Lymphatic System Overview
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Transcript of Lymphatic System Overview
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Lymphatic System Overview
Immune ResponseSpring 2007
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Functions
Draining interstitial fluids Return lymph fluid to veins
Transporting dietary lipids Protecting against invasion
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Lymphatic Vessels Lymphatic capillaries
Slightly larger than blood capillaries Allow interstitial fluid to flow in but not out
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Lymphatic Vessels Cap. unite to form lymphatic vessels
Resemble veins Thinner walls and more valves Lymph nodes-masses of B cells & T cells
Thoracic Duct Drains most of the body
Right Lymphatic Duct Drains upper right side of body
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Organs
2 groups based on function Primary lymphatic organs
Sites where stem cells mature into B cells & T cells
Red bone marrow & thymus Secondary lymphatic organs &
tissues Lymph nodes, spleen, lymphatic nodules
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Thymus Consists of T cells,
macrophages, and epithelial cells
Produce thymic hormones Promote the
proliferation & maturation of T cells
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Lymph Nodes 600 bean shaped organs Usually occur in groups Contain B cells that develop into
plasma cells Secrete antibodies, T cells, &
macrophages Filter lymphatic fluid Method of metastasis of cancer
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Lymph Node
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Spleen Largest mass of lymphatic tissue in
body 2 tissue types
White pulp▪ Lymphatic tissue▪ Consists of lymphocytes and macrophages
Red pulp▪ Blood filled sinuses▪ Splenic tissues- RBC’s, macrophages,
lymphocytes, plasma cells, and granular leukocytes
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Spleen
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Enlarged Spleen
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Lymphatic Nodules
Not enclosed with a capsule Includes tonsils
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Nonspecific Resistance to Disease 1st line of defense-Skin and mucous
membranes Epidermis Mucous membranes▪ Hairs▪ Cilia
Lacrimal apparatus Saliva Sweat
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Nonspecific Resistance to Disease 2nd line of defense-internal defenses
Antimicrobial proteins Phagocytes Natural killer cells Fever Inflammation
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Antimicrobial Proteins
Found in blood & interstitial fluid Interferons
Interfere with viral replication Complement
Cytolysis, chemotaxis, oponization Transferrins
Bind iron = inhibit growth of some bacteria
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Natural Killer & Phagocytosis Natural killer (NK)
Cytolysis Phagocytes
Phagocytosis-ingestion of microbes or other particles
During infection monocytes enlarge into macrophages
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Phagocytosis
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Inflammation
Can be caused by pathogens, abrasions, chemical irritations, distortion or disturbances of cells, extreme temps
4 symptons Redness Pain Heat swelling
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Inflammation (con’t) 3 stages
1. Vasodilation and increased permeability of blood vessels▪ Increased blood flow to area
2. Phagocyte emigration▪ Neutrophils, then monocytes, then
wandering macrophages3. Repair▪ Pus-WBC’s & dead tissue debris
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Inflamatory Response