Long Sensory Pathways (Somatic Sensation)
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Transcript of Long Sensory Pathways (Somatic Sensation)
Long Sensory Pathways (Somatic Sensation)
David A. Morton, Ph.D.Thursday January 31st, 2013
- Anterolateral System (Pain and Temperature Pathway)
- DCML (Vibration and Proprioception)
Objectives• Somatic (general) sensation• ALS and DCML pathways• Identify pathways on sections
Somatic Sensation Pathway OverviewHow many neurons are involved in somatic sensation?
Somatic Sensation Pathway OverviewWhat structures are involved in these pathways?
Somatic Sensation Pathway OverviewWill decussation occur? If so, where?
Somatic Sensation Pathway OverviewDescribe the neurons involved:
Somatic Sensation
General sensation.
Somatic Sensation
General sensation.
Crude (non-discriminative) touch. Cannot localize sensation.
Temperature
Pain
Proprioception
Vibration
Fine (discriminative) touch. Can localize sensation.
Anterior lateral system(ALS)
Dorsal column-Medial Lemniscus(DCML)
Receptor distribution is NOT uniform over the body surface; receptor density varies, as does receptive field size. Results in distorted cortical maps representing different parts of the body.
Anterior Lateral System (ALS)
General sensation.
• Crude (non-discriminative) touch. Cannot localize sensation.
• Temperature
• Pain
1° Order neuron• Location of cell body.• Location of synapse.• Collaterals.• Reflex connections.
Anterior Lateral System (ALS)
1° Order neuron• Location of cell body.• Location of synapse.• Collaterals.• Reflex connections.
Anterior Lateral System (ALS)
2° Order neuron• Location of cell body.• Decussation.• Course of axons.• Location of synapse.
Anterior Lateral System (ALS)
2° Order neuron• Location of cell body.• Decussation.• Course of axons.• Location of synapse.
Anterior Lateral System (ALS)
VPL
Internal capsulePost-ce
ntral g
yrus
Thalamus
3° Order neuron• Location of cell body.• Course of axons.• Location of synapse.
Anterior Lateral System (ALS)
Primary Somatosensory Cortex• Brodmann’s areas.• Somatotopic organization. • Homunculus.
Contrast cortex area for hand to elbow.
A vascular lesion of which cerebral artery would result in loss of somatic sensation from the hand? From the foot?
* *
Medial viewLateral view
Anterior view
• Ascending visceral afferent input travels in the
anterolateral system (dashed) and through
multisynaptic circuits via the reticular formation of
the brain stem (spino-reticulo-thalamic pathway)
(solid).
• These fibers influence both specific and diverse
areas of the cerebral cortex.
• Thalamic relays include intralaminar and midline
nuclei and cortical areas include orbitofrontal
cortex, insula and anterior cingulate gyrus.
Explain the sensory loss with a pathological enlargement of the central canal at the level of C 5,6,7. Why might there be atrophy of the hand muscles?
Define a dermatome and explain why they are useful. Know the dermatomes represented at the level of the back of the head, shoulder, thumb, middle finger, small finger, nipple, umbilicus, inguinal ligament, big toe, small toe and anus.
Somatic SensationPart II: DCML
Proprioception, vibration, fine touch
Dorsal column
1° Order neuron• Location of cell body.• Location of synapse.
Dorsal Column-Medial Lemniscus (DCML)
Grac
ile tr
act
Cune
ate t
ract
1° Order neuron• Location of cell body.• Location of synapse.
Dorsal Column-Medial Lemniscus (DCML)
2° Order neuron• Location of cell body.• Location of synapse.
Dorsal Column-Medial Lemniscus (DCML)
Medulla oblongata (caudal)
ALS
Med
ial
lem
nisc
us
Gracile nucleus
Cuneatenucleus
2° Order neuron• Location of cell body.• Location of synapse.
Dorsal Column-Medial Lemniscus (DCML)
Sensory dissociation
The somatotopic organization of the Medial Lemniscus (ML):
• "Feet down" in medulla.
• "Feet lateral" in pons.
• "Feet up" in midbrain
Dorsal Column-Medial Lemniscus (DCML)
3° Order neuron• Location of cell body.• Course of axons.• Location of synapse.
Dorsal Column-Medial Lemniscus (DCML)
Trace.
Dorsal Column-Medial Lemniscus (DCML)
Locate the ALS and DCML on the following sections:
ALS
Spinal Cord
DCML
Olivary nucleus
Pyramid
4th ventricle
XIIX
IX, XALS
Med
lem
Medulla
ALSMed lem
V
CN V
Pons
What happened in the Pons?
Cerebral peduncle
AQ
III
Red nucleusSubstantia nigra
ALS
ML
Midbrain
Diencephalon
Midbrain
IC
Cereb ped
RN
Mamillary bodies
3rd ventricle
The yellow represents area of a lesion. What sensory loss would you expect?
RL
RL
The yellow represents area of a lesion. What sensory loss would you expect?
Below the lesion:• Loss of pain and temp from left side• Loss of proprioception/vibration from right side
The right side of the pons is lesioned. What sensory loss would you expect?