M&A in Healthcare and Pharma in France - H1 2017 … · M&A in Healthcare and Pharma in ... an...

24
M&A in Healthcare and Pharma in France - H1 2017 Funding innovation through to Megadeals

Transcript of M&A in Healthcare and Pharma in France - H1 2017 … · M&A in Healthcare and Pharma in ... an...

Page 1: M&A in Healthcare and Pharma in France - H1 2017 … · M&A in Healthcare and Pharma in ... an innovative plant-based ingredient ... the fifth position to the top 3 in the world Pharma

M&A in Healthcare and Pharma in France - H1 2017Funding innovation through to Megadeals

Page 2: M&A in Healthcare and Pharma in France - H1 2017 … · M&A in Healthcare and Pharma in ... an innovative plant-based ingredient ... the fifth position to the top 3 in the world Pharma

PwC

Highlights

2

For the first time, we take a combined look at deals that took place in both Pharmaceuticals and Healthcare sectors. In scope: deals involving at least one French party (acquirer or target company) and completed during the first semester of 2017. Deals also include the most significant fund raisings that occurred in the sector.

• M&A activity in Pharma and Healthcare was ripe with a total of almost 100 deals in H1 2017.

• This was mainly driven by sustained corporate M&A activity(two thirds of deal volume, including stock market operations)whilst Private Equity remains very active: one third of deal

volume and 6 out of the top 10 transactions in value terms.

• The three most active market segments in deal volume are PrivateHealthcare (27 transactions), busy with ongoing consolidation, Medtech (25) where PE supports technology development and Biotech (21) where investors help support development in strategic therapies (oncology, heart diseases, diabetes, etc.).

• Domestic deals represented ~60% of the activity. Foreignplayers’ investments mainly targeted French Biotechs which develop new treatments but they also play a key role in the PrivateHealthcare sector consolidation (>20% of inbounds deals).

• 4 out of the 5 largest corporate deals are cross-border: (yet to be completed) Essilor-Luxottica’s giant eyewear merger, Merial/Sanofi-Boehringer assets swap, Ipsen’s grab of Merrimack’s oncology products and Ecolab / Anios.

• At the other end of the spectrum, small size transactions(≤€10m in deal value or target turnover) represent half of deal volume. Key themes in this deal range include financing of innovation in Biotech / Medtech and consolidation in segments that are still relatively fragmented (e.g. local deals in specialty healthcare).

Page 3: M&A in Healthcare and Pharma in France - H1 2017 … · M&A in Healthcare and Pharma in ... an innovative plant-based ingredient ... the fifth position to the top 3 in the world Pharma

PwC 3

Target Country Acquiror Country Type Deal description Deal size

(€m)

Target

Revenues

(€m)

ESSILOR-LUXOTTICA FRLUXOTTICA /

DELFINIT Stock Market

French leading lens manufacturer Essilor and Italian

company Luxottica are expected to complete their merger

and strengthen their global leadership. Synergies are

expected to reach between €400m and €600m

46 000 15 537*

MERIAL SAS FRBOEHRINGER

INGELHEIM GMBHDE

Corporate

(100%)

Sanofi and Boehringer finalized their strategic exchange of

activities. Sanofi swapped its animal health business

Merial with Boehringer's consumer healthcare business.

Boehringer becomes the 2nd largest animal health

business in the world

4 700 -

DOMUSVI FR ICG / SRS UK/FRIndividual / PE

(majority stake)

ICG and SRS (holding of the founder of the Group)

acquired the majority stake held by PAI Partners in

DomusVi. The Group, which operates 334 facilities, is the

third private operator of nursing homes in Europe with

leading positions in France and in Spain. The investment

aims at financing a new phase of development.

2 300 1 300

MEDIPOLE

PARTENAIRESFR GROUPE ELSAN FR Corporate

Merger of "equals" in the French private clinical sector with

the take over of the 3rd largest clinic group Medipole

Partenaires by the 2nd one Elsan. Elsan will have to sell 3

clinics to meet with French competition regulation authority

requirements

- 866*

CERBA Healthcare FRPARTNERS GROUP

/ PSPCH/CA

PE

(Majority Stake)

PAI Partners sold Cerba Healthcare to the Swiss PE fund

Partners Group and the Canadian pension fund PSP.

Cerba's objective is to double its sales size within seven

years in EMEA, and extend its testing range

1 800 630

MERRIMACK

PHARMACEUTICALS

GLOBAL ONCOLOGY

ASSETS

US IPSEN FRCorporate

(Majority Stake)

French drug maker Ipsen acquired Merrimack's main

oncology asset to strengthen its capabilities in the US 950 -

LABORATOIRES

ANIOS FR ECOLAB INC. US

Corporate

(100%)

Ecolab, a global leader in water, hygiene and energy

technologies, acquired French-based Laboratoires Anios

to reinforce its position in the hygiene and disinfection

market for the healthcare sector

750 228

UNITHER

PHARMACEUTICALSFR

ARDIAN, ,

KEENSIGHT

CAPITAL,

PARQUEST

CAPITAL

FRPE

(Majority Stake)

Unither Pharmaceuticals, a French-based CDMO

specialized in sterile single-doses, was acquired by Ardian,

Keensight and Parquest. The capital will be used to

accelerate its growth in the US and South America, where

it already operates manufacturing plants, and begin

expansion in Asia

675 260

COLISEE GROUP FR

IK INVESTMENT

PARTNERS

LIMITED /

TEYCHENEY

FAMILY

UK/FRIndividual / PE

(majority stake)

IK Investment Partners (“IK”) acquired a majority stake in

Colisée Group. The management team and the founder

reinvested alongside IK. Colisée will continue its growth

strategy both organic and through add-on acquisitions in

France and across Europe

650 215

THE ELITECH

GROUPFR

PAI PARTNERS

SASFR

PE (Majority

Stake)

PAI Partners invested in in-vitro diagnosis specialist

ELITech Group – with growth prospects in both mature

and emerging markets

350 125

Subject to competition commission approval

* Note: 2015 Target Company revenues

Source: Zephyr, Capital Finance, Merger Market, Trade Press, PwC analysis

Page 4: M&A in Healthcare and Pharma in France - H1 2017 … · M&A in Healthcare and Pharma in ... an innovative plant-based ingredient ... the fifth position to the top 3 in the world Pharma

PwC

At a glance

4

International features

Private EquityCorporate

> €100m <= €10m€10-100m (included)

Number of deals where deal value or target revenue is …

Number of deals by investor type

Domestic deals Inbound deals Outbound deals

Number of deals by segment

60 21 16

14 30 44

51

Transactions with no deal size / revenues not included

Stock Market

1234

Private Healthcare Biotechnology

Others (CRO/CMO)

Medtech

Pharmaceuticals

Page 5: M&A in Healthcare and Pharma in France - H1 2017 … · M&A in Healthcare and Pharma in ... an innovative plant-based ingredient ... the fifth position to the top 3 in the world Pharma

PwC

Pharma: Soft start to the year

5

Big Pharma: Feed the drug pipeline through acquisitions to prepare for the future

• As announced mid-2016 by its new CEO, Ipsen has set a target of new launches or new indications for existing products every year to maintain its growth pattern. In H1 2017, Ipsen completed the largest deal of its history with the €950m acquisition of Merrimack’s strategic pancreatic cancer drug. Following the European Commission (EC) competition’s decision over the 2016 Sanofi-Boehringer deal, Ipsen took the opportunity to seal a tactical deal acquiring Sanofi’s 5 Consumer Healthcare products. EC divestiture requirements create a continuous Pharma deal flow in Europe.

• Sanofi was positioned to potentially acquire Swiss-based biotech Actelion which eventually fell under Johnson & Johnson’s ownership for €28bn. Sanofi is expected to look for new targets in H2, as evidenced by its takeover of flu vaccine maker Protein Sciences in August 2017.

• In line with its internationalization strategy, Servier’ssubsidiary Biogaran has chosen Nigeria-based generic drug manufacturer Swipha as the entry point for its first acquisition in Africa. It announced a commercial partnership with CardioRenal in August with a new e-health solution in the field of cardiology.

Specialty Pharma: Speed up the international development

• Family-owned pharmaco focused on rare diseases Serb Pharmaceuticals completed its first buy-out transaction with UK Private Equity fund Charterhouse. This operation supports its life sustaining product portfolio development in the US and future drug acquisitions.

• CycloPharma, specialized in molecular imaging in oncology and neurology, gets ~€5m further backingfrom Denos Pharma (Health Management) and welcomes IXO PE to finance R&D investments for new molecules and develop international partnerships (80% of sales in France).

• PAI-backed Ethypharm sealed its acquisition of Martindale Pharma, a UK specialty Pharmaco focused on segments with high unmet medical needs (opioid addiction, emergency care, etc.). Ethypharmstrengthens its UK footprint and significantly broadens its geographical reach (50 countries vs 30 today).

Natural Healthcare on the rise, driven by a global mega trend

• Ponroy Santé lab, well positioned to capture natural healthcare growth and benefit from convergence between Consumer and Pharmaceutical players,raised €150m from UK-based PE fund 3i. The French lab’s objective is to double sales in a 5-year span through both organic and external growth, especially in Asia.

• World leader in homeopathic medicines, Laboratoires Boiron pursues its consolidation strategy and acquired ArkoPharma's subsidiary Laboratoire Ferrier. ArkoPharma repositions itself on phytotherapy and nutritional supplements.

Animal Healthcare: “bullish” M&A activity

• Sanofi swapped its animal Health business Merialfor Boehringer's Consumer Healthcare asset. Boehringer becomes the second largest animal health business in the world. Following EC requirements, Ceva acquired some of Merial’s vaccines and Pharmaceutical products for horses and swines.

• Neovia (formerly InVivo NSA) realized 2 acquisitions of horses, ruminants and swines specialists in Mexico and France.

Other

• Roquette, an innovative plant-based ingredient specialist for food, nutrition and Pharma, acquires the Brazilian company Itacel to reinforce its Pharma excipient business and expand its presence in fast-growing markets. Roquette's ambition is to move from the fifth position to the top 3 in the world Pharma excipient market.

Pharma half-year M&A activity has been relatively quiet. Pharma is the less active sector in volume with 15 deals struck over the 6-month period despite several drivers favoring near-term M&A (patent expiries, new therapeutic areas…). Fortunes of big Pharma is contrasted. Natural Healthcare is a hot topic.

Page 6: M&A in Healthcare and Pharma in France - H1 2017 … · M&A in Healthcare and Pharma in ... an innovative plant-based ingredient ... the fifth position to the top 3 in the world Pharma

PwC

Target Country Acquiror Country Type Deal description Deal size

(€m)

Target

Revenues

(€m)

Big Pharmaceuticals

MERRIMACK

PHARMACEUTICALS

INC.'S GLOBAL

ONCOLOGY ASSETS

US IPSEN FR

Corporate

(Majority

Stake)

French drugmaker Ipsen, traditionally focused on endocrinology,

boosted its oncology portfolio with the acquisition of Merrimack's

US pancreatic drug assets (Onivyde). Merrimack will use the

resources to fund the development of new compounds, targeting

pancreatic, lung and other cancers

950 -

OTC products of

SANOFIFR IPSEN FR

Corporate

(Majority

Stake)

Ipsen acquired 5 leading Consumer Healthcare products (OTC)

from Sanofi and strengthens its Primary Care division footprint

(Eastern Europe). This transaction helps Sanofi to meet the

divestiture requirements set by the European Commission

following the asset swap with Boehringer

83 -

SWIPHA PHARMA NIG

LTDNG BIOGARAN FR

Corporate

(95%)

The acquisition of Swipha, a Nigerian Pharmaceutical company

specialized in generic drugs (tranquillizers, antimalarial drugs,

antibiotics), aligns with Biogaran’s international external growth

strategy. It gives Biogaran (Servier) its first foothold in Africa in a

184 million people country with growing demand. Swipha was

the first ISO 9001 Nigerian Pharma company (2007)

- 20

Specialty Pharma

SERB

PHARMACEUTICALSFR

CHARTERHOUSE /

FAMILY / MANAGERSUK PE

Charterhouse Capital Partners acquired a majority stake in

specialty Pharmaceutical group Serb to support portfolio

development in the US and drug acquisitions from big

Pharmaceuticals. Charterhouse completed several acquisitions

in the Pharma segment over the past 2 years (Cooper,

Vemedia, DOC Generici)

250 65

LABORATOIRES

CYCLOPHARMAFR

IXO PRIVATE EQUITY

/ DENOS PHARMA /

SOFIMAC

FR

PE

(Majority

Stake)

CycloPharma, specialized in the development and marketing of

molecular imaging in oncology and neurology, raised €5.4m to

develop new biomarkers molecules and increase its US (Joint-

Venture) and European footprints. CycloPharma aims at

doubling revenues within four years mainly with the

commercialization of two new cancer diagnosis molecules in

Europe

5 24

LABORATOIRE

FERRIERFR

LABORATOIRES

BOIRONFR

Corporate

(100%)

World leader in homeopathic medicines, Laboratoires Boiron,

pursues its consolidation strategy and acquired all shares of

ArkoPharma's subsidiary Laboratoire Ferrier specialized in

homeopathic remedies sold in French drugstores. ArkoPharma

repositions itself on phytotherapy and nutritional supplements

2 2*

MARTINDALE

PHARMAUK ETHYPHARM FR

Corporate /

PE

PAI Partners backed Pharmaceutical company Ethypharm to

acquire UK-based specialty Pharma Martindale, specialized in

opioid addiction, emergency care and sterile injectables. The

combined group will significantly broaden its geographical reach

- 85

FLAMEL

TECHNOLOGIESFR

AVADEL

PHARMACEUTICALS

PLC

IECorporate

(100%)

Following its restructuring strategy, Flamel Technologies, a

French specialty pharma company specialized in drug delivery,

completed a cross-border merger with its Irish subsidiary Avadel

Pharmaceuticals

- 23

Animal Health

MERIAL FRBOEHRINGER

INGELHEIM GMBHDE

Corporate

(100%)

Sanofi and Boehringer finalized their strategic exchange of

assets. Sanofi swapped its own animal Health business Merial

against Boehringer's Consumer Healthcare business.

Boehringer thus reinforces its position in the animal health

segment and becomes the second largest animal Health

business in the world

4 700 -

MERIAL SAS /

BOEHRINGER

INGELHEIM GMBH

FR CEVA FRCorporate

(100%)

Animal Healthcare company Ceva acquired vaccines and

Pharmaceutical products for horses and swines from Merial, as

Boehringer was not allowed by the European Commission to

acquire the totality of Merial's assets

114-

APLIGEN MX NEOVIA FR Corporate

Neovia, formerly InVivo NSA, acquired Mexican-based and

family-owned company Apligén, specialized in animal nutrition,

more specifically in ruminants and swines. Neovia thus becomes

one of the 5 market leaders in Mexico for premix nutrition

- 30

AGRANIX SAS FR NEOVIA FRCorporate

(100%)

Neovia acquired Agranix, a nutritional products specialist

company for ruminants and horses, expanding its premium

products range and strengthening its position in France

- 2*

APPLIFARM FR

NEOVIA / INNOVAL /

CEVA / EILYPS /

COGEDIS / ADISSEO

FR Corporate

Cluster of companies are injecting capital to create and support

Applifarm, a big data app for services in the ruminant sector,

counting on the soaring use of connected objects in the

agricultural sector

- -

6

* Note: 2015 revenues

Page 7: M&A in Healthcare and Pharma in France - H1 2017 … · M&A in Healthcare and Pharma in ... an innovative plant-based ingredient ... the fifth position to the top 3 in the world Pharma

PwC 7

Target Country Acquiror Country Type Deal description Deal size

(€m)

Target

Revenues

(€m)

Other

PONROY SANTE FR 3i UK

PE

(Majority

Stake)

PE fund 3i invested €150m in French Natural Consumer

Healthcare lab Ponroy. Ponroy's objective is to double its size in

a 5-year span through both organic and external growth,

especially in Asia

150 170*

ITACEL BR ROQUETTE FR Corporate

Family-owned specialty food and pharmaceutical excipients

group Roquette completed the acquisition of the Brazilian

Pharma excipients company Itacel (Blanver Group) to reinforce

its Pharma activity, natural based excipients solutions and

position itself in fast growing markets. Roquette's ambition is to

move from the fifth position to the top 3 in the world Pharma

excipient market

- -

Page 8: M&A in Healthcare and Pharma in France - H1 2017 … · M&A in Healthcare and Pharma in ... an innovative plant-based ingredient ... the fifth position to the top 3 in the world Pharma

PwC

Biotech: In-Vitro Diagnosis (IVD), cancer, heart diseases & diabetes “attractiveness”

8

Biotech diagnosis & testing: Gain scale through acquisitions

• Following the acquisition of InGen Biosciences in 2012, France-based Diaxonhit acquired its other competitor Eurobio to reach critical size and build a European leader in in-vitro specialty solutions (IVD) for research in Life-Sciences.

• Global leader in bio-analytical testing “serial acquirer” Eurofins Scientifics pursues its European marketconsolidation with the takeover of Genoma Group, an Italian specialty diagnostics testing provider (non-invasive pre-natal testing, oncology) and Hygel, a German clinical diagnosis provider mainly operating in Northern Ruhr area.

• MBO partners invested in Icare, a French microbiological analysis specialist previously owned by Private Equity firms Naxicap and Sofimac. The new partner will support the testing services diversification and international acquisitions (Germany, Brazil, US).

• To strengthen its positioning in cosmetics and healthcare, international player in pharmaceutical synthesis and specialty chemicals Novacap acquired two French manufacturers specialized in botanical ingredients (ID Bio) and products for in-vitro diagnosis (H2B).

Therapies: Raise funds to pursue cancer, diabetes and heart diseases scientific developments and complete clinical trials

• French emerging biotech Vivet Therapeutics closeda €37m funding round from a syndicate of venture capitalists to further develop its pipeline of genetherapies for rare and inherited metabolic diseases.

• French clinical stage nanomedicine biotech Nanobiotix raised funds from European and US institutional investors in a private placement to advance the clinical development of its cancer programs.

• Chinese Pharmaceutical company Tasly invested €20m in French-based Pharnext specialized in neurodegenerative disorders and plans to create an R&D joint-venture to develop new molecules.

• French cardiometabolic diseases specialist Valbiotisraised a total of €12.5m during an IPO on Alternext. In line with their 2019 strategy, the resources will be used to increase the R&D team size, to accelerate clinical programs and buy new commercialization licences.

• Biotech company CellProthera raised €8.3m from nine family offices to complete the scientific development of cell therapies for myocardial infarction as well as launch new clinical trials, including in Singapore.

• French biotech Neovacs raised ~€10m in two private placements with US and European biotechnology institutional investors to support the development of its immunotherapy technologies.

Marine biotech: Find partner to capture high growth potential (€6bn+ market in 2025*)

• Nutrition company and Israel-based Maabarotacquired 40% in France-based Algaia, specialized in seaweed-based products. This acquisition reflects its strategy of international and capability expansion.

• HeMarina, the Breton marine biotech specialized in oxygen carriers, raised €8m to further develop and commercialize an innovative carrier solution.

Biotech has been an active segment in H1 2017 with 21 deals. Biotechs focused on diagnosis and testing seek critical mass through acquisitions while therapy developers raise funds to further advance scientific development targeting strategic therapeutic areas. Marine biotech is also on the rise.

* Marine Biotech study by EFIP

Page 9: M&A in Healthcare and Pharma in France - H1 2017 … · M&A in Healthcare and Pharma in ... an innovative plant-based ingredient ... the fifth position to the top 3 in the world Pharma

PwC

Target Country Acquiror Country Type Deal description

Deal

size

(€m)

Target

Revenues

(€m)

Diagnosis & Testing

LABORATOIRES

EUROBIOFR DIAXONHIT FR

Corporate

(100%)

Following the acquisition of InGen Biosciences in 2012, France-

based Diaxonhit acquired its other competitor Eurobio to reach

critical size and build a European leader in in-vitro specialty

diagnosis for research in life-science

29 16

ICARE FR MBO PARTENAIRES FR PE (44%)

MBO partners enters Icare's capital, a microbiological analysis

specialist, by acquiring shares previously owned by Private

Equity firms Naxicap and Sofimac

10 13

HYGEL GE EUROFINS SCIENTIFIC FR

Corporate

(Majority

Stake)

World bio-analytical test leader Eurofins pursues its European

development by acquiring Hygel, a German clinical diagnosis

provider mainly operating in Northern Ruhr area

- 35

GENOMA GROUP IT EUROFINS SCIENTIFIC FRCorporate

(100%)

After several clinical lab acquisitions in France and Germany,

French lab testing group Eurofins acquired the Italian specialty

diagnostics firm Genoma, focused on noninvasive prenatal and

oncology tests, to enter the Italian market and strengthen its

European footprint

- 20

H2B; ID BIO FR NOVACAP FR Corporate

To strengthen its positioning in Cosmetics and Healthcare

markets, Novacap acquired 2 manufacturers specialized in

botanical ingredients (ID Bio) and products for in-vitro diagnosis

(H2B)

- -

Therapies

VIVET

THERAPEUTICSFR

COLUMBUS VENTURE /

HEALTHCAP / KURMA /

NOVARTIS VENTURE /

ROCHE VENTURE /

YSIOS

INT

Early

stage

fund

raising

Biotech Vivet Therapeutics received €37.5m from an

international pool of investors, to fund the development of its

first gene therapy to treat inherited metabolic diseases

38 -

NANOBIOTIX FRINSTITUTIONAL

INVESTORSEU/US

Stock

Market

French clinical stage nanomedicine biotech raised funds from

European and US institutional investors in a private placement

to advance the clinical development of its cancer programs

22 2

PHARNEXT FR TASLY CN

Stock

Market

(12.6%)

Chinese Pharmaceutical company Tasly invested €20m in

Pharnext (Parkinson, Alzheimer…), and plans to create a

Research and Development Joint-Venture. Pharnext will also

license its leader product on the Chinese market

20 0-10

VALBIOTIS FRINVESTORS

(ALTERNEXT)FR

Stock

Market

French biotech Valbiotis raised a total of €12.5m during an IPO

on Alternext, aligned with their 2019 strategy the resources will

be used to increase the R&D team size, to accelerate diabetes

clinical programmes and buy new commercialization licences

13 0-10

CELLPROTHERA FR FAMILY OFFICES FR

PE /

Venture

Capital

Cell regeneration cardiac therapy company CellProthera raised

€8.3m from 9 family offices to complete product development

and launch new clinical trials, including in Singapore

8 0-10

NEOVACS FRINSTITUTIONAL

INVESTORSUS

Stock

Market

French biotech Neovacs raised €6m in a private placement with

US biotechnology institutional investors to support the

development of its immunotherapy technologies in the US

6 0-10

NEOVACS FR EUROPEAN INVESTORS EUStock

Market

French biotech Neovacs raised €3.7m in a private placement

with European investors to support the development of its

immunotherapy technologies

4 0-10

FEELIGREEN FR

FAMILY OFFICES /

INNOVACOM / SEB

ALLIANCE

FR

PE /

Venture

Capital

Derma-therapeutic and Cosmetic company Feeligreen raised

€3.5m from a family office and its historical partners Seb

Alliance and Innovacom to develop activities both in the US and

China

4 0-10

VECT-HORUS FRSCR PROVENÇALE ET

CORSEFR

PE /

Venture

Capital

To fund clinical programs, biotech company specialized in brain

drug vectors Vect-Horus raised €2.5m from family offices and

SCR Provencale et Corse (Banque Populaire Méditerranée's

subsidiary) to fund its next 2 years developments

3 0-10

ACTICOR

BIOTECH FR

CAP DECISIF

MANAGEMENTFR

PE /

Venture

Capital

Backed by Venture Capital fund CapDecisif, Acticor raised

€1.5m to start clinical trial programs for two of its stroke

emergency treatments

2 1

TXCELL FR

BPI FRANCE / AURIGA /

CVIINVESTMENTS /

NYENBURGH

FRStock

Market

French biotech company Txcell, specialized in cellular

immunotherapy, realized a €11m capital increase to finance

new research and development programs

11 1

POXEL SA FR GSA CAPITAL UKStock

Market

Biotech company Poxel, specialized in diabetes treatment

raised funds from new investors to finance product

diversification and its international expansion, especially

focused on Asia

- 0-10

SR2B FR BIOSYNEX FRCorporate

(100%)

To complete its offer in parasitology and tap potential growth in

Africa, South-East Asia and Latin America, quick diagnosis

company Biosynex acquired market pure player SR2B

- 0-10

9

Page 10: M&A in Healthcare and Pharma in France - H1 2017 … · M&A in Healthcare and Pharma in ... an innovative plant-based ingredient ... the fifth position to the top 3 in the world Pharma

PwC10

Target Country Acquiror Country Type Deal description

Deal

size

(€m)

Target

Revenues

(€m)

Marine Biotech

HEMARINA FR

BUSINESS ANGELS /

CMC-CIC INNOVATION /

FORCE29 / FAMILY

OFFICES

FR

PE /

Venture

Capital

HeMarina, the Breton marine biotech specialized in oxygen

carrier, completed its third round and raised €8m from historical

and new investors to further develop and commercialize two

breakthrough carriers for emergency care and organ

preservation applications

8 0-10

ALGAIA (40%

STAKE)FR

MAABAROT PRODUCTS

LTDIS

Corporate

(40%)

Nutrition company and Israel-based Maabarot acquired 40% in

Algaia, specialized in seaweed-based products. This acquisition

aligns with its strategy of international and capability expansion

5 0-10

CARGILL

(ALGINATE

BUSINESS)

FR ALGAIA FR

Corporate

(Majority

Stake)

Algaia acquired Pharmaceuticals company Cargill's alginate

business and its manufacturing plant in Brittany. Algaia plans to

invest €2m in the plant and thus reinforces its position as marine

ingredients specialist

0-20 -

Page 11: M&A in Healthcare and Pharma in France - H1 2017 … · M&A in Healthcare and Pharma in ... an innovative plant-based ingredient ... the fifth position to the top 3 in the world Pharma

PwC

Medtech: PE finances innovation

11

Technical equipment: PE-driven deals reflect capital needs to fund material developments. Deals are domestic

Biggest deal in diagnosis equipment

• ELITech Group, an in-vitro diagnostic products manufacturer and distributor, has been acquired by PAI Partners for €350m. ELITech is willing to play a key role in the consolidation of the IVD market.

• Oncology diagnosis equipment company Vitadxraised €2m from 2 investment funds as well as private investors. Vitadx aims at finalizing the development of its first product, an oncology test using artificial intelligence, to reach commercialization by 2020.

• The only outbound deal in Medtech is US-based neurodiagnosis target Moberg. Micromed, a portfolio company of ArchiMed, a PE investor focused on Healthcare, invested €3m to support innovation in the treatment of emergency brain injuries.

Medical Imagery represents more than a third of deals in technological Equipment

• Big player Supersonic Imagine raised €11.5m from multiple investors to launch a new echography platform.

• Rythm raised €8m from MAIF Avenir to commercialize its sleep data analysing headset (top 10 French Innovator award - MIT 2017).

• Other big player EOS Imaging, specialized in 2D/3D imagery, raised ~€8m to finance its investment program in product design and industrial processes.

• To push the development and commercialization of its skin imagery device, award-winning start-up DamaeMedical raised €2m from a pool of investors.

• Start-up Cardiawave raised €1.4m from business angels to develop its ultrasound imagery device treating aortic valve heart disease.

Dynamic Orthopaedics Care

• In’tech Medical, a surgical orthopaedic manufacturer, raised €78m from Eurazeo PME. The funds will support international growth to reach its goal of doubling revenues in the next 5 years.

• Safe Orthopaedics, specialized in one-time-use devices for spine operations, has increased its capital to finance R&D projects and focus on emerging markets.

• Spine operations smart devices company Spineguard has raised €2m to focus on increasing sales in the US and partnering with industrials.

Without a clear French champion as yet, medical equipment and disposable medical devices segments show signs of consolidation

• Within the disposal medical devices segment, Novomed acquired Mediq France and Amatsigroup took over Disposable Lab.

• Within the medical equipment segment, Bastide Le Confort Medical enhanced its product portfolio through four acquisitions, consolidating its position in a growing and partially fragmented market.

E-health platforms and services raise funds to reach commercialization and roll-out phases

• Care Labs, creator of the “Chèques Santé” raised ~€5m, backed primarily by private equity fund IXO, to develop its offer in the US and Canada.

• Facilitating remote medical monitoring, start-ups Hellocare and Nouveal e-santé both raised €1m to respectively develop their telemedicine and medical follow-up apps. Nouveal e-santé was backed by Mutual health insurance Malakoff Médéric.

• Oscadi, backed by Nexa, raised funds to commercialize its ultrasound device made for Ipad.

Medtech has been the 2nd most active segment M&A-wise, following Private Healthcare, with 25 deals completed over the 6-month period. A vast majority of the deals were domestic (80%). PE are the key Medtech deal makers (~60%) funding mainly technological equipment manufacturers. Consolidation ongoing in some sub-segments.

Page 12: M&A in Healthcare and Pharma in France - H1 2017 … · M&A in Healthcare and Pharma in ... an innovative plant-based ingredient ... the fifth position to the top 3 in the world Pharma

PwC

Target Country Acquiror Country Type Deal description

Deal

size

(€m)

Target

Revenues

(€m)

Technical equipment

THE ELITECH GROUP FR PAI PARTNERS FR

PE

(Majority

Stake)

PAI partners invested in in-vitro diagnosis manufacturing

specialist ELITech Group to support acquisitions in both

mature and emerging markets

350 125

IN'TECH MEDICAL FR

EURAZEO PME /

EDMOND DE

ROTHSCHILD

INVESTMENT

PARTNERS /

MANAGERS

FR

PE

(Majority

Stake)

Surgical orthopaedics manufacturer In'Tech Medical, which

operates in France, the US and Malaysia, welcomed a new

majority stakeholder to support its international growth and

double its revenues in the next 5 years

78 55

SUPERSONIC IMAGINE FR MULTIPLE INVESTORS FRStock

Market

Supersonic Imagine successfully managed a €11,5m share

capital increase, to launch its new echography platform and

finance its development

12 23

EOS IMAGING FR

BPIFRANCE

INVESTISSEMENT /

ACTIONNAIRES /

EURONEXT (BOURSE)

FR

Stock

Market

(Minority

Stake)

2D/3D imagery company EOS Imaging realized a €7,8m fund

raising to accelerate its investments in industrial processes

and product conception, aiming at improving its net

operational profitability. BPI, historical shareholder of the

company, participated for €1,7m

8 31

RYTHM FR MAIF AVENIR FR

PE /

Venture

Capital

Rythm raised €8m through health insurance fund MAIF

Avenir, in order to commercialize in France a sleeping data

analyzing headset, its first product

8 -

SAFE ORTHOPAEDICS FR

KURMA PARTNER /

FINANCIERE ARBEVEL /

SIGMA GESTION /

IDINVEST / RMA AM /

TURGOT AM

FR

Stock

Market

(Minority

Stake)

Safe Orthopaedics raised €5,8m to finance R&D projects and

the development of its operations in Europe and in developing

markets

6 3*

ROBOCATH FR

M CAPITAL PARTNERS

(EX MIDI CAPITAL) /

NORMANDIE

PARTICIPATIONS / GO

CAPITAL / NCI GESTION

/ BUSINESS ANGEL(S)

FR

PE /

Venture

Capital

(Majority

Stake)

Robocath raised €4,7m through multiple investors to pursue

its internal growth strategy and commercialize its first medical

robotic platform in Europe and Middle-East by 2018

5 0-20

MOBERG US MICROMED FR

Corporate

/ Private

Investors

(Minority

Stake)

Micromed, a portfolio company of ArchiMed Healthcare

investment fund, acquired minority stake in the US-based

manufacturer Moberg to support innovation in the precision

management of critical brain injuries

3 3

SPINEGUARD FR

INVESTISSEURS

INSTITUTIONNELS 'LP'S‘

/ SALARIES /

ACTIONNAIRES

FRStock

Market

Smart devices for spine operations company Spineguard

raised €2m from European institutional investors, employees

and shareholders to develop its sales in the US and also

contract partnerships with industrials

2 8

DAMAE MEDICAL FR

KURMA PARTNERS /

IDINVEST PARTNERS /

NEWS INVEST /

PARTECH VENTURES /

BUSINESS ANGEL(S)

FR

PE /

Venture

Capital

(Minority

Stake)

To push the development and commercialization of its main

product, skin-specialized imagery start-up Damae raised €2m

from a pool of investors, led by Kurma Partners and Idinvest

2 0-20

VITADX FR

GO CAPITAL / AURIGA

PARTNERS /

PERSONNE(S)

PHYSIQUE(S)

FR

PE /

Venture

Capital

Diagnostis Medtech Vitadx raised €1,6m through 2

investment funds GO (Capital and Auriga IV, private

investors) to finance the development and commercialization

of its main product, an oncology test using artificial

intelligence

2 0-20

CARDIAWAVE FR

ANGEL SOURCE / PARIS

BUSINESS ANGELS /

ANGELS SANTÉ /

ANGELS BAY INVEST

FR

Early

stage

fund

raising

Start-up Cardiawave raised €1,4m to fund the development of

its single product, an ultrasound medical device treating aortic

valve heart disease

1 0-20

DIAGAST FRCROISSANCE NORD-

PAS-DE-CALAIS / GEIFR

PE

(Minority

Stake)

Croissance Nord Pas de Calais and GEI invested in

transfusion specialist Diagast, a subsidiary of l'Etablissement

Français du Sang. The capital will be used to launch a new

product and double production size

- 35

12

* Note: 2015 revenues

Page 13: M&A in Healthcare and Pharma in France - H1 2017 … · M&A in Healthcare and Pharma in ... an innovative plant-based ingredient ... the fifth position to the top 3 in the world Pharma

PwC 13

Target Country Acquiror Country Type Deal description

Deal

size

(€m)

Target

Revenues

(€m)

E-Health

CARE LABS FR

IXO PRIVATE EQUITY /

SORIDEC / SOCIÉTÉ

FINANCIÈRE DU

LANGUEDOC

ROUSSILLON /

SOFIMAC

FR

PE / Venture

Capital

(Minority

Stake)

“Health Cheques” company Care Labs raised €5,2m, IXO

PE being the major investor, to strenghten its leadership

position in France and to develop its offer globally,

especially in Anglo-Saxon countries

5 -

NOUVEAL E-SANTÉ FR MALAKOFF MÉDÉRIC FR Corporate

Lyon-based start-up Nouveal e-santé received €1m from

Mutual health insurance Malakoff Mederic to accelerate

the development of its digital assistant for medical follow-

up

1 0-20

HELLOCARE FR INOVALIS / P.FACTORY

FR &

foreign

investors

Early stage

fund raising

Created in 2016, French e-Health Hellocare raised €1m

from start-up accelerator and real estate investment fund

to support the development of its telemedicine app

1 -

OSCADI FR NEXA FRPE (Minority

Stake)

Oscadi, based in La Reunion, raised funds from the local

agency for development, to support the commercialization

of the first Ultrasound made for iPad

- 0-20

Multiple/single use equipment

HYGECO FRABENEX CAPITAL /

MANAGERSFR

MBO

(Majority

Stake)

Dutch Group De Facultatieve subsidiary Hygeco

completed Management Buy-Out with the support from

Abenex Capital which takes a majority stake. The plan is

to further develop medical devices manufacturing activities

in France and abroad

- 31

MEDIQ FRANCE (ex NM

MEDICAL)FR NOVOMED GROUP FR

Corporate

(100%)

To build a French medical equipment champion in Europe

and accelerate its digital transition, disposable medical kits

Novomed group acquired Mediq France's shares from its

Dutch parent company

- 26

MMO INTERNATIONAL FR MEDSTROM LTD. UK

Corporate

(Majority

Stake)

Acting as a UK distributor for the French-based hospital

beds and furniture manufacturer MMO International,

Medstrom acquired a controlling stake in MMO to become

the only UK independent hospitals bed manufacturer

- 16*

ATS / AIR+ SANTÉ /

MEDSOFT / BORDO²

MÉDICAL

FRBASTIDE LE CONFORT

MEDICALFR

Corporate

(100%)

Medical home care specialist Bastide Le Confort Medical

enhanced its product portfolio through four acquisitions,

consolidating its position in a growing and partially

fragmented market

- 8

DISPOSABLE LAB FR AMATSIGROUP FR

Corporate

(Majority

Stake)

After acquiring the Belgian process development and

biologicals manufacturing company Q-Biologicals in 2016,

Amatsigroup acquired the medtech company Disposable

Lab in January 2017

- 2

PULSSAR

TECHNOLOGIESFR TECAN GROUP LTD CH Corporate

Swiss laboratory instruments company Tecan extended its

product range in liquid handling technologies through the

acquisition of French-based medtech Pulssar, specialized

in manufacturing pumps for in-vitro diagnostic

- 0-20

RTD FR DENTSPLY SIRONA US

Corporate

(Majority

Stake)

The American dental solutions company Dentsply Sirona

acquired its former French supplier RTD to offer a more

comprehensive offer for dental professionals, and they will

benefit from geographical and product-related synergies

- -

Other

REVOL GROUPE FR PROCHILAB FR

Corporate

(Majority

Stake)

Through the acquisition of the Revol Group, a selling

platform for laboratories, medtech Prochilab aims at

creating a central purchasing organization for big

Pharmaceutical companies wanting to rationalize

purchases

- 4,5

* Note: 2015 revenues

Page 14: M&A in Healthcare and Pharma in France - H1 2017 … · M&A in Healthcare and Pharma in ... an innovative plant-based ingredient ... the fifth position to the top 3 in the world Pharma

PwC14

Page 15: M&A in Healthcare and Pharma in France - H1 2017 … · M&A in Healthcare and Pharma in ... an innovative plant-based ingredient ... the fifth position to the top 3 in the world Pharma

PwC

Private Healthcare: Market consolidation by corporate companies and PE funds

15

Clinics: Ongoing consolidation at national and regional levels continues.

• Merger of "equals" in the French private clinics with the take over of the 3rd largest clinic group MedipolePartenaires by number two Elsan. The new company will be the French co-leader with Généralede Santé which was acquired by Ramsay in 2014.

• Private Healthcare company Groupe Clinique Saint-Gatien acquired Polyclinique Bordeaux Tondu from C2S. The group, which is primarily present in Ile-de-France, is reinforcing its position in the Bordeaux area.

• Normandy-based Clinique DéveloppementGroup raised €15m to acquire Le Normandy, one of the largest rehabilitation centers in France.

Elderly care: PE funds and Corporates’ appetite for “silver deals”. Large room for consolidation in retirement housing

• DomusVi’s founder (SRS) partners with ICG, a UK PE fund, to acquire the majority stake from PAI Partners. The Group operates 334 establishments both in France and Spain and will continue its European expansion strategy.

• Colisée Group acquired 12 nursing homes from GDP Vendôme. In April, the Group also welcomed IK Investment Partners as its new majority shareholder as a replacement for Eurazeo PME. The management team and the founder reinvested alongside IK to support the growth strategy of the Group.

• Domidep raised €90m to support its external growth strategy in France.

• Continuing its European consolidation strategy, Orpea acquired Anavita, making the company an elderly care market leader in Czech Republic, and the Austrian group Dr. Wagner.

• After entering Belgium in 2016, Korian reinforces its position as local market leader with the acquisition of 8 additional facilities.

• As part of its diversification strategy, La Posteentered the Healthcare market by acquiring the home care company Asten Santé.

Eyewear: Largest player in the eyewear market

• French lens manufacturer Essilor announced the merger with Italy top glasses maker Luxottica(RayBan, Oakley) to capture growth of prescription glasses and sunglasses driven by ageing population and increasing awareness about eye care. Essilor also strengthens its online retail.

Medical biology laboratories: Continuing interest for M&A to further consolidate the fragmented French market and expand internationally

• PAI Partners sold the French leading operator of biological testing laboratories Cerba Healthcare to Partners Group and PSP. The objective is to double sales within 7 years in EMEA and extend its testing range.

• Biogroup LCD group pursues its domestic market consolidation with the takeover of Les LaboratoiresAssociés which operates 10 laboratories in the West of France and Laboratoire St-Remy positioned in the East of France.

Other Healthcare

• Ecolab, global leader in water, hygiene and energy technologies acquired French-based LaboratoiresAnios from co-owners and PE fund Ardian to reinforce its position in the hygiene and disinfection products for hospitals and Healthcare operators.

Private Healthcare is the most dynamic segment (27 deals) and has witnessed significant consolidation in the clinics, retirement homes and biological testing laboratories sub-segments. French Private Healthcare corporates are very active, playing a part in more than half of deal activity. PE funds also remain very active in the sector.

Page 16: M&A in Healthcare and Pharma in France - H1 2017 … · M&A in Healthcare and Pharma in ... an innovative plant-based ingredient ... the fifth position to the top 3 in the world Pharma

PwC16

Target Country AcquirorCou

ntry Type Deal description

Deal

size

(€m)

Target

Revenues

(€m)

Medical Biology Laboratories

CERBA Healthcare FR PARTNERS GROUP / PSPCH/C

A

PE (Majority

Stake)

PAI Partners sold Cerba Healthcare to the Swiss PE fund

Partners Group and the Canadian pension fund PSP.

Cerba's objective is to double its sales size within seven

years in EMEA, and extend its testing range

1 800 630

LES LABORATOIRES

ASSOCIÉSFR

BIOGROUPFR

Corporate

(Majority

Stake)

Biogroup LCD, mainly located in Ile-de-France and

eastern France, pursues its domestic market

consolidation with the takeover of Les Laboratoires

Associés which operates 10 laboratories in western

France

- 15

LABORATOIRE SAINT-

REMYFR BIOGROUP-LCD FR

Corporate

(100%)

France third biggest medical analysis laboratory Biogroup

LCD pursues its acquisition strategy with the takeover of

Laboratoire St-Remy from its founder to consolidate its

volume and position in eastern part of France

- 8

MECHEM SGP EUROFINS SCIENTIFIC FR Corporate

In line with its international testing services consolidation

strategy, Eurofins Scientic acquired Mechem which will

become its entry platform in Singapore

- 0-10

Clinics

MEDIPOLE

PARTENAIRESFR GROUPE ELSAN FR Corporate

Merger of "equals" in the French private clinical sector

with the take over of the 3rd largest clinic group Medipole

Partenaires by the 2nd one Elsan. Elsan will have to sell

3 clinics to meet with French competition regulation

authority requirements

- 866*

POLYCLINIQUE DE

BORDEAUX TONDUFR

GROUPE CLINIQUE SAINT-

GATIENFR

Corporate

(Majority

Stake)

Private Healthcare company Groupe Clinique Saint-

Gatien acquired Polyclinique Bordeaux Tondu from C2S.

The group, well implanted in Ile-de-France, is reinforcing

its position in the Bordeaux area, where it already owns

two other clinics

30 15

LE NORMANDY FRGROUPE CLINIQUE

DEVELOPPEMENTFR

Corporate /

PE (Minority

Stake)

Normandy-based Clinique Développement group

acquired rehabilitation center and health institution Le

Normandy (Granville), one of the largest rehabilitation

center in France

- 36

CLINIQUE SOURDILLE

(80% STAKE)FR GROUPE ELSAN FR

Corporate

(80%)

Elsan reinforced its position in Pays de la Loire through

the acquisition of the eye clinic clinic Sourdille in Nantes.

The ambition of the Group is to transform the clinic into

an European eye care center

- 15

CENTRE CLINIQUE DE LA

PORTE DE SAINT-CLOUDFR

AMERICAN HOSPITAL OF

PARISFR

Corporate

(Majority

Stake)

The American Hospital of Paris acquired Centre Clinique

de la Porte de Saint-Cloud, and thus progresses towards

its 2020 Horizon strategic plan and complete its oncology

offer

- 10

CADE FR DIAVERUM SW Corporate

Renal care company Diaverum acquired the dialysis

center Cade in Ile-de-France, strengthening its foothold

in the region, where it already acquired two centers in

2016

- 2

ACURA KLINIKEN

RHEINLAND-PFALZ | IRDDE/CH RAD-X FR

Corporate

(100%)

French-based RAD-x acquired two health centers in

Switzerland and Germany, participating in the medical

imagery’s consolidation in the European market

- -

* Note: 2015 revenues

Page 17: M&A in Healthcare and Pharma in France - H1 2017 … · M&A in Healthcare and Pharma in ... an innovative plant-based ingredient ... the fifth position to the top 3 in the world Pharma

PwC 17

Target Country AcquirorCou

ntry Type Deal description

Deal

size

(€m)

Target

Revenues

(€m)

Elderly Care

DOMUSVI FR ICG / SRSUK/F

R

Individual /

PE (majority

stake)

ICG and SRS (holding of the founder of the Group)

acquired the majority stake held by PAI Partners in

DomusVi. The Group, which operates 334 facilities, is the

third private operator of nursing homes in Europe with

leading positions in France and in Spain. The investment

aims at financing a new phase of development.

2 300 1 300

COLISEE GROUP FR

IK INVESTMENT

PARTNERS LIMITED /

TEYCHENEY FAMILY

UK/F

R

Individual /

PE (majority

stake)

IK Investment Partners (“IK”) acquired a majority stake in

Colisée Group. The management team and the founder

reinvested alongside IK. Colisée will continue its growth

strategy both organic and through add-on acquisitions in

France and across Europe.

650 215

DOMIDEP FR

UI GESTION / BPIFRANCE

INVESTISSEMENT / BNP

PARIBAS

DEVELOPPEMENT /

CREDIT AGRICOLE

REGIONS

INVESTISSEMENT

FRPE (Minority

Stake)

Domidep raised €90m backed by its current investors to

support its external growth strategy in France, by

acquiring independent facilities or small groups

90 200

ASTEN SANTE FR GROUPE LA POSTE FRCorporate

(53%)

La Poste entered the Healthcare market and realized its

biggest acquisition in the service sector with home

Healthcare company Asten Santé, reflecting the

diversification strategy of La Poste

- 100

DR. WAGNER AT ORPEA FR Corporate

Orpea continues its acquisitions in central Europe with

the take over of the Austrian group Dr. Wagner, a major

player in the Austrian elderly care market

- 60

ANAVITA CZ ORPEA FR CorporateOrpea acquired Anavita, making the Group an elderly

care market leader in Czech Republic - 7

VOTRE OPTICIEN A

DOMICILEFR IMPACT PARTENAIRES FR PE

Impact Partenaires, specialized in social impact

investments, invested an undisclosed amount in French

optician company VOAD, specialized in home

consultation for dependent patients

- 0-20

8 nursing homes in

BelgiumBE KORIAN FR Corporate

After entering the Belgian elderly care market in 2016,

Korian reinforces its position as local market leader with

the acquisition of 8 new facilities

- -

2 clinics located in Salon

de Provence and IstresFR ALMAVIVA SANTE FR Corporate

Almaviva Santé acquired 2 clinics from Ramsay

Générale de Santé to strengthen its coverage in

Provence Alpes Côte d’Azur

- 21

INCISIV FR IMPACT PARTENAIRES FR PE

Created in 2013, Incisiv, a dental care provider for

seniors and disabled persons raised fund to deal with a

distress situation

- 0-20

12 nursing homes of GDP

VENDOMEFR GROUPE COLISEE FR Corporate

Still very active in the sector’s consolidation movement,

Colisée pursued its external growth strategy in France

with the acquisition of 12 elderly care centers

- -

CETTEFAMILLE

(CANNETROTTER)FR

FAMILY OFFICES / MAIF

INVESTISSEMENTFR

PE / Venture

Capital

(Minority

Stake)

CetteFamille backed by a family office and Maif

Investissement Social et Solidaire raised €0,5m to work

on their development before exporting its business model

in southern Europe

1 0-20

Other

ESSILOR-LUXOTTICA FR LUXOTTICA / DELFIN IT Stock Market

French leading lens manufacturer Essilor and Italian

company Luxottica have merged to become a global

eyewear powerhouse. Synergies are expected to reach

between €400m and €600m

46 000 15 537

LABORATOIRES ANIOS FR ECOLAB INC. US Corporate

Ecolab, global leader in water, hygiene and energy

technologies acquired French-based Laboratoires Anios

to reinforce its position in the hygiene and disinfection

products manufacturing for the Healthcare market

750 228

OXYMASTER CO AIR LIQUIDE FR Corporate

Air Liquide pursues its growth strategy in Home

Healthcare services in South America with the acquisition

of Oxymaster, national leader in Colombia

- 9

INTERNATIONAL

HEALTH SOLUTIONS

(IHS)

FR/AFRI

CAINTERNATIONAL SOS SGP Corporate

In line with its 2020 strategic plan, Europ Assistance

decided to divest its African medical onsite service

business, taken over by Singapore-based International

SOS

- -

Page 18: M&A in Healthcare and Pharma in France - H1 2017 … · M&A in Healthcare and Pharma in ... an innovative plant-based ingredient ... the fifth position to the top 3 in the world Pharma

PwC

CRO/CMO are investing in Pharmaceuticals’ non-core assets…

• Contract Development and Manufacturing Organization Cenexi acquired Merck Sharp and Dohme’s Schering Plough Pharmaceutical plant to solve a production’s capacity issue and reach its goal of doubling revenue by 2020.

• Pharmaceutical company Bertin Pharma sold its non-core Pharmaceutical development assets to CDMO Amatsi (which also acquired the medtechcompany Disposable Lab in H1 2017).

...consolidating the local and European/global markets

• Unither Pharmaceuticals, French-based CDMO specialized in sterile single-doses, has been acquired by Ardian Mid Cap Buyout, Keensight Capital and Parquest Capital for c. €675m. The capital will be used for its international development in the US and South America where it already operates manufacturing plants, and its expansion in Asia.

• Leader in biopharmaceutical testing CDMO Eurofins Scientific acquired Canadian CDMO Alphora, to strengthen its drug development business unit. Eurofins Scientific is the serial acquirer in H1, with four acquisitions (2 in Biotech, 1 in Private Healthcare and 1 pure CRO/CDMO).

• Pharmaceutical CMO P&B Group acquired distress family-owned CMO Laboratoire M Richard to consolidate the local market, and plans to invest €2m in the production site to develop dietary supplements and new technologies.

• German subsidiary of analytic instrumentation

company Shimadzu acquired CDMO French

company AlsaChim to extend its portfolio of analytical standards.

Others: the continuing consolidation of the CRO/CDMO* market

18

The Others segment involved 9 deals during H1 2017. Contract Research/ Manufacturer Organizations (CRO, CMO) is the most active sub-segment with 8transactions. CRO/CMO’s key objectives are to consolidate the market, and build capability and scale.

* Contract Research Organization (CRO), Contract Development and Manufacturing Organization (CDMO)

Page 19: M&A in Healthcare and Pharma in France - H1 2017 … · M&A in Healthcare and Pharma in ... an innovative plant-based ingredient ... the fifth position to the top 3 in the world Pharma

PwC19

Target Country Acquiror Country Type Deal description Deal size

(€m)

Target

Revenues

(€m)

Sub-Contracting (Contract Research Organization - CRO, Contract Manufacturing Organization - CDMO/CMO)

UNITHER

PHARMACEUTICALSFR

ARDIAN,

KEENSIGHT

CAPITAL,

PARQUEST CAPITAL

FR

PE

(Majority

Stake)

Unither Pharmaceuticals, a French-based CDMO

specialized in sterile single-doses, was acquired by Ardian,

Keensight and Parquest. The capital will be used to

accelerate its growth in the US and South America, where

it already operates manufacturing plants, and begin

expansion in Asia

675 260

ALPHORA RESEARCH CAEUROFINS

SCIENTIFICFR

Corporate

(100%)

Leader in biopharmaceutical testing, Eurofins Scientific,

acquired Alphora, a Canadian contract research,

development and manufacturing company. Eurofins thus

strengthens its integration of drug development processes

- 20

BERTIN Pharma FR AMATSIGROUP FR Corporate

Contract Research Organization Bertin Pharma sold its

non-core Pharmaceuticals development activity to industry

pure player Amatsigroup

- 16

JACO FR SANNER GMBH DE

Corporate

(Majority

Stake)

German desiccant packaging manufacturer for

Pharmaceutical and Healthcare sectors Sanner completed

its first major acquisition with Plastina Holding, the parent

company of the French-based printed and unprinted

plastic tubes manufacturer

- 13

IMMR FRMBO PARTENAIRES

/ MANAGERSFR

MBO

(Majority

Stake)

IMMR, a Contract Research Organization specialized in

pre-clinical surgery research sold a majority stake to MBO

Partenaires and Managers with the objective to finance its

future growth

- 10

LABORATOIRE M

RICHARDFR P&B GROUP FR

Corporate

(70%)

Pharmaceutical and Cosmetics sub-contractor P&B Group

integrated distress family-owned Laboratoire M Richard

and plan to invest ~€2m to on the production site and in

new technologies

- 5

ALSACHIM FRSHIMADZU EUROPA

GMBHDE

Corporate

(100%)

To enhance its analytical standards portfolio, Germany-

based Shimadzu acquired AlsaChim, a French contract

research, development and manufacturing company

- 0-20

SCHERING PLOUGH

(HEROUVILLE-SAINT-

CLAIR PLANT)

FR CENEXI FR Corporate

To reach its goal of doubling revenue size by 2020 and

solve a production capacity issue, CDMO Cenexi acquired

the Schering Plough Pharmaceutical plant from Merck

Sharp and Dohme

- -

Retail

SANTÉDISCOUNT FR ARDIAN FR PE

ParaPharmacy online retailer Santédiscount opened its

capital to private investment company Ardian, to take

advantages of upcoming external growth opportunities in

Europe

- 15

Page 20: M&A in Healthcare and Pharma in France - H1 2017 … · M&A in Healthcare and Pharma in ... an innovative plant-based ingredient ... the fifth position to the top 3 in the world Pharma

PwC

Our involvement during H1 2017

20

CADE

2017Assisted Boehringer

Ingelheim in the separation of its OTC business sold to

Sanofi.

2017Assisted Merial on

separation matters in the context of its disposal of c.10 Animal Health vaccines and NSAIDs to CEVA following

its acquisition by BI.

2017Provided financial, tax, IT

and environmental due diligence, and tax structuring

services to Partners Group for their acquisition of

Cerba Healthcare, a leading European operator of

medical biology laboratories.

2017Financial, tax and social due

diligence to one Private Equity fund in connection

with the not completed acquisition of Unither.

2017Provided financial, legal and

social due diligence to Recherche Techniques

Dentaires (RTD), a company that patents and commercialises

fiber-reinforced endodontic posts, for their divestiture to

Dentsply Sirona.

2017Provided financial due

diligence to ICG and SRS for the acquisition of the majority stake of PAI

Partners in DomusVi, a group of care nursing homes

present in France andin Spain.

2017Provided financial due

diligence to Eurazeo PME for the acquisition of a majority stake in In’Tech Medical, an industry leader in surgical

instruments for the orthopaedic industry.

2017Provided financial, IT, tax, tax structuring, legal and

social due diligence to 3i for the acquisition of a majority

stake in Ponroy Santé, a leader in the natural

Consumer Healthcare industry in France.

2017Provided financial, tax, and

social due diligence to Diaverum for their

acquisition of CADE (Centre d’Autodialyse

d’Epinay), an auto-dialysis center based in the

Paris area.

Page 21: M&A in Healthcare and Pharma in France - H1 2017 … · M&A in Healthcare and Pharma in ... an innovative plant-based ingredient ... the fifth position to the top 3 in the world Pharma

PwC21

Confidential

2017Support Management of a

major Pharma co in the definition of its e-health

development strategy

2017Post merger Integration

support following Ipsen'sacquisition of Merrimack's

oncology assets

2017Financial and operational

due diligence to HRA Pharma for the acquisition of

Compeed from J&J.

2017Provided financial, tax, legal

and social due diligence to IK Investment Partners for the

acquisition of a majority stake in Group Colisée, a

leading player in the elderly care segment in France.

2017Financial and tax due

diligence to two Private Equity in connection with

the not completed acquisition of Laboratoires

SERB.

2017Financial due diligence to

Sanofi for the acquisition of Protein Sciences in the US.

2017Performed a carve out due

diligence and synergy review for HRA Pharma in the

context of its acquisition of the Compeed brand.

2017Provided Financial due

diligence to La Poste Silver for their acquisition of Asten

Santé, a private company specialised in ambulatory

care and homecare services.

2017Provided financial due

diligence to Montagu Private Equity

for the refinancing of Arkopharma, a

pharmaceutical laboratory specialised in phytotherapy.

Page 22: M&A in Healthcare and Pharma in France - H1 2017 … · M&A in Healthcare and Pharma in ... an innovative plant-based ingredient ... the fifth position to the top 3 in the world Pharma

PwC

• Identify and assess value creation levers and related financial impact with fully integrated due diligences: Finance, Strategy, Operations inc.carve out, and ESG – Environment, Social, Governance, Tax & Legal aspects

• Assist, prepare and negotiate transition contracts

• Plan & execute Take Over (“Day-1” plan)

• Define Integration Strategy

• Prepare 100-Day plan

• Set up Integration Management Office

• Deep dive into target’s business and operational performance and design value creation plan

• Execute 100-Day plan

• Assist on the integration / transformation and track synergy delivery

• Manage change and acculturation

• Corporate and Business Unit strategy

• Determine and validate deal rationale

• Identify potential acquirers or build-up opportunities and assess Target’s potential

• Prepare divestment and conduct carve-out project

• Review strategy, identify further growth opportunities and assess potential

• Diagnose and improve operational performance (sales and marketing, supply chain, manufacturing, footprint, support functions…)

• Turnaround and restore profitability with restructuring plan

• Review ESG risks and opportunities and assist on ESG strategic plan

PwC Deals Strategy & Operations

22

2

Ops.

Fin.

Strat.

1

5

3

Services provided by Deals Strategy & Operations teams along the Deal cycle

4

Thought leadership

Strategy

Pre deal

Deal execution

1 2

4

5 3Deal cycle

supports Private Equity and Corporates in every steps of their acquisition, integration and divestment processes

Page 23: M&A in Healthcare and Pharma in France - H1 2017 … · M&A in Healthcare and Pharma in ... an innovative plant-based ingredient ... the fifth position to the top 3 in the world Pharma

PwC23

Page 24: M&A in Healthcare and Pharma in France - H1 2017 … · M&A in Healthcare and Pharma in ... an innovative plant-based ingredient ... the fifth position to the top 3 in the world Pharma

PwC

Your contacts in France

24

Benoit Cambournac

Partner - PwC TransactionsHealthcare Leader

[email protected]

+33 1 56 57 71 38

Anne-Lise Glauser

Partner - Strategy&

[email protected]

+33 1 56 57 84 53

Loic Le Claire

Partner - PwC Société d’Avocats

Health Industries Leader

[email protected]

+33 1 56 57 45 51

Marion Le Moign

Marketing & Business Development Health industries

[email protected]

+33 1 56 57 17 54

Transactions Deals Strategy & Operations

Health industries

Philippe Loiselet

Partner - Strategy&

[email protected]

+33 1 56 57 59 41

Thomas Abier

Manager - Strategy&

[email protected]

+33 1 56 57 82 47

Philip Dykstra

Partner - PwC TransactionsPharma & Life-Sciences Leader

[email protected]

+33 1 56 57 82 06

Pierre-Mikhael Voyer

Senior Manager - PwC Transactions

[email protected]

+33 1 1 56 57 76 64

Cécile Debin

Partner - PwC Société d’Avocats - Transactions

[email protected]

+33 1 56 57 81 93