Loschmidt Laboratories Enantis, Ltd. PROTEIN ENGINEERING.
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Transcript of Loschmidt Laboratories Enantis, Ltd. PROTEIN ENGINEERING.
Loschmidt Laboratories
Enantis, Ltd.
PROTEIN ENGINEERING
LOSCHMIDT LABORATORIES & ENANTIS
17 years experience in protein science
multi-disciplinary team
LOSCHMIDT LABORATORIES & ENANTIS
17 years experience in protein science
multi-disciplinary team
laboratories and facilities (1.5 mil EUR)
University Campus and Biotechnology Incubator, Brno
LOSCHMIDT LABORATORIES & ENANTIS
17 years experience in protein science
multi-disciplinary team
laboratories and facilities (1.5 mil EUR)
University Campus and Biotechnology Incubator, Brno
molecular biology and microbiology
LOSCHMIDT LABORATORIES & ENANTIS
17 years experience in protein science
multi-disciplinary team
laboratories and facilities (1.5 mil EUR)
University Campus and Biotechnology Incubator, Brno
molecular biology and microbiology
bioinformatics and molecular modelling
17 years experience in protein science
multi-disciplinary team
laboratories and facilities (1.5 mil EUR)
University Campus and Biotechnology Incubator, Brno
molecular biology and microbiology
bioinformatics and molecular modelling
biochemistry and biophysics
LOSCHMIDT LABORATORIES & ENANTIS
LOSCHMIDT LABORATORIES & ENANTIS
BIOSENSING
DECONTAMINATION
BIOCATALYSIS
DEVELOPMENT OF BIOCATALYTIC PROCESS
GENETIC DATABASES
EXTREMOPHILES
DEVELOPMENT OF BIOCATALYTIC PROCESS
DIRECTED EVOLUTION
resistance to organic solvents
DEVELOPMENT OF BIOCATALYTIC PROCESS
DIRECTED EVOLUTION
RATIONAL DESIGN
thermostability enhancement
DEVELOPMENT OF BIOCATALYTIC PROCESS
DIRECTED EVOLUTION
RATIONAL DESIGN
thermostability enhancement
DEVELOPMENT OF BIOCATALYTIC PROCESS
DIRECTED EVOLUTION
RATIONAL DESIGN
thermostability enhancement
0
0.2
0.4
0.6
0.8
1
1.2
30 40 50 60 70 80
Nat
ive
stru
ctur
e
Temperature [°C]
20°C
DEVELOPMENT OF BIOCATALYTIC PROCESS
OPTIMIZED EXPRESSION
FERMENTATION
DOWN STREAM
21.5
29.0
35.4
52.9
92.0113.0
1 2 3 4
DhaA-LinB
DEVELOPMENT OF BIOCATALYTIC PROCESS
MEDIUM ENGINEERING
IMMOBILISATION
DEVELOPMENT OF BIOCATALYTIC PROCESS
HOTSPOT WIZARD
Hot Spot Wizard
RCSB PDB
user
Hot Spot Wizard
RCSB PDB
CSAUniProt
user
PDBSWS
HOTSPOT WIZARD
Hot Spot Wizard
RCSB PDB
CSAUniProt
user CAVER
CASTp
PDBSWS
HOTSPOT WIZARD
Hot Spot Wizard
RCSB PDB
CSAUniProt
user CAVER
CASTp
PDBSWS
tunnels
Cd-hit
BLAST NRDB
MUSCLERate4Site
HOTSPOT WIZARD
low highmutability
HOTSPOT WIZARD
1,3-1,4--glucanase PDB-ID 1GBG
haloalkane dehalogenasePDB-ID 1BN6
phosphotriesterasePDB-ID 1I0D
-lactamasePDB-ID 1BLS
HOTSPOT WIZARD
Estimated mutability
hot spotsregion
Pro
po
rtio
n o
f m
uta
tio
ns
HOTSPOT WIZARD
positive and neutral
Estimated mutability
hot spotsregion
Pro
po
rtio
n o
f m
uta
tio
ns
HOTSPOT WIZARD
positive and neutral slightly negative
positive and neutral slightly negative deleterious
Estimated mutability
hot spotsregion
Pro
po
rtio
n o
f m
uta
tio
ns
HOTSPOT WIZARD
HOTSPOT WIZARD
Pavelka et al. Nucl. Acids Res. 37: W376 2009