A Systematic Review of Experimental Studies Investigating ...
Locating studies for your Systematic review
Transcript of Locating studies for your Systematic review
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Locating studies for your systematic review
Ruth Mitchelland Gail Higgins
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What are we trying to achieve?
● Up-to-date, relevant, unbiased systematic reviews of the effects of interventions for particular health care problems
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How do we achieve this?
● Locate all possible randomised controlled trials of interventions for these health care problems
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Locating all possible RCTs
● Sources◆ electronic databases◆ handsearching◆ reference lists◆ personal communication
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Use a strategic approach
● Start at highest yield source and work down● Electronic databases
◆ Cochrane Review Group register◆ Cochrane Controlled Trials Register◆ MEDLINE◆ EMBASE◆ Other appropriate databases
● Handsearching (reference lists, conference proceedings)
● Personal communication
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Minimise bias
● Sources of bias◆ language◆ source (which journal, database etc)◆ publication status (full article, conference
abstract, unpublished etc)
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Designing a search strategy
● Two-stage process:
◆ Formulate your question
◆ Identify your key concepts
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Formulate your question● Translate the clinical problem into a
structured question and identify key concepts
e.g. Is cannabis effective in treating pain?
Standard Rx or placebo
CannabisPainComparisonInterventionClinical Problem
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Identify your search terms (i)● Select database e.g. MEDLINE, and
identify the subject headings that match your key concepts
Standard Rx or placebo
CannabisPainComparisonInterventionClinical Problem
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Identify your search terms (ii)
● Use “text words” for
◆ synonyms – e.g. bed sore (decubitus ulcer)
◆ spelling – e.g. fetal (foetal)– marijuana or marihuana
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Identify your search terms (iii)
● Add the type of study you want ◆ e.g. randomised controlled trial
● For Cochrane systematic reviews ◆ use the Cochrane highly sensitive search
strategy for randomised controlled trials in MEDLINE
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RandomisedControlled Trials
Cochrane SearchStrategy506,604
Pain(MeSH headings
OR text words)
201,806
Cannabis(MeSH headings
ORtext words)
10,507
ANDAND
AND
31
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Tips for saving time and effort
● Look at the terms used in citations you know are relevant
● Add search terms to your strategy, use on part of a database, and see what you get back
● Don’t search before an intervention was invented
● Get up-to-date advice from someone who knows
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When do we stop searching?
● No right answer, be guided by◆ The return you’re getting◆ Resources◆ Time constraints
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Documenting your search● Important so you can remember what
you’ve done● Important for users of your review● Document
◆ what you searched ◆ when you searched ◆ how you searched
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Anticoagulants for heart failure in sinus rhythm
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Managing references
● Use specialised software e.g. ProCite, EndNote, IdeaList, Reference Manager
◆ saves typing ◆ reduces transcription errors◆ helps identify duplicates◆ helps keep track of studies
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Don’t be shy – ask for help!
● Retrieving studies is not simple● Ask your Collaborative Review Group’s
Trials Search Coordinator for advice● Section 5 of the Reviewers’ Handbook● Medical librarians