Luncheon Seminar 1
Transcript of Luncheon Seminar 1
MEMO WCHR201710th World Congress for Hair ResearchVisiting old, find new
Department of Dermatology, Perelman School of Medicine, University of PennsylvaniaGeorge Cotsarelis, ProfessorProstaglandins and androgenetic alopecia.Speaker1
Centre for Cell Biology and Cutaneous Research, Blizard Institute, Queen Mary University London.Mike Philpott, Professor
Revisiting the Warburg effect and the importanceof hair follicle metabolism in health and disease.
Speaker2
Luncheon Seminar 1Wednesday Novemver 1,2017 12:15-13:20Date
Kyoto International Conference CenterAnnex Hall 2 (Main)
Location
Co-president of 10th World Congress for Hair ResearchSatoshi Itami, M.D., PhDChair
Centre for Skin Sciences, University of BradfordValerie Randall, ProfessorCo-Chair
Sponsored by
Satoshi Itami, M.D., PhDCo-president of 10th World Congress forHair Research
Education and Training1978 Graduated from Osaka University
Medical School1978-1980 M.D., Osaka University Medical
School
Appointments and Position1980-1985 Instructor, Department of
Dermatology, Oita Medical University
1982-1984 Research Fellow, Department of DermatologyUniversity of Miami, USA
1985 Awarded the degree of PhD from Osaka University
1985-1993 Assistant professor, Department of Dermatology, Oita Medical University
1993-1995 Associate Professor, Department of Dermatology, Oita Medical University
1995-2005 Associate Professor, Department of Dermatology, Course of Molecular Medicine, Graduate School of Medicine, Osaka University
2006- Endowed Chair Proffessor, Department of Regenerative Dermatology, Graduate School of Medicine, Osaka University
Research Focus1.Transgenic mice model for skin diseases2.Androgen action in skin3.Signal transduction in keratinocytes and dermal papilla cells
Professor Val Randall is Professor of Skin Sciences in the Centre for Skin Sciences, University of Bradford, UK, Fellow of the Institute of Biomedical Science and Fellow of the Royal Society of Biology. Her research interests in endocrinology and skin sciences developed while carrying out her PhD on endocrine regulation of sebaceous glands with Professor John Ebling, University of Sheffield. They were extended during postdoctoral positions with Professor Ebling studying hirsutism and seasonal changes in human hair growth and with Professor Ian Mainwaring, University of Leeds, on androgens and the prostate. As an independent academic her research has focussed on hair follicle biology, particularly now the regulation of human hair growth by androgens and prostanoids. Her research has been supported by both the Medical and Biotechnology & Biological Sciences Research Councils, charities and international industry. It has resulted in 3 edited books, numerous publications and invited book chapters and 21 research student graduations.
Valerie Randall, ProfessorCentre for Skin Sciences,University of Bradford
Mike Philpott, Professor
Centre for Cell Biology and Cutaneous Research,Blizard Institute, Queen Mary University London.
George Cotsarelis, Professor
Department of Dermatology, University of Pennsylvania
Prostaglandin pathways have major effects on
mouse and human hair growth. Prostaglandin D2
(PGD2) and its synthesizing enzyme, PGD2
synthase, are present at higher levels in balding
ve r su s n on - b a l d i ng s c a l p i n men w i t h
androgenetic alopecia. In a mouse model, PGD2
inhibits hair growth via CRTH2/ PTGDR2, one of
two PGD2 receptors, leading us to hypothesize that
PTGDR2 is the key receptor mediating the hair
growth inhibitory activity of PGD2 in human
follicles. We tested several pharmacological
PTGDR2 antagonists for their anti-PGD2 activity on
human hair growth in vitro and found that
PTGDR2 antagonists reversed the growth
inhibition mediated by PGD2, in a dose-dependent
manner, by reducing PGD2-triggered apoptosis
and maintaining keratinocyte proliferation.
Topical administration of PGD2 to mice resulted in
shortening of the anagen phase and accelerated
entry into catagen, while applying a PTGDR2
antagonist to mice extended anagen phase,
resulting in longer hair. RNA-Seq analysis on
cultured human hair follicles showed decreased
expression of hair follicle progenitor cell markers,
such as CD34 and K19, in the PGD2 treated group.
FACS analysis of mouse sk in cel ls showed
decreased Ki67-positive cells in the secondary hair
germ population prior to anagen re-entry in PGD2
treated mice. These results suggest that PGD2
suppresses the activation of the secondary germ/
hair progenitor cells . Our findings fur ther
underscore the key role of PGD2 in regulating hair
growth and indicate that pharmacological
antagonism of PTGDR2 may be an effective
approach in preventing and/or treating alopecia in
patients sensitive to PGD2.
George Cotsarelis, M.D serves as the Milton B. Hartzell Professor and Chairman of the Department of Dermatology at the University of Pennsylvania School of Medicine. His research focuses on epithelial stem cells, hair follicle biology, wound healing and skin regeneration.
Hair follicles (HF) are dynamic mini-organs with
high demand for energy and biosynthesis
precursors. The HF mainly engages in aerobic
glycolysis and glutamine metabolism with
lactate generation despite the presence of
oxygen known as the Warburg effect. However,
t h e H F i s a l s o c a p a b l e o f o x i d a t i v e
phosphorylation. We propose that aerobic
glycolysis and glutaminolysis generate large
fluxes of metabol i tes for anabol ism and
generation of the hair fibre and that as such the
HF probably balances aerobic glycolysis ,
glutaminolysis and oxidative phosphorylation
and that differences in aerobic glycolysis and
oxidative phosphorylation between highly
p ro l i fe rat ive and d ifferent iat ion t i s sue
compartments of the hair foll icle may be
important regulators of hair follicle function. We
have also shown that dermal papilla cells from
balding scalp are much more sensitive to
ox idat i ve s t ress and ROS than DP f rom
non-balding scalp and have proposed that
imbalance of aerobic glycolysis and oxidative
phosphorylation may be an important factor in
hai r loss d isorders . F inal ly there i s now
increasing evidence that the outer root sheath
may in fact be the ‘powerhouse’ of the hair
follicle and we have proposed that glycogen
metabolism in the ORS may be involved in
maintaining high rates of cell proliferation in
hair follicle.
Mike Philpott D.Phil is Professor of Cutaneous Biology at the Centre for Cell Biology and Cutaneous Research, Blizard Institute, Queen Mary University London. His research focuses on in vitro models of human hair growth with a strong interest in hair follicle metabolism, basal cell carcinoma and the role of steroids in skin biology.
Revisiting the Warbureffectand the importanceof hair follicle metabolismin health and disease.
Prostaglandins andandrogenetic alopecia.
Chair
Co-Chair
Speaker1 Speaker2
Satoshi Itami, M.D., PhDCo-president of 10th World Congress forHair Research
Education and Training1978 Graduated from Osaka University
Medical School1978-1980 M.D., Osaka University Medical
School
Appointments and Position1980-1985 Instructor, Department of
Dermatology, Oita Medical University
1982-1984 Research Fellow, Department of DermatologyUniversity of Miami, USA
1985 Awarded the degree of PhD from Osaka University
1985-1993 Assistant professor, Department of Dermatology, Oita Medical University
1993-1995 Associate Professor, Department of Dermatology, Oita Medical University
1995-2005 Associate Professor, Department of Dermatology, Course of Molecular Medicine, Graduate School of Medicine, Osaka University
2006- Endowed Chair Proffessor, Department of Regenerative Dermatology, Graduate School of Medicine, Osaka University
Research Focus1.Transgenic mice model for skin diseases2.Androgen action in skin3.Signal transduction in keratinocytes and dermal papilla cells
Professor Val Randall is Professor of Skin Sciences in the Centre for Skin Sciences, University of Bradford, UK, Fellow of the Institute of Biomedical Science and Fellow of the Royal Society of Biology. Her research interests in endocrinology and skin sciences developed while carrying out her PhD on endocrine regulation of sebaceous glands with Professor John Ebling, University of Sheffield. They were extended during postdoctoral positions with Professor Ebling studying hirsutism and seasonal changes in human hair growth and with Professor Ian Mainwaring, University of Leeds, on androgens and the prostate. As an independent academic her research has focussed on hair follicle biology, particularly now the regulation of human hair growth by androgens and prostanoids. Her research has been supported by both the Medical and Biotechnology & Biological Sciences Research Councils, charities and international industry. It has resulted in 3 edited books, numerous publications and invited book chapters and 21 research student graduations.
Valerie Randall, ProfessorCentre for Skin Sciences,University of Bradford
Mike Philpott, Professor
Centre for Cell Biology and Cutaneous Research,Blizard Institute, Queen Mary University London.
George Cotsarelis, Professor
Department of Dermatology, University of Pennsylvania
Prostaglandin pathways have major effects on
mouse and human hair growth. Prostaglandin D2
(PGD2) and its synthesizing enzyme, PGD2
synthase, are present at higher levels in balding
ve r su s n on - b a l d i ng s c a l p i n men w i t h
androgenetic alopecia. In a mouse model, PGD2
inhibits hair growth via CRTH2/ PTGDR2, one of
two PGD2 receptors, leading us to hypothesize that
PTGDR2 is the key receptor mediating the hair
growth inhibitory activity of PGD2 in human
follicles. We tested several pharmacological
PTGDR2 antagonists for their anti-PGD2 activity on
human hair growth in vitro and found that
PTGDR2 antagonists reversed the growth
inhibition mediated by PGD2, in a dose-dependent
manner, by reducing PGD2-triggered apoptosis
and maintaining keratinocyte proliferation.
Topical administration of PGD2 to mice resulted in
shortening of the anagen phase and accelerated
entry into catagen, while applying a PTGDR2
antagonist to mice extended anagen phase,
resulting in longer hair. RNA-Seq analysis on
cultured human hair follicles showed decreased
expression of hair follicle progenitor cell markers,
such as CD34 and K19, in the PGD2 treated group.
FACS analysis of mouse sk in cel ls showed
decreased Ki67-positive cells in the secondary hair
germ population prior to anagen re-entry in PGD2
treated mice. These results suggest that PGD2
suppresses the activation of the secondary germ/
hair progenitor cells . Our findings fur ther
underscore the key role of PGD2 in regulating hair
growth and indicate that pharmacological
antagonism of PTGDR2 may be an effective
approach in preventing and/or treating alopecia in
patients sensitive to PGD2.
George Cotsarelis, M.D serves as the Milton B. Hartzell Professor and Chairman of the Department of Dermatology at the University of Pennsylvania School of Medicine. His research focuses on epithelial stem cells, hair follicle biology, wound healing and skin regeneration.
Hair follicles (HF) are dynamic mini-organs with
high demand for energy and biosynthesis
precursors. The HF mainly engages in aerobic
glycolysis and glutamine metabolism with
lactate generation despite the presence of
oxygen known as the Warburg effect. However,
t h e H F i s a l s o c a p a b l e o f o x i d a t i v e
phosphorylation. We propose that aerobic
glycolysis and glutaminolysis generate large
fluxes of metabol i tes for anabol ism and
generation of the hair fibre and that as such the
HF probably balances aerobic glycolysis ,
glutaminolysis and oxidative phosphorylation
and that differences in aerobic glycolysis and
oxidative phosphorylation between highly
p ro l i fe rat ive and d ifferent iat ion t i s sue
compartments of the hair foll icle may be
important regulators of hair follicle function. We
have also shown that dermal papilla cells from
balding scalp are much more sensitive to
ox idat i ve s t ress and ROS than DP f rom
non-balding scalp and have proposed that
imbalance of aerobic glycolysis and oxidative
phosphorylation may be an important factor in
hai r loss d isorders . F inal ly there i s now
increasing evidence that the outer root sheath
may in fact be the ‘powerhouse’ of the hair
follicle and we have proposed that glycogen
metabolism in the ORS may be involved in
maintaining high rates of cell proliferation in
hair follicle.
Mike Philpott D.Phil is Professor of Cutaneous Biology at the Centre for Cell Biology and Cutaneous Research, Blizard Institute, Queen Mary University London. His research focuses on in vitro models of human hair growth with a strong interest in hair follicle metabolism, basal cell carcinoma and the role of steroids in skin biology.
Revisiting the Warbureffectand the importanceof hair follicle metabolismin health and disease.
Prostaglandins andandrogenetic alopecia.
Chair
Co-Chair
Speaker1 Speaker2
Satoshi Itami, M.D., PhDCo-president of 10th World Congress forHair Research
Education and Training1978 Graduated from Osaka University
Medical School1978-1980 M.D., Osaka University Medical
School
Appointments and Position1980-1985 Instructor, Department of
Dermatology, Oita Medical University
1982-1984 Research Fellow, Department of DermatologyUniversity of Miami, USA
1985 Awarded the degree of PhD from Osaka University
1985-1993 Assistant professor, Department of Dermatology, Oita Medical University
1993-1995 Associate Professor, Department of Dermatology, Oita Medical University
1995-2005 Associate Professor, Department of Dermatology, Course of Molecular Medicine, Graduate School of Medicine, Osaka University
2006- Endowed Chair Proffessor, Department of Regenerative Dermatology, Graduate School of Medicine, Osaka University
Research Focus1.Transgenic mice model for skin diseases2.Androgen action in skin3.Signal transduction in keratinocytes and dermal papilla cells
Professor Val Randall is Professor of Skin Sciences in the Centre for Skin Sciences, University of Bradford, UK, Fellow of the Institute of Biomedical Science and Fellow of the Royal Society of Biology. Her research interests in endocrinology and skin sciences developed while carrying out her PhD on endocrine regulation of sebaceous glands with Professor John Ebling, University of Sheffield. They were extended during postdoctoral positions with Professor Ebling studying hirsutism and seasonal changes in human hair growth and with Professor Ian Mainwaring, University of Leeds, on androgens and the prostate. As an independent academic her research has focussed on hair follicle biology, particularly now the regulation of human hair growth by androgens and prostanoids. Her research has been supported by both the Medical and Biotechnology & Biological Sciences Research Councils, charities and international industry. It has resulted in 3 edited books, numerous publications and invited book chapters and 21 research student graduations.
Valerie Randall, ProfessorCentre for Skin Sciences,University of Bradford
Mike Philpott, Professor
Centre for Cell Biology and Cutaneous Research,Blizard Institute, Queen Mary University London.
George Cotsarelis, Professor
Department of Dermatology, University of Pennsylvania
Prostaglandin pathways have major effects on
mouse and human hair growth. Prostaglandin D2
(PGD2) and its synthesizing enzyme, PGD2
synthase, are present at higher levels in balding
ve r su s n on - b a l d i ng s c a l p i n men w i t h
androgenetic alopecia. In a mouse model, PGD2
inhibits hair growth via CRTH2/ PTGDR2, one of
two PGD2 receptors, leading us to hypothesize that
PTGDR2 is the key receptor mediating the hair
growth inhibitory activity of PGD2 in human
follicles. We tested several pharmacological
PTGDR2 antagonists for their anti-PGD2 activity on
human hair growth in vitro and found that
PTGDR2 antagonists reversed the growth
inhibition mediated by PGD2, in a dose-dependent
manner, by reducing PGD2-triggered apoptosis
and maintaining keratinocyte proliferation.
Topical administration of PGD2 to mice resulted in
shortening of the anagen phase and accelerated
entry into catagen, while applying a PTGDR2
antagonist to mice extended anagen phase,
resulting in longer hair. RNA-Seq analysis on
cultured human hair follicles showed decreased
expression of hair follicle progenitor cell markers,
such as CD34 and K19, in the PGD2 treated group.
FACS analysis of mouse sk in cel ls showed
decreased Ki67-positive cells in the secondary hair
germ population prior to anagen re-entry in PGD2
treated mice. These results suggest that PGD2
suppresses the activation of the secondary germ/
hair progenitor cells . Our findings fur ther
underscore the key role of PGD2 in regulating hair
growth and indicate that pharmacological
antagonism of PTGDR2 may be an effective
approach in preventing and/or treating alopecia in
patients sensitive to PGD2.
George Cotsarelis, M.D serves as the Milton B. Hartzell Professor and Chairman of the Department of Dermatology at the University of Pennsylvania School of Medicine. His research focuses on epithelial stem cells, hair follicle biology, wound healing and skin regeneration.
Hair follicles (HF) are dynamic mini-organs with
high demand for energy and biosynthesis
precursors. The HF mainly engages in aerobic
glycolysis and glutamine metabolism with
lactate generation despite the presence of
oxygen known as the Warburg effect. However,
t h e H F i s a l s o c a p a b l e o f o x i d a t i v e
phosphorylation. We propose that aerobic
glycolysis and glutaminolysis generate large
fluxes of metabol i tes for anabol ism and
generation of the hair fibre and that as such the
HF probably balances aerobic glycolysis ,
glutaminolysis and oxidative phosphorylation
and that differences in aerobic glycolysis and
oxidative phosphorylation between highly
p ro l i fe rat ive and d ifferent iat ion t i s sue
compartments of the hair foll icle may be
important regulators of hair follicle function. We
have also shown that dermal papilla cells from
balding scalp are much more sensitive to
ox idat i ve s t ress and ROS than DP f rom
non-balding scalp and have proposed that
imbalance of aerobic glycolysis and oxidative
phosphorylation may be an important factor in
hai r loss d isorders . F inal ly there i s now
increasing evidence that the outer root sheath
may in fact be the ‘powerhouse’ of the hair
follicle and we have proposed that glycogen
metabolism in the ORS may be involved in
maintaining high rates of cell proliferation in
hair follicle.
Mike Philpott D.Phil is Professor of Cutaneous Biology at the Centre for Cell Biology and Cutaneous Research, Blizard Institute, Queen Mary University London. His research focuses on in vitro models of human hair growth with a strong interest in hair follicle metabolism, basal cell carcinoma and the role of steroids in skin biology.
Revisiting the Warbureffectand the importanceof hair follicle metabolismin health and disease.
Prostaglandins andandrogenetic alopecia.
Chair
Co-Chair
Speaker1 Speaker2
MEMO WCHR201710th World Congress for Hair ResearchVisiting old, find new
Department of Dermatology, Perelman School of Medicine, University of PennsylvaniaGeorge Cotsarelis, ProfessorProstaglandins and androgenetic alopecia.Speaker1
Centre for Cell Biology and Cutaneous Research, Blizard Institute, Queen Mary University London.Mike Philpott, Professor
Revisiting the Warburg effect and the importanceof hair follicle metabolism in health and disease.
Speaker2
Luncheon Seminar 1Wednesday Novemver 1,2017 12:15-13:20Date
Kyoto International Conference CenterAnnex Hall 2 (Main)
Location
Co-president of 10th World Congress for Hair ResearchSatoshi Itami, M.D., PhDChair
Centre for Skin Sciences, University of BradfordValerie Randall, ProfessorCo-Chair
Sponsored by
MEMO WCHR201710th World Congress for Hair ResearchVisiting old, find new
Department of Dermatology, Perelman School of Medicine, University of PennsylvaniaGeorge Cotsarelis, ProfessorProstaglandins and androgenetic alopecia.Speaker1
Centre for Cell Biology and Cutaneous Research, Blizard Institute, Queen Mary University London.Mike Philpott, Professor
Revisiting the Warburg effect and the importanceof hair follicle metabolism in health and disease.
Speaker2
Luncheon Seminar 1Wednesday Novemver 1,2017 12:15-13:20Date
Kyoto International Conference CenterAnnex Hall 2 (Main)
Location
Co-president of 10th World Congress for Hair ResearchSatoshi Itami, M.D., PhDChair
Centre for Skin Sciences, University of BradfordValerie Randall, ProfessorCo-Chair
Sponsored by