Main lines of treatmentin diseased animals proff. dr hamed attia
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Professor Dr Hamed AttiaProf. of veterinary internal medicine
Zagazig University-EgyptEmail:[email protected]
Mobil No :00966547209365
Main Lines of treatment of diseases
in farm animals
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4 dS To Success in Treatment
Correct Diagnosis
Drug UsedDose
&Route
Duration
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Main Line of Treatment
Hyagenic Medical Supportive T
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11--Main Lines of treatmentMain Lines of treatment of enteritis of enteritis
1-Anti-acid (systemic).2-Fluid therapy.3-Anti-inflammatory4-Antibiotic 5-Antiparastic drugs6-Intestinal astringent
and coating
Clinical signs of diarrheaCalves are weak ,depressed ,anorexicAffected animals either recovered or dieAfter five days.
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In Calf ScourLook on the animal
not on the feces
1-Appetite
2-Temperature
3-General condition•Standing position
•Recumbent
4-Dehydration
Important Notes
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Metabolic effects of calf scourMetabolic effects of calf scourDehydrationAcidosisElectrolyte imbalance
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11 - -Anti-acid (systemic)Anti-acid (systemic)..
• R/Na bicarbonate 1.3% 0.5-1 L I/V according to the degree of acedemia
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Oral Fluid Therapy
I/V Fluid Therapy
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33--Non steriodal anti-inflammatoryNon steriodal anti-inflammatory• R/ Dicloprima 5%• Dose:• 2 Ml/ 100Kg B.W
N B: Non Steroidal anti-inflammatory should be given after
hydration of the calf
Anti-inflammatory
Strong analgesic
Atipyretic
Anti-endotoxic
Advantages
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Antibiotice more effective on E coli & Salmonelle
Nuflor Marbocele Cefotaxim Borgal(Sulfa &Trimethoprime)
4-Broad spectrum antibiotic
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66--AntiparasiticAntiparasitic agentsagents--- ---
• R/ Ivermectine 1cc /50 Kg. B.w. S/C
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General line for treatment of General line for treatment of AcidosisAcidosis
• 1-Evacuation of rumen content:• • By using 3 liter Paraffin oil by stomach tube• 2-Antiacid• (a) Local: 500 g sodium bicarbonate• &• (b)Systemic: 2 liter isotonic sodium bicarbonate 1.3% I/V• 3-Fluid therapy:• Nacl 0.9% 4-6 liter I/V• • According to degree of dehydration• 4-Antihistaminic:• R/Antistamine 30-40 Ml I/V
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General line for treatment of General line for treatment of AcidosisAcidosis
• 5-Antinflamatory• 6-Antibiotic• Orally (procaine penicillin 10million IU
orally)• &• Systemic• 7-Ruminal tonic stomachic• -Bykahepar -genabell• -Hepanol -propylene glycol
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General line for treatment of General line for treatment of simple indigestionsimple indigestion
• 1-Antiacid• 0.5 kg sodium bicarbonate/orally• 2-Ruminal tonic stomachic• -Bykahebar -
Genabel• 3-Purgative• 0.5 kg orally of Mg oxide• OR• 2 liter of Paraffin oil• 4-Massage of rumen from left flank• 5-Rectal enema, back racking &exercise
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General line for treatment of General line for treatment of MasititisMasititis
• 1-AntiBiotic• Systemic: Gentamycin,
Cefotaxim Snylox-Pentomycin• Pentomycin• 2-Antinflammatory• 3 days Non steroidal AI• 3-Antihistaminic• 1st day• 4-Oxytocin• 5-Vitamin AD3E&C
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General line of treatment of General line of treatment of pneumoniapneumonia
• Broad spectrum antibiotic• Ant inflammatory• Bronchodilator• Mucolytics & Expectorants• Antihistaminic
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Antibiotic used in pneumoniaAntibiotic used in pneumonia
1. 1-In less sever cases:1-Oxytetracycline drugs2-EnerofloxacineIN sever cases (Shipping fever): Flurphenicol Cephalosporion . Sulfa &Trimethoprime Marboflxacine
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Metabolic DiseasesMetabolic Diseases
TherapyTherapy
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General line for treatment General line for treatment of milk feverof milk fever
• 1)Source of Calcium A-Small cow(300- 400 Kg):
R/500 ml (375 ml IV very slowly and
125 ml SC after 30 min. at different sites.
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• Large cow( More than 500 Kg B .w.)
• 1 Liter:• ½ Liter at morning• ½ Liter at evening
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Examples of Ca preparationExamples of Ca preparation
• R/Ca boro-gluconate (20% or 25%)• OrR/ Cal. D. Mg (Ca & Dextrose & Mg)R/Calcium amino-plex (Ca & amino acids). NB:• I/v Ca solution should be slowly to
prevent cardiac arrest. • Continue for 3-5 days days or till complete
recovery
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(2) Compounds which increasing calcium level in blood:
R/ AD3E&C (15 ml / daily IM).& R/ACTH 400-500 IU I/M 3) Anti-inflammatory (Non Steroidal) R/Declo-phenac Na 2.5% 4 ml/100 Kg B W.(4) Supportive treatment:R/Dextrose 25% or 40% 2 liter IV.
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Medical General lines for treatment of hypo-phosphatemia
Source of ph Hematincs Saline
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1-Source of ph
I/V&I/M S/C Orally
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2-Hematinics
A-Blood transfusion)In sever cases( Iron & VitB12.
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((11 ) )Sources of phosphorusSources of phosphorus
• A) IV slowly administration of 60 of sodium acid phosphate in 300 ml of distilled water on the first day .
• Followed by further SC injections of similar doses at 12-hours intervals till recovery.
• Similar daily doses (60 g) by mouth
NB:Treatment should be continued till 3-5 days after disappearance of red urine (complete recoverty).
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• B) patent phosphorus preparation as:
• R/ Tonophosphan (Ph 10%)• R/ 50ml( 25 ml IV daily&25 ml I/M till
recovery).
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• C) Oral dosing with bone meal (120 g) twice daily or dicalcium phosphate daily for 5 days till recovery.
• Or:• Superphos Sachets 3• One sachet daily (oral route)
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• (2) Hematinic preparation:• (A) in sever cases:• Blood transfusion 3-4 L of whole blood to a
450 kg cow is indicated in severe cases.• Additional transfusion is necessary if cow is
still weak and mucous membranes are pale.• (B) In less sever cases:• iron, copper, cobalt, vitamin B12. (4)
R/Antoplex 15 ml I/M
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• (3) Supportive therapy:• (Glucose 25%) to treat ketosis &
hypoglycemia.• (4)Kidney wash:• (Glucose 5% or saline(0.9%NaCl ( to
minimize the danger of hemoglobinuric nephritis.
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3- General Lines Of Treatment of Ketosis
1-Dextrose 25%
2-Propylene glycol
3-Dexamethasone
Make Glucose
Decreased Production(less glucose demand)
Increased Appetite
4-Insuline Facilitate transport glucose into the cell
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Medical treatmentMedical treatment
• 1-Sources of glucose:• IV injection of dextrose 25-40%
500ml for cattle (in ewes 150-250 ml) IV, twice daily for 3-5 successive days causing temporary hyperglycemia.
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• Oral hyperglycemic agents: propylene glycol .05 Liter orally
• Or:• Glycerol or glycerin 0.25 Liter or
sodium propionate )100-200 gm (once daily for 3 day(. R/Primaton : .025 L orally • They are glucogenic and thus
produce glucose.
Primaton
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2-Hormonal therapy:A-Glucocorticoids: Such as dexamethazone 10 ml )30
mg( I/M one or two doses for cattle to increase the blood sugar level & reduces ketone bodies formation by utilization of acetyl coenzyme A.
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Line of treatment of blood parasitesLine of treatment of blood parasites
• Fever (40-41C)• Red Urine• Partial loss of appetite• Jaundice
1-Babesiosis
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I- TreatmentI- Treatment::
• Important Notes:• Treatment should be tried early before the animal becomes anemic· Care must also be taken to avoid complete
sterilization of the blood before sufficient antibody is produced to provide a durable immunity.
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Drugs usedDrugs used
1- Diminazen aceturate (Batrinil-Berinil) · Aqueous solution7% )1.05gm vial dissolved in
12.5 ml water(.· Dose 1ml/20kg ·2-Imidocarb dipropionate (Imisol) 2ml/100Kg B W.
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Symptomatic treatmentSymptomatic treatment
• Non steroidal ant inflammatory• R/ Decloflam )1CC/25kg I/M(• -Blood transfusion:-• - In Sever cases 1Liter/100 Kg B W.• General hematinics.• R/Antoplex 15mlI/M• Or Iron 100 1 ml /100Kg B W.
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Line of treatment of blood parasitesLine of treatment of blood parasites
• Fever (40-41C)• Corneal opacity• Partial loss of appetite• Enlarged pre-scapular
L.N
2-Theleriasis
Corneal opacity
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TreatmentTreatment
R/butalex injection 1CC /20 Kg I/MOr:
Oxytetracycline L.A(5 Doses)+ Arsinal for 5 days
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Line of treatmentOf
urinary tract affections
Anti-inflammatory
Urinary Antiseptic
Antibiotic
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Types of Antibiotic
Peniclline &
streptomycine
Sulpha &
Trimethprime
CephalosporineGentamycine
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Types of AntibioticAccording to species
Rumminant Cephalosporine
penicillines
EquinesSulpha & Trimethoprime
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Duration of
Antibiotic
Chronic pyogenic2-4 weeks
Chronic7-10 D
Acute3-5 days
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2-Urinary Antiseptic
Urinary lavage
IV glucose
SystemicColi-urinalHexamin
Local use of
catheters
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3-Anti-inflammatory
Ketoprofen FinadyineDecloprema
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Causes Antibiotic FailureCauses Antibiotic Failure• 1-Exposure to strong sunlight • 2-Too-much-water • 3-Frequency-of-dose ( daily treatment
but we decided to just double the dose and give it every other day).
• 4-Duration is not enough.
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• 5-The causative agent is virus not bacteria• 6-The drug is not specific against the
pathogen• 7-Contaminated needle back into the bottle.
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Bacterial vaccines
Viralvaccines
2. Covexin* 8& 10
3 Ultrabac® 8
Mixed vaccines
1. PNEUMO 3
2. PNEUMO 4
1. Pneumo - Bac 1. Entero – 3 Vaccine
3. Cattle Master44. Vira Shield 5
2. Scour Guard 3
3-Rotvec vaccine
E Coli + Rota & Corana Virus
4-Coli immune-oral5-Nasal Gene
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VACCINE FAILURESVACCINE FAILURES• NO RESPONSE :• Efficacy- expire Date• stress• Malnutrition• Improper Dose .
• Improper Route.