LIST OF C O N T E N T S

D E C E M B E R

RECENT ADVANCES IN STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

PROCEEDINGS OF THE l lth INTERNATIONAL SYMPOSIUM OF THE JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Preface vii

List of Participants ix

Steroid Receptor Structure and Function on Gene Expression

Mathias Truss, J6rg Bartsch, 1 Chromatin structure modulates transcription factor binding to the mouse Robert S. G. Haehe and mammary tumor virus (MMTV) promoter Miguel Beato

Anthony P. H. Wright, Johanna Zilliacns, lain J. McEwan, Karin Dihlmte-Wright, Tova Alml6f, Jan Carlstedt-Duke and Jan-~ke Gustafsson

11 Structure and function of the glucocorticoid receptor

BHgitte Happ and Bernd Groner 21 The activated mammary gland specific nuclear factor (MGF) enhances in vitro transcription of the p-casein gene promoter

Jack E. BodweH, Li-Ming Hu, Jiong-Ming Hu, Eduardo Orti and Allan Munck

31 Glucocorticoid receptors: ATP-dependent cycling and hormone-dependent hyperphosphorylation

Benita S. Katzenellenbogen, Bhavna Bhardwaj, Henry Fang, B. Avery Ince, Farzad Pakdel, Joseph C. Reese, David Schodin and Carol K. Wrenn

39 Hormone binding and transcription activation by estrogen receptors: analyses using mammalian and yeast systems

Timothy J. Cole, Jnlie A. Blendy, Woifgnng Schmid, Uwe Strildc and Gfinther Schfitz

49 Expression of the mouse glucocorticoid receptor and its role during development

Ping Shen, Zi-Jian Xie, Hui Li and Edwin R. Sinchez

55 Glucocorticoid receptor conversion to high affinity nuclear binding and transcription enhancement activity in Chinese hamster ovary cells subjected to heat and chemical stress

Grigorios Krey, Hansjfrg Keller, Abderrahim Mahfoudi, Jeffrey Medin, Keiko Ozato, Christine Dreyer and Walter Wahli

65 Xenopus peroxisome proliferator activated receptors: genomic organiz- ation, response element recognition, heterodimer formation with retinoid X receptor and activation by fatty acids

Thomas WeRe, SonjaoPhiHpp, Carol Cairns, Jan-Ake Gustafsson and Wolfgang Doppler

75 Glucocorticoid receptor binding sites in the promoter region of milk protein genes

C. Kent Osborne

Steroids, Anti-steroids, Growth Factors and Cancer

83 Mechanisms for tamoxifen resistance in breast cancer: possible role of tamoxifen metabolism

III

IV

Bunzo Sato, Harnhiko Kmthara, Masafumi Koga, Sop Kusaysml~ Hiroshi Salto, Satoru Sumitani, Kunlhlko Hashimoto, Tadamitsu Kiahimoto, Akira Tanaka and Keishi Matsumoto

Robert L. Sutherinnd, Colin K. W. Watts and Elizabeth A. Musgrove

Alan E. Wakeling

Baiqing Tang and Erlin Guspide

C. Marth, M. Widschwendter and G. Daxenbichler

F. Kaspar, A. C. B. Cato, A. Denninger, J. Eberle, C. Rndmayr, J. Glatzl, G. Bartsch and H. Klocker

Cornelius Knnbbe, Hartmut Klein, Gerhard Zugmaler and Klaus Dieter Voigt

Jan Richardson, Charu Kanshie and Charles R. Wira

91

99

107

115

123

127

137

143

List of Contents

Androgen-induced growth factor and its receptor: demonstration of the androgen-induced autocrine loop in mouse mammary carcinoma cells

Cyclin gene expression and growth control in normal and neoplastic human breast epithelium

Are breast tumours resistant to tamoxifen also resistant to pure anti- oestrogens?

Direct effect of gonadotropins on decidualization of human endometrial stromal cells

Mechanism of synergistic action of all-trans- or 9-cis-retinoic acid and intefferons in breast cancer cells

Characterization of two point mutations in the androgen receptor gene of patients with perineoscrotal hypospadia

Hormonal regulation of transforming growth factor fl-2 expression in human prostate cancer

Estradiol regulation of secretory component: expression by rat uterine epithelial cells

Molecular Biology of Enzymatic Processes in Steroid Transformation

J. I. Mason, K. Ushilims~ K. M. Dnndy, K. Nngai, D. Navilh, J. R. Head, L. Mllewich, W. E. Ralney and M. M. Ralph

151 Regulation of expression of the 3/~-hydroxysteroid dehydrogenases of human placenta and fetal adrenal

A. S. Bhatnagar, C. Batzl, A. Hlusler 161 The role of estrogen in the feedback regulation of follicle-stimulating and V. Nogu6s hormone secretion in the female rat

Samantha M. Pfeifer, Fmma E. Furth, Takushi Ohba, Yush J. Chang, Hanna Rennert, Norinki Sakurngi, Jeffrey T. Billheimer and Jerome F. Strauss HI

167 Sterol cartier protein 2: a role in steroid hormone synthesis?

Steroids in the Neuroendocrine System (Including Reproduction)

Junzo Kato, Shuji ltirata, Akira Nozawa and Naoko Mnnri

E. Ronald de Kloet, Win Sutanto, D6sir6e T. W. M. van den Berg, Margaret P. Carey, Aernout D. van Hanrst, C. Diane Horusby, Onno C. Meljer, Nynke Y. Rots and Melly S. Oitzl

Margaret Warner, Maria Str6mstndt, Adrian Wyss and Jan-]kke Gustafsson

L. Martini, R. C. Melcangi and R. Maggi

Z. Q. Ma, G. P. Bondiolottt, M. Olusmu, E. Vioinni, C. Patrone, G. B. Picot//and A. Mnggt

173 The ontogeny of gene expression of progestin receptors in the female rat brain

183 Brain mineralocorticoid receptor diversity: functional implications

191 Regulation of cytochrome P450 in the central nervous system

195 Androgen and progesterone metabolism in the central and peripheral nervous system

207 Estrogen modulation of catecholamine synthesis and monoamine oxidase A activity in the human neuroblastoma cell line SK-ER3

List of Contents V

Adrenal Steroids: New Developments Related to Hypertension

Jiirg Maner and Maja Oertle 213 Separate induction of the two isozymes of cytochrome P-450H~ in rat adrenal zona glomerulosa cells

S U B J E C T I N D E X

Adrenal glomerulosa cells separate induction of the two isozymes of cytochrome P450.p in, 213

Androgen(s) receptor(s)

characterization of two point mutations in the, gene of patients with perineoscrotal hypospadia, 127

Antiestrogen(s) are breast tumours resistant to tamoxifen also resistant to pure, ?, 107

Brain functional implications of, mineralocorticoid receptor diversity, 183 ontogeny of gene expression of progestin receptor in the, of female rat, 173

Breast cancer are, turnouts resistant to tamoxifen also resistant to pure antioestrogens?, 107 mechanisms for tamoxifen resistance in, 83

Breast cancer cells mechanism of synergistic action on all-trans- or 9-cis-retinoic acid and interferons in, 123

Breast epithelium cyclin gene expression and growth control in normal and neoplastic human, 99

fl-Casein gene promoter, transcription of, in mammary gland, 21

Catecholamine estrogen modulation of, synthesis in the human neuroblastoma cell line SK-ER3, 207

Central nervous system androgen and progesterone metabolism in, 195 regulation of cytochrome P450 in, 191

Chromatin modulates transcription factor binding to the MMTV promoter, 1

Cyclin gene expression and growth control in normal and neoplastic human breast epithelium, 99

Cytochrome P450 regulation of, in the central nervous system, 191 separate induction of the two isozymes of, in rat adrenal zona glomerulosa cells, 213

Decidualization direct effect of gonadotropins on, of human endometrial stromal cells, 115

Endometrial stromal cells direct effect of gonadotropins on decidualization of human, 115

Estradiol regulation of secretory component: expression by rat uterine epithelial cells, 143

Estrogen(s) modulation by, of catecholamine synthesis and monoamine oxidase A activity in the human

neuroblastoma cell line SK-ER3, 207 receptor(s)

hormone binding and transcription activation by, in mammalian and yeast systems, 39 role of, in the feedback regulation of follicle-stimulating hormone secretion in the female rat,

161

VII

VIII Subject Index

Fatty acids Xenopus peroxisome proliferator activated receptors: genomic organization, response element

recognition, heterodimer formation with RXR and activation by, 65 Fetal adrenal(s)

regulation of expression of the 3fl-hydroxysteroid dehydrogenases of human, 151 Follicle-stimulating hormone

role of estrogen in the feedback regulation of, secretion in the female rat, 161

Gene(s) androgen receptor, in patients with perincoscrotal hypospadia, 127 cyclin, expression and growth control in normal and neoplastic human breast epithelium, 99 milk protein, glucocorticoid receptor binding sites in the promoter region of, 75 transcription of the fl-casein, is enhanced by activated mammary gland specific nuclear factor,

21 Glucocorticoid(s)

receptor(s) ATP-dependent cycling and hormone-dependent hyperphosphorylation of, 31 binding sites in the promoter region of milk protein genes, 75 conversion of, to high affinity nuclear binding and transcription enhancement activity in

Chinese hamster ovary cells, 55 expression of the mouse, and its role during development, 49 structure and function of, 11

Gonadotropin(s) direct effect of, on decidualization of human endometrial stromal cells, 115

Growth factor(s) androgen-induced, and its receptor in mouse mammary carcinoma cells, 91

3fl-Hydroxysteroid dehydrogenase regulation of expression of, in human placenta and fetal adrenal, 151

Interferon(s) mechanism of synergistic action ofall-trans- or 9-cis-retinoic acid and, in breast cancer cells, 123

Mammary cancer cell(s) androgen-induced growth factor and its receptor in, of mouse, 91

Mineralocorticoid(s) receptor(s)

functional implications of brain, diversity, 183 MMTV promoter

chromatin modulates transcription factor binding to, 1

Perineoscrotal hypospadia characterization of two point mutations in the androgen receptor geiae of patients with, 127

Peripherous nervous system androgen and progesterone metabolism in, 195

Placenta regulation of expression of the 3/~-hydroxysteroid dehydrogenases of human, 151

Progestin(s) receptor(s)

ontogeny of expression of, in the female rat brain, 173 Prostate cancer

hormonal regulation of TGFfl-2 expression in human, 137 Protein 2

sterol carrier: a role in steroid hormone synthesis?, 167

Subject Index IX

Receptor(s) androgen(s)

characterization of two point mutations in the, gene of patients with perineoscrotal hypospadia, 127

estrogen(s) hormone binding and transcription activation by, in mammalian and yeast systems, 39

glucocorticoid(s) ATP-dependent cycling and hormone-dependent hyperphosphorylation of, 31 binding sites in the promoter region of milk protein genes, 75 conversion of, to high affinity nuclear binding and transcription enhancement activity in

Chinese hamster ovary cells, 55 expression of the mouse, and its role during development, 49 structure and function of, 11

mineralocorticoid(s) functional implications of brain, diversity, 183

progestin(s) ontogeny of expression of, in the female rat brain, 173

Retinoic acid mechanism of synergistic action ofall-trans- or 9-cis-, and interferons in breast cancer cells, 123

mRNA of 3fl-hydroxysteroid dehydrogenases in human placenta and fetal adrenal, 151 of mouse glucocorticoid receptor and its role during development, 49 of progestin receptors: ontogeny of expression of, in the female rat brain, 173

Steroid hormone synthesis role of sterol carrier protein 2 in, 167

Tamoxifen are breast tumours resistant to, also resistant to pure antioestrogens?, 107 mechanisms for, resistance in breast cancer, 83

Transforming growth factor fl-2 hormonal regulation of, expression in human prostate cancer, 137

Uterine epithelial cells estradiol regulation of secretory component: expression by, of the rat, 143

AUTHOR INDEX

Alml6f T., 11

Bartsch G., 127 Bartsch J., 1 Batzi C., 161 Beato M., I van den Berg D. T. W. M., 183 Bhardwaj B., 39 Bhatnagar A. S., 161 Billheimer J. T., 167 Blendy J. A., 49 Bodwell J. E., 31 Bondiolotti G. P., 207

Cairns C., 75 Carey M. P., 183 Carlstedt-Duke J., 11 Cato A. C. B., 127 Chang Y. J., 167 Cole T. J., 49

Dahlman-Wrisht K., 11 Daxenbichler G., 123 Denninger A., 127 Doody K. M., 151 Doppler W., 75 Dreyer C., 65

Eberle J., 127

Fang H., 39 Furth E. E., 167

Glatzl J., 127 Groner B., 21 Gurpide E., 115 Gustafsson J.-A., I 1, 75, 191

van Haarst A. D., 183 Hache R. S. G., 1 Happ B., 21 Hashimoto K., 91 H/iusler A., 161 Head J. R., 151 Hirata S., 173 Hornsby C. D., 183 Hu J.-M., 31 Hu L-M., 31

InceB. A., 39

Kasayama S., 91 Kaspar F., 127 Kato J., 173 Katzenellenbogen B. S., 39 Kaushic C., 143 Keller H., 65 Kishimoto T., 91 Klein H., 137 Klocker H., 127 de Kloet E. R., 183 Knabbe C., 137 Koga M., 91 Kouhara H., 91 Krey G., 65

Li H., 55

Ma Z. Q., 207 Maggi A., 207 Maggi R., 195 Mahfoudi A., 65 Marth C., 123 Martini L., 195 Mason J. I., 151 Matsumoto K., 91 McEwan I. J., 11 Medin J., 65 Meijer O. C., 183 Melcangi R. C., 195 Milewich L., 151 Mouri N., 173 Mfiller J., 213 Munck A., 31 Musgrove E. A., 99

Nagai K., 151 Naville D., 151 Nogu6s V., 161 Nozawa A., 173

Oertle M., 213 Ohba T., 167 Oitzl M. S., 183 Olasmaa M., 207 Orti E., 31 Osborne C. K., 83 Ozato K., 65

Pakdel F., 39 Patrone C., 207

Pfeifer S.M., 167 PhilippS., 75 PicotfiG. B., 207

RadmayrC., 127 RaineyW. E., 151 Ralph M. M., 151 ReeseJ. C., 39 Renne~H., 167 Richardson J., 143 Rots N. Y., 183

Saito H., 91 Sakuragi N., 167 S~nchez E. R., 55 Sato B., 91 Schmid W., 49 Schodin D., 39 Schfitz G., 49 Shen P., 55 Str~hle U., 49 Strauss III J. F., 167 Str6mstedt M., 191 Sumitani S., 91 Sutanto W., 183 Sutherland R. L., 99

Tanaka A., 91 Tang B., I15 Truss M., 1

Ushijima K., 151

Violani E., 207 Voigt K. D., 137

Wahli W., 65 Wakeling A. E., 107 Warner M., 191 Watts C. K. W., 99 WeRe T., 75 Widschwendter M., 123 Wira C. R., 143 W~nn C. K., 39 Wright A. P. H., 11 Wyss A., 191

Xie Z.-J., 55

Zilliacus J., 11 Zugmaier G., 137

XI