Magette Eudora High School Notes 7.14.1: Blood. Magette Eudora High School Volume and Composition...

MagetteEudora High School

Notes 7.14.1: Blood


Volume and Composition

• Varies due to:– Size– Hydration– Body composition

• 8% of body weight

• About 5 Liters


Figure 14.3

Page 531


“Hemocytoblast”:

-Type of stem cell

-Red bone marrow


Red Blood Cells

-”Erythrocytes”

-95% of cellular blood


Platelets

-”Thrombocytes”

-<5% of cellular blood


White Blood Cells

-”Leukocytes”

-<1% of cellular blood


Erythrocytes

• “Red Cells”• 95% of cellular blood• Bi-Concave disc• Non-nucleated• Hemoglobin

– 1/3 of volume

• 4-7 million/mm3


Erythrocytes


How Much Did You Give?



• 4-7 million RBC’s /mm3 of blood




• 1 mm3 = 100 mL




• 1 mm3 = 100 mL

• You gave 1 pint




• 1 mm3 = 100 mL

• You gave 1 pint

• 1 pint = 473.2 mL



• 4-7 million RBC’s /mm3 of blood• 1 mm3 = 100 mL• You gave 1 pint• 1 pint = 473.2 mL• 4,000,000 x 100 x 473.2 = 189,280,000,000• 7,000,000 x 100 x 473.2 = 331,240,000,000



• 4-7 million RBC’s /mm3 of blood• 1 mm3 = 100 mL• You gave 1 pint• 1 pint = 473.2 mL• 4,000,000 x 100 x 473.2 = 189,280,000,000• 7,000,000 x 100 x 473.2 = 331,240,000,000

• You gave 190-330 Billion erythrocytes!


Hemoglobin

• 1/3 of RBC volume• Globular protein


Hemoglobin

• 1/3 of RBC volume• Globular protein• “Heme” groups

containing iron


Hemoglobin

• 1/3 of RBC volume• Globular protein• “Heme” groups

containing iron• Carries oxygen• Similar to myoglobin• Responsible for red

color of blood


Questions:

• Is blood sometimes blue?


Questions:


• How does this relate to what we know about iron-deficiency anemia?


Questions:


• How does this relate to what we know about iron-deficiency anemia?

• How do the CSI people get DNA from blood?


RBC Production

• “Erythropoiesis”

• Red Bone Marrow

• Erythropoietin: hormone released from kidneys and liver that stimulates production of RBC’s


Control of RBC Production

Negative Feedback:



Negative Feedback:

1.Trigger



Negative Feedback:

1.Trigger

2.Hormone Release



Negative Feedback:

1.Trigger

2.Hormone Release

3.Result



Negative Feedback:

1.Trigger

2.Hormone Release

3.Result

4.Inhibition


RBC Breakdown

• Liver and spleen• RBC is destroyed by

macrophages• Hemoglobin is broken

down into “heme” groups and globular proteins

• Proteins are broken down to amino acids and metabolized


RBC Breakdown

• Heme group is broken down into iron and biliverdin

• Iron is stored and/or reused

• Biliverdin is converted to orange pigment (bilirubin)

• “Bilis-” are secreted in bile


Leukocytes


Thrombocytes


Plasma

Magette Eudora High School Notes 7.14.1: Blood. Magette Eudora High School Volume and Composition...

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