Longevity & Medical News

Kidneys grown from stem cells

• Kidneys grown from stem cells from amniotic fluid and animal foetal cells

• Depends on patient’s own amniotic fluid being saved at birth

• No risk or rejection

SENS News

• Review– “Strategies for Enigneered Negligible Senescence”– Seven major areas:

• Cell loss, tissue atrophy => RepleniSENS• Nuclear [epi]mutatitions(cancer) => OncoSENS• Mutant mitochondria => MitoSENS• Death-resistant cells => ApoptoSENS• Tissue stiffening => GlycoSENS• Extracellular aggregates => AmyloSENS• Intracellular aggregates => LysoSENS

SENS 2010 Research Report• LysoSENS

• A2E synthesis ability • Modified versions of eight microbial hyrolases• Developed HPLC assay

• AptoSENS and ReplenSENS– Constructed T-cell “scubber”

• OncoSENS – Method to determine gene-specific DNA mythalation patterns in single cells

• AmyloSENS– New project gearing up in Dublin and University of Texas in Huston

• MitoSENS– Obviating mitochondrial DNA deletions– Tranisent expression of mitochondrially-encode proteins

Stem cell study may bring treatment for muscle wasting

Artificial tissue promoting skin growth in wounds

New biomaterial closer mimic of human tissue

Neurons produced from human skin cells

• Use of 4 proteins can convert skin cells to neurons in 4-5 weeks– Stanford University School of Medicine– No need to create pluripotent stem cell first• Could news because some pluripotent techniques

result in rejection

– Work can be used to study neurological function and diseases more easily in lab

Stem cell therapy could reshape orthopedics

Regenerative Cell Therapy Efficacy• Human clinical trials:

– Crohn’s fistula– Stroke

• Ongoing human trials:– Advanced heart failure– Heart bypass– Osetoarthritics– Fractures– Liver disease– Kidney disease

• Animal results– Osteoarthritis– Tendon repair– Fractures– Cerebral infarction– Muscular dystrophy– Autoimmune disorders

More Stem Cell News

• Means to grow stem cells in suspension– Also work of growing spheres of stem cells

• New growth factor stimulates expansion and regeneration of blood forming stem cells

• Pluripotent stem cells from blood• 100x more efficient programming of stem cells

Medical Tricorder XPrize

• Qualcomm and Xprize are offering $10 million for a medical tricorder– Mobile solutions diagnosing many common

conditions as well as medical certified doctors– Depends on advances in sensing, microfluidics,

computation• Chip based radars are relevant to scanning• Small blood samples and microfluidics for in field blood

work

Extreme exercise for longer life?

• Tour of France cyclist live on average 8 years longer

• A little damage or stress increases mitochondrial oxygen consumption

• Reactive oxygen species (ROS) seems to increase stress resistance and longevity– Contrary to the oxidation (and anti-oxidant)

notions of aging– Anti-oxidants can actually interfere with ROS