Lung Cancer During Pregnancy - 2
Transcript of Lung Cancer During Pregnancy - 2
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Letters
Lung Cancer During Pregnancy
To the Editor: We would like to describe an additional case oflungcancer complicating pregnancy, which is similar to the one reportedby Dr. Van Winter and colleagues in the April 1995 issue of theMayo Clinic Proceedings (pages 384 to 387). A 43-year-oldwoman (gravida 4, para 3) sought medical assessment during thethird trimester of pregnancy because of onset of severe dyspnea.She had a 60-pack-year history of smoking but no prior medicalproblems. Echocardiography revealed pericardial and left pleuraleffusion. Thoracentesis demonstrated an exudate with cytologicfindings positive for adenocarcinoma.
A month before medical assessment, the patient noticed a reddish, raised coinlike lesion. A biopsy revealed metastaticadenocarcinoma. Bronchoscopy also disclosed adenocarcinoma.Computed tomography of the abdomen showed a shadow in the lefthepatic lobe, consistent with metastatic involvement. At 37 weeks'gestation, the patient was delivered of a healthy female neonate. Noplacental lesions were found. The patient died 1 month afterdiagnosis. Her infant has remained healthy.
Whether pregnancy alters the course of lung cancer remainsunresolved. The maternal outcome of the previous patients suggests that the combination of young age, adenocarcinoma, andpregnancy is associated with aggressive tumors. The increasedincidence of smoking in the female population seems to account forthe increase in lung tumors.
Remberto J. Bitar, M.D.Nicholas Melillo, M.D.Jeffrey L. Pesin, M.D.JohnF. Kennedy Medical CenterEdison, New Jersey
To the Editor: Dr. Van Winter and colleagues described a case andprovided a comprehensive literature review of lung cancer complicating pregnancy. Survival of 10 of the 12 patients in whom it wasreported ranged from 2'1z to 42 months (mean, 9.1). The mean ageof the patients was 36.4 years. Five of the patients had small-cellcancers, three had adenocarcinomas, two had large-cell cancers,and one had a squamous cell cancer (this patient lived 42 monthsafter diagnosis).
In January 1990, we treated a nonsmoking 29-year-old woman(gravida 3, para 2, aborta 1) who was hospitalized during the thirdmonth of pregnancy because of multiple lung masses. A biopsyrevealed bronchoalveolar carcinoma. After a therapeutic abortion,the patient received three courses of combination chemotherapywith cisplatin and etoposide.
The patient did not seek medical care again until February 1995,when she experienced a cough, fever, weight loss, and anteriorchest pain. Bipulmonary basilar infiltrates and cavitary subpleuralmasses were evident on chest roentgenography and computedtomography. Sputum cultures grew Streptococcus pneumoniae,and a lung biopsy by videothoracoscopy yielded evidence ofpneumonitis and bronchoalveolar carcinoma. Intravenous administration of penicillin led to abatement of fever and disappearance of
the infiltrates in the lower lobes of the lung, but the subpleuralmasses persisted.
Bronchoalveolar carcinoma of the lung is considered by manypathologists to be a distinct adenocarcinoma! that arises in thebronchial glands. These tumors are multifocal in 25% of cases,occur equally in men and women, may be monoclonal, have anassociated 5-year survival rate, and occur often in nonsmokers. Arecent report described an increase in bronchoalveolar lung cancerin women,' and this histologic type now constitutes 26% of allpulmonary neoplasms in women and 8% of those in men.
To our knowledge, our patient is the first to have a bronchoalveolar carcinoma that occurred during pregnancy. She is still alive 62months after diagnosis. With the changing patterns of lung cancer,additional instances of this type of tumor will certainly be encountered during pregnancy. In light of the good prognosis associatedwith bronchoalveolar carcinomas, clinical decisions about treatment and fetal preservation must be carefully considered.
Lawrence A. Cone, M.D., D.Sc.April C. Dawson, M.D., M.P.H.Abigail M. Mata, R.N.Eisenhower Medical CenterRancho Mirage, California andRiverside County Health DepartmentPalm Springs, California
REFERENCESI. Hirata H, Noguchi M, Shimosato Y, Dei Y, Goya T. Clinicopathologic
and immunohistochemical characteristics of bronchial gland cell typeadenocarcinoma of the lung. Am J Clin Pathol 1990; 93:20-25
2. Barsky SH, Cameron R, Osann KE, Tomita D, Holmes EC. Risingincidence of bronchioloalveolar lung carcinoma and its uniqueclinicopathologic features. Cancer 1994; 73:1163-1170
In response: The letter from Dr. Remberto Bitar and colleaguespresents another example of a lung cancer diagnosed during pregnancy that progressed rapidly and resulted in a fatal outcome.Although pregnancy may delay the diagnosis of lung cancer, itseffect on the course of the cancer is unknown. As long as smokingcontinues to increase among female adolescents, the incidence oflung cancer in women of reproductive age can also be expected toincrease.
The case described by Dr. Lawrence Cone and coauthors is anexcellent example of a subtype of lung cancer that has an associatedgood prognosis. This situation contrasts that of our patient, whoexperienced a rapidly progressive and fatal outcome.
My colleagues and I assume that the term "therapeutic abortion"refers to facilitating the start of chemotherapy, inasmuch as abortion per se does not seem to improve the prognosis associated withlung cancer.
Jo T. Van Winter, M.D.Mayo Clinic RochesterRochester, Minnesota
Mayo Clin Proc 1995; 70: 1130 1130 © 1995 Mayo Foundation for Medical Education and Research
For personal use. Mass reproduce only with permission from Mayo Clinic Proceedings.