Male genital pathology. 62 year old male SCC of the penis, spreading through the vessels of the...
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Transcript of Male genital pathology. 62 year old male SCC of the penis, spreading through the vessels of the...
PATHOLOGY PICTURES
Male genital pathology
62 year old male
SCC of the penis, spreading through the vessels of the corpora cavernosa
Malignant penile carcinoma
59 year old male with haemochromatosis and cirrhosis
Testicular atrophy
Low power
High power
Atrophic testis
Low power: tunica albuginea (long arrow); seminiferous tubules (short arrow)
High power: Leydig cells (long arrow); atrophic tubules (short arrows); thickened basement membrane; lack of spermatogenesis
A: normal testis
B: testicular atrophy tubules have Sertoli cells but no spermatogenesis; thickened basement membrane; apparent increase in interstitial Leydig cells
30 year old man with dystrophia myotonica
Advanced testicular atrophy
Epididymitis and orchitis
71 year old male with prostatic hyperplasia
Chronic granulomatous epididymo-orchitis
Blue arrows: cream nodules comprising lipid-laden macrophages
Black arrows: hydrocoele
Tuberculous epididymo-orchitis
Predominantly affecting the epididymis (arrows)
Tertiary syphilis
Gumma (arrows) of the testis
Multiple irregular areas of necrosis surrounded by a zone of dense fibrosis
No recognisable testicular tissue remains
Haemorrhagic infarction of testis due to torsion of spermatic cord
Testis which has recently undergone infarction
Low power: tunica albuginea (long arrow); infarcted tubule (small arrow)
High power: necrotic seminiferous tubules (long arrows); oedema separating tubules (short arrows)
Haemorrhagic necrosis of the testis and epididymis due to torsion of the spermatic cord
Testicular torsion
Torsion of the testicular appendix
Bilateral cysts of epididymis
40 year old male
Seminoma of the testis
Homogeneous cream colour
Testicular tumours are usually a mixture of seminoma and teratoma components
Seminoma of the testis
Fairly well circumscribed, pale, fleshy, homogeneous mass
Embryonal carcinoma
Haemorrhagic mass
Choriocarcinoma
Small size; marked haemorrhage and necrosis
17 year old male
Malignant teratoma of the testis
Varied macroscopic appearance from one area to another
Immature testicular teratoma
Low power: tunica (A); residual seminiferous tubules (B); varied picture within and between fields
High power: immature mesenchyme (A); immature cartilage (B); seminoma (C) seminoma can form a component of a mixed germ cell tumour
High power view of seminoma component: tumour cells (arrows) have large central nuclei and clear cytoplasm; fibrous connective tissue septae infiltrated with chronic inflammatory cells (arrowheads)
Man aged 35 with ‘cannon ball’ secondaries in the lungs and a positive pregnancy test
Immature teratoma of the testis with a choriocarcinoma component
Haemorrhagic necrosis of choriocarcinoma component (characteristic due to tumour cells invading blood vessels)
Homogenous white areas: seminoma
Teratoma of the testis
Variegated cut surface with cysts
Mature teratoma
Immature teratoma
72 year old male
Hydrocoele (blue arrows) with atrophic testis (red arrows)
6 year old male
Hydrocoele of the spermatic cord
Chronic haematocoele (blue arrows) with testicular atrophy (red arrows)
Man aged 58
Varicocoele (blue arrows)
Appendix of epididymis (red arrows)
Hydatid of Morgagni (black arrow) with twisted pedicle
72 year old male with DM complicating haemochromatosis
Prostatic abscess
Blue arrows: pyogenic membrane (abscess contents removed)
83 year old male
Nodular hyperplasia of the prostate and muscle hypertrophy and trabeculation of the bladder
Low power
High power
Medium power
Low power: increased stroma and proliferated glands (arrows)
High power: double layer of nuclei (long arrows); regular nuclei and inconspicuous nucleoli (arrowheads)
Prostatic hyperplasia
Hypertrophy of bladder muscle
Cystitis
Bilateral hydroureter and hydronephrosis
Suppurative pyelonephritis
BPH
Well-define nodules compress the urethra into a slit-like lumen
Histology: nodules of hyperplastic glands on both sides of the urethra
Carcinoma in the posterior prostate
Low power
High power
Adenocarcinoma of the prostate
Low power: proliferation of closely-packed small glands; infiltrating into surrounding stroma
High power: glands are closely applied (long arrows); enlarged, hyperchromatic nuclei; nuclei are irregularly arranged in the cells (arrowheads)
Poorly differentiated prostatic adenocarcinoma
Almost complete loss of the glandular architecture, pleomorphic nulei, prominent nucleoli
Advanced carcinoma of the prostate
Adenocarcinoma of the prostate
Lower left is posterior aspect (where carcinomatous tissue is)
Solid white tissue of cancer unlike spongy appearance of benign peripheral zone