Golden M. Opposing and hierarchical roles of leukotrienes in innate immune and vascular responses in a model of sepsis. J Immunol 2005; 174(3):1616-1620, PMID: 15661924

123. White ES, Atrasz RG, Dickie EG, Aronoff DM, Peters-Golden M. Prostaglandin E2 inhibits fibroblast migration by EP2 receptor-mediated increase in PTEN activity. Am J Respir Cell Mol Biol 2008; 39(2):252, PMID: 15539859

124. Moore BB, Ballinger MN, White ES, Green ME, Herrygers AB, Wilke CA, Toews GB, Peters-Golden M. Bleomycin-induced E prostanoid receptor changes alter fibroblast responses to prostaglandin E2. J Immunol 2005; 174(9):5644-5649, PMID: 15843564

125. Charbeneau RP, Peters-Golden. Eicosanoids: mediators and therapeutic targets in fibrotic lung disease. Clin Sci (Lond) 2005; 108(6):479-491, PMID: 15896193

126. Peters-Golden M, Henderson WR, Jr. The role of leukotrienes in allergic rhinitis. Ann Allergy Asthma Immunol 2005; 94(6):609-618, PMID: 15984591

127. Serezani CH, Aronoff DM, Jancar S, Mancuso P, Peters-Golden M. Leukotrienes enhance the bactericidal activity of alveolar macrophages against Klebsiella pneumoniae through the activation of NADPH oxidase. Blood 2005; 106(3):1067-1075, PMCID: PMC1985163

128. Lama VN, Murray S, Mumford JA, Flaherty KR, Chang A, Toews GB, Peters-Golden M, Martinez FJ. Prognostic value of bronchiolitis obliterans syndrome stage 0-p in single lung transplant recipients. Am J Respir Crit Care Med 2005; 172(3):379-383, PMCID: PMC2718475

129. Brock TG, Lee Y-J, Maydanski E, Marburger TL, Paine R III, Peters-Golden M. Nuclear localization of leukotriene A4 hydrolase in type II alveolar epithelial cells in normal and fibrotic lung. Am J Physiol Lung Cell Mol Physiol 2005; 289(2):L224-232, PMID: 15805137

130. Luo M, Jones SM, Flamand N, Aronoff D, Peters-Golden M, Brock TG. Phosphorylation by protein kinase A inhibits nuclear import of 5-lipoxygenase. J Biol Chem 2005; 280(49):40609-40616, PMID: 16230355


131. Serezani CH, Aronoff DM, Jancar S, Peters-Golden M. Leukotriene B4 mediates p47phox phosphorylation and membrane translocation in polyunsaturated fatty acid-stimulated neutrophils. J Leukoc Biol 2005; 78(4):976-984, PMID: 16006535

132. Mancuso P, Huffnagle GB, Olszewski MA, Phipps J, Peters-Golden. Leptin corrects host defense defects after acute starvation in murine pneumococcal pneumonia. Am J Respir Crit Care Med 2006; 173(2):212-218, PMID: 16210671

133. Aleksandrov D, Zagryagskaya A, Pushkareva M, Bachschmid M, Peters-Golden M, Werz O, Steinhilber D, Sud’ina G. Cholesterol and its anionic derivatives inhibit 5-lipoxygenase activation in polymorphonuclear leukocytes and MonoMac 6 cells. FEBS Lett 2006; 273(3):548-557, PMID: 16420478

134. Moore BB, Peters-Golden. Opposing roles of leukotrienes and prostaglandins in fibrotic lung disease. Expert Rev Clin Immunol 2006; 2(1):87-100, PMID: 20477090

135. Peters-Golden M, Swern A, Bird SS, Hustad CM, Grant E, Edelman JM. Influence of body mass index on the response to asthma controller agents. Eur Respir J 2006; 27(3):495-503, PMID: 16507848

136. Gupta SK, Peters-Golden M, Fitzgerald JF, Croffie JM, Pfefferkorn MD, Molleston JP, Lim JR. Cysteinyl leukotriene levels in esophageal mucosal biopsies of children with eosinophilic inflammation: are they all the same? Am J Gastroenterol 2006; 101(5):1125-1128, PMID: 16573772

137. Peters-Golden M, Gleason MM, Togias A. Cysteinyl leukotrienes: multifunctional mediators in allergic rhinitis. Clin Exp Allergy 2006; 36(6):689-703, PMCID: PMC1569601

138. Canetti C, Choe M, Flamand N, Aronoff D, Wettlaufer S, Toews GB, Chen-G-H, Peters-Golden M. Differential regulation by leukotrienes and calcium of Fc receptor-induced phagocytosis and Syk activation in dendritic cells vs. macrophages. J Leukoc Biol 2006; 79(6):1234-1241, PMID: 16574771

139. Serezani CH, Perrela JH, Russo M, Peters-Golden M, Jancar S. Leukotrienes are essential for the control of Leishmania amazonensis infection and contribute to strain variation in susceptibility. J Immunol 2006; 177(5):3201-3208, PMID: 16920959

140. Ballinger MN, Aronoff DM, McMillan TR, Cooke KR, Olkiewicz K, Toews GB, Peters-Golden M, Moore, BB. Critical role of prostaglandin E2 overproduction in impaired pulmonary host response following bone marrow transplantation. J Immunol 2006; 177(8):5499-5508, PMID: 17015736

141. Aronoff DM, Carstens JK, Chen G-H, Toews GB, Peters-Golden M. Short Communication: differences between macrophages and dendritic cells in the cyclic AMP dependent regulation of lipopolysaccharide-induced cytokine and chemokine synthesis. J Interferon Cytokine Res 2006; 26(11):827-833, PMID: 17115901

142. Aronoff DM, Peres CM, Serezani CH, Ballinger MN, Carstens JK, Coleman N, Moore BB, Peebles RS, Faccioli LH, Peters-Golden M. Synthetic prostacyclin analogs differentially regulate macrophage function via distinct analog-receptor binding specificities. J Immunol 2007; 178(3):1628-1634, PMID: 17237412

143. Huang S, Wettlaufer SH, Hogaboam C, Aronoff DM, Peters-Golden M. Prostaglandin E2 suppresses collagen expression and proliferation in patient-derived normal lung fibroblasts via E prostanoid 2/cyclic AMP/protein kinase A. Am J Physiol Lung Cell Mol Physiol 2007; 292(2):L405-413, PMID: 17028262

144. Peres CM, De Paula L, Medeiros AI, Soares EG, Sorgi CA, Carlos D, Peters-Golden M, Silva CL, Faccioli LH. Leukotrienes are an essential regulator of the protective immune response in murine tuberculosis. Microbes Infect 2007; 9(4):483-489, PMCID: PMC2581410, NIHMS23156

145. Lama VN, Smith L, Badri L, Flint AJ, Andrei A, Murray S, Wang Z, Hui L, Toews GB, Krebsbach PH, Peters-Golden M, Pinsky DJ, Martinez FJ, Thannickal VJ. Evidence for Tissue-Resident Mesenchymal Stem Cells in Human Adult Lung from Studies of Transplanted Allografts. J Clin Invest 2007; 117(4):989-996, PMCID: PMC1810571

146. Wenzel S, Busse W, Calhoun W, Panettieri Jr. R, Peters-Golden M, Dube L, Walton-Bowen K, Russel H, Harris J. The safety and efficacy of zileuton controlled-release (CR) tablets as adjunctive therapy to usual care (UC) in the treatment of moderate persistent asthma. J Asthma 2007; 44(4):305-310, PMID:17530230

147. Brock TG, Peters-Golden M. Activation and regulation of cellular eicosanoid biosynthesis. ScientificWorldJournal 2007; 7:1273-84, PMID: 17767350

148. Thomas PE, Peters-Golden M, White ES, Moore BB. PGE2 inhibition of TGF-1-induced myofibroblast differentiation is SMAD-independent but involves cell shape and adhesion-dependent


signaling. Am J Physiol Lung Cell Mol Physiol 2007; 293(2):L417-28, PMCID: PMC2846428, NIHMS170131

149. Peres CM, Aronoff DM, Serezani CH, Flamand N, Faccioli LH, Peters-Golden M. Specific leukotriene receptors couple to distinct G proteins to effect stimulation of alveolar macrophage host defense functions. J Immunol 2007; 179:5454-61, PMID: 17911632

150. Serezani CH, Chung J, Ballinger MN, Moore BB, Aronoff DM, Peters-Golden M. Prostaglandin E2 suppresses bacterial killing in alveolar macrophages by E prostanoid receptor 2/4-mediated inhibition of NADPH oxidase activation. Am J Respir Cell Mol Biol 2007; 37(5):562-70, PMCID: PMC2048683

151. Peters-Golden M, Henderson WR, Jr. Leukotrienes. N Engl J Med 2007; 357(18):1841-1854.152. Coffey MJ, Serezani CH, Phare SM, Peters-Golden M. NADPH oxidase deficiency results in reduced

alveolar macrophage 5-lipoxygenase expression and decreased leukotriene synthesis. J Leukoc Biol 2007; 82(6):1585-91, PMID: 17761955

153. Vannella KM, McMillan TR, Charbeneau RP, Wilke CA, Toews GB, Peters-Golden M, Moore BB. Cysteinyl leukotrienes are autocrine and paracrine regulators of fibrocyte function. J Immunol 2007; 179(11):7883-90, PMID: 18025235

154. Canetti C, Serezani CH, Atrasz RG, White ES, Aronoff DM, Peters-Golden M. Activation of phosphatase and tensin homologue on chromosome 10 (PTEN) mediates the inhibition of Fc receptor phagocytosis by prostaglandin E2 in alveolar macrophages. J Immunol 2007; 179(12):8350-6, PMID: 18056380

155. Huang SK, Wettlaufer SH, Hogaboam C, Flaherty KR, Martinez FJ, Myers JL, Colby TV, Travis WD, Toews GB, Peters-Golden M. Variable resistance to prostaglandin E2 suppression in lung fibroblasts from patients with usual interstitial pneumonia. Am J Respir Crit Care Med 2008; 177(1):66-74, PMCID: PMC2176116

156. Grishina Z, Pushkareva M, Pletyushkina O, Reiser G, Peters-Golden M, Sud’ina G. Sulfatides inhibit leukotriene synthesis in human polymorphonuclear granulocytes by a mechanism involving lipid rearrangement in intracellular membranes. Int J Biochem Cell Biol 2008; 40(1):110-24, PMID: 17822942

157. Brock TG, Serezani CH, Carstens JK, Peters-Golden M, Aronoff DM. Effects of prostaglandin E2 on the subcellular localization of Epac-1 and Rap1 proteins during Fc gamma receptor-mediated phagocytosis in alveolar macrophages. Exp Cell Res 2008; 314(2):255-63, PMCID: PMC 2390918

158. Aronoff DM, Serezani CH, Carstens JK, Marshall T, Gangireddy SR, Peters-Golden M, Reddy RC. Stimulatory effects of peroxisome proliferator-activated receptor-γ on Fcγ receptor-mediated phagocytosis by alveolar macrophages. PPAR Res 2007; 2007:1-8, PMCID: PMC2220046

159. White KE, Ding Q, Moore BB, Peters-Golden M, Ware LB, Matthay MA, Olman MA. Prostaglandin E 2 mediates IL-1β-related fibroblast mitogenic effects in acute lung injury through differential utnlization of prostanoid receptors. J Immunol 2008; 180(1):637-46, PMCID: PMC2789491

160. Aronoff DM, Hao Y, Chung J, Coleman N, Lewis C, Peres CM, Serezani CH, Chen G-H, Flamand N, Brock TG, Peters-Golden M. Misoprostol impairs female reproductive tract innate immunity against Colstridium sordellii. J Immunol 2008; 180(12):8222-30, PMCID: PMC2667109

161. Huang SK, Peters-Golden M. Eicosanoid lipid mediators in fibrotic lung diseases: ready for prime time? Chest 2008; 133(6):1442-50, PMCID: PMC2582216

162. Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M. Cyclic AMP: master regulator of innate immune cell function. Am J Respir Cell Mol Biol 2008; 39(2)127-32, PMCID: PMC272142

163. Peters-Golden M. Expanding roles for leukotrienes in airway inflammation. Curr Allergy Asthma Reports 2008; 8(4):367-73, PMID: 18606091

164. Coffey MJ, Phare SM, Peters-Golden M. Guanylyl cyclase and protein kinase G mediate nitric oxide suppression of 5-lipoxygenase metabolism in alveolar macrophages. Biochim Biophys Acta 2008; 1781(6-7):299-305, PMID: 18474265, NIHMS57223

165. Ballinger M, Hubbard L, McMillan T, Toews G, Peters-Golden M, Paine R, Moore B. Paradoxical role of alveolar macrophage-derived granulocyte macrophage colony stimulating factor in pulmonary host defense post-bone marrow transplantation. Am J Physiol Lung Cell Mol Physiol 2008; 295(1):L114-22, PMCID: PMC2494794


166. Huang SK, Wettlaufer SH, Chung J, Peters-Golden M. Prostaglandin E2 inhibits lung fibroblast proliferation and collagen expression via distinct cAMP effector pathways: differential roles of PKA and Epac-1. Am J Respir Cell Mol Biol 2008; 39(4):482-9, PMCID: PMC 2551707

167. Jarvinen L, Badri L, Wettlaufer S, Ohtsuka T, Pinsky DJ, Toews GB, Peters-Golden M, Lama VN. Lung resident mesenchymal stem cells isolated from human lung allografts inhibit T cell proliferation via a soluble mediator. J Immunol 2008; 181(6):4389-96, PMID: 18768898, NIHMS384498

168. Weinlich R, Bortoluck KR, Chehab CF, Serezani CH, Ulbrich AG, Peters-Golden M, Russo M, Amarante-Mendes GP. TLR4/MYD88-dependent, LPS-induced synthesis of PGE2 by macrophages or dendritic cells prevents anti-CD3-mediated CD95L upregulation in T cells. Cell Death Differentiation 2008; 15(12):1901-9, PMID: 18820644

169. Chung J, Serezani CH, Huang SK, Jagirdar R, Brock TG, Aronoff DM, Peters-Golden M. Rap1 activation is required for Fc receptor-dependent phagocytosis. J Immunol 2008; 181(8):5501-9, PMCID: PMC3077557

170. Nair P, Radford K, Fanat A, Janssen LJ, Peters-Golden M, Cox PG. The effects of leptin on airway smooth muscle responses. Am J Respir Cell Mol Biol 2008; 39(4):475-81, PMID: 18421018

171. Lee SP, Serezani CH, Ballinger MN, Medeiros A, Peters-Golden M. Crosstalk between prostaglandin E2

and leukotriene B4 regulates phagocytosis in alveolar macrophages via combinatorial effects on cyclic AMP. J Immunol 2009; 182(1):530-7, PMID: 19109185

172. Flamand N, Luo M, Peters-Golden M, Brock TG. Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export. J Biol Chem 2009; 284(1):306-13, PMCID: PMC2610501

173. Campos MRM, Serezani CH, Peters-Golden M, Jancar S. Differential kinase requirement for enhancement of FcR-mediated phagocytosis in alveolar macrophages by leukotriene B4 vs. D4. Molec Immunol 2009; 46(6):1204-11, PMID: 19223078

174. Medeiros AI, Serezani CH, Lee SP, Peters-Golden M. Efferocytosis impairs pulmonary macrophage and lung antibacterial function via PGE2/EP2 signaling. J Exp Med 2009; 206(1):61-8, PMCID: PMC2626688

175. Peters-Golden M. Putting on the brakes: cyclic AMP as a multipronged controller of macrophage activation. Perspective. Sci Signal 2009; 2(75)::pe37, PMID: 19531801

176. Aronoff DM, Lewis C, Serezani CH, Eaton KA, Phipps JJ, Peters-Golden M, Mancuso P. E prostanoid 3 receptor deletion improves pulmonary host defense and protects mice from death in severe Streptococcus pneumoniae infection. J Immunol 2009; 183(4):2642-9, PMID: 19635910

177. Huang SK, White ES, Wettlaufer SH, Grifka H, Hogaboam CM, Thannickal VJ, Horowitz JC, Peters-Golden M. Prostaglandin E2 induces fibroblast apoptosis by modulating multiple survival pathways. FASEB J 2009; 23(12):4317-26, PMCID: PMC2812040

178. Serezani CH, Aronoff DM, Sitrin RG, Peters-Golden M. FcRI ligation leads to a complex with BLT1 in lipid rafts that enhances lung macrophage antimicrobial functions. Blood 2009; 114(15):3316-24, PMCID: PMC2759654

179. Sagana RL, Yan M, Cornett AM, Tsui JL, Stephenson DA, Huang SK, Moore BB, Ballinger MN, Aronoff DA, Peters-Golden M, White ES. Phosphatase and tensin homologue on chromosome 10 (PTEN) directs prostaglandin E2-mediated fibroblast responses via regulation of E prostanoid 2 receptor expression. J Biol Chem 2009; 284(47):32264-71, PMCID:PMC2781639

180. Costa MF, de Souza-Martins R, de Souza MC, Benjamim CF, Piva B, Diaz BL, Peters-Golden M, Henriques MG, Canetti C, Penido C. Leukotriene B4 mediates γδ T lymphocyte migration in response to diverse stimuli. J Leukoc Biol 2010; 87(2):323-32, PMID: 19880577

181. Mancuso P, Lewis C, Serezani CH, Goel D, Peters-Golden M. Intrapulmonary administration of leukotriene B4 enhances pulmonary host defense against pneumococcal pneumonia. Infect Immun. 2010, 78(5): 2264-71, PMCID: PMC2863513


182. Horowitz JC, Peters-Golden M. Prostaglandin E2's new trick: "decider" of differential alveolar cell life and death. Editorial. Am J Respir Crit Care Med 2010; 182:2-3, PMID: 20601589

183. Bauman KA, Wettlaufer SH, Okunishi K, Vannella KM, Stoolman JS, Huang SK, Courey AJ, White ES, Hogaboam CM, Simon RH, Toews GB, Sisson TH, Moore BB, and Peters-Golden M. The antifibrotic effects of plasminogen activation occur via prostaglandin E2 synthesis in humans and mice. J Clin Invest 2010; 120(6):1950-60, PMCID: PMC2877926

184. Narala VR, Adapala RK, Brock TG, Peters-Golden M, Reddy RC. LTB4 is a physiologically relevant endogenous peroxisome proliferators-activated receptor-α agonist. J Biol Chem 2010; 285(29):22067-74, PMCID: PMC2903376

185. Zhu L, Maruvada R, Sapirstein A, Malik KU, Peters-Golden M, Kim KS. Arachidonic acid metabolism regulates Escherichia coli penetration of the blood-brain barrier. Infect Immun 2010; 78(10):4302-10, PMCID: PMC2950368

186. Huang SK, Fisher AS, Scruggs AM, White ES, Hogaboam CM, Richardson BC, Peters-Golden M. Hypermethylation of PTGER2 confers prostaglandin E2 resistance in fibrotic fibroblasts from humans and mice. Am J Pathol 2010; 177(5):2245-55, PMCID: PMC2966784

187. Montuschi P, Peters-Golden M. Leukotriene modifiers for asthma treatment. Clin Exp Allergy 2010; 40: (12)1732-41, PMID: 21059119

188. Ballinger MN, Welliver T, Straight S, Peters-Golden M, Swanson JA. Transient increase in cyclic AMP localized to macrophage phagosomes. PLOS One 2010; 5(11):e13962, PMID: 21055604

189. Mancuso P, Peters-Golden M, Goel D, Goldberg J, Brock TG, Myers MG, Jr. Deletion of leptin receptor mediated STAT3 signaling enhances pulmonary host defense against pneumococcal pneumonia. J Immunol 2011; 186(2):1081-90, PMCID: PMC3133444

190. Serezani CH, Lewis C, Jancar S, Peters-Golden M. Leukotriene B4 amplifies NFB activation in mouse macrophages by reducing SOCS1 inhibition of MyD88 expression. J Clin Invest 2011; 121(2):671-82, PMCID: PMC3026722

191. Kim S-H, Serezani CH, Okunishi K, Aronoff DM, Peters-Golden M. Distinct protein kinase A anchoring proteins direct prostaglandin E2 modulation of toll-like receptor signaling in alveolar macrophages. J Biol Chem 2011; 286(11):8875-83, PMCID: PMC3058957

192. Badri L, Walker NM, Ohtsuka T, Wang Z, Delmar M, Flint A, Peters-Golden A, Toews GB, Pinsky DJ, Krebsbach PH, Lama VN. Epithelial interactions and local engraftment of lung-resident mesenchymal stem cells. Am J Respir Cell Mol Biol 2011; 45(4):809-16, PMCID: PMC3208618

193. Okunishi K, Peters-Golden M. Leukotrienes and airway inflammation. Biochim Biophys Acta 2011; 1810(11):1096-102, PMCID: PMC3136588

194. Walker N, Badri L, Wettlaufer S, Flint A, Krebsbach PH, Keshamouni VG, Peters-Golden M, Lama VN. Resident tissue-specific mesenchymal progenitor cells contribute to fibrogenesis in human lung allografts. Am J Pathol 2011; 178(6):2461-9, PMCID: PMC3124120

195. Monteiro APT, Pinheiro CS, Luna-Gomes T, Alves LR, Maya-Monteiro CM, Porto BN, Barja-Fidalgo C, Benjamim CF, Peters-Golden M, Bandeira-Melo C, Bozza MT, and Canetti C. Leukotriene B4 mediates neutrophil migration induced by heme. J Immunol 2011; 186(11):6562-7, PMID: 21536805

196. Peres-Buzalaf C, de Paula L, Frantz FG, Soares EM, Medeiros AI, Peters-Golden M, Silva CL, Faccioli LH. Control of experimental pulmonary tuberculosis depends more on immunostimulatory leukotrienes than on the absence of immunosuppressive


prostaglandins. Prostaglandins Leukotrienes Essential Fatty Acids 2011; 85(2):75-81. PMCID: PMC3397385, NIHMS387547

197. Morato-Marques M, Campos MM, Kane S, Rangel AP, Lewis C, Ballinger MN, Kim S-H, Peters-Golden M, Jancar S, Serezani CH. Leukotrienes target F-actin/cofilin-1 to enhance alveolar macrophage anti-fungal activity. J Biol Chem 2011; 286(33):28902-13, PMCID: PMC3190697

198. Okunishi K, Sisson TH, Huang SK, Hogaboam CM, Simon RH, Peters-Golden. Plasmin overcomes resistance to prostaglandin E2 in fibrotic lung fibroblasts. J Biol Chem. 2011, 286: 32231-43. Epub 2011 Jul 27. PMCID: PMC3173171.

199. Stumm CL, Wettlaufer SH, Jancar S, Peters-Golden M. Airway remodeling in murine asthma correlates with a defect in PGE2 synthesis by lung fibroblasts. Am J Physiol Lung Cell Mol Physiol 2011; 301(5):L636-44, PMCID: PMC3213985

200. Ballinger MN, Peters-Golden M, Moore BB. Impaired neonatal macrophage phagocytosis is not explained by overproduction of prostaglandin E2. Respir Res 2011;12:155. PMCID: PMC3287971

201. Walker NM, Badri LN, Wadhwa A, Wettlaufer S, Peters-Golden M, Lama VN. Prostaglandin E2 as an inhibitory modulator of fibrogenesis in human lung allografts. Am J Respir Crit Care Med 2012; 185(1):77-84, PMID: PMC3262036

202. Zasłona Z, Serezani CH, Okunishi K, Aronoff DM, Peters-Golden M. Prostaglandin E2 restrains macrophage maturation via E prostanoid receptor 2/protein kinase A signaling. Blood 2012; 119(10):2358-67, PMCID: PMC3311259

203. Serezani CH, Medeiros AI, Kane S, Kim SH, Marques MM, Lee SP, Lewis Cornett CA, Bourdonnay E, Ballinger MN, White ES, Peters-Golden M. PTEN directly activates the actin depolymerization factor cofilin-1 during PGE2-mediated inhibition of phagocytosis of fungi. Sci Signal 2012; 7(210):ra12, PMCID: PMC3400468, NIHMS385040

204. Aronoff DM, Bergin IL, Lewis C, Goel G, O'Brien E, Serezani CH, Peters-Golden M, Mancuso P. E-Prostanoid 2 receptor signaling suppresses lung innate immunity against Streptococcus pneumoniae. Prostaglandins Other Lipid Mediators 2012; 98(1-2):23-30, PMCID: PMC3350638, NIHMS368166

205. Bourdonnay E, Serezani CH, Aronoff DM, Peters-Golden M. Regulation of alveolar macrophage phagocyte oxidase through its carrier protein p40phox: hierarchy of activating kinases and their inhibition by prostaglandin E2. J Leukoc Biol. 2012; 92(92):219-31, PMCID: PMC3382311

206. Serezani CH, Kane S, Collins L, Morato-Marques M, Osterholzer JJ, Peters-Golden M. Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis. J Immunol. 2012; 189:(2)906-15, PMCID: PMC3392366, NIHMS378651

207. Mancuso P, Myers MJ, Jr., Goel D, Serezani CH, O’Brien E, Goldberg J, Aronoff DM, Peters-Golden M. Ablation of leptin receptor mediated extracellular regulated kinase activation impairs host defense against Gram-negative pneumonia. J Immunol. 2012; 189(2):867-75, PMCID: PMC3392451, NIHMS377212

208. Huang SK, Scruggs AM, Donaghy J, McEakin R, Fisher AS, Richardson BC, Peters-Golden M. Prostaglandin E2 increases gene-specific and global DNA methylation via increased DNA methyltransferase expression. FASEB J. 2012; 26(9):3703-14, PMCID: PMC3425823

209. Peters-Golden M, Klinger JR, Carson SS. The case for increased funding for research in pulmonary and critical care. Am J Respir Crit Care Med. 2012;186(3):213-5, PMID 22582163

210. Kaul V, Bhattacharya D, Singh Y, Van Kaer L, Peters-Golden M, Bishai WR, Das G. An important role of prostanoid receptor EP2 in host resistance to Mycobacterium tuberculosis infection in mice. J Infect Dis. 2012;206(12):18186-25, PMCID: PMC3502376


211. Zaslona Z, Peters-Golden M. A lipid mediator controls neutrophil recruitment in acute lung injury – should we really be surprised? Crit Care. 2012;16(5):161, PMID: 23102473

212. Brogliato AR, Antunes CA, Carvalho RS, Monteiro APT, Bozza MT, Canetti C, Peters-Golden M, Kunkel SL, Vianna-Jorge R, Benjamim CF. Ketoprofen reverses immunosuppression induced by severe sepsis and reveals an important role for prostaglandin E2. Shock. 2012;38(6):620-629, PMID: 23143054

213. Garrison G, Huang SK, Okunishi K, Scott J, Penke LRK, Scruggs AM, Peters-Golden M. Reversal of myofibroblast differentiation by prostaglandin E2. Am J Respir Cell Mol Biol. In press.

214. Mor-Vaknin N, Legendre M, Yu Y, Serezani CHC, Garg S, Jatzek A, Swanson MD, Teitz-Tennenbaum S, Punturieri A, Engleberg NC, Banerjee R, Kao J, Peters-Golden M, Markovitz DM. Murine colitis is mediated by vimentin. Sci Rep. In press.

215. Scott JP, Peters-Golden M. Anti-leukotriene agents for the treatment of lung disease. Invited review, Am J Respir Crit Care Med. [Submitted]

216. Tian W, Jiang X, Tamosiuniene R, Sung YK, Dhillon G, Gera L, Farkas L, Rabinovitch M, Manickam S, Fridlib M, Rajadas J, Peters-Golden M, Voelkel NF, Nicolls MR. The role of macrophage-derived leukotriene B4 in pulmonary hypertension. [Submitted]

217. Monteiro AP, Soledade E, Pinheiro CS, Dellatorre-Teixeira L, Oliveira GP, Oliveira MG, Peters-Golden M, Rocco PRM, Benjamim CF, Canetti C. Pivotal role of 5-lipoxygenase pathway in lung injury after experimental sepsis. [Submitted]

218. Okunishi K, DeGraaf AJ, Zaslona Z, Peters-Golden M. Inhibition of protein translation as a novel mechanism for prostaglandin E2 regulation of cell functions. [Submitted]

219. Huang SK, Scruggs AM, Donaghy J, Horowitz JC, Zaslona Z, White ES, Peters-Golden M. Histone modifications are responsible for decreased Fas expression and apoptosis resistance in fibrotic lung fibroblasts. [Submitted]

220. Brogliato AR, Moor A, Kesl S, Peters-Golden M, Canetti C, Gould L, Benjamim CF. Critical role of 5-lipoxygenase and heme oxygenase 1 on wound healing. [Submitted]

221. Mason KL, Rogers LM, Soares EM, Bani-Hashemi T, Erb Downward J, Agnew D, Peters-Golden M, Weinberg JB, Crofford LJ, Aronoff DM. Intrauterine group A Streptococcal infections are exacerbated by prostaglandin E2. [Submitted]

222. Zasłona Z, Okunishi K, Domingo-Gonzalez R, Moore BB, Lukacs NW, Aronoff DM, Peters-Golden M. Prostaglandin E2 suppresses allergic sensitization and lung inflammation by targeting the E prostanoid 2 receptor on T cells. [Submitted]

Chapters in Books:

1. Brock TG, Peters-Golden M: Localization of 5-lipoxygenase to the nucleus of resting rat basophilic leukemia cells. In: Samuelsson B, Paoletti R, Ramwell P (eds): Ninth International Congress on Prostaglandins and Related Compounds, 1994; 23:151-153

2. Peters-Golden M. Lipid mediators synthesis by lung macrophages. In: Lipscomb MF, Russell S (eds): Lung Macrophages and Dendritic Cells in Health and Disease. Marcel Dekker, Inc., New York, NY, 1997, pp. 151-182

3. Peters-Golden M. Intracellular localization of eicosanoid-forming enzymes. In: Szczeklik A, Gryglewski R, Vane JR (eds): Eicosanoids, Aspirin and Asthma. Marcel Dekker, Inc., New York, NY, 1998, pp. 91-109

4. Peters-Golden M. Molecular mechanism of leukotriene synthesis: The changing paradigm. In: Rodger I, Botting J, Dahlen S-E (eds): Leukotrienes: New Concepts and Targets for Therapy. Kluwer Academic Publisher, Boston, 1998, pp. 1-9.


5. Peters-Golden M, Standiford T. Antimicrobial defense capabilities of the lung. In: Emerging Therapeutic Targets. Vol. 2(1) P Smith, P Warne (eds), Ashley Publications, London, UK, 1998, pp. 15-18

6. Peters-Golden M. Pulmonary diseases other than asthma as potential targets for anti-leukotriene therapy. In: Simon RA and Wenzel SE (eds): Clinical Reviews in Allergy and Immunology. Humana Press, Totowa, NJ, 1999, pp. 247-260

7. Peters-Golden M, Coffey M. Role of leukotrienes in antimicrobial host defense of the lung. In: Simon RA and Wenzel SE (eds): Clinical Reviews in Allergy and Immunology. Humana Press, Totowa, NJ, 1999, pp. 261-269

8. Peters-Golden M, Brock TG. 5-Lipoxygenase and the nucleus: where, when how, and why? In: Paoletti R and Samuelsson B (eds): Advances in Prostaglandin and Leukotriene Research. Kluwer Academic Publishers, Dordrecht, The Netherlands, 2001, pp. 9-15

9. Peters-Golden M. Eicosanoids as mediators and therapeutic targets in airway inflammation. In: Eissa NT and Huston D (eds): Therapeutic Targets of Airway Inflammation. Marcel Dekker, Inc., New York, NY, 2003, pp. 627-656

10. Peters-Golden M. Arachidonic acid metabolites: potential mediators and therapeutic targets in pulmonary fibrosis. In: Lynch JP III (ed): Idiopathic Pulmonary Fibrosis. Marcel Dekker, Inc., New York, NY, 2004, pp. 419-449

11. Peters-Golden M. Lipid mediators: overview. In: Laurent GJ and Shapiro SD (eds): Encyclopedia of Respiratory Medicine. Elsevier Ltd, Oxford, UK, ISBN (Set): 0-12-438360-2, 2006, pp.572-579.

12. Peters-Golden M. Prostaglandins. In: Laurent GJ and Shapiro SD (eds): Encyclopedia of Respiratory Medicine. Elsevier Ltd, Oxford, UK, ISBN (Set): 0-12-438360-2, 2006, pp. 584-588

13. Bone-Larson, C, Peters-Golden, M. Agents affecting the 5-lipoxygenase pathway in treatment of asthma. UpToDate. 2007

14. Peters-Golden M. Pneumonia. In: Schraufnagel D (ed): Respiratory Disease in America. 2010.15. Okunishi K and Peters-Golden M. Leukotrienes. In: Holgate S, Wills-Karp M, and Izuhara K (eds):

Inflammation and Allergy Drug Design. Blackwell Publishing Ltd, Oxford, UK. 16. Peters-Golden M. Slow contractions and rapid progress: the leukotriene story. In: Sheikh A, Platts-Mills

T, Worth A, Holgate S (eds): Landmark Papers in Allergy: Seminal Papers in Allergy with Expert Commentaries. Oxford University Press, Oxford, UK. In press


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