Magnetic Fluid Hyperthermia
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Transcript of Magnetic Fluid Hyperthermia
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Magnetic Fluid Hyperthermia:Focus on SuperparamagneticIron Oxide Particles (SPIONs)
Sophie Laurent, Silvio Dutz, Urs O. Hfeliand Morteza Mahmoudi
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OBJECTIVES
Acknowledge the use of SPIONs aspossible means for treating cancer
Provide a more efficient way of killingcancer cells through magneticnanoparticles
Conduct more studies regarding thefeasibility of SPIONS as possible curefor cancer
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MAGNETIC FLUID HYPERTHERMIA
A promising technique for treatingcancer cells
Refers to the heating of tissues usingmagnetic nanoparticles at 42-45C
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TYPES OF HYPERTHERMIA
Local hyperthermia
Regional hyperthermia
Whole body hyperthermia
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WAYS OF INTRODUCING MAGNETICNANOPARTICLES (MNP)
Arterial injection
Direct injection
In situ implant formation Active targeting
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SPIONs
Superparamagnetic iron oxide particles
Occur in two forms
Magnetite (Fe3O
4)
Maghemite (-Fe2O3)
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Characteristics of SPIONS
Biocompatibility
Nontoxicity
Ability to escape from thereticuloendothelial system (RES)
Low protein adsorption
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Why coat SPIONs?
Preventing the opsonization of SPIONs
Avoiding agglomeration of SPIONs inbiological medium
Achieving the desired surface charge for theSPIONs surface main task
Preserving the functionalities of thenanomaterials
Exhibiting the protein adsorption on theSPIONs and their corresponding denaturation
Ensuring biocompatibility of SPIONs
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HOW IS IT DONE?
MAGNETIC
NANOPARTICLES
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High Frequency Induction Machinefor Hyperthermia
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Schematic diagram for hyperthermia
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Predicted and actual SPION andtemperature distribution for recurrent
cervical cancer
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Predicted and actual SPION andtemperature distribution for recurrent
prostate carcinoma
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RESULTS AND DISCUSSIONS
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Balivada et.al. Magnetic Hyperthermia ofMelanoma Mediated by Iron oxide CoreNanoparticles, 2010
Influence of biomagnetic Fe3O4core/shell MNP combined with shortexternal alternating magnetic field
exposure on the growth ofsubcutaneous mouse melanomas
Decrease in tumor size was observedafter IV administration of the MNPfollowed by three consecutive days ofAMF exposure 24 h after injection
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Matsuoka et. al. Hyperthermia Using MagnetiteCationic Liposomes for Hamster Osteosarcoma2004
Investigated the effect of magnticcationic liposomes in vivo as treatementfor hamster osteosarcoma
Tumor was heated above 42C andcomplete regression was observed in100% of the treated group hamsters
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Matsuoka et. al. Hyperthermia Using MagnetiteCationic Liposomes for Hamster Osteosarcoma2004
Investigated the effect of magnticcationic liposomes in vivo as treatementfor hamster osteosarcoma
Tumor was heated above 42C andcomplete regression was observed in100% of the treated group hamsters
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Tseng et.al. Nanobiotechnology 2009
Developed a feedback temperaturesystem to keep the MNP at a constanttemperature to prevent overheating in
the tumors
Authors found experimentally that thesurvival rate of cancer cells could be
greatly reduced when CT-26 cancer cellswere heated above 45C.
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Le Renard et.al. Hyperthermia 2009
Investigated a new heat deliverytechnique for the local treatment ofsolid tumors injecting a formulation
that solidifies to form an implant in situ
After treatement with 12 mT field, five ofeleven mice (45%) survived one year
without any tumor recurrence
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CONCLUSIONS
SPIONs play an important role in thedevelopment of hyperthermia fortreatment of tumors in vivo.
SPIONs are very suitable to serve asheating source during magnetic fluidhyperthermia and further research in thefield will lead to a feasible solution orreduction of the abovementioned
problems which enables a more profoundtesting of this promising therapeuticmethod for cancer treatment.