7/25/2019 Malathion Word

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Group 5 -Toxicology Lab - B.S. Pharmacy - 4A

Members:Boiser, Gaebrelle AnneCagas, Dianna Feb

Davocol, Dahna LaizaKasid, Sittie NamraidaMalabarbas, AlbertMasaya, !ly"a

MALATH!"

#hemical #omposi$io%:Malao#on

Mecha%ism o& Toxici$y: Malathion is a cholinesterase inhibitor, a diverse $amilyo$ chemicals% &'on !'ta"e into the target organism, it binds irreversibly toseveral, random cysteine resid!es on the cholinesterase enzyme, (ith 'ero#ideas the leaving gro!', the res!ltant 'hos'hoester gro!' bonds to cholinesteraseand denat!res 'roteins%

'ses: )esticide* +%- 're'aration are !sed $or head lice and body lice

Toxic (&&ec$s:Air(ays and l!ngs. Chest tightness and di$$ic!lty in breathingBladder and Kidneys. /ncreased !rination0eart and blood. Lo( or 0igh Blood )ress!re* Slo( or 1a'id 0eart 1ate

Nervo!s System. Agitation, An#iety, Coma, Con$!sion

A%$i)o$e:2reatment $or malathion 'oisoning consists o$ thoro!gh decontamination,

cardiores'iratory s!''ort and administration o$ the antidote atro'ine and'ralido#ime% /n cases o$ severe 'oisoning, diaze'am sho!ld be administered%