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M 1.Profilul Thelper 2 2.Reactia de Hsensibilitate de tip 1 3.Infectii si neoplazii la pacientii transplantati 4.Raspunsul imun antitumoral nespecific 1.Profilul T helper 2 -sursa primara: TH2, TC2 , cel NK1.1, TCR γδ , mastocite, eozinofile, cel rezidente -interleukine implicate: IL4, IL5, IL6, IL9, IL 13 IL4 -promoveaza profilul TH2, inhiba profilul TH1 -stimuleaza LB si sinteza IgE, stimuleaza cresterea si functiile mastocitului si eozinofilului -inhiba sinteza de monokine -stimuleaza macrofagele cu determinarea de sitneza de arginaza si colagen si promovarea fagocitozei microbilor IL5 -prezinta efecte pe eozinofile: -stimulare hematopoieza si eliberare medulara -chemotaxie, expresia VCAM -activare si degranulare -prelungirea supravieturii tisulare prin inhibarea apoptozei IL9 -este factor de crestere si activare a mastocitelor -proliferarea LT, efect antiapoptotic peLT -prelungirea supravietuirii tisulare a eozinofilelor

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imunologie

Transcript of M

Page 1: M

M

1.Profilul Thelper 2

2.Reactia de Hsensibilitate de tip 1

3.Infectii si neoplazii la pacientii transplantati

4.Raspunsul imun antitumoral nespecific

1.Profilul T helper 2

-sursa primara: TH2, TC2 , cel NK1.1, TCR γδ , mastocite, eozinofile, cel rezidente

-interleukine implicate: IL4, IL5, IL6, IL9, IL 13

IL4

-promoveaza profilul TH2, inhiba profilul TH1

-stimuleaza LB si sinteza IgE, stimuleaza cresterea si functiile mastocitului si eozinofilului

-inhiba sinteza de monokine

-stimuleaza macrofagele cu determinarea de sitneza de arginaza si colagen si promovarea fagocitozei microbilor

IL5

-prezinta efecte pe eozinofile:-stimulare hematopoieza si eliberare medulara

-chemotaxie, expresia VCAM-activare si degranulare

-prelungirea supravieturii tisulare prin inhibarea apoptozei

IL9

-este factor de crestere si activare a mastocitelor

-proliferarea LT, efect antiapoptotic peLT

-prelungirea supravietuirii tisulare a eozinofilelor

-timopoieza, hematopoieza

-secretie de mucus, hiperplazia celulelor calciforme

IL13

-prezinte efecte sinergice cu IL4

Page 2: M

-efecte profibrotice in bolile inflamatorii cronice: astm, fibroza pulmonara, sclerodermie, boli parazitare

-stimuleaza sinteza de mucus in astm

-stimuleaza recrutarea de granulocite si monocite in tesuturi


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