Macromol. Rapid Commun. 15/2008
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Back Cover: A novel method to prepare a three-dimen- sional nano-structured protein hydrogel (3-D NPH), which is composed of protein-polymer hybrid nanoparticles has been discovered. The 3-D NPH can be easily prepared by dispensing a protein and polymer mixture on a substrate (as shown on the cover). Surprisingly, gold particles conjugated with protein A diffuse into the 3-D NPH which is made of Mouse IgG through the pores. The protein chips made using this 3-D NPH method show a tremendously improved sensitivity in detecting protein-protein interac- tions as compared to that of direct protein immobilization methods. Further details can be found in the article by H. Tanaka, T. Isojima, M. Hanasaki, Y. Ifuku, H. Takeuchi, H. Kawaguchi, and T. Shiroya* on page 1287.
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Transcript of Macromol. Rapid Commun. 15/2008
Back Cover: A novel method to prepare a three-dimen-sional nano-structured protein hydrogel (3-D NPH), whichis composed of protein-polymer hybrid nanoparticles hasbeen discovered. The 3-D NPH can be easily prepared bydispensing a protein and polymer mixture on a substrate(as shown on the cover). Surprisingly, gold particlesconjugated with protein A diffuse into the 3-D NPH whichis made of Mouse IgG through the pores. The protein chipsmade using this 3-D NPH method show a tremendouslyimproved sensitivity in detecting protein-protein interac-tions as compared to that of direct protein immobilizationmethods. Further details can be found in the article by H.Tanaka, T. Isojima, M. Hanasaki, Y. Ifuku, H. Takeuchi, H.Kawaguchi, and T. Shiroya* on page 1287.
