Luca Scorrano, M Scorrano...Luca Scorrano, M.D., Ph.D. 2000 Special Fellowship, Leukemia- Lymphoma...

Luca Scorrano, M.D., Ph.D.


Date of birth: September 6, 1971 Citizenship: Italian Work address: Dept. of Biology Venetian Institute of Molecular Medicine University of Padova Via G. Colombo 3 – 35121 Padua, Italy Phone: +39 0498276320 +39 0497923210 +39 0497923284 (PA) Email: [email protected]

Education

2000 Ph.D. Dept. of Biomedical Sciences, University of Padova, Italy (Molecular and Cellular Biology and Pathology)

1997 Licensure # 8271, Italian Physician Association (General Medicine) 1996 M.D. summa cum laude, University of Padova Medical School, Italy

Research and Professional Experience

2000-2003 Postdoctoral Research Fellow (Apoptosis, Dr. S.J. Korsmeyer) Harvard Medical School, Dana-Farber Cancer Institute, Boston, USA

1996-2000 Research Fellow (Mitochondrial Pathophysiology, Dr. P. Bernardi) Dept. of Biomedical Sciences, University of Padova, Italy

1998 Medical Lieutenant, Head of Sanitary Service (Medicine, Compulsory Military Service), Padova Military Heliport, Italy

1996-1997 Internship (Medicine) University Hospital, Padova, Italy

Academic appointments

2014-present Scientific Director, Venetian Institute of Molecular Medicine, Padova, Italy 2013-present Full Professor of Biochemistry (Chiara Fama-equivalent to Endowed Chair), Dept. of

Biology, University of Padova, Italy 2007-2013 Full Professor, Department of Cell Physiology and Metabolism, University of Geneva

Medical School, Switzerland 2007-2017 Senior Telethon Scientist, Dulbecco-Telethon Institute, Venetian Institute of

Molecular Medicine, Padova, Italy 2003-2007 Assistant Telethon Scientist, Dulbecco-Telethon Institute, Venetian Institute of

Molecular Medicine, Padova, Italy

Fellowships

2000-2003 Long Term Fellowship, Human Frontier Science Program Organization


2000 Special Fellowship, Leukemia-Lymphoma Society of America (declined) Long Term Fellowship, EMBO (declined) 1999 “Fontana-Lionello” Fellowship, Italian Cancer Research Foundation 1996-1999 Research Doctorate Fellowship, Italian Ministry of University, Scientific and

Technological Research (MURST)

Awards and Honors

2013 2013 ESCI Award for Excellence in Basic/Translational Research, European Society for Clinical Investigation

2012 Elected Member, EMBO Chair, Keystone Symposium “Mitochondrial Dynamics and Physiology” Banff (Canada)

2011 “Chiara D’Onofrio” Prize, The D’Onofrio Foundation ERC Consolidator grant 2006 Eppendorf European Young Investigator Award, Eppendorf-Nature

EMBO Young Investigator 2005 “Angelo Minich” Prize for Medicine, Venetian Institute of Science, Letter and Arts Rotary Prize for Science, Rotary Padova (Italy) 2004 Career Development Award, HFSP 2003 “AICC-Onlus” Prize, Italian Association of Cell Culture (AICC) 2001 “G. Capozza” Prize, Italian Group of Bioenergetics and Biomembranes (GIBB)

Editorial activities

Editor in Chief 2010-2012 The Open Cell Signalling Journal Editorial Board 2017-present Trends in Physiological Sciences 2013-present Cardiovascular Research 2013-2017 PLOS One 2011-present Senior Editor, Biology Open The World Scientific Journal Associate Editor, Frontiers in Mitochondrial Research 2010-present The EMBO Journal BBA-Molecular Cell Research 2008-present Cell Death and Differentiation Reviewer Several leading Journals including Nature, Science, Nature Cell Biology; Molecular Cell; Cell Metabolism; EMBO Journal; PNAS; Journal of Cell Biology; EMBO Reports; Current Biology and others (average 1 paper/week) Guest Editor BBA-Molecular and Cellular Research, Special issue “Mitochondrial dynamics in cell life and death”, with B. Westermann. Cell Death and Differentiation, Special issue “Bcl-2 family members”, with A. Letai and C. Borner Seminars in Cell and Developmental Biology, Special Issue on mitochondrial dynamics BBA-Molecular and Cellular Research, Special issue “Mitochondrial dynamics”, with H. McBride.


Committees and steering activities

2017-present Member, Institut Necker Enfants Malades Scientific Advisory Board (Paris, France) Chair, EMBO Fellowship Committee 2016-present Member, National Agency of Research (ANR) Cell Biology Panel (Paris, France)

Member, ERC Consolidator Grant LS4 panel 2016 Member, Search Committee for 1 Mid Career Group Leader, Pasteur Institute (Paris,

France) Member, Evaluation Group GEV05, Italian University and Research Evaluation

Agency (Rome, Italy) 2015 Member, CNR Institute of Cell Biology and Neuroscience SAB (Rome, Italy) 2014-present Member, FWO (Flemish Science Fund) Panel MED/4 (cancer biology and research) Member, Steering committee of the Dept. of Biology, University of Padova, Italy 2013-present Member, FinMit Scientific Advisory Board (U. of Helsinki and Tampere, Finland)

Member, EMBO Fellowship Committee 2013 Member, Academy of Finland Biomedical Centre of Excellence Selection Panel 2012-2014 Member, SAB of the InSPIRE Consortium, U. of Athens (Greece) 2009-2012 Member, Steering committee of the Dept. of Cell Physiology and Metabolism,

University of Geneva, Switzerland 2012 Chair, Committee for the promotion of 1 Associate Professors in Dentistry,

University of Geneva Medical School 2011 Member, Committee for the selection of 3 Assistant/Associate Professors in Basic

Medical Sciences, University of Geneva Medical School Member, Committee for the selection of 1 Assistant Professor in Basic Medical Sciences, University of Geneva Medical School Promotion Committee, Dept. of Pathology, New York University, NY, USA

2010 Promotion Committee, LaTrobe University, Melbourne, Australia 2005-2008 Member of the Steering Council, Italian Group of Bioenergetics and Biomembranes

Grant reviewing activity

2016 Ad hoc peer review, Wellcome Trust, UK 2015 Ad hoc peer review, European Research Council Starting, Consolidator, Advanced

Grants Ad hoc peer review, Swiss National Foundation Ad hoc peer review, MRC UK

Ad hoc peer review, the Helmholtz Association Ad hoc peer review, DFG Germany Ad hoc peer review, FNRS France

2014 Ad hoc peer review, AXA Foundation Ad hoc peer review BBSRC UK Ad hoc peer review, European Research Council Starting Grants Ad hoc peer review, European Research Council Advanced Grants

2013 Ad hoc peer review, AXA Foundation Ad hoc peer review BBSRC UK

Ad hoc peer review, Austrian Science Fund Ad hoc peer review, European Research Council Starting Grants Ad hoc peer review, European Research Council Advanced Grants

2012 Ad hoc peer review, Alzheimer’s Association Ad hoc peer review, Swiss National Funds

Ad hoc peer review, Agence Nationale de la Recherche, France Ad hoc peer review, Association Française contre le Myopathies


Ad hoc peer review, Italian Ministry of Health Ad hoc peer review, Italian Ministry of Research

Ad hoc peer review, EMBO Fellowship Program Ad hoc peer review, European Research Council Starting Grants Ad hoc peer review, European Research Council Advanced Grants

2011 Ad hoc peer review, Alzheimer’s Association Ad hoc peer review, Oncosuisse Ad hoc peer review, AXA Foundation

Ad hoc peer review, Italian Ministry of Health Ad hoc peer review, EMBO Fellowship Program

Ad hoc peer review, European Research Council Starting Grants Ad hoc peer review, European Research Council Advanced Grants

2010 Ad hoc peer review, Swiss National Funds Ad hoc peer review, Alzheimer’s Association Ad hoc peer review, EMBO Fellowship Program Ad hoc peer review, European Research Council Starting Grants

2009 Ad hoc peer review, Swiss National Funds Ad hoc peer review, INSERM Genopat

Ad hoc peer review, Agence Nationale de la Recherche, France Ad hoc peer review, Cancer Research UK Ad hoc peer review, EMBO Fellowship Program Ad hoc peer review, Czech Research Foundation Ad hoc peer review, Oncosuisse Ad hoc peer review, Alzheimer’s Association 2008 Ad hoc peer review, Swiss National Funds

Ad hoc peer review, EMBO Fellowship Program Ad hoc peer review, Cancer Research UK

Ad hoc peer review, European Research Council Advanced Grants Ad hoc peer review, Medical Research Council UK Ad hoc peer review, INSERM Genopat

2007 Ad hoc peer review, Medical Research Council UK Ad hoc peer review, EMBO Fellowship Program Ad hoc peer review, Human Frontier Science Program Ad hoc peer review, Wellcome Trust UK Ad hoc peer review, Agence Nationale de la Recherche, France 2006 Ad hoc peer review, Austrian Science Foundation

Ad hoc peer review, Association Française contre le Myopathies Ad hoc peer review, Medical Research Council UK

2004 Ad hoc peer review, Israel Science Foundation Ad hoc peer review, Health Research Board of Ireland

Ad hoc peer review, Austrian Science Foundation

Organizational Activities

2016 EMBO Workshop Organelle contact sites: Intracellular communication and role in disease Domus de Maria (Italy) – Chair

2014 Gordon Research Conference Mitochondria and Chloroplasts Il Ciocco (Italy) – Chair 2012 Keystone Symposium “Mitochondrial Dynamics and Physiology” Banff (Canada) –

Chair 2011 Barcelona Biomedical Conferences, “Mitochondrial dynamics and mitophagy”

Barcelona (Spain) – Co-Chair


Workshop “Mitochondrial dynamics in cell life and death”, Chia Laguna (Italy) – Co-Chair

2007 Workshop “Frontiers in Mitochondrial Research: from Bioenergetics to Dynamics”, Bertinoro (Italy) – Member of the Scientific Committee

2005 FEBS-IUBMB Advanced Workshop “Mitochondrial dynamics in cell life and death”, Padova (Italy) – Chairman of the Scientific Committee, Organizer

Professional Societies Membership

2007-present American Society of Cell Biology 2004-present American Biophysical Society 2004-present Italian Association of Cellular and Developmental Biology 2003-present Italian Association of Cell Culture 1998-present Italian Group of Bioenergetics and Biomembranes 1997-present Italian Physician Association

Patents

1. SJ Korsmeyer, L Scorrano BID polypeptides and methods of inducing apoptosis US Patent 7,247,700 B2 Issued 24 Jul 2007

Invited Lectures

2019 1. Plenary Lecture, Fusion Conference Mitochondria, Nassau (BH) 2. The 44th FEBS Congress, Krakow (PL) 3. EMBO Workshop Mitochondria Apoptosis and Cancer, Prague (CZ) 4. EMBO Workshop Mitochondria in disease, Dubrovnik (HR)

2018

5. Society for Neuroscience Neuroscience Annual Meeting, San Diego (US) 6. 15th NuGo Week, Mitochondria, Nutrition and Health, Newcastle (UK) 7. CSHL Mitochondria Meeting, Cold Spring Harbor (US) 8. 9th World Congress on Targeting Mitochondria, Berlin (DE) 9. EMBO Workshop Membrane contact sites in health and disease, Arosa (CH) 10. ISHR-ESC Annual Meeting, Amsterdam (NL) 11. Plenary Lecture Biennial Congress, Society for Free Radical Research-International, Lisbon (PT) 12. Plenary Lecture 20th European Bioenergetics Conference, Budapest (HU) 13. Plenary Lecture International Society for Advancement of Cytometry 33rd Congress, Prague

(CZ) 14. Keystone Symposium Mitochondrial Biology, Kyoto (JP) 15. International PhD Program in Cancer Biology and Oncology, IOSI, Bellinzona (CH) 16. 1st Conference Emerging Concepts in Mitochondrial Biology, Weizmann Institute (IL) 17. IDIPABS Lecture, IDIPABS, Barcelona (ES) 18. International Symposium Advances in Heart Failure London (UK)

2017

19. Distinguished lecture, Dept. of Fundamental Neurosciences, University of Lausanne (CH) 20. Red Top Seminar, Dept. of Cell Biology, Harvard Medical School, Boston (US) 21. Lectio Magistralis, Collegio Ghislieri, University of Pavia Medical School, Pavia (IT)


22. Dept. of Biochemistry, University of Goettingen (DE) 23. IMPRS Distinguished Guest Seminar, MPI Dortmund (DE) 24. 17th Euromit, Cologne (DE) 25. EMBO Workshop Mitochondrial quality control, Xi’an (CN) 26. CSH Asia Conference Mitochondria, Souzhou (CN) 27. EMBO Workshop “Mitochondria Apoptosis and Cancer” Bled (SLO) 28. ISHR-ESC Annual Meeting, Hamburg (DE) 29. FEBS-EMBO Lecture Course “Mitochondria in cell life and death”, Bari (IT) 30. Keystone Symposium Mitochondria Communication, Taos (NM) (US)

2016

31. 39th Annual Meeting of the Molecular Biology Society of Japan, Yokohama (JP) 32. Institute for Frontier Science Initiative, Cancer Research Institute, Kanazawa University (JP) 33. Plenary Speaker American Society for Nephrology Kidney Week 2016, San Diego, CA (US) 34. Plenary Speaker Neuroscience 2016, San Diego, CA (US) 35. EMBO Conference Structure and function of the endoplasmic reticulum, Girona (ES) 36. Keynote Speaker, Nordic Autophagy Network Annual Meeting, Keflavik (IS) 37. Plenary Speaker, the 19th European Bioenergetics Conference, Riva del Garda (IT) 38. GRC Mitochondria and Chloroplasts, Mount Snow, West Dover, VT (US) 39. NHLBI/NIDDK Mitochondrial Biology Symposium: Novel Roles of Mitochondria in Health and

Disease Bethesda, MD (US) 40. Wellcome Genome Campus Scientific Conference Mitochondrial Medicine: Developing New

Treatments for Mitochondrial Disease Cambridge (UK) 41. XXII World Congress of the ISHR, Buenos Aires (AR) 42. Keystone Symposium Mitochondrial Dynamics, Steamboat Springs (CO) (US) 43. Dept. of Toxicology, University of Konstanz (DE) 44. DIMET, Bicocca University, Milan (IT) 45. EACR Conference A Matter of Life or Death: Mechanisms and Relevance of Cell Death for

Cancer Biology and Treatment, Amsterdam (NL) 46. Life Sciences Colloquium, Weizmann Institute, Rehovot (IL)

2015

47. Keynote Speaker, Annual Conference of the Greek Society of Biochemistry and Molecular Biology, Athens (GR)

48. Plenary Speaker, 11th International Congress on Coronary Artery Disease, Florence (IT) 49. Plenary Speaker, Cold Spring Harbor Asia Meeting, Souzhou (CN) 50. Plenary Speaker, ComBio Meeting, Australia Society for Biochemistry and Molecular Biology,

Melbourne (AU) 51. Plenary Speaker ABCD, Bologna (IT) 52. EMBO Workshop Autophagy, Chia Laguna (IT) 53. Cell Symposium: Mitochondria, Chicago (US) 54. American Heart Association Basic Cardiovascular Science Annual Meeting, New Orleans (US) 55. International Society for Heart Research annual meeting, Bordeaux (FR) 56. EMBO-EMBL Symposium Mechanism of Neurodegeneration, Heidelberg (DE) 57. Plenary Lecture, European Society of Human Genetics, Glasgow (UK) 58. European Association for the study of the liver Annual Meeting, Vienna (AT) 59. BCSB Annual Meeting, Warwick (UK) 60. Japanese Pharmacological Society annual meeting, Kobe (JP) 61. Plenary Joint Lecture Keystone Symposia Mitochondria, Metabolism and Heart Failure

Diabetes and Metabolic Dysfunction, Santa Fe (US), 62. Mount Sinai Medical School, New York (US) 63. Medical University of South Carolina, Charleston (US)


2014

64. Shanghai Tech-SIAIS BioForum 2014- Cellular Processing of Information, Shanghai (China) 65. 11th Conference of the Asian Society of Mitochondrial Research and Medicine, Taiwan

(Taiwan) 66. IMBC, Porto (PT) 67. European Cell Death Organization Meeting, Heraklion (Greece) 68. Institute Gulbenkian, Lisbon (PT) 69. Congress Building the Cell, Pasteur Institute, Paris (FR) 70. Danish Cancer Society Research Center, Copenhagen (DK) 71. Keynote speaker European Society for Investigative Dermatology, Copenhagen (DK) 72. EMBO Plenary Lecture, 7th EuroMIT, Tampere (Finland) 73. 32nd Annual Meeting of the European Section of the ISHR, Barcelona (ES) 74. ASBMB Annual Meeting, San Diego (USA) 75. Keynote speaker Japan Endocrinological Society Annual Meeting, Fukuoka (Japan) 76. 2014 Keystone Symposia on Mitochondrial Dynamics and Physiology, Santa Fe (USA) 77. EMBO Workshop Protein and lipid function in secretion and endocytosis, Goldegg (AT)

2013

78. ASCB Annual Meeting, Minisymposium Co-chair and speaker, New Orleans (USA) 79. Keynote speaker Mitochondrial Dynamics meeting, Okinawa (Japan) 80. 10th Conference of the Asian Society of Mitochondrial Research and Medicine, Seoul (Korea) 81. EMBO Workshop on Cell-Cell Fusion, Ein Gedi (Israel) 82. EMBO Members Meeting, Heidelberg (DE) 83. The World Parkinson Meeting, Montreal (Canada) 84. EMBO Workshop Mitochondria Apoptosis and Cancer, Stockholm (SE) 85. The European Calcium Society Annual Meeting, Leuven (BE) 86. Cell Press Symposium Mitochondria: from Signalling to Disease, Lisbon (PT) 87. ISN/ASN meeting, Cancun (Mexico) 88. Keynote speaker ESCI Meeting, Albufeira (PT) 89. Gordon Research Conference “Ca2+ Signaling”, Il Ciocco (IT)

2012

90. Genes and Cancer Meeting, Warwick (UK) 91. Institute of Hepatology Lecture Series, UCL (UK) 92. Inaugural Lecture, PhD seminars, Dept. of Pharmacology, Milan (IT) 93. 3rd International Workshop “Expression, Structure and Function of Membrane Proteins”,

Florence (IT) 94. Plenary Lecture, 17th European Bioenergetics Conference, Freiburg (DE) 95. The 2012 EMBO Meeting, Nice (FR) 96. ECDO “20th Euroconference on Apoptosis”, Rome (IT) 97. Gordon Research Conference “Cardiac Regulatory Mechanisms”, New London (USA) 98. Fifth Annual Pfizer Frontiers in Human Disease Symposium, New York (USA) 99. The Annual Porto Cancer Meeting, Porto (PT) 100. European Society of Cardiology “ESC Congress 2012”, Munich (DE) 101. Abcam “Mitochondrial Trafficking and Function in Neuronal Health and Disease” Meeting,

Boston (USA) 102. Frankfurt Institute for Molecular Life Sciences, Frankfurt (DE) 103. FEBS | EMBO Lecture Course “Mitochondria in life, death and disease”, Crete (GR) 104. European Society of Cardiology “Frontiers in CardioVascular Biology 2012”, London (UK) 105. EMBO Workshop “Programmed cell death in model organisms”, Ein Gedi (IL)

2011


106. Biochemical Society Hot Topic: “Keeping the engine clean: role of mitophagy in physiology and pathology”, London (UK)

107. Plenary lecture Accademia Medica di Roma, Roma (IT) 108. Center for Neuroscience, University of Coimbra (PT) 109. Joint “9th Congress of the Slovenian Biochemical Society and 5th Congress of the Slovenian

Microbiological Society”, Maribor (SLO) 110. ASBMB Meeting “Cellular Traffic of Lipid and Calcium at Membrane contact sites” Snowbird,

CO (USA) 111. Cell Stress Society International “Fifth International Congress on Stress Responses in Biology

and Medicine”, Quebec City (CA) 112. American Diabetes Association Annual Meeting, San Diego (USA) 113. D’Onofrio Lecture, 36th FEBS Congress, Turin (IT) 114. The 7th European Conference on Intermediate Filaments in Health and Disease, Mykonos

(GR) 115. Janelia Farm HHMI Meeting “The Expanding Roles of Mitochondria in Cell Biology and

Disease”, Janelia Farm (USA) 116. X Annual Convention, Telethon Foundation, Riva del Garda (IT) 117. Featured Lecture Department of Cell Biology, University College London (UK) 118. European Society of Cardiology “Heart Failure Winter Research Meeting 2011”, Les

Diablerets (CH) 2010

119. Ottawa Heart Institute, Ottawa (Canada) 120. Meeting “Mitochondria: Function and Dysfunction” Dead Sea (Israel) 121. Meeting “The First National Conference on Health Research”, Cernobbio (IT) 122. Featured Lecture, Brain Mind Institute, EPFL, Lausanne (CH) 123. DZNE Meeting “Mitochondria in Neurodegeneration”, Ringberg Castle (DE) 124. Swiss Apoptosis Meeting, Bern (CH) 125. Featured Lecture, American Heart Association’s Basic Cardiovascular Sciences conference,

Palm Springs, CA (USA) 126. Plenary Lecture, XV Meeting of the Brazilian Society for Cell Biology, Sao Paulo (BRA) 127. Plenary Lecture, 2nd German-ATn-Swiss meeting “Mitochondrial Medicine”, Munich (DE) 128. Gordon Research Conference “Mitochondria and Chloroplasts”, Il Ciocco (IT) 129. 35th FEBS Congress, Goteborg (SE) 130. FASEB SRC “Calcium and Cell Function” Steamboat, AZ (USA) 131. International Cell Death Society meeting “Multidisciplinary Approaches in Cell Death

Research,” Side (TK) 132. 9th International Conference on Brain Energy Metabolism “Mitochondrial-Cytosolic

Interactions: From Energetics to Pathogenesis” Budapest (HU) 133. Plenary Lecture, Annual SIBBM Meeting, Padova (IT) 134. 20th ISHR World Congress “Paradigm Shift to Integrated Cardiology: Gene, Function and Life”

Kyoto (JP) 135. Annual Seminar Series, School of Biosciences, University of Birmingham, Birmingham (UK) 136. Freidrich-Miescher Institute, Basel (CH) 137. Sigma-Tau Lecture, University of Rome La Sapienza (IT) 138. Seminars on Drug Discovery and Development, Dept. of Pharmacology, University of Basel,

Basel (CH) 139. Plenary Lecture, XXIII International Winter Meeting “Growth and Death in the Nervous

System” St. Moritz (CH) 140. Fondation des Treilles Meeting “Assembly of Mitochondrial Membranes in Health and

Disease”, Tourtour (FR) 141. Cologne Spring Meeting "Protein homeostasis: make it, guide it and break it", Cologne (DE)

2009


142. Interfaculty Institute for Biochemistry, University of Tuebingen (DE) 143. Dept. of Developmental Biology, University of Roma II, Roma (IT) 144. Featured Lecture, CNIC Seminar Series, Spanish National Cardiovascular Research Center,

Madrid (ES) 145. Department of Cell Biology, Yale Medical School, New Haven (USA) 146. Wilf Family Cardiovascular Research Institute, Einstein Medical College, New York (USA) 147. Italian Society of Neurology Annual Meeting, Padova (IT) 148. Institute for Cancer Research and Treatment, Torino (IT) 149. Meeting “Structure and Function of Membrane Proteins”, Freiburg (DE) 150. Graduate Seminar Series, Adolf-Butenandt-Institute for Neurodegenerative Alzheimer and

Parkinson Diseases Research, Munich (DE) 151. FEBS Advanced Lecture Course “Mitochondria in Life, Death and Disease”, Aussois (FR) 152. 34th FEBS Congress, Prague (Czech Republic) 153. Gordon Research Conference “Molecular and Cellular Bioenergetics”, Andover (USA) 154. Meeting “Protein Coupling in Cellular Networks - Signaling and Sorting”, Freiburg (DE) 155. Heart Failure 2009, Nice (FR) 156. Neurex Meeting, Basel (CH) 157. EMBO Lecture Course “Mitochondrial Medicine: from genetics to biological mechanisms and

beyond”, Bologna (IT) 158. Department of Pharmacology, University of Bern (CH) 159. Plenary Lecture, Joint Keystone Symposium “Cell Death Pathways/Mitochondrial Dynamics

and Physiology”, Whistler, BC (Canada) 160. IX Annual Convention, Telethon Foundation, Riva del Garda (IT) 161. Keynote Lecture, XI ApoReunion, Salobrena (ES) 162. MRC Dunn Institute, Cambridge (UK)

2008 163. Department of Pathology, Skirball Institute, NYU, New York (USA) 164. National Institutes of Health Conference on Mitochondrial Biology in Cardiovascular Health

and Diseases, NIH, Bethesda (USA) 165. Friedrich Miescher Institute, Basel (CH) 166. GRC “Neurobiology Of Brain Disorders”, Oxford (UK) 167. PhD Meeting “Life and Death: cellular response to stress”, Milano (IT) 168. Bari International Symposium on "Mitochondrial Physiology and Pathology" Bari (IT) 169. European Bioenergetics Conference 2008, Dublin (Ireland) 170. Janelia Farm Research Conference “New Frontiers in Mitochondrial Science: Integration into

Cell Signalling”, Janelia Farm (USA) 2007

171. IUBMB Workshop “Frontiers in Mitochondrial Research: from Bioenergetics to Dynamics”, Bertinoro (IT)

172. Institute of Biomedicine, Biomedicum Helsinki, Helsinki (FI) 173. 17th European Cell Death Organization Meeting, Porto Roz (SLO) 174. FASEB Summer Research Conference “Assembly of the Mitochondrial Respiratory Chain”,

Tucson, AZ (USA) 175. Life Sciences 2007– Glasgow (UK) 176. Workshop “Programmed Cell Death”, Villa Vigoni, Menaggio (IT) 177. Institute for Research in Biomedicine, Parc Científic de Barcelona, Barcelona (ES) 178. Research Institute Hospital Vall d’Hebron, Barcelona University, Barcelona (ES) 179. Telethon Institute of Genetics and Medicine, Naples (IT) 180. PhD Program in Genetics, University of Turin, Turin (IT) 181. Workshop “Cellular and molecular mechanisms of tissue damage and repair” Academia

Europea, Heidelberg (DE) 182. Cours de Biologie Moleculaire de la Cellule 2007, Institut Pasteur, Paris (FR)


183. “Scientific Tuesday” Lecture, C. Besta National Neurological Institute, Milan (IT) 184. EMBO Workshop – 6th International Annaberg Conference on Protein and Lipid Sorting in the

Secretory Pathway (AT) 2006

185. Novartis Foundation Symposium 287 “New perspectives on mitochondrial biology”, London (UK)

186. “Green Seminar” VIB, KUL, Leuven (BE) 187. Annual Meeting of the European Association for Vision & Eye Research, Vilamoura (PT) 188. Plenary Lecture, European Bioenergetics Conference 2006, Moscow (Russia) 189. Human Frontier Science Program Organization Awardees Annual Meeting, Paris (FR) 190. Master BMC “Homeostasis of biological systems” Ecole normale supérieure de Lyon (FR) 191. Department of Physiology, University College of London (UK) 192. MRC Unit of Toxicology, Leicester (UK) 193. Institute for Research in Biomedicine, Bellinzona (CH) 194. First “Death in the Alps” International Meeting, Innsbruck (AT)

2005 195. International Conference "Mitochondria, from molecular insight to physiology and

pathology": 40 years of Bari Meeting, Bari (IT) 196. Montagsseminar, Department of Molecular Biology, Max Planck Institute for Infection

Biology, Berlin (DE) 197. Italian Federation of Life Sciences annual meeting (FISV 2005), Riva del Garda (IT) 198. “Frontiers in Biology" Seminar Series, University of Geneva (CH) 199. FEBS-IUBMB Workshop “Mitochondrial dynamics in cell life and death”, Padova (IT) 200. Dibit Monday Seminar, San Raffaele Scientific Institute, Milano (IT) 201. International Research Doctorate in Molecular and Cellular Pharmacology, Dept. of

Pharmacology, University of Padova (IT) 202. Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA (USA) 203. Biophysical Society Annual Meeting, Long Beach CA (USA) 204. Dept. of Oncology and Surgery, University of Padova (IT)

2004 205. Adolf-Butenandt-Institut Physiologische Chemie, Ludwig-Maximilians-Universitaet, Munich

(DE) 206. Workshop Mitochondria and Cancer, Beatson Cancer Institute, Glasgow (UK) 207. Chairman, Mitochondrial Dynamics workshop, European Bioenergetic Conference 2004, Pisa

(IT) 208. Dept. Molecular Cell Biology, Faculty of Medicine, K.U.L., Leuven (BE) 209. Istituto di Genetica e Biofisica "Adriano Buzzati-Traverso", CNR, Naples (IT) 210. Istituto di Tecnologie Biomediche CNR, Milan (IT) 211. Istituto di Neuroscienze CNR, Pisa (IT)

2003 212. Italian Association of Cell Culture Annual Meeting, Modena (IT) 213. Plenary Lecture, Argentinian Society of Neurochemistry Annual Meeting, Los Cocos, Cordoba

(Argentina) 214. Chairman and speaker, Apoptosis Workshop, Italian Federation of Life Sciences annual

meeting (FISV 2003), Rimini (IT) 215. Dept. of Oncology and Surgery, University of Padova (IT) 216. Dept. of Cell Biology and Biomedical Technologies, University of Udine (IT) 217. Dept. of Cell Biology, University of Geneva (CH) 218. CNRS-LBMP, Universitè Paul Sabatier, Toulouse (FR) 219. Apoptosis 2003 Meeting, Luxembourg (Luxembourg)

2002 220. Dept. of Neurology and Neurosciences, Cornell University Medical Center, New York (USA).


221. Human Frontier Science Program 2nd Annual Meeting, Ottawa (Canada). 2001

222. Biophysical Society 45th Annual Meeting, Boston (USA). 2000

223. Lecture “G. Capozza”, Italian Group of Bioenergetics and Biomembranes 21st Annual Meeting, Cividale del Friuli (IT).

1998 224. Workshop “Apoptosis Day”, Milano (IT).

Funding history (research)

2018-2022 AIRC Enhancing cancer cell death and reducing cancer angiogenesis by Opa1 inhibition (PI, 726,000€)

2016-2018 Telethon Italy Extending the Optic atrophy 1 dependent cristae remodeling: from models to a therapy of autosomal dominant optic atrophy (PI, 375,000€)

2016-2017 EFSD Novo-Nordisk Program The role of the mitochondria-shaping protein Opa1 in fat browning and insulin sensitivity (PI, 100,000 €)

2016-2021 Fondation Leduq Transatlantic Network of Excellence Targeting autophagy to treat Cardiovascular Diseases (European Coordinator, 6,000,000 USD to be divided among 7 investigators, approx. 1,000,000 as PI)

2015-2017 AIRC Targeting Opa1-dependent mitochondrial cristae remodeling to enhance cancer cell death (PI, 451,000€)

2014-2017 Telethon Italy MitCare-2 (Coordinator of multicentric grant, total grant: 1,000,000€ to be divided among 4 units, 300,300€ as PI)

2013-2017 FP7 Career Integration Grant CristOpa (PI, 100,000 €) 2012-2017 ERC Consolidator Grant Molecular anatomy and pathophysiology of the ER-

mitochondria interface (PI, 1,500,000 €) 2012-2016 FIRB Automed: Autophagy in health and disease (multicentre; PI, 631,000 €) 2012-2015 MOH Young Researcher Exploring Opa1-dependent mitochondrial cristae

remodelling as a therapeutic target in cancer (PI, 532,000 €) 2012-2014 FP7 People Action, IEF MitofusinPARKIN (Coordinator, 228,000 €) 2012-2014 FP7 People Action, IEF Cop1Drp1 (Coordinator, 286,000 €) 2010-2013 Swiss National Fund (PI, 600,000 CHF) Bonus of Excellence, Extending mitochondrial

dynamics in cell life and death: from molecular mechanisms to animal models 2010-2012 Association Francaise contre les Myopathies (PI, 44,000 €) The role of ER-

mitochondria tethering in the pathogenesis of Charcot-Marie-Tooth IIa 2010-2013 Swiss National Fund Sinergia (Coordinator, 1,450,000 CHF) Nanoscale approaches to

dissect mitochondrial dynamics in cell life and death 2010 Novartis Foundation (PI, 60,000 CHF) The role of mitochondria in autophagy 2009-2011 FP7 People Action, IEF DynaMito (Coordinator, 228,000 €) 2008-2011 OncoSuisse (PI 347,000 CHF) Exploring the role of mitochondria-shaping proteins in

apoptosis: novel therapeutic targets to drive death of cancer cells 2008 Telethon Suisse (PI 70,000 CHF) Exploring the role of endoplasmic reticulum

structure, function and tethering to mitochondria in the pathogenesis of Charcot-Marie-Tooth 2a

2008 Foundation Schmidheiny (PI, 30,000 CHF) Extending mitochondrial dynamics in cell life and death: from molecular mechanisms to animal models

2008 Association Francaise contre les Myopathies (PI 45,000 €) Role of Mitofusin-2, mutated in Charcot-Marie-Tooth IIa, in organelle tethering and function

2007-2012 Telethon Italy (PI, 1,500,000 €) Approaches to understand pathogenesis and establish a treatment for dominant optic atrophy


2007-2010 Swiss National Fund (PI 539,000 CHF) Extending mitochondrial dynamics in cell life and death: from molecular mechanisms to animal models

2007-2009 EMBO (PI, 58,000 €) EMBO Young Investigator Award 2007-2009 Fondazione Mariani Italy (PI, 175,000 €) Understanding the role of OPA1, mutated in

dominant optic atrophy, in apoptosis: from cell biology to animal models 2006-2009 Telethon Italy (PI, multicentre grant, 112,500 €) Exploring the role of mitochondrial

membranes in triggering cell loss in Huntington disease: patients, animal models and molecular mechanisms

2006-2008 Muscular Dystrophy Association USA (PI, 180,000 $) Insights into Charcot-Marie-Tooth IIa pathogenesis: mitofusin-2, organelle shape, function and apoptosis

2005-2007 United Mitochondrial Disease Fund USA (PI, 96,000 $) Role of mitofusin-2, a mitochondria-shaping protein mutated in Charcot-Marie-Tooth 2a, in controlling mitochondrial function and apoptosis

2005-2007 Italian Cancer Research Association (PI, 120,000 €) Role of proteins controlling mitochondrial shape in apoptosis

2004-2007 Compagnia di San Paolo Italy (PI, multicentre grant, 145,000 €) Analysis of interactions and dysfunction in molecular mechanisms involved in genetic diseases

2004-2007 HFSPO, Career Development Award (PI, 180,000 $) Molecular mechanisms controlling mitochondrial shape during life and death of the cell

2004 Glaucoma Research Foundation USA Pilot Project (PI, 35,000 $) Role of OPA1 and of mitochondrial remodelling in retinal ganglion cell death

2004 Italian Cancer Research Association (PI, 40,000 €) Role of mitochondrial dynamin related proteins in apoptosis

2003-2007 Telethon Italy (PI, 427,000 €) Mitochondrial apoptotic pathways and mitochondrial remodelling in human hereditary optic atrophies

Funding history (organizational)

2015 EMBO w16/24 (Chair, 30,000€) Organize the “Organelle contact sites: Intracellular communication and role in disease” Workshop

2004 FEBS 05-33W (Chair, 18,000 €) Organize the “Mitochondrial dynamics in cell life and death” Workshop

2003 IUBMB Workshop IG233 (Chair 4,500 $) Organize the “Mitochondrial dynamics in cell life and death” Workshop

Report of teaching

Undergraduate 2016-2017 Biochemistry, BSc Degree in Molecular Biology, Padova University

60 hrs contact, 120 hrs preparation, 80 students per class. Designed Taught course, examined, graded students

2015-2016 Biochemistry, BSc Degree in Molecular Biology, Padova University 60 hrs contact, 120 hrs preparation, 80 students per class. Designed Taught course, examined, graded students Biochemistry, BSc Degree in Biotechnology, Padova University 60 hrs contact, 120 hrs preparation, 80 students per class. Designed Taught course, examined, graded students

2014-2015 Biochemistry, BSc Degree in Molecular Biology, Padova University 60 hrs contact, 120 hrs preparation, 80 students per class. Designed Taught course, examined, graded students


Biochemistry, BSc Degree in Biotechnology, Padova University 60 hrs contact, 120 hrs preparation, 80 students per class. Designed Taught course, examined, graded students

2013-2014 Biochemistry, BSc Degree in Molecular Biology, Padova University 60 hrs contact, 120 hrs preparation, 80 students per class. Designed Taught course, examined, graded students Biochemistry, BSc Degree in Biotechnology, Padova University 60 hrs contact, 120 hrs preparation, 80 students per class. Designed Taught course, examined, graded students

2012-2013 Biochemistry, BSc Degree in Molecular Biology, Padova University 60 hrs contact, 120 hrs preparation, 80 students per class. Taught course, examined, graded students

2006-2007 General Pathology & Pathophysiology, Degree in Nursing, Padova University Medical School 50 hrs contact, 100 hrs preparation, 50 students per class. Designed and taught course, examined, graded students

2004-2006 Cellular and Molecular Mechanisms of General Pathology, Degree in Audiology, Padova University Medical School 12 hrs contact, 24 hrs preparation, 20 students per class. Designed and taught course, examined, graded students General Pathology & Pathophysiology, Degree in Nursing, Padova University Medical School 50 hrs contact, 100 hrs preparation, 50 students per class. Designed and taught course, examined, graded students

Cell Biology, Degree in Speech Therapy, Padova University Medical School 12 hrs contact, 24 hrs preparation, 20 students per class. Designed and taught course, examined, graded students

2003 Cellular and Molecular Mechanisms of General Pathology, Degree in Audiology, Padova University Medical School 12 hrs contact, 24 hrs preparation, 20 students per class. Designed and taught course, examined, graded students

Graduate and Medical 2016-2017 Biochemistry of Disease, MSc Degree in Health Biology, Padova University

48 hrs contact, 90 hrs preparation, 8 MSc students per class. Designed, taught course, examined, graded students

2012-2013 “Apprentisage par Probleme: Maladies cardiovasculaires” Faculte de Medecine, University of Geneva 16 hrs contact, 32 hrs preparation, 8 medical students per class. Taught course, examined, graded students Tutor for “Chapitres Choisis” University of Geneva 12 hrs contact, 24 hrs preparation, 8 PhD students per class. Taught course, examined, graded students “Course à option” “En Route verse le Cancer” Faculte de Medecine, University of Geneva 3 hrs contact, 6 hrs preparation, 25 medical students per class. Taught course, examined, graded students

2011-2012 “Apprentisage par Probleme: Maladies cardiovasculaires” Faculte de Medecine, University of Geneva 16 hrs contact, 32 hrs preparation, 8 medical students per class. Taught course, examined, graded students Tutor for “Chapitres Choisis” University of Geneva


12 hrs contact, 24 hrs preparation, 8 PhD students per class. Taught course, examined, graded students “Course à option” “En Route verse le Cancer” Faculte de Medecine, University of Geneva 3 hrs contact, 6 hrs preparation, 25 medical students per class. Taught course, examined, graded students

2010-2011 “Apprentisage par Probleme: Maladies cardiovasculaires” Faculte de Medecine, University of Geneva 16 hrs contact, 32 hrs preparation, 8 medical students per class. Taught course, examined, graded students Tutor for “Chapitres Choisis” University of Geneva 12 hrs contact, 24 hrs preparation, 8 PhD students per class. Taught course, examined, graded students “Course à option” “En Route verse le Cancer” Faculte de Medecine, University of Geneva 3 hrs contact, 6 hrs preparation, 25 medical students per class. Taught course, examined, graded students

2009-2010 “Course à option” “En Route verse le Cancer” Faculte de Medecine, University of Geneva 3 hrs contact, 6 hrs preparation, 25 medical students per class. Taught course, examined, graded students Tutor for “Chapitres Choisis” University of Geneva 12 hrs contact, 24 hrs preparation, 8 PhD students per class. Taught course, examined, graded students

2008-2009 “Course à option” “Role of mitochondrial fusion and fission in cell death” Faculte de Medecine, University of Geneva 4 hrs contact, 6 hrs preparation, 25 medical students per class. Taught course “Chapitres Choisis” “The changing shape of mitochondrial death” PhD School in Biology, University of Geneva 2 hrs contact, 3 hrs preparation, 25 PhD students per class. Taught course

2007-2012 Faculty, Ph.D. School in Biology and Medicine, University of Geneva Medical School. Since 2007, supervisor of 8 PhD students

2005-2007 Molecular Pathology, Residency Program in Clinical Pharmacology & Toxicology, University of Padova Medical School 10 hrs contact, 15 hrs preparation, 10 postdoctoral students per class

2004 Short Course “Role of Bcl-2 family members in apoptosis”, Ph.D. School in Biosciences, University of Padova. 4 hrs contact, 6 hrs preparation, 30 graduate students per class

2003-2007 Faculty, Ph.D. School in Biosciences, University of Padova. Supervisor of 7 PhD students

Trainees

Postdoctoral Years Name Current position 2018- Lukas Alan (CZ) current Isotta Lorenzi (DE) current Satoko Shinjo (JP) current (Nomura Foundation Fellowship) 2017- Masafumi Noguchi (JP) current (JSPS Fellowship) 2015- Keitaro Shibata (JP) current (Canon Foundation Fellowship) 2014- Camilla Bean (IT) current Akiko Omori (JP) current (EU FP7 DTI-IMPORT Fellowship)


Lena F. Pernas (US) current (LSRF Fellowship) Stephanie Herkenne (BE) current (Veronesi Foundation Fellowship) 2013-2017 Francesca Grespi (IT) Staff Scientist, Thermo Fisher (IT) Emilie Schrepfer (FR) Editor, Frontiers, Lausanne (CH) 2013-2014 Etienne Hebert-Chatelain (CA) Assistant Professor, University of Moncton (CA) 2012-2016 Marta Giacomello (IT) Assistant Professor, University of Padova (IT) Ruben Quintana-Cabrera (ES) Assistant Professor, University of Salamanca (ES) 2011-2014 Domenico Migliorini (IT) Founder, TranSalus (CH) Elena Ziviani (UK) Associate Professor, University of Padova (IT)

Claudia Savoia (IT) Scientist, Nestle Health Science Institute (CH) 2011-2012 Stephanie Maret (CH) Editor, Frontiers in Neuroscience (CH) 2010- Martina Semenzato (IT) current Deborah Naon (AR) current 2009-2014 M. Eugenia Soriano (ES) Assistant Professor, University of Padova (IT) 2008-2013 Atsuko Kasahara (JP) Assistant Professor, University of Kanazawa (JP) 2008-2010 Violeta Lamarca Guy (ES) High School teacher (ES) 2007-2011 Silvia Campello (IT) Associate Professor, University of Rome II (IT) 2007-2010 Luiza Sanjuan Szklarz (PL) unknown Michal Wasilewski (PL) Junior Group Leader, IRMB (Poland) 2005-2007 Kai Stefan Dimmer (DE) Assistant Professor, U. of Tubingen (DE) 2004-2010 Grazia M. Cereghetti (CH) Clinical Study Coordinator, University of Zurich (CH) 2004-2007 Vasiliki Anesti (GR) Regulatory Affairs Officer, Help Pharmaceuticals (GR) Graduate Year Name Current position 2017- Tiago Fonseca (PT) current Marta Medaglia (IT) current 2016- Anna Pellattiero (IT) current 2015- Maya Chergova (BU) current 2014- Annalisa Serafini (IT) postdoctoral fellow, IRCCS S. Lucia Rome (IT) 2012- Christina Glytsou (GR) postdoctoral fellow, NYU School of Medicine (US) Dijana Samardzcic (SR) current Elisa Barbieri (IT) Quality Manager, Lonza Life Sciences (CH) Sowmya Lakshminaranayan(IN) High school teacher, (IN) 2012-2016 Charlotte Quirin (DE) Scientific Manager, Max-Delbruck Institute (DE)

Alice Nardin (IT) postdoctoral fellow, U. of Dundee (UK) 2010-2015 Tatiana Varanita (MD) Postdoctoral fellow, U. of Padova (IT)

Sebastian Zamorano (CL) Safety Scientist, UBC (CH) Marta Zaninello (IT) Postdoctoral fellow, U. of Cologne (DE) Mauro Corrado (IT) postdoctoral fellow, MPI Freiburg (DE)

2008-2013 Aswin Pyakurel (NP) Postdoctoral fellow, Sion Eye Institute, Sion (CH) Bjorn Oettinghaus (DE) Postdoctoral fellow, U. of Basel (CH) 2008-2012 Valentina De Battisti (IT) postdoctoral fellow, Thomas Jefferson University (US) Sara Cogliati (IT) postdoctoral fellow, CNIC Madrid (ES) 2006-2011 Ligia Carina Gomes (PT) Scientist, CMC Biologics (DK) 2006-2010 Cristina Cerqua (IT) Postdoctoral fellow, U. of Padova (IT) 2006-2010 Veronica Costa (IT) Researcher, Roche (Bern, CH) 2005-2008 Christian Frezza (IT) Group Leader, MRC Hutchison, Cambridge (UK) 2005-2008 Sara Cipolat (IT) Scientific Advisor (Italy) 2005-2007 Emilie Alirol (FR) Staff, Hopital Universitaire de Geneve (CH) 2004-2009 Olga Martins de Brito (PT) Research Associate, Université du Luxembourg (LU)


Publications * denotes equal contribution Research Articles 1. V. Petronilli, P. Costantini, L. Scorrano, R. Colonna, S. Passamonti and P. Bernardi, The Voltage Sensor

of the Mitochondrial Permeability Transition Pore Is Tuned by the Oxidation-Reduction State of Vicinal Thiols. J. Biol. Chem., 269 (24): 16638-16642 (1994).

2. L. Scorrano, V. Petronilli and P. Bernardi, On the Voltage Dependence of the Mitochondrial Transition Pore. A Critical Appraisal. J. Biol. Chem., 272 (19): 12295-12299 (1997).

3. L. Scorrano, A. Nicolli, E. Basso, V. Petronilli and P. Bernardi, Two Modes of Activation of the Permeability Transition Pore: the Role of Mitochondrial Cyclophilin. Mol. Cell. Biochem., 174: 181-184 (1997).

4. L. Scorrano, V. Petronilli, R. Colonna, F. Di Lisa, and P. Bernardi Chloromethyltetramethylrosamine (Mitotracker Orange™) Induces the Mitochondrial Permeability Transition and Inhibits Complex I. Implications for the Mechanism of Cytochrome c Release. J. Biol. Chem., 274 (35): 24657-24663 (1999).

5. L. Scorrano, V. Petronilli, F. Di Lisa, and P. Bernardi, Commitment to Apoptosis by GD3 Ganglioside Depends on Opening of the Permeability Transition Pore. J. Biol. Chem. 274 (32): 22581-22586 (1999).

6. V.K. Mootha, M.C. Wei, K.F. Buttle, L. Scorrano, V. Panoutsakopoulou, C.A. Mannella, and S.J. Korsmeyer. A reversible component of mitochondrial respiratory dysfunction in apoptosis can be rescued by exogenous cytochrome c. EMBO J. 20: 661-671 (2001).

7. L. Scorrano, D. Penzo, V. Petronilli, F. Pagano, and P. Bernardi. Arachidonic acid causes cell death through the mitochondrial permeability transition. Implications for TNFα Apoptotic Signaling. J. Biol. Chem. 276: 12035-12040 (2001).

• Comment in: J.J. Lemasters. Cytochrome c: which way out? Hepatology. 34:605-607 (2001) 8. V. Petronilli, D. Penzo, L. Scorrano, P. Bernardi, and F. Di Lisa. The mitochondrial permeability

transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situ. J. Biol. Chem. 276: 12030-12034 (2001).

9. I. Aifantis*, F. Gounari*, L. Scorrano, C. Borowski, and H. von Boehmer. Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-kB and NFAT. Nat. Immunol.; 2: 403-9 (2001).

10. D.A. Thomas*, L. Scorrano*, G.V. Putcha, S.J. Korsmeyer and T.J. Ley. Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAK and BAX or cytochrome c release. Proc. Natl. Acad. Sci. USA, 98: 14985-14990 (2001).

11. L. Scorrano, M. Ashiya, K. Buttle, S. Weiler, S.A. Oakes, C.A. Mannella and S.J. Korsmeyer, A Distinct Pathway Remodels Mitochondrial Cristae and Mobilizes Cytochrome c during Apoptosis. Dev. Cell 2: 55-67 (2002).

• Comment in: J.C. Reed and D.R. Green. Remodeling for demolition: changes in mitochondrial ultrastructure during apoptosis. Mol Cell. 9:1-3 (2002).

• Featured in: R. Lewis Hot Paper: Deciphering Death's Circuitry. Milestones reached in understanding how BCL-2 family members control the apoptotic process The Scientist 17:32 (2003)

• FFa 6 Faculty of1000 Biology, R. Youle 12. V.R. Fantin, M.J. Berardi, L. Scorrano, S.J. Korsmeyer and P. Leder. A novel mitochondriotoxic small

molecule that selectively inhibits tumor cell growth. Cancer Cell 2: 29-42 (2002) 13. Gugliucci, L. Ranzato, L. Scorrano, R. Colonna, V. Petronilli, C. Cusan, M. Prato, M. Mancini, F.Pagano

and P. Bernardi. Mitochondria are direct targets of the lipoxygenase inhibitor MK886. A strategy for


cell killing by combined treatment with MK886 and cyclooxygenase inhibitors J.Biol.Chem. 277: 31789-31795 (2002)

14. L. Scorrano*, S.A. Oakes*, J.T. Opferman, E.H. Cheng, M.D. Sorcinelli, T. Pozzan and S.J. Korsmeyer. BAX and BAK Regulation of Endoplasmic Reticulum Ca2+: A Control Point for Apoptosis. Science 300: 135-139 (2003).

• Comment in: N. Demaurex and C. Distelhorst. Apoptosis--the calcium connection. Science. 300:65-67 (2003).

15. H. Johnson, L. Scorrano, S. J. Korsmeyer, and T. J. Ley. Cell death induced by Granzyme C. Blood 101:

3093-3101 (2003) 16. N.N. Danial, C.F. Gramm, L. Scorrano, C.Y. Zhang, A.M. Ranger, L.J. Licklider, B.B. Lowell, S.P. Gygi and

S. J. Korsmeyer. BAD integrates glycolysis and apoptosis trough a mitochondrial macromolecular complex with glucokinase. Nature. 424: 952-956 (2003)

• Comment in: J. Downward. Metabolism meets death. Nature. 424:896-897 (2003). • FFa 9 Faculty of1000 Biology, K. Carraway and A. Gross

17. P.C. Klohn*, M.E. Soriano*, W. Irwin, D. Penzo, L. Scorrano, A. Bitsch, H.G. Neumann and P. Bernardi.

Early resistance to cell death and to onset of the mitochondrial permeability transition during hepatocarcinogenesis with 2-acetylaminofluorene. Proc. Natl. Acad. Sci. U S A. 100:10014-19 (2003)

18. S.A. Oakes, J.T. Opferman, T. Pozzan, S.J. Korsmeyer and L. Scorrano. Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members. Biochem.Pharmacol. 66:1335-40 (2003)

19. S. Krauss*, C.Y. Zhang*, L. Scorrano, L.T. Dalgaard, J. St.Pierre, S.T. Grey and B. B. Lowell Superoxide-mediated activation of UCP2 causes pancreatic -cell dysfunction. J. Clin. Invest. 112:1831-42 (2003)

20. M.C. Bassik, L. Scorrano, S.A. Oakes, T. Pozzan and S.J. Korsmeyer Phosphorylation of BCL-2 Regulates ER Ca2+ Homeostasis and Apoptosis EMBO J. 23:1207-16 (2004)

21. D. Penzo, V. Petronilli, A. Angelin , C. Cusan, R. Colonna, L. Scorrano, F. Pagano, M. Prato, F. Di Lisa, P. Bernardi. Arachidonic acid released by phospholipase A2 activation triggers Ca2+-dependent apoptosis through the mitochondrial pathway J. Biol. Chem. 279:25219-25 (2004)

22. S. Cipolat, O. Martins de Brito, B. Dal Zilio and L. Scorrano OPA1 requires mitofusin 1 to promote mitochondrial fusion Proc. Natl. Acad. Sci. U S A. 101:15927-32 (2004).

23. S.A. Oakes, L. Scorrano, J.T. Opferman, M.C. Bassik, M. Nishino, T. Pozzan and S.J. Korsmeyer. Proapoptotic BAX and BAK Regulate IP3-R1 and Calcium Leak From the Endoplasmic Reticulum Proc. Natl. Acad. Sci. U S A. 102:105-10 (2005)

24. E. Buytaert, G. Callewaert, N. Hendrickx, L. Scorrano, D. Hartmann, L. Missiaen, J.R. Vandenheede, I. Heirman, J. Grooten and P.Agostinis. Role of endoplasmic reticulum depletion and multidomain proapoptotic BAX and BAK proteins in shaping cell death after hypericin-mediated photodynamic therapy FASEB J. 20:756-758. (2006)

25. S. Cipolat*, T. Rudka*, D. Hartmann*, V. Costa, L. Serneels, K. Craessaerts, K. Metzger, C. Frezza, W. Annaert, L. D’Adamio, C. Derks, T. Dejaegere, L. Pellegrini, R. D’Hooge, and L. Scorrano‡, B. De Strooper‡. ‡corresponding authors. Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1 dependent cristae remodeling. Cell 126:163-75 (2006)

• Comment in: E. Gottlieb. OPA1 and PARL Keep a Lid on Apoptosis. Cell 126:27-9 (2006). • Comment in: P. Delivani and S.J. Martin Mitochondrial membrane remodeling in apoptosis: an

inside story Cell Death and Differentiation 13: 2007-10 (2006). • Comment in: In brief, Nature Reviews Molecular and Cellular Biology 7:625 • FFa 6 Faculty of1000 Biology, B. Conradt

26. C. Frezza, S. Cipolat, O. Martins de Brito, M. Micaroni, G.V. Beznoussenko, T. Rudka, D. Bartoli, R.S.

Polishuck, N.N. Danial, B. De Strooper and L. Scorrano. OPA1 Controls Mitochondrial Cristae Remodelling Independently from Mitochondrial Fusion During Apoptosis. Cell 126:176-89 (2006)


• Comment in: E. Gottlieb. OPA1 and PARL Keep a Lid on Apoptosis. Cell 126:27-9 (2006). • Comment in: P. Delivani and S.J. Martin Mitochondrial membrane remodeling in apoptosis: an

inside story Cell Death and Differentiation 13: 2007-10 (2006). • FFa 9, Faculty of1000 Biology, B. Conradt and D. Xue

27. E. Alirol, D. James, D. Huber, A. Marchetto, L. Vergani, J-C Martinou‡, and L. Scorrano‡. ‡corresponding

authors. The mitochondrial fission protein hFis1 requires the endoplasmic reticulum gateway to induce apoptosis. Mol. Biol. Cell 17:4593-605 (2006)

• FFa 6 Faculty of1000 Biology, D. Andrews 28. S. Campello, M. Bettella, R.A. Lacalle, S. Mañes, L. Scorrano, and A. Viola. Orchestration of lymphocyte

chemotaxis by mitochondrial dynamics. J. Exp. Med. 203:2879-86 (2006) • Cover Article, J. Exp. Med. 203(13) • Comment in: Position of Power J. Exp. Med. 203:2782 (2006) • FFa 9 Faculty of1000 Biology, M. Gold/A. Chan

29. C. Frezza, S. Cipolat and L. Scorrano. Organelle Isolation: functional mitochondria from mouse liver,

muscle and cultured fibroblasts. Nature Prot. 2:287-95 (2007) 30. K.S. Dimmer, F. Navoni, A. Casarin, E. Trevisson, S. Endele, A. Winterpacht, L. Salviati, and L. Scorrano.

LETM1, deleted in Wolf-Hirschhorn Syndrome is required for normal mitochondrial morphology and cellular viability. Hum Mol Genet. 17:201-214 (2008)

31. L.C. Gomes and L. Scorrano, High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy. Biochim. Biophys. Acta 1777: 860-866 (2008).

32. M. Spinazzi, S. Cazzola, M. Bortolozzi, A. Baracca, E. Loro, A. Casarin, G. Solaini, G. Sgarbi, G. Casalena, G. Cenacchi, A. Malena, C. Frezza, F. Carrara, C. Angelini, L. Scorrano, L. Salviati, L. Vergani. A novel deletion in the GTPase domain of OPA1 causes defects in mitochondrial morphology and distribution, but not in function. Hum Mol Genet. 17:3291-3302. (2008)

• FFa 8 Faculty of1000 Medicine, A. Oldfors 33. G.M. Cereghetti, A. Stangherlin, O. Martins de Brito, C.R. Chang, C. Blackstone, P. Bernardi and L.

Scorrano Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria. Proc. Natl. Acad. Sci. USA. 105:15803-15808 (2008).

34. O. Martins de Brito and L. Scorrano Mitofusin 2 tethers mitochondria and endoplasmic reticulum. Nature 456:605-10 (2008).

• Comment in: K. Merkwirth and T. Langer. Mitofusin 2 builds a bridge between ER and mitochondria. Cell 135:1165-7 (2008).

• Comment in: A. Parekh. Calcium signalling: mitofusins promote interorganellar crosstalk. Curr Biol. 19:R200-3. (2009)

• Comment in: In brief, Nature Reviews Molecular and Cellular Biology 10:5 • FFa 15, Faculty of1000 Biology, T Frey/Y. Yamashita/H. Osiewacz/D. Green • FFa 8, Faculty of1000 Medicine, N. Bresolin

35. A. Vecchione, M. Fassan, V. Anesti, A. Morrione, S. Goldoni, G. Baldassarre, D. Byrne, D. D'Arca, J.P.

Palazzo, J. Lloyd, L. Scorrano, L.G. Gomella, R.V. Iozzo, R. Baffa. MITOSTATIN, a putative tumor suppressor on chromosome 12q24.1, is downregulated in human bladder and breast cancer. Oncogene 28:257-69 (2009)

36. O. Martins de Brito and L. Scorrano Mitofusin-2 regulates mitochondrial and endoplasmic reticulum morphology and tethering: the role of Ras. Mitochondrion 9:222-6. (2009)

37. V.A. Morais, P. Verstreken, A. Roethig, J. Smet, A. Snellinx, M. Vanbrabant, D. Haddad, C. Frezza, W. Mandemakers, D. Vogt-Weisenhorn, R. Van Coster, W. Wurst, L. Scorrano, and B. De Strooper,


Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function. EMBO Mol Med 1, 99-111. (2009)

• Comment in: A. Murphy, In a flurry of PINK, mitochondrial bioenergetics takes a leading role in Parkinson's disease EMBO Mol Med 1, 81-84. (2009)

38. V. Romanello, E. Guadagnin, L. Gomes, I. Roder, C. Sandri, Y.Petersen, G. Milan, E. Masiero, P. Del

Piccolo, M. Foretz, L Scorrano, R. Rudolf and M. Sandri Mitochondrial fission and remodeling contributes to muscle atrophy. EMBO J. 29:1774-85 (2010)

39. C. De Palma, S. Falcone, S. Pisoni, S. Cipolat, C. Panzeri, A. Pisconti, R. Allevi, M.T. Bassi, T. Pozzan, G. Cossu, S. Moncada, L. Scorrano, E. Clementi and S. Brunelli Nitric oxide inhibition of Drp1 mediated mitochondrial fission is critical for myogenic differentiation Cell Death Differ. 17:1684-96 (2010)

40. F.Calore, C. Genisset, M. Rossato, M. Degli Esposti, and L. Scorrano‡, Marina de Bernard‡ BAX, BAK-dependent endosome-mitochondria juxtaposition during apoptosis induced by H. pylori VacA Cell Death Differ. ‡corresponding authors 17:1707-16 (2010)

41. G. Cereghetti, V. Costa and L. Scorrano Inhibition of Drp1-dependent mitochondrial fragmentation and apoptosis by a polypeptide antagonist of calcineurin Cell Death Differ. 17:1785-94 (2010)

42. C. Cerqua, V. Anesti, A. Pyakurel, D. Liu, D. Naon, R. Baffa, G. Wiche, K.S. Dimmer and L. Scorrano Trichoplein/Mitostatin regulates ER-mitochondria juxtaposition EMBO Rep. 11:854-60 (2010)

43. V. Costa, M Giacomello, R. Hudec, R. Lopreiato, G. Ermak, D. Lim, W. Malorni, K.J.A. Davies, E. Carafoli, and L. Scorrano Mitochondrial fission and cristae disruption increase the response of cell models of Huntington’s disease to apoptotic stimuli EMBO Mol. Med. 2:490-503. (2010)

• Comment in: J.M.A. Oliveira and R.N. Lightowlers Could successful (mitochondrial) networking help prevent Huntington’s disease? EMBO Mol Med 2:487-9. (2010)

• FFa 8 Faculty of1000 Medicine, S. Di Donato 44. K Singaravelu, C Nelson, D Bakowski, O Martins de Brito SW, Ng, J Di Capite, T Powell, L Scorrano , AB

Parekh. Mitofusin 2 regulates STIM1 migration from the Ca2+ store to the plasma membrane in cells with depolarised mitochondria. J Biol Chem. 286:12189-201. (2011)

45. L. Gomes, G. Di Benedetto and L. Scorrano During autophagy mitochondria elongate, are spared from degradation and sustain cell viability Nat. Cell. Biol. 13:589–598 (2011)

• Cover Article, Nat. Cell. Biol. 13 (5) • Comment in: C. Blackstone and C.R. Chang Mitochondria unite to survive Nat. Cell. Biol.

13:521-2 (2011) • Comment in: K. H. Wrighton Autophagy: Shaping the fate of mitochondria Nat. Rev. Mol. Cell

Biol. 12:344-5 (2011) • Comment in: L. Galluzzi, O. Kepp, and G. Kroemer Mitochondrial dynamics: a strategy for

avoiding autophagy. Curr Biol. 21:R478-80 (2011). • Editor’s Choice in: S.M. Hurtley Don't Eat Me Science 332: 514-5 (2011). • FFa 10 Faculty of1000 Biology, H. Osziewacz

46. L.C. Gomes, G. Di Benedetto, and L. Scorrano Essential amino acids and glutamine regulate induction

of mitochondrial elongation during autophagy. Cell Cycle. 10:2635-9 (2011) 47. Ferraro E, Pesaresi MG, De Zio D, Cencioni MT, Gortat A, Cozzolino M, Berghella L, Maria Salvatore A,

Oettinghaus B, Scorrano L, Pérez-Payà E, and Cecconi F. Apaf1 plays a pro-survival role by regulating centrosome morphology and function. J Cell Sci. 124:3450-63 (2011)

48. Sanjuan Szklarz,L.K. and L. Scorrano. (2012). The antiapoptotic OPA1/Parl couple participates in mitochondrial adaptation to heat shock. Biochim. Biophys. Acta 1817, 1886-1893.

49. Wasilewski, M., Semenzato,M., Rafelski,S.M., Robbins,J., Bakardjiev,A.I., and L. Scorrano (2012). Optic atrophy 1-dependent mitochondrial remodeling controls steroidogenesis in trophoblasts. Curr. Biol. 22, 1228-1234.


50. Maltecca,F., De,S.D., Cassina,L., Consolato,F., Wasilewski,M., L. Scorrano., Rizzuto,R., and Casari,G. (2012). Respiratory dysfunction by AFG3L2 deficiency causes decreased mitochondrial calcium uptake via organellar network fragmentation. Hum. Mol. Genet. 21, 3858-3870.

51. Ramonet, D., Perier,C., Recasens,A., Dehay,B., Bove,J., Costa,V., L. Scorrano, and Vila,M. (2013). Optic atrophy 1 mediates mitochondria remodeling and dopaminergic neurodegeneration linked to complex I deficiency. Cell Death. Differ. 20:77-85

52. Supale S, Thorel F, Merkwirth C, Gjinovci A, Herrera PL, Scorrano L, Meda P, Langer T, Maechler P. . (2013) Loss of prohibitin induces mitochondrial damages altering Beta-cell function and survival and responsible for gradual diabetes development. Diabetes. 62:3488-99.

53. Santo-Domingo J, Giacomello M, Poburko D, Scorrano L, Demaurex N. (2013) OPA1 promotes pH flashes that spread between contiguous mitochondria without matrix protein exchange. EMBO J 32:1927-40

54. Pla-Martín D, Rueda CB, Estela A, Sánchez-Piris M, González-Sánchez P, Traba J, de la Fuente S, Scorrano L, Renau-Piqueras J, Alvarez J, Satrústegui J, Palau F. (2013) Silencing of the Charcot-Marie-Tooth disease-associated gene GDAP1 induces abnormal mitochondrial distribution and affects Ca2+ homeostasis by reducing store-operated Ca2+ entry. Neurobiol Dis. 55:140-51

55. Quintens R, Singh S, Lemaire K, De Bock K, Granvik M, Schraenen A, Vroegrijk IO, Costa V, Van Noten P, Lambrechts D, Lehnert S, Van Lommel L, Thorrez L, De Faudeur G, Romijn JA, Shelton JM, Scorrano L, Lijnen HR, Voshol PJ, Carmeliet P, Mammen PP, Schuit F. (2013) Mice deficient in the respiratory chain gene Cox6a2 are protected against high-fat diet-induced obesity and insulin resistance. PLoS One. 8:e56719.

56. S. Cogliati, C. Frezza, M.E. Soriano, T. Varanita, R. Quintana Cabrera, M. Corrado, S. Cipolat, V. Costa, A. Casarin, L.C. Gomes, E. Perales-Clemente, L. Salviati, P. Fernandez-Silva, and J.A. Enriquez, L. Scorrano. (2013) Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency. Cell;155:160-71

• Comment in: Stroud DA, Ryan MT. Mitochondria: Organization of Respiratory Chain Complexes Becomes Cristae-lized Curr Biol. (2013) 23:R969-71.

57. A. Kasahara, S. Cipolat, Y. Chen, and G.W. Dorn 2nd, L. Scorrano. (2013) Mitochondrial fusion directs

cardiomyocyte differentiation via calcineurin and Notch signaling. Science 342:734-7 • Comment in: S. M. Hurtley, Mitochondrial Fusion and Heart Development. Sci. Signal. 6, ec277

(2013). • FFa 10 Faculty of1000 Biology, H. Bellen/M. Sack

58. V Debattisti, D Pendin, E Ziviani, A Daga, and L. Scorrano. Reduction of endoplasmic reticulum stress

attenuates the defects caused by Drosophila mitofusin depletion. J Cell Biol. 204:303-12 (2014) 59. ES Marini, C Giampietri, S Petrungaro, S Conti, A Filippini, and L. Scorrano‡, E Ziparo‡. ‡corresponding

authors The endogenous caspase-8 inhibitor c-FLIP(L) regulates ER morphology and crosstalk with mitochondria. Cell Death Differ. 22:1131-43 (2015).

60. SB Ong, AR Hall, RK Dongworth, S Kalkhoran, A Pyakurel, L. Scorrano, DJ Hausenloy. Akt protects the heart against ischaemia-reperfusion injury by modulating mitochondrial morphology. Thromb Haemost. 113:513-21 (2015).

61. M. Song, K. Mihara, Y. Chen, L. Scorrano, and GW Dorn 2nd. Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts. Cell Metab. 21:273-85.(2015)

62. A Pyakurel, C. Savoia, D. Hess and L. Scorrano Extracellular regulated kinase phosphorylates Mitofusin 1 to control mitochondrial morphology and apoptosis. Mol. Cell, 58:244-54 (2015)

63. A Ferreira-da-Silva, C Valacca, E Rios, H Pópulo, P Soares, M Sobrinho-Simões, L. Scorrano, V Máximo, and S Campello. Mitochondrial dynamics protein drp1 is overexpressed in oncocytic thyroid tumors and regulates cancer cell migration. PLoS One 10:e0122308. (2015).

64. T. Varanita, M.E. Soriano, V. Romanello, T. Zaglia, R. Quintana Cabrera, M. Semenzato, R. Menabò, V. Costa, G. Civiletto, P. Pesce, C. Viscomi, M. Zeviani, F. Di Lisa, M. Mongillo, M. Sandri, and L. Scorrano


The Opa1-dependent mitochondrial cristae remodeling pathway controls atrophic, apoptotic and ischemic tissue damage Cell Metab. 21:834-44 (2015)

• Cover Article, Cell Metab. 21(6) 65. G Civiletto*, T Varanita*, Cerutti R, Gorletta T, Barbaro S, Marchet S, Lamperti C, Viscomi C and L.

Scorrano‡, M. Zeviani‡. ‡corresponding authors Opa1 overexpression ameliorates the clinical phenotype of two mitochondrial disease mouse models Cell Metab. 21:845-54 (2015)

• Cover Article, Cell Metab. 21(6) 66. Cahill TJ, Leo V, Kelly M, Stockenhuber A, Kennedy NW, Bao L, Cereghetti G,Harper AR, Czibik G, Lao C,

Bellahcene M, Steeples V, Ghaffari S, Yavari A, Mayer A, Poulton J, Ferguson DJ, L. Scorrano, Hettiarachchi NT, Peers C, Boyle J, Hill RB, Simmons A, Watkins H, Dear TN, Ashrafian H. Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure. J Biol Chem. 290:25907-19. (2015)

67. Managò A, Leanza L, Carraretto L, Sassi N, Grancara S, Quintana-Cabrera R, Trimarco V, Toninello A, L. Scorrano, Trentin L, Semenzato G, Gulbins E, Zoratti M, Szabò I. Early effects of the antineoplastic agent salinomycin onmitochondrial function. Cell Death Dis. Oct 22;6:e1930 (2015).

68. B. Oettinghaus, J.M. Schulz, L.M. Restelli, M. Licci, C. Savoia, A. Schmidt, K. Schmitt, A. Grimm, L. Morè, J. Hench, M. Tolnay, A. Eckert, P. D'Adamo, P. Franken, N. Ishihara, K. Mihara, J. Bischofberger, and L. Scorrano‡, S Frank‡. ‡corresponding authors Synaptic dysfunction, memory deficits and hippocampal atrophy due to ablation of mitochondrial fission in adult forebrain neurons. Cell Death Differ. 23:18-28 (2016)

69. B. Oettinghaus, D. D'Alonzo D, E. Barbieri, LM Restelli, C Savoia, M. Licci, M. Tolnay, and S Frank‡ L. Scorrano‡. ‡corresponding authors DRP1-dependent apoptotic mitochondrial fission occurs independently of BAX, BAK and APAF1 to amplify cell death by BID and oxidative stress. Biochim Biophys Acta. Mar 17. doi: 10.1016/j.bbabio.2016.03.016. [Epub ahead of print]. (2016)

70. A Sala-Vila, I Navarro-Lérida, M Sánchez-Alvarez, M Bosch, C Calvo, JA López, E Calvo, C Ferguson, M Giacomello, A Serafini, L Scorrano, JA Enriquez, J Balsinde, RG Parton, J Vázquez, A Pol, MA Del Pozo. Interplay between hepatic mitochondria-associated membranes, lipid metabolism and caveolin-1 in mice. Sci Rep. Jun 6; 6:27351. doi: 10.1038/srep27351 (2016)

71. M Corrado, FR Mariotti, L Trapani, L Taraborrelli, F Nazio, V Cianfanelli, ME Soriano, E Schrepfer, F Cecconi, L Scorrano and S Campello. Macroautophagy inhibition maintains fragmented mitochondria to foster T cell receptor-dependent apoptosis. EMBO J. 35:1793-80 (2016).

72. Naon D, Zaninello M, Giacomello M, Varanita T, Grespi F, Lakshminaranayan S, Serafini A, Semenzato M, Herkenne S, Hernández-Alvarez MI, Zorzano A, De Stefani D, Dorn GW 2nd, Scorrano L. Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum-mitochondria tether. Proc Natl Acad Sci U S A. 113:11249-11254. (2016)

73. Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Büttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F. Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat Med. 22:1428-1438. (2016)

74. Cahill TJ, Leo V, Kelly M, Stockenhuber A, Kennedy NW, Bao L, Cereghetti GM, Harper AR, Czibik G, Liao C, Bellahcene M, Steeples V, Ghaffari S, Yavari A, Mayer A, Poulton J, Ferguson DJ, Scorrano L, Hettiarachchi NT, Peers C, Boyle J, Hill RB, Simmons A, Watkins H, Dear TN, Ashrafian H. Resistance of dynamin-related protein 1 oligomers to disassembly impairs mitophagy, resulting in myocardial inflammation and heart failure. J Biol Chem. 291:25762. (2016)


75. Glytsou C, Calvo E, Cogliati S, Mehrotra A, Anastasia I, Rigoni G, Raimondi A, Shintani N, Loureiro M, Vazquez J, Pellegrini L, Enriquez JA, Scorrano L‡, Soriano ME‡. ‡corresponding authors Optic Atrophy 1 Is Epistatic to the Core MICOS Component MIC60 in Mitochondrial Cristae Shape Control. Cell Rep. 17:3024-3034. (2016)

76. Guedouari H, Daigle T, Scorrano L, Hebert-Chatelain E. Sirtuin 5 protects mitochondria from fragmentation and degradation during starvation. Biochim Biophys Acta. 1864:169-176 (2017).

77. Tezze C, Romanello V, Desbats MA, Fadini GP, Albiero M, Favaro G, Ciciliot S, Soriano ME, Morbidoni V, Cerqua C, Loefler S, Kern H, Franceschi C, Salvioli S, Conte M, Blaauw B, Zampieri S, Salviati L, Scorrano L‡, Sandri M‡. corresponding authors Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence. Cell Metab. 25:1374-1389. (2017)

78. Tsakiri EN, Terpos E, Papanagnou ED, Kastritis E, Brieudes V, Halabalaki M, Bagratuni T, Florea BI, Overkleeft HS, Scorrano L, Skaltsounis AL, Dimopoulos MA, Trougakos IP. Milder degenerative effects of Carfilzomib vs. Bortezomib in the Drosophila model: a link to clinical adverse events. Sci Rep. Dec 19:17802. (2017)

79. Cieri D, Vicario M, Giacomello M, Vallese F, Filadi R, Wagner T, Pozzan T, Pizzo P, Scorrano L, Brini M, Calì T. SPLICS: a split green fluorescent protein-based contact site sensor for narrow and wide heterotypic organelle juxtaposition. Cell Death Differ. Dec 11. doi: 10.1038/s41418-017-0033-z. [Epub ahead of print] (2017)

80. Rehklau K, Hoffmann L, Gurniak CB, Ott M, Witke W, Scorrano L, Culmsee C, Rust MB. Cofilin1-dependent actin dynamics control DRP1-mediated mitochondrial fission. Cell Death Dis. 8:e3063 (2017).

81. Loubiere C, Clavel S, Gilleron J, Harisseh R, Fauconnier J, Ben-Sahra I, Kaminski L, Laurent K, Herkenne S, Lacas-Gervais S, Ambrosetti D, Alcor D, Rocchi S, Cormont M, Michiels JF, Mari B, Mazure NM, Scorrano L, Lacampagne A, Gharib A, Tanti JF, Bost F. The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells. Sci Rep. 7:5040. (2017)

82. P. Galanos, G. Pappas, A. Polyzos, A. Kotsinas, I. Svolaki, N.N. Giakoumakis, C. Glytsou, I.S. Pateras, U. Swain, V.L. Souliotis, A.G. Georgakilas, N. Geacintov, L. Scorrano, C. Lukas, J. Lukas, Z. Livneh, Z. Lygerou, D. Chowdhury, C.S. Sorensen, J. Bartek, V.G. Gorgoulis, Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability, Genome Biology, 19 (2018).

83. M. Fakruddin, F.Y. Wei, T. Suzuki, K. Asano, T. Kaieda, A. Omori, R. Izumi, A. Fujimura, T. Kaitsuka, K. Miyata, K. Araki, Y. Oike, L. Scorrano, T. Suzuki, K. Tomizawa, Defective Mitochondrial tRNA Taurine Modification Activates Global Proteostress and Leads to Mitochondrial Disease, Cell Rep., 22: 482-496 (2018).

84. L. Pernas, C. Bean, J.C. Boothroyd, L. Scorrano, Mitochondria Restrict Growth of the Intracellular Parasite Toxoplasma gondii by Limiting Its Uptake of Fatty Acids, Cell Metab., 27:886-897 (2018).

Reviews and commentaries (Peer-reviewed) 85. P. Bernardi, E. Basso, R. Colonna, P. Costantini, O. Eriksson, E. Fontaine, F. Ichas, M. Forte, S. Massari,

A. Nicolli, V. Petronilli and L. Scorrano, Perspectives on the mitochondrial permeability transition. Biochim. Biophys. Acta, 1365: 200-206 (1998).

86. P. Bernardi, R. Colonna, P. Costantini, O. Eriksson, E. Fontaine, F. Ichas, S. Massari, A. Nicolli, V. Petronilli and L. Scorrano, The Mitochondrial Permeability Transition. BioFactors, 8: 273-281 (1998).

87. P. Bernardi, R. Colonna, P. Costantini, O. Eriksson, A. Nicolli, V. Petronilli and L. Scorrano, Chemical Modification of the Mitochondrial Permeability Transition Pore by Specific Amino Acid Reagents. Drug Dev. Res., 46 (1): 14-17 (1999).

88. P. Bernardi, L. Scorrano, R. Colonna, V. Petronilli, and F. Di Lisa, Mitochondrial and Cell Death. Mechanistic Aspects and Methodological Issues. Eur. J. Biochem., 264: 687-701 (1999).

89. L. Scorrano and S. J. Korsmeyer. Mechanisms of cytochrome c release by proapoptotic BCL-2 family members. Biochem.Biophys.Res.Comm. 304: 437-444 (2003)

90. L. Scorrano Divide et impera: Ca2+ signals, mitochondrial fission and sensitization to apoptosis. Cell Death Differ. 10:1287-9 (2003)


91. L. Scorrano Proteins that fuse and fragment mitochondria in apoptosis: con-fissing a deadly con-fusion? J.Bioenerg.Biomembr. 37:165-70 (2005)

92. V. Anesti and L. Scorrano The relationship between mitochondrial shape and function and the cytoskeleton. Biochim. Biophys. Acta-Bioenergetics 1757:692-99 (2006)

93. K. S. Dimmer and L. Scorrano (De)constructing mitochondria: what for? Physiology (Bethesda). 21:233-41 (2006)

94. S. Cipolat and L. Scorrano To fuse and to protect. A novel role for CED-9 in mitochondrial morphology reveals an ancient function. Cell Death. Differ. 13:1833-4 (2006).

95. G. M. Cereghetti and L. Scorrano The many shapes of mitochondrial death Oncogene 25:4717-24 (2006)

96. L. Pellegrini and L. Scorrano A cut short to death: Parl and Opa1 in the regulation of mitochondrial morphology and apoptosis. Cell Death Diff. 14:1275-84 (2007).

97. D.J. Hausenloy and L. Scorrano Targeting cell death. Clin Pharmacol Ther. 82:370-3. (2007) 98. O. Martins de Brito and L. Scorrano Mitofusin 2: a mitochondria-shaping protein with signaling roles

beyond fusion. Antioxid. Redox Signal. 10:621-33 (2008). 99. L. Scorrano Caspase-8 goes cardiolipin: a new platform to provide mitochondria with microdomains of

apoptotic signals? J. Cell Biol. 183:579-81 (2008) 100. Galluzzi, L., Aaronson, S.A., Abrams, J., Alnemri, E.S., Andrews, D.W., Baehrecke, E.H., Bazan, N.G.,

Blagosklonny, M.V., Blomgren, K., Borner, C., Bredesen, D.E., Brenner, C., Castedo, M., Cidlowski, J.A., Ciechanover, A., Cohen, G.M., De, L., V, De Maria R., Deshmukh, M., Dynlacht, B.D., El-Deiry, W.S., Flavell, R.A., Fulda, S., Garrido, C., Golstein, P., Gougeon, M.L., Green, D.R., Gronemeyer, H., Hajnoczky, G., Hardwick, J.M., Hengartner, M.O., Ichijo, H., Jaattela, M., Kepp, O., Kimchi, A., Klionsky, D.J., Knight, R.A., Kornbluth, S., Kumar, S., Levine, B., Lipton, S.A., Lugli, E., Madeo, F., Malorni, W., Marine, J.C., Martin, S.J., Medema, J.P., Mehlen, P., Melino, G., Moll, U.M., Morselli, E., Nagata, S., Nicholson, D.W., Nicotera, P., Nunez, G., Oren, M., Penninger, J., Pervaiz, S., Peter, M.E., Piacentini, M., Prehn, J.H., Puthalakath, H., Rabinovich, G.A., Rizzuto, R., Rodrigues, C.M., Rubinsztein, D.C., Rudel, T., Scorrano, L., Simon, H.U., Steller, H., Tschopp, J., Tsujimoto, Y., Vandenabeele, P., Vitale, I., Vousden, K.H., Youle, R.J., Yuan, J., Zhivotovsky, B., and Kroemer, G Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death. Differ 16:1093-107. (2009).

101. L. Scorrano Opening the doors to cytochrome c: Changes in mitochondrial shape and apoptosis. Int J Biochem Cell Biol. 41:1875-83. (2009)

102. V Lamarca and L Scorrano. When separation means death: killing through the mitochondria, but starting from the endoplasmic reticulum EMBO J. 28:1681-3. (2009)

103. D. Liu and L. Scorrano The SUMO arena goes mitochondrial with MAPL. EMBO Rep. 10:694-6. (2009) 104. N. Demaurex and L. Scorrano. Reactive oxygen species are NOXious for neurons. Nat Neurosci. 12:819-

20. (2009) 105. M. Wasilewski and L. Scorrano The changing shape of mitochondrial apoptosis. Trends Endocrinol

Metab. 20:287-94. (2009) 106. O.M. de Brito and L. Scorrano An intimate liaison: spatial organization of the endoplasmic reticulum-

mitochondria relationship. EMBO J. 29:2715-23 (2010) 107. S. Campello, and L. Scorrano Mitochondrial shape changes: orchestrating cell pathophysiology. EMBO

Rep. 11:678-84 (2010) 108. G.W. Dorn 2nd and L. Scorrano Two close, too close: sarcoplasmic reticulum-mitochondrial crosstalk

and cardiomyocyte fate. Circ Res. 107:689-99 (2010) 109. M.Semenzato, S. Cogliati, and L. Scorrano Prohibitin(g) cancer: aurilide and killing by Opa1-dependent

cristae remodeling. Chem. Biol 18:8-9 (2011) 110. M.E. Soriano and L. Scorrano Traveling Bax and forth from mitochondria to control apoptosis. Cell

145:15-7 (2011) 111. B. Oettinghaus, S. Frank, and L. Scorrano Tonight, the same old, deadly programme: BH3-only

proteins, mitochondria and yeast. EMBO J. 30:2754-6. (2011)


112. GM Cereghetti, and L. Scorrano Phagocytosis: Coupling of Mitochondrial Uncoupling and Engulfment. Curr Biol. 2011 21:R852-4 (2011)

113. V. Costa and L. Scorrano Shaping the role of mitochondria in the pathogenesis of Huntington's disease. EMBO J. 31:1853-6. (2012)

114. LC Gomes and L. Scorrano Mitochondrial morphology in mitophagy and macroautophagy. Biochim Biophys Acta. 1833:205-12 (2012)

115. B Oettinghaus, M Licci, L. Scorrano, S Frank. Less than perfect divorces: dysregulated mitochondrial fission and neurodegeneration. Acta Neuropathol. 123:189-203 (2012).

116. E Ziviani and L. Scorrano In Epilepsy, BAD Is Not Really Bad. Neuron. 74:600-2. 2012 117. Nowikovsky,K., Pozzan,T., Rizzuto,R., L. Scorrano, and Bernardi,P. (2012). Perspectives on: SGP

symposium on mitochondrial physiology and medicine: the pathophysiology of LETM1. J. Gen. Physiol 139, 445-454.

118. M. Corrado, L. Scorrano and S Campello. (2012). Mitochondrial dynamics in cancer and neurodegenerative and neuroinflammatory diseases. Int. J. Cell Biol. 2012, 729290.

119. De Strooper B and L. Scorrano Close encounter: mitochondria, endoplasmic reticulum and Alzheimer's disease. EMBO J. 2012 Nov 5;31(21):4095-7.

120. Debattisti,V. and L. Scorrano. (2013). D. melanogaster, mitochondria and neurodegeneration: small model organism, big discoveries. Mol. Cell Neurosci. 55:77-86

121. L. Scorrano Keeping mitochondria in shape: a matter of life and death. (2013) Eur J Clin Invest. 43:886-93.

122. E Barbieri, and L. Scorrano. When numbers matter: mitochondrial DNA and gliomagenesis. (2013) Cell Death Differ. 20:1601-2.

123. Semenzato M, and L. Scorrano. O ROM(e)O1, ROM(e)O1, wherefore art thou ROM(e)O1? (2014) Sci Signal. 7:pe2.

124. A. Kasahara and L. Scorrano. Mitochondria: from cell death executioners to regulators of cell differentiation. Trends Cell Biol. 24:761-770 (2014)

125. D. Naon and L. Scorrano. At the right distance: ER-mitochondria juxtaposition in cell life and death. Biochim Biophys Acta. 1843:2184-94 (2015)

126. L.F. Pernas and L. Scorrano Mito-Morphosis: Mitochondrial Fusion, Fission, and Cristae Remodeling as Key Mediators of Cellular Function. Annu Rev Physiol. 78:505-31 (2016).

127. S. Cogliati, J.A. Enriquez, and L. Scorrano Mitochondrial Cristae: Where Beauty Meets Functionality. Trends Biochem Sci. 41:261-73 (2016)

128. E. Schrepfer and L. Scorrano Mitofusins, from Mitochondria to Metabolism. Mol Cell. 61:683-94 (2016) 129. M Corrado, L Scorrano, S Campello. Changing perspective on oncometabolites: from metabolic

signature of cancer to tumorigenic and immunosuppressive agents. Oncotarget. 2016 Apr 13. doi: 10.18632/oncotarget.8727. [Epub ahead of print] (2016).

130. Ziviani E, Scorrano L. Cell biology: The organelle replication connection. Nature. 538:326-327 (2016) 131. Lakshminarayanan S, Scorrano L. Judging a tumor cell by its cover: a matter of mitochondrial contact

sites. EMBO J. Mar 16. [Epub ahead of print] (2017) 132. Naon D, Zaninello M, Giacomello M, Varanita T, Grespi F, Lakshminaranayan S, Serafini A, Semenzato

M, Herkenne S, Hernández-Alvarez MI, Zorzano A, De Stefani D, Dorn GW 2nd, Scorrano L. Reply to Filadi et al.: Does Mitofusin 2 tether or separate endoplasmic reticulum and mitochondria? Proc Natl Acad Sci U S A. 114:E2268-E2269 (2017)

133. A. Pellattiero, L. Scorrano, Flaming Mitochondria: The Anti-inflammatory Drug Leflunomide Boosts Mitofusins, Cell Chem Biol, 25:231-233 (2018).

134. L. Galluzzi, I. Vitale, S.A. Aaronson, J.M. Abrams, D. Adam, P. Agostinis, E.S. Alnemri, L. Altucci, I. Amelio, D.W. Andrews, M. Annicchiarico-Petruzzelli, A.V. Antonov, E. Arama, E.H. Baehrecke, N.A. Barlev, N.G. Bazan, F. Bernassola, M.J.M. Bertrand, K. Bianchi, M.V. Blagosklonny, K. Blomgren, C. Borner, P. Boya, C. Brenner, M. Campanella, E. Candi, D. Carmona-Gutierrez, F. Cecconi, F.K.M. Chan, N.S. Chandel, E.H. Cheng, J.E. Chipuk, J.A. Cidlowski, A. Ciechanover, G.M. Cohen, M. Conrad, J.R. Cubillos-Ruiz, P.E. Czabotar, V. D'Angiolella, T.M. Dawson, V.L. Dawson, V. De Laurenzi, R. De Maria, K.M. Debatin, R.J. DeBerardinis, M. Deshmukh, N. Di Daniele, F. Di Virgilio, V.M. Dixit, S.J. Dixon, C.S.


Duckett, B.D. Dynlacht, W.S. El-Deiry, J.W. Elrod, G.M. Fimia, S. Fulda, A.J. Garcia-Saez, A.D. Garg, C. Garrido, E. Gavathiotis, P. Golstein, E. Gottlieb, D.R. Green, L.A. Greene, H. Gronemeyer, A. Gross, G. Hajnoczky, J.M. Hardwick, I.S. Harris, M.O. Hengartner, C. Hetz, H. Ichijo, M. Jaattela, B. Joseph, P.J. Jost, P.P. Juin, W.J. Kaiser, M. Karin, T. Kaufmann, O. Kepp, A. Kimchi, R.N. Kitsis, D.J. Klionsky, R.A. Knight, S. Kumar, S.W. Lee, J.J. Lemasters, B. Levine, A. Linkermann, S.A. Lipton, R.A. Lockshin, C. Lopez-Otin, S.W. Lowe, T. Luedde, E. Lugli, M. MacFarlane, F. Madeo, M. Malewicz, W. Malorni, G. Manic, J.C. Marine, S.J. Martin, J.C. Martinou, J.P. Medema, P. Mehlen, P. Meier, S. Melino, E.A. Miao, J.D. Molkentin, U.M. Moll, C. Munoz-Pinedo, S. Nagata, G. Nunez, A. Oberst, M. Oren, M. Overholtzer, M. Pagano, T. Panaretakis, M. Pasparakis, J.M. Penninger, D.M. Pereira, S. Pervaiz, M.E. Peter, M. Piacentini, P. Pinton, J.H.M. Prehn, H. Puthalakath, G.A. Rabinovich, M. Rehm, R. Rizzuto, C.M.P. Rodrigues, D.C. Rubinsztein, T. Rudel, K.M. Ryan, E. Sayan, L. Scorrano, F. Shao, Y.F. Shi, J. Silke, H.U. Simon, A. Sistigu, B.R. Stockwell, A. Strasser, G. Szabadkai, S.W.G. Tait, D.L. Tang, N. Tavernarakis, A. Thorburn, Y. Tsujimoto, B. Turk, T. Vanden Berghe, P. Vandenabeele, M.G.V. Heiden, A. Villunger, H.W. Virgin, K.H. Vousden, D. Vucic, E.F. Wagner, H. Walczak, D. Wallach, Y. Wang, J.A. Wells, W. Wood, J.Y. Yuan, Z. Zakeri, B. Zhivotovsky, L. Zitvogel, G. Melino, G. Kroemer, Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018, Cell Death Differ, 25:486-541 (2018).

135. L. Pernas, L. Scorrano, RevAMPing Mitochondrial Shape to Live Longer, Cell Metab, 26:805-806 (2017). 136. M. Giacomello, L. Scorrano, The INs and OUTs of mitofusins, J Cell Biol, 217:439-440 (2018).

Editorials, Book Chapters 137. L. Scorrano, V. Petronilli, R. Colonna, F. Di Lisa, and P. Bernardi, Interactions of

Chloromethyltetramethylrosamine (Mitotracker Orange™) with Isolated Mitochondria and Intact Cells. Ann. N.Y. Acad. Sci., 893: 391-395 (1999).

138. L. Scorrano Stanley J. Korsmeyer (1950-2005). J Bioenerg Biomembr. 37:109. (2005) 139. B. Westermann and L. Scorrano Mitochondrial dynamics in cell life and death. Biochim. Biophys. Acta

1763:413 (2006). 140. A. Letai and L. Scorrano Laying the foundations of programmed cell death. Cell Death. Differ. 13:1245-

47 (2006). 141. C. Frezza, S. Cipolat and L. Scorrano Measuring mitochondrial shape changes and their consequences

on the mitochondrial involvement during apoptosis. Methods Mol. Biol. 372:405-20 (2007). 142. L. Scorrano (2008). Multiple Functions of Mitochondria-Shaping Proteins. In Mitochondrial Biology:

New Perspectives, D.J.Chadwick and J.Goode, eds. (Wiley Interscience), pp. 47-59. 143. S. Campello, and L. Scorrano (2009). The Mitochondrial Pathway: Focus on Shape Changes. In

Essentials of Apoptosis. A Guide for Basic and Clinical Research, X.M.Yin and Z.Dong, eds. (Humana Press), pp. 151-175.

144. L. Scorrano (2010). Cristae Remodeling and Mitochondrial Fragmentation: A Checkpoint for Cytochrome c Release and Apoptosis? In Apoptosome. An up-and-coming therapeutical tool, M.D'Amelio and F.Cecconi, eds. (Springer Netherlands), pp. 253-270.

145. M.E. Soriano and L. Scorrano (2010). The Interplay between Bcl-2 Family Proteins and Mitochondrial Morphology in the Regulation of Apoptosis. In BCL2 Protein Family: Essential Regulators of Cell Death, C.Hetz, ed. (Landes Biosciences).

146. L. Pellegrini, L. Scorrano, An ode to mitochondria biologists, new and old, Biochem Biophys Res Comm, 500:1-1 (2018).

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