M ultiscale modelling to predict the risk of osteoporotic bone fractures

$: M ultiscale modelling to predict the risk of osteoporotic bone fractures$
Multiscale modelling to predict the risk of osteoporotic bone

fracturesVPHOP Integrated project

Copyright © 2008-2012 VPHOP Consortium - All right reserved 2

Osteoporosis is a killer• OP fractures kill as many women as breast

cancer • 30 to 50% of all women and 15 to 30% of all

men will face an osteoporotic fracture in their lifetime

• 4,000,000 fractures every year cost Europe €30,000,000,000

• Forecast to double by 2050• 250,000 elders will die of related

complications within 12 months, all others will remain impaired


The VPHOP Consortium

• 21 partners• 7 industrial partners• 5 clinical centres• Research leaders in:

Biomechanics, biomaterials, computer sciences, biomedical informatics, mechanobiology, CAS, technology assessment, medical imaging & instrument.


EOSTM Dual Energy system

• Scanning area: 5-175 cm (sitting - upright)

• Sim. bi-planar acquisition, 20 s, head-to-toe

• Low dose (÷ 10 vs. film/screen)• 3D reconstruction of ext. geometry• Bi-planar DXA


Actibelt®

• 3D accelerometer integrated in belt buckle

• Objective measurement of neuromuscular condition during ambulatory visit

• Monitoring long term activity (5 days)


Organ-level Model

Bone RemodellingModel

AugmentationModel

Tissue-levelModel

Clinical workflow

Body-level Model

Loading spectru

m

Constitutive

Equation

Personalised riskof fracture

Dise

ase

& ph

arm

a(p

re-

com

pute

d) Effect of augmentation


VPHOP PR(t) curve [predicted]


Disclaimer• VPHOP is a project co-funded by the European

Commission Seventh FRAMEWORK PROGRAMME• The research reported upon in this presentation has

either directly or indirectly been supported by the European Commission, Directorate General Information Society and Media, Brussels.

• The results, analyses and conclusions derived there from reflect solely the views of its authors and of the presenter.

• The European Community is not liable for any use that may be made of the information contained therein.

M ultiscale modelling to predict the risk of osteoporotic bone fractures

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